malnutrition Flashcards
link between coeliac and which HLA
DQ2 and DQ8
what is the thing in coelica
α-gliadin
what is α-gliadin
peptide
where do you find α-gliadin
food containing gluten
how does coeliac disease work
Gliadin is passes through damaged epithelial barrier where it is deaminated and interacts with APCs in the lamina propria via HLA DQ2 and DQ8 and activates gluten-sensitive T cells = inflammation
where does gliadin enter the body
small intestine
what is the gliadin deaminated by
tissue transglutaminase
typical histological features of coeliac
villous atrophy and crypt hyperplasia
investigations of coeliac disease
Serum antibodies
Distal duodenal biopsies
Blood count
Bone densitometry
what serum antibodies are found in coeliac disease
IgA tissue transglutaminase
commonest cause of villous atrophy
coeliac
common findings on coeliac blood count
folate deficiency
iron deficiency
why is Bone densitometry done in coeliac
increased risk of osteoporosis
management of coeliac disease
gluten free diet
vitamin supplements
pneumococcal vaccine
why is Pneumococcal vaccine given for coeliac
coeliac disease is associated
with hyposplenism
