peptic ulcer disease and GORD drugs

Question 1

what is Magnesium trisilicate

Answer 1

an antacid

Question 2

what does Aluminum hydroxide bind, aaaand

Answer 2

bile acids and growth factors and delivers growth factors to injured mucosa

Question 3

what do antacids promote

Answer 3

angiogenesis

Question 4

what do antacids inhibit

Answer 4

peptic activity

Question 5

what do heavy metals suppress

Answer 5

H pylori

Question 6

competitive H2 receptor antagonist example

Answer 6

ranitidine

Question 7

ranitidine target

Answer 7

Histamine H2 receptor in gastric parietal cell

Question 8

what does ranitidine binding do

Answer 8

reduces stimulation of gastric acid secretion

Question 9

when to give ranitidine

Answer 9

GORD; Peptic Ulcer Disease; Dyspepsia

Question 10

common ranitidine side effects

Answer 10

Diarrhoea, Headache, Dizziness

Question 11

bad ranitidine side effects

Answer 11

Gynaecomastia, impotence

Question 12

which H2 receptor antagonist causes impotence

Answer 12

cimetidine

Question 13

when not to give ranitidine

Answer 13

pregnancy

hepatic/renal impairment

Question 14

why be cautious about giving ranitidine

Answer 14

it may mask the symptoms of malignancy

Question 15

important thing about ranitidine apart from impotence

Answer 15

Cimetidine is a cytochrome P450 inhibitor = avoid in patients stablised on warfarin, theophylline and phenytoin

Question 16

what drug is better than ranitidine

Answer 16

PPIs

Question 17

omeprazole class

Answer 17

PPI

Question 18

omeprazole target

Answer 18

H+ K+ ATPase pump at the secretory surface of gastric parietal cells

Question 19

what does omeprazole do to help

Answer 19

stops H getting into the stomach

Question 20

when to give PPI

Answer 20

gastric and duodenal ulcers
Prevention and treatment of NSAID-associated ulcers  
Helicobacter pylori eradicaton
(GORD)  
Zollinger-Ellison syndrome

Question 21

when to give a lower dose of PPI

Answer 21

hepatic impairment

Question 22

important side effects of omeprazole

Answer 22

Hepatitis
Interstitial nephritis
Blood disorders – leucopenia, leucocytosis, pancytopenia, thrombocytopenia,
Increased risk of C dif

Question 23

when to be cautious about starting PPI

Answer 23

mask cancer

Question 24

what do some PPI do to warfarin

Answer 24

increase anticoagulant effect

Question 25

what do some PPIs do to clopidogrel

Answer 25

reduce antiplatelet effect