gastric cancer

Question 1

What is the most common type of gastric cancer?

Answer 1

gastric adenocarcinoma

Question 2

What are the two types of gastric adenocarcinoma and how do they differ?

Answer 2

1. Intestinal -
   - well differentiated
   - h - pylori induced
   - better prognosis
2. Diffuse
   - poorly differentiated

• genetic cause
• Younger patients

Question 3

Name some aetiological factors causing Gastric ca?

Answer 3

1. diet
2. h.pylori
3. smoking
4. gastric polyps/FAP

Question 4

What is the disease course of Gastric ca?

Answer 4

1. chronic gastritis
2. atrophy
3. metaplasia
4. premalignant dysplasia
5. malignancy

Question 5

What is the difference in histology in intestinal vs diffuse?

Answer 5

1. intestinal -
   - mimics intestinal epithelium
   - glandular
2. diffuse -
   - signet cell morphology
   - increased mucous production

Question 6

Name 4 main symptoms of gastric cancer?

Answer 6

1. history of recent dyspepsia
2. loss of appetite
3. weight loss
4. vomiting and nausea

Question 7

Name 4 signs likely to be seen in a patient with gastric ca?

Answer 7

1. epigastric mass
2. ascites / hepatosplenomegaly
3. Virchow’s node - swelling of supraclavicular lymphadenopathy indicate gastric ca