Peptic Ulcer Disease Flashcards
1
Q
Difference between erosion and ulcer
A
peptic ulcer is >5mm and extends to the submucosa
2
Q
What are duodenal ulcers most commonly associated with?
A
H.Pylori
3
Q
What are gastic ulcers most commonly associated with?
A
NSAIDs
4
Q
Pathophysiology of h.pylori assocated ulcers
A
Hypersecretion of gastric acid related to microbe
=imparied secretion of somatostatin so more gastrin release
=acidic environment
5
Q
Pathophysiology of NSAID associated ulcers
A
Results from an imbalance between damaging factors:
- gastric juices
- H. pylori
- NSAIDs
and defense mechanisms:
- mucous layer
- integrity of cell junctions
6
Q
RFs for duodenal ulcers
A
Increased age Smoking NSAIDs H. pylori \+FMHx Alcohol
7
Q
RFs for gastric ulcers
A
H. pylori Smoking Drugs Delayed gastric disease Stress
8
Q
Difference in presentation of types of ulcers
A
Both present with epigastric pain Duo: relieved by eating food Duo: pain before meals and at night Gas: worse on eating gas: wt. loss
9
Q
Mx of PUD
A
conservative: wt. loss, reduce rf’s
medical: PPI, h. Pylori eradication
