pemphigus vulgaris Flashcards
1
Q
symptoms
A
blistering pruritic rash
affects upper and lower limbs
history- ulcers/blisters in mouth, any recent meds, any recent insect bites?
2
Q
differentials
A
pemphigoid
fixed drug eruption
insect bites
3
Q
nikolsky’s sign
A
sliding pressure is applied to the edge of the lesion which will cause the epidermis to break away
4
Q
treatment of pemphigus vulgaris
A
corticosteroids
immunosupresants- azathioprine
IV immunoglboulins
rituximab
5
Q
pathophysiology
A
an autoimmune disorder caused by an antibody to desmoglzins 1 and 3 in the epidermis.
