Peptic Ulcer Disease Flashcards
Peptic Ulcer Disease types?
- Gastric
2. Duodenal
Gastric PUD Etiology?
H pylori infection (70%);
NSAIDs;
seen in older patients
Duodenal PUD Etiology?
H pylori infection;
seen in younger patients and
in patients with blood group O
PUD development also associated with?
chronic gastritis,
smoking,
Zollinger- Ellison syndrome, hyperparathyroidism,
MEN type I
Gastric PUD pathogenesis?
arises because of decreased mucosal protection against gastric acid
- Motility defects
- Mucosal ischemia
- Mucosal inflammation
Duodenal PUD pathogenesis?
arises because of increased gastric acid and pepsin secretion in combination with decreased mucosal protection.
Gastric PUD gross fx?
Mucosal defect with clean, punched-out margins occurring in antral and prepyloric regions
Duodenal PUD gross fx?
Mucosal defect with clean, punched-out margins occurring in duodenum (usually the first part)
Gastric PUD histo fx?
Varies depending on stage of ulcer;
active ulcers demonstrate:
necrotic fibrinoid debris
neutrophilic infiltrate
granulation tissue
Duodenal PUD histo fx?
Varies depending on stage of ulcer;
active ulcers demonstrate:
necrotic fibrinoid debris
neutrophilic infiltrate
granulation tissue
hypertrophy of Brunner glands
Gastric PUD clinical signs?
Epigastric pain greater with meals; weight loss
Duodenal PUD clinical signs?
Epigastric pain decreases with meals; weight gain.
Gastric PUD Lab findings?
decreased H+ secretion,
increased gastrin levels
Duodenal PUD Lab findings?
increased H+ secretion
Peptic Ulcer Disease Complications?
GI bleed, perforation, and obstruction
