Myaesthenia gravis Flashcards
1
Q
Presentation
A
Bilateral fatiguable ptosis - worse on up gaze
Variable strabismus and diplopia
Bilateral facial muscle weakness
WEakness of the neck muscles
Weak voice with nasal twang
Proximal weakness with fatiguability
2
Q
Pathophysiology
A
Autoimmune disorder against nicotinic AChR
3
Q
Investigations
A
Anti-nAChR
Anti MuSK
4
Q
Drugs exacerbating MG
A
Penicillamine, aminoglycosides, fluoroquinolones, macrolides, beta blockers, calcium channel blockers, lithium, phenytoin
5
Q
Lambert Eaton myaesthenic syndrome
A
Paraneoplastic
Attacks pre-synaptic voltage gated calcium channels
6
Q
Management
A
Anticholinesterase - pyridostigmine
Steroids
Steroid sparing agents - azathioprine, ciclosporin
7
Q
Thymectomy?
A
Can result in medication free remission
