Cholinergic

Question 0

Tropicamide

Answer 0

M3 antagonist

Mydriatic

Question 1

Atropine

Answer 1

M2, 3 antagonist

Aaabm

Anaesthetic: reduce mucus secretion

Antidote

Bradycardia( resuscitation)

Anti spasmodic and diarrhoea

Mydriatic

Question 2

Carbachol

Answer 2

M3 agonist

Stimulate M receptor on ciliary muscle and sphincter pupillae

For glaucoma, miosis during cataract surgery

Con: acute iritis

SE: ciliary spasm, temporary decrease of visual acuity

Question 3

Pilocarpine

Answer 3

M3 agonist

Stimulate SM contraction and gland secretion

For: Dry mouth, glaucoma, CF

Question 4

Bethanechol

Answer 4

M3 agonist

Urinary retention result from anaesthetic, delivering a baby.

Question 5

M agonist

Answer 5

Con: asthma, peptic ulcer, coronary insufficiency, hyperthyroidism, intestinal obstruction

SE: sweating, salivation, bronchospasm, bradycardia, hypotension, diarrhoea, ciliary spasms and miosis

Question 6

Oxybutynin: Tolterodine

Answer 6

M3 antagonist

Inhibit micturition

Urinary incontinence

Question 7

Ipratropium

Answer 7

M3 antagonist

Asthma

Onset action slow

Used in combination with a short acting B2 agonist

Question 8

Pirenzepine

Answer 8

M1 antagonist

Peptic ulcer

Question 9

M antagonist

Answer 9

Retention of urine
Blurred vision 
Dry mouth 
Hyperthermia
CNS excitation if cross BBB

Question 10

Vareniclline

Answer 10

N partial

Agonist: alleviate symptoms of craving and withdrawal

Antagonist: blocking the rewarding and reinforcing effects of smoking

Question 11

Hexamethonium

Answer 11

Ganglionic blocker

For hypertensive

Question 12

Trimethaphan

Answer 12

Ganglionic blocker

For hypertensive

Question 13

Vecuronium

Answer 13

NMJ blocker

Non depolarising
Competitive antagonist

For relaxing muscle during surgery

Question 14

Succinylcholine

Answer 14

NMJ agonist

Depolarising

Imitate ACh

Hydrolysis by plasma cholinesterase

For: skeletal muscle relaxant during emergency intubation

SE: apnea, bradycardia, hyperkalemia

Question 15

Botox

Answer 15

Neurotoxin

Block exocytosis of Ach

Release light chain, breaking SNARE protein, vesicles can’t fuse

For lazy eye, overacting bladder

Question 16

Neostigmine

Answer 16

AChE inhibitors

Medium duration

For reversing neuromuscular junction blockage, urinary retention, myasthenia gravis ( pyridostigmine)