Gingival Diseases 2 Flashcards
True or False: When gingival lesions are of systemic origin, controlling plaque has no effect because it is not the cause of inflammation.
False: although it is NOT the cause, plaque makes the lesions worse
Gingival lesions of systemic origin include _______ disorders such as: lichen planus, pemphigoid, pemphigus vulgaris, erythema multiforme, lupus erythematosus.
mucocutaneous
_______ _______ is a mucocutaneous disorder of which oral involvement alone is common and for which there are characteristic Wickham Striae.
Lichen Planus
What are Wickham Striae?
lesions that are red with projecting web-like white lines
True or False: Lichen planus is rare in children.
True
What are the various clinical appearances of Lichen Planus?
- Papular
- Reticular
- Plaque-like
- Atrophic
- Ulcerative
- Bullous
True or False: Lichen Planus can occur on any area of the oral mucosa.
True
Atrophic and Ulcerative lesions are usually associated with _____.
Pain
____ is a large blister or skin vesicle filled with fluid.
Bulla
What does “reticular” mean?
meshlike, in the form of a network
Sometimes if a biopsy is taken for the lichen planus, nothing will be seen. What is the test that should be done (labeling of specific proteins)?
immunohistochemistry
What are “oral lichenoid lesions”?
a mucocutaneous disorder of uncertain background, that could be associated with dental restoration contact, medication reactions, or systemic disease (such as liver disease)
How is lichen planus differentiated from oral lichenoid lesions?
Oral immunohistochemistry:
- heavy accumulation of CD4 and CD8 at the basement membrane for Lichen Planus
A group of disorders in which autoantibodies toward components of the basement membrane results in detachment of epithelium from the connective tissue. This definition describes?
Pemphigoid
True or False: Complement-mediated cell destructive processes may be involved in the pathogenesis of pemphigoid disorders.
True
For pemphigoid disorders, autoantibody reactions occur against _______ and _______ components.
hemidesmosome
lamina lucida
What is the Nicholsky sign?
removal of epithelium that occurs after rubbing of the gingiva and creation of a bulla; associated with pemphigoid disorders (ie. disorders in which autoantibodies result in detachment of epithelium)
What are the three manifestations of pemphigoid disorders?
- bullous
- benign mucous membrane
- cicatricial (scar formation)
Pemphigoid disorders are associated with deposits of C3, Ig___ and other _____.
G
antibodies
When pemphigoid lesions are suspected, which other body part should you inspect?
the eyes, scars can cause blindness
What is pemphigus vulgaris?
formation of intraepithelial bullae in the skin and mucous membranes; like a “pimple at the basal membrane”
- strong genetic background (Jewish/mediterranean)
- Painful desquamative lesions
- Recurrent bullae, chronic course
- middle age and ederly most common
- acantholysis = clearing of CT
Clearing of connective tissue is also known as ________ and is associated with pemphigus vulgaris.
acantholysis
What is erythema multiforme?
vesiculobullous disease affecting both mucous membranes and skin
- red skin lesions
- swollen lips with crust formation
- bullae rupture and leave ulcers
- sometime recurrent
- Characteristic: iris appearance + bullae
- occurs at any age but mostly young
Extensive Necrosis (of eyes, skin, genitals, and mouth) associated with Erythema multiforme is known as _____ syndrome.
Stevens-Johnson