Pericardium 1.29.18 Flashcards
Pericarditis differential diagnosis
- STEMI, NSTEMI
- pulmonary embolism
- heart failure
- pericardial effusion
- cardiac tamponade
- aortic dissection
- pneumothorax
- GERD
- Musculoskeletal pain/costochondritis
Name the layers of pericardium superficial to deep
- Fibrous pericardium
- serous layer
a. Parietal pericardium
~~~~pericardial fluid ~~~
b. Visceral pericardium
Pericardial cavity usually contains how much plasma ultrafiltrate?
15-50mL (about a shot glass worth)
Dressler’s syndrome
Post-cardiac injury immune response targeting the pericardium
What is the most common disorder of the pericardium?
Acute pericarditis
When is the peak time you might see acute pericarditis?
spring and fall (coincides with viral illnesses)
Acute pericarditis is often either idiopathic or viral infection. Which are two of the most likely viral offenders?
- Coxsackie virus B
2. Influenza
What is the main presenting symptoms in more than 95% of patients with acute pericarditis?
- Chest pain, improves with leaning forward
- radiation to the trapezius ridge is specific
worse with coughing, inspiration, lying flat
What is a highly specific physical exam finding for Acute pericarditis?
pericardial friction rub (scratchy, squeaky quality)
-Loudest at left sternal border
What is the most important ECG change in acute pericarditis?
Diffuse ST elevation!
-PR depression is highly specific but often overlooked
What will ECG acute pericarditis in stage 1 look like?
diffuse ST elevation and PR depression
What will ECG of acute pericarditis in stage 2 look like?
normalization of ST and PR
What will ECG of acute pericarditis in stage 3 look like?
diffuse, deep T wave inversions
What will ECG of acute pericarditis in stage 4 look like?
normalization
Name 3 differences between acute pericarditis and STEMI ECG
- ST elevation is diffuse
- ST is concave up
- No reciprocal changes
Using echocardiography what might you find if effusion present?
“swinging heart”
When should pericardiocentesis be peformed
if patient is not responding to medical therapy or if hemodynamic compromise
When should a biopsy be considered in pericarditis?
- illness lasting more than 3 weeks
- recurrent
What may labs look like in acute pericarditis?
- Elevated troponin
- CRP
- ESR
- WBC
If needing further workup and patient is not improving, what labs would you get (pericarditis)
- ANA
- Rheumatoid factor
- TB test
- HIV
- malignancy workup
What are the (4) diagnostic criteria of pericarditis? How many of these are needed to diagnose?
- Typical chest pain (sharp, pleuritic, improved with sitting up and leaning forward)
- Pericardial frictino rub
- Characteristic ECG changes (diffuse ST elevation)
- New/worsening pericardial effusion
NEED 2 OF THESE
High risk patients need to be admitted for pericarditis. Name some risk factors
*anticoagulants (may develop hemorrhagic effusion!)
- Trauma
- Fever
- Immunocompromised
Name 3 overal treatment goals for pericarditis
- Pain relief
- Resolve inflammation
- Prevent recurrence
What medication(s) is/are used to managed pericarditis?
NSAIDS +/- colchicine
When do you use glucocorticoids for pericarditis and why isn’t it first line treatment?
- used if NSAIDS are contraindicated
- glucocorticoids associated with higher recurrence rates