Gastrinoma

Question 1

Gastrinoma causes?

Answer 1

Zollinger-Ellison Syndrome

Question 2

What is Gastrinoma?

Answer 2

pancreatic islet cell tumor

Question 3

Gastrinoma etiology?

Answer 3

most gastrinomas are sporadic, but 25% are associated with MEN I

Question 4

Gastrinoma pathogenesis?

Answer 4

1. May arise in the pancreas or duodenum or in tissues surrounding pancreas; often
   malignant and metastasize to the liver but, histologically: rarely show anaplasia
2. secrete gastrin causing acid hypersecretion, leading to peptic
   ulcers and pancreatic enzyme inactivation

Question 5

Gastrinoma clinical signs?

Answer 5

Peptic ulcer disease (usually in duodenum) often complicated by ulcer perforation;

diarrhea,

steatorrhea,

weight loss (caused by pancreatic enzyme inactivation)

Question 6

Gastrinoma Lab findings?

Answer 6

Increased gastrin levels, decreased gastric pH

Question 7

Gastrinoma Treatment?

Answer 7

Surgical removal of gastrinoma; control of gastric acid secretion with proton pump inhibitors

Question 8

What is Insulinoma?

Answer 8

tumor of the islet cells of the pancreas that is characterized by increased secretion
of insulin and increased C-peptide (molecule that is cleaved from proinsulin during insulin synthesis)
levels

Question 9

Insulinoma associated with?

Answer 9

Whipple triad

1. episodic hyperinsulinemia and hypoglycemia,
2. hypoglycemic CNS dysfunction,
3. reversal of CNS dysfunction upon resolution of hypoglycemia