Perio and Systemic Health Flashcards
The ________ reaction cascade is a mechanism by which periodontitis could potentially influence systemic disease (which gives some truth to the Focal Infection Concept).
acute-phase
What is the “focal infection concept?”
spread of bacteria from the oral cavity causes many chronic diseases
What 3 problems were found with the Focal Infection Concept?
- extracting teeth didn’t necessarily cure disease
- People with good oral health/no infection still developed systemic disease
- People with no teeth still developed systemic disease
What are the steps involved in an Acute-Phase Reaction cascade?
Triggering factors –> Local Reaction –> Mediators(cytokines) –> Secondary Systemic Reaction
Infection, necrosis, radiation, neoplasia, and surgery are all examples of ______ in the Acute-Phase Reaction Cascade.
Triggering Factors
Macrophages, Fibroblasts, and endothelial cells are ______ factors in the Acute-Phase Reaction.
Local Reaction
Mediators of the Acute-Phase Reaction Cascade involve the production/release of _______ _______ such as TNFalpha, IL-1, IL-6, and IFNgamma.
inflammatory cytokines
Fever, serum, complement, and alternative synthesis of proteins describe the ________ phase of the Acute-Phase Reaction Cascade.
Secondary Systemic Reaction
What are the five important “acute phase proteins?”
- Complement components (lysis, chemotaxis, opsonize)
- Protease Inhibitors (alpha1 macroglobulin)
- C-reactive Protein (opsonization)
- Fibrinogen (coagulation, chemotaxis)
- Plasminogen (breaks down clots)
In addition to complement components, which Acute-Phase protein is involved in chemotaxis?
fibrinogen
How does periodontitis result in systemic exposure to bacteria and inflammatory cytokines?
- Periodontal pockets = LARGE SURFACE AREA exposed to gram negative bacteria
- infection results in INCREASED INFLAMMATION
What are the seven conditions that define a risk factor?
- Consistency of _____
- Strength of _______
- Correct _______
- Specificity of ______
- Degree of ______
- Biological ______
- Support from ________
- consistency of association
- strength of association
- correct time sequence
- specificity of association
- degree of exposure
- biological plausibility
- support from experimental evidence
True or False: The potential factor relating periodontitis must precede the occurrence of systemic disease, it cannot be coincident.
True
What are the four systemic diseases that are associated with periodontitis?
- Atherosclerotic Vascular Disease
- Adverse Pregnancy Outcomes (low birth weight)
- Diabetic complications
- Respiratory complications (pneumonia, COPD)
What are the three layers that are present in healthy elastic arteries?
intima
media
adventitia