Peripheral neuropathy

Question 1

Presentation

Answer 1

Shiny, dry skin with hair loss
Ulcers and calloses on the soles
Charcot joints
Distal wasting and weakness
Depressed reflexes
Bilateral sensory loss in a stocking distribution
Sensory ataxia
Pseudoathetosis

Question 2

Small or large fibre?

Answer 2

Small - pain, temperature, autonomic
Large - vibration and proprioception

Question 3

Causes of sensorimotor neuropathy?

Answer 3

Alcohol
Diabetes
Hypothyroidism
Uraemia
Sarcoidosis
Vasculitis
Paraneoplastic
CIDP
GBS
HSMN

Question 4

Causes of motor neuropathy

Answer 4

Porphyria
Lead
Diphtheria
CIDP/GBS
Myotonic dystrophy
Inclusion body myositis

Question 5

Causes of sensory neuropathy

Answer 5

Alcohol
Diabetes
Hypothyroidism
Uraemia
Sarcoidosis
Vasculitis
Paraneoplastic
Vit B12 deficiency
Amyloidosis
Infections
Drugs

Question 6

Causes of autonomic neuropathy

Answer 6

GBS
Botulism
Porphyria
Paraneoplastic
Diabetes

Question 7

Causes of demyelinating polyneuropathies

Answer 7

CIDP
MM
MGUS
HMSN

Question 8

Drugs causing sensory neuropathy

Answer 8

Isoniazid
Metronidazole
Hydralazine
Flecanide

Question 9

Drugs causing motor neuropathy

Answer 9

Dapsone

Question 10

Drugs causing sensorimotor neuropathy

Answer 10

Vincristine
Vinblastine
Cisplatin
Nitrofurantoin
Amiodarone
Gold