Neuronal Pain Pathway

Question 1

What is the structure of the nociceptor?

Answer 1

Pseudounipolar Neuron with peripheral and central axon

Question 2

Which channels detect the noxious stimuli?

Answer 2

Cation

Question 3

What is TRPV1 a receptor for, how many transmembranes make the pore, how many subunits is it made of and what is it permeable to?

Answer 3

Capsaicin
6
4
Sodium and calcium

Question 4

What channels generate the action potential?

Answer 4

Voltage gated sodium channels

Question 5

Which voltage gated sodium channels are sensitive and insensitive to tetrodotoxin?

Answer 5

Sensitive- Nav - 1.1, 1.6,1.7

Non - 1.8, 1.9

Question 6

What nerve fibres are nociceptors and proprioception made from?

Answer 6

N -A delta and C fibres

P - A beta

Question 7

What is the main excitatory transmitter released from the nociceptor and what facilitates its release?

Answer 7

Glutamate

Voltage gated calcium channels facilitate release

Question 8

What receptor does glutamate primarily bind to after release and what channel does it bind to?

Answer 8

AMPA

Ligand gated

Question 9

What other glutamate receptors are there?

Answer 9

NMDA
kainate
Metabotropic

Question 10

What is the neural physiological process of encoding and processing noxious stimuli?

Answer 10

Nociception