Anti- Inflammatory

Question 0

Thromboxane

Answer 0

Platelet aggregation

Vasoconstriction

Question 1

Prostaglandin

Answer 1

Vasodilation
vascular permeability
oedema
Sensitive nocireptice fibres to stimulation by other inflammatory mediators

Question 2

Prostaglacyclin

Answer 2

Inhibit platelet aggregation and vasodilation

Question 3

Leukotriene

Answer 3

Increase vascular permeability

Promote leukocyte chemotaxis

Question 4

COX1

Answer 4

Skipl

Question 5

Aspirin

Answer 5

Non selective inhibitor

Inhibit cox
Inhibit platelet aggregation
Anti platelet in cardiovascular disorder

Question 6

Ibuprofen

Answer 6

Non selective NSAIDs

Reversible COX inhibitors

For mild to moderate pain

SE: GIT

Question 7

Rofecoxib

Answer 7

COX2 inhibitors

Fewer GIT side effects

No cardioprotective effect

Question 8

Paracetamol

Answer 8

Analgesic, antipyretic, little anti inflammatory

Reversible non competitive inhibitor

COX2

Hepatotoxicity: NAPBQI

Antidote: NAC

Question 9

Diclofenac/ ketorolac

Answer 9

Topical opthalmic

Corneal abrasion, ocular inflammation

Question 10

Betamethasone

Answer 10

Glucocorticoid

Bronchial asthma
Rheumatoid arthritis
Inflammatory bowel condition
Inflammatory skin condition

Anti inflammatory: inhibitor arachidonic acid by synthesising lipocortin, inhibit prostaglandins and leukotrienes

Immunosuppressant: Tam pani 
T cell suppression 
Antibody produced
Antigen processed
Monocytes
Neutrophils
Phagocytosis 
IL2

SE: CG DB WIB
Cushing syndrome
Growth suppression
Diabetes
Bone metabolism 
Wound healing impaired
Immune system suppressed

Question 11

DMARD

Answer 11

Gold salts

Hold joint damage

Question 12

Infliximab

Answer 12

Anti cytokines

Target TNF-a

Question 13

Basiliximab

Answer 13

Monoclonal antibodies against a chain of IL2 receptor

Question 14

Cetirizine

Answer 14

H1 receptor antagonist

Allergic: hay fever, insect bites, drug hypersensitivity, antiemetic, sedation