Medicinal Chemistry Of Opioid Analgesics Flashcards
1
Q
Which OH group is important for analgesic activity?
A
The one attached to the third carbon
2
Q
What is the pro drug for morphine?
A
Codeine
3
Q
What are the two natural opioids produced by the body?
A
Endorphins
Enkephalins
4
Q
What drugs are more likely to cross the BBB?
A
Lipophilic drugs such as 6-acetylmorphine and heroin rather than polar morphine
