Arachidonic Acid Metabolism And NSAIDs Flashcards
1
Q
What catalyses the cleavage of phospholipids into arachidonic acid?
A
cPLA2
2
Q
What facilitates membrane binding in cPLA2?
A
Calcium
3
Q
What converts arachidonic acid into prostaglandins?
A
Prostaglandin H2 synthase simply called COX thoooo
4
Q
What do both isoforms of COX contain
A
Homodimers
Haem group
AA channel
5
Q
Where are PGs synthesised and how are they transported?
A
Inside the cell
Via ABC transporters
6
Q
When should Coxibs and NSAIDs be used?
A
Coxibs- in GI
NSAIDs - CV risk
7
Q
What is cox responsible for?
A
For one step conversion of membrane phospholipids into prostanoids
