Peptic ulcer disease

Question 1

what is the definition of ‘peptic ulcer disease’

Answer 1

1. includes both gastric and duodenal ulceration

2. ulcer is a break in the mucous membrane as a result of chronic inflammation and damage to tissue

Question 2

3 major clinical features of PUD?

Answer 2

1. dyspepsia - reflux and epigastric pain
2. weightloss + anorexia + anaemia
3. haematemesis

Question 3

4 major causes of PUD?

Answer 3

1. Hpylori infection
2. NSAID
3. Smoking
4. Stress

Question 4

Pathogenesis of h-pylori infection causing PUD?

Answer 4

1. h. pylori produces urease which converts urea to ammonia
2. ammonia lowers gastric ph
   increased gastric acid production results in damage

Question 5

Name 3 major clinical features?

Answer 5

1. dyspepsia - reflux and epigastric pain
2. weightloss, anorexia and anaemia
3. haematemesis - if ulcer perforates