Peptic Ulcer Disease

Question 0

What are the common places to find a peptic ulcer?

Answer 0

• Duodenal cap

- Lesser curvature of stomach

Question 1

Define peptic ulcer disease.

Answer 1

A break in superficial epithelial cells penetrating down to the muscularis mucosa layer.

Question 2

What are the causes of peptic ulcer disease?

Answer 2

• Use of NSAIDs

- H. pylori infection

Question 3

What are the symptoms of PUD?

Answer 3

• Recurrent epigastric pain (May subside with antacids)
• Nausea/ vomiting
• Haematemesis
• Persistent severe pain suggests penetration of ulcer into other organs
• Back pain suggests penetrating posterior ulcer

Question 4

Symptoms specific to a duodenal ulcer

Answer 4

Pain is worse at night and when hungry. Relieved on eating.

Question 5

Symptoms specific to a gastric ulcer.

Answer 5

Weight loss and anorexia.

Question 6

What investigations would you carry out?

Answer 6

• Investigate H. pylori infection

- Endoscopy to exclude cancer