Colorectal Carcinoma

Question 1

Colorectal Adenocarcinoma etiology?

Answer 1

Risk Factors:
adenomatous polyps,

long-standing ulcerative colitis,

low-fiber diet,

old age,

Epidemiology positive family history,

hereditary nonpolyposis colorectal cancer (HNPCC),

familial adenomatous polyposis (FAP)

Question 2

Colorectal Adenocarcinoma Epidemiology?

Answer 2

Most commonly occurs between the ages of 60 and 80

Question 3

Colorectal Adenocarcinoma gross fx?

Answer 3

Appearance varies from:
1. polypoid mass (proximal colon) to

2. lesions with ulcerated centers and irregular margins that circumscribe bowel (distal colon)

Question 4

Colorectal Adenocarcinoma histo fx?

Answer 4

1. Dysplastic columnar cells in glandular formation;
2. may produce mucin,
3. some tumors may be anaplastic

Question 5

Colorectal Adenocarcinoma clinical signs?

Answer 5

Can be asymptomatic;

if symptomatic, presents with:
pallor, 
weight loss, 
intermittent diarrhea, 
LLQ pain 
obstruction

Question 6

Colorectal Adenocarcinoma Lab findings?

Answer 6

Positive stool guaiac test;

increased serum CEA;

microcytic, hypochromic anemia (iron deficiency anemia secondary to GI bleed)

Question 7

Colorectal Adenocarcinoma Treatment?

Answer 7

Surgical resection;

chemotherapy (5-FU)