Adrenergic Drugs

Question 0

Isoprenaline

Answer 0

B agonist

Increase strength and rate of the heart contraction. Relax bronchial SM, several muscle vasculature and GI tract

Tachycardia, hypotension, flushing, headache

IV

Question 1

Sulbutamol/ Terbutaline

Salmeterol ( long acting)

Answer 1

B2 agonist

Relaxation of Bronchial SM, blood vessel. Decrease duration of skeletal muscle contraction and increase glycolysis and glycogenolysis

Hypotension,Flushing, skeletal muscle tremor, tachycardia( palpitation), disturb carbs metabolism

Over use leads to tolerance, drug interaction with B blocker, correct use of anti inflammatory min use of B agonist, banned during competition

Oral or IV

Question 2

Dobutamine

Answer 2

B1 agonist

Increase the tone of the heart contraction.

Tachycardia, increase or decrease blood pressure

Question 3

Metoprolol

Answer 3

B1 antagonist

Reduce in heart rate, renin release, reduction in cardiac output. Oxygenation is improved.

For hypertension

Con: hypotension, heart failure

SE: cardiac failure, at high dose: hypoglycaemia, bronchospasm

Question 4

Propranolol

Answer 4

B antagonist

Reduce heart rate, renin release. Reduce cardiac output. Myocardium better oxygenated.

Contract Bronchial SM. Decrease insulin level

For hypertension, glaucoma

Con: hypotension, asthma, hypoglycaemia

SE: cardiac failure, bradycardia, hypoglycaemia, bronchospasm

Question 5

Phenylephrine

Answer 5

A1 agonist

Vasoconstriction: Redistribute local blood flow.

For nasal congestion.

Con: antidepressant, cardiac condition

SE: hypertension, tachycardia

Question 6

Clonidine

Answer 6

A2 antagonist

Inhibit release of NorAdr, decrease blood pressure and heart rate.

For: hypertension (not anymore!!!), glaucoma, menopausal flushing

Con: bradyarrhythmia

SE: dizziness, dry mouth

Question 7

Prazosin

Answer 7

A1 antagonist

Inhibit vasoconstriction, decrease in total peripheral resistance, inhibit SM contraction.

For hypertension, prostatic hyperplasia, raynauld’s disease.

Con: hypotension

SE: hypotension, blurred vision, nasal congestion, tachycardia, priapism

Question 8

Tamsulosin

Answer 8

A1a

Inhibit SM contraction. Relaxation of prostate SM

For: prostatic hyperplasia

Con: hypotension

SE: abnormal ejaculation ( dopamine and serotonin)