MS Flashcards
1
Q
Common plaque sites
A
- Optic nerve - optic atrophy, RAPD
- Brainstem - INO, facial sensory loss, facial weakness, diplopia
- Cerebellum - ataxia, dysarthria
- Spinal cord - pyramidal weakness
- Spinal cord dorsal columns - loss of vibration and proprioception, L’hermitte’s sign, pseudoathetosis
2
Q
Pathophysiology
A
idiopathic demyelinating disorder - demyelinating plaques separated in space and time
3
Q
Types
A
Relapsing-remitting
Secondary progression
Primary progressive
Progressive-relapsing
4
Q
L-hermitted sign
A
Neck flexion -> electric shock like feeling down the arms and legs - MS, cervical myelopathy, subacute combined degeneration of the cord
5
Q
Uhtoff’s phenomenom
A
Raised body temperature –> exacerbation of symptoms
6
Q
Investigations
A
MRI - T2 hyperintense lesions
CSF - oligoclonal bands
7
Q
Treatment
A
Acute attacks - methylpred
Prevent relapses - interferon beta, glatirimer acetate, natalizumab
Symptomatic management
