Peptic Ulcer

Question 0

Aluminium hydroxide

Magnesium hydroxide

Answer 0

Constipation

Diarrhoea

Over the count antacid

Release mild heartburn

Question 1

H.pylori

Answer 1

UFAMAV

Adenocarcinoma

Grastritis

Question 2

Cimetidine

Answer 2

Anti-acid

H2 antagonist

For: Gastroesophageal reflux disease, stress related mucosal bleeding, peptic ulcer

Con: drug interaction, inhibit 450 and reduce oxidative drug metabolism e.g. Theophylline

Question 3

Omeprazole

Answer 3

Anti-acid

Parton pump inhibitor

Inhibit gastric H K ATPase

For: stress related mucosal bleeding, GERD

SE: may increase GI infection

Question 4

Eradication

Answer 4

Omeprazole,

Amoxicillin ( bacterial wall) Clarithromycin (inhibit acid secretion)

Question 5

Misoprostol

Answer 5

Prostaglandin E1 analogue

EP agonist, stimulate mucus and bicarbonate secretion and enhance mucosal blood flow

Inhibit cAMP, reduce gastric acid secretion

For: NSAID induced ulcer

SE: diarrhoea, cramping abdominal pain, stimulate uterine contraction

Question 6

Pirenzepine

Answer 6

Limited use