Movement Disorders 4.8.18 Flashcards
What is the most common movement disorder
Essential tremor
What are the two risk factors for essential tremor
- Age
2. Genetics
Alternating or synchronous contractions of antagonistic muscles?
Essential tremor
What is the first line treatment for essential tremor?
Propranolol
also can do Primidone, or Alprazolam
Early signs of PD
- Depression
- Constipation
- Micrographia
- resting “pill rolling” tremor**
What is the test for confirming PD?
Acute dopaminergic challenge test–> clinical improvement after one hour (+)
What is the most common cause of secondary parkinsonism?
Neuroleptics: dopamine blocking drugs
Does secondary parkinsonism respond well to levodopa?
NO
UK Brain Bank Criteria
- Resting tremor
- Asymmetrical
- good response to levadopa
What repeat is associated with HD and which chromosome is is located on?
CAG repeat >40 on the end of the HD gene
-Chromosome 4
What are the 3 defining symptoms of HD?
- Behavioral (ie irritable, aggressive)
- Chorea*
- Dementia (ie memory)
Important physical exam findings for HD?
- restless
- quick involuntary hand movements
- Brisk deep tendon reflexes**
What is 1st line treatment for restless leg syndrome?
Dopamine Agonists: Pramipexole or Ropinorole
Name 5 diagnostic criteria for restless leg syndrome
- Urge to move legs due to uncomfortable sensations
- Begin while at rest
- Relief with movement
- Worse at night
- Not caused by something else
What blood test is important to get with restless leg syndrome?
Ferretin (can be the cause of RLS if <75)
