Gastric Cancer Flashcards
Gastric Carcinoma Etiology?
Risk factors:
Helicobacter pylori chronic gastritis, dietary nitrosamines cigarette smoking excessive sodium intake Barrett esophagus
Gastric Carcinoma Epidemiology?
More common in men > 50 years of age and in patients with blood group A
Gastric Carcinoma types?
- Intestinal type
2. Diffuse type
Intestinal type gross fx?
Lesion with irregular necrotic base and heaped-up margins
Usually located in the lesser curvature or the antrum or prepyloric region
Exophytic growth or excavated growth
Intestinal type histo fx?
Intestinal histological morphology
Glandular formation of mucin-producing cells
Diffuse type gross fx?
infiltrative process with flat/depressed growth
producing rigid stomach wall (linitis plastica or leather
bottle stomach)
Diffuse type histo fx?
clusters of gastric-type mucous cells (signet-ring cells) within gastric wall
Involves CDH1 mutation (encodes E-cadherin)
Gastric Carcinoma metastasizes to?
early, aggressive, local metastasis to the lymph nodes and liver
Gastric Carcinoma clinical signs?
no specific symptoms: anorexia, weight loss, vomiting, and gnawing epigastric pain not relieved by antacids
Insidious clinical course: remains asymptomatic until late in its course
Gastric Carcinoma lab findings?
Hypochromic microcytic anemia
Gastric Carcinoma treatment?
Surgical resection
How is Virchow node related to Gastric carcinoma?
Virchow node is involvement of the left supraclavicular node by metastasis of stomach or other GI cancer
How is Krukenberg tumor related to Gastric carcinoma?
Krukenberg tumor is bilateral metastasis of GI (usually stomach) cancer to ovaries.
Histologically, the tumor has abundant mucus and signet-ring cells.
How is Acanthosis nigricans related to Gastric carcinoma?
Acanthosis nigricans refers to hyperpigmentation and epidermal thickening of the flexural areas.
Suggestive of a visceral malignancy, including cancer of the stomach, lung, breast, or uterus.
