Peripheral And Central Sensitisation

Question 1

How can hypersensitivity be a good thing and a hindrance?

Answer 1

Good- protect and preserve, AIDS healing and repair

Bad- chronic conditions in which pain doesn’t resolve

Question 2

Define allodynia and hyperalgesia

Answer 2

Allodynia- pain in response to normally innocuous stimulus

Hyperalgesia- pain in response to a noxious stimuli with exaggerated response

Question 3

What is peripheral sensitisation?

Answer 3

Nociceptor activation threshold lowered as nociceptor starts firing more and more and this is experienced as pain

Question 4

What is central sensitisation?

Answer 4

Spinal cord Neurons changed so that they show increased responsiveness to peripheral input

Question 5

How do nociceptors Fire a response?

Answer 5

Express receptors which recognise factors this leads to depolarisation and activation of threshold causing excitation

Question 6

What is ASICs?

Answer 6

Acid sensitive ion channels

Question 7

What are P2X receptors?

Answer 7

Ligand gated ion channels

Question 8

For nociception is the threshold of activation high?

Answer 8

Yes