Pelvic mass Flashcards

1
Q

6-8 weeks

AMENORRHOEA - sexually active
lower ABDO pain –>
later develops vaginal BLEEDING ?dark

?Shoulder tip pain and
?cervical excitation

Ix? Imaging?

What criteria would you base management of ectopic on?
_________

5-day POST-PARTUM
-neonate bleeding gums
-neonate bleed from umbilical wound
NO FHx of bleed dx…

ddx?
_________

Preg:

ACEi ?
Cocaine ?
Valproate/Carbemaz = ?
-? MOST teratogenic
\_\_\_\_\_\_\_
Phenytoin = ?Syndrome
-? MOST teratogenic
Warfarin courmarins = ?
Thalidomide - ? 
\_\_\_\_\_\_\_
Di-Ethyl-Stil-BESTROL @mum = ?
Isotret = ?
Misoprostol = ?
\_\_\_\_\_\_\_
Downs - ?
Noonan = ?
William = ?
Turners = ?
DiGeorge = ?
\_\_\_\_\_\_\_
MIFEPRISTONE ONLY USED IN WHAT BASTARD?!

Miscarriage Tx?

When do Med/Surg Mx?

(remember miscarriage = WMVE, abortion =
MMSE 9 13 15)
___________

Abortion tx < 24w
9 13 15 
MM SE
DS 
DE

(Remember
miscarriage WMVE,
Abortion MMSE 9 13 15)
_______

ovarian FIGO

  1. inside ovary
  2. outside ovary i.e. @pelvis
  3. abdomen
  4. distant mets
A

Ectopic pregnancy

  • hcg/preg test
  • TVUSS!!!!!!!!!!!!
  • HCG
    1. <1500
    2. >1500

HBeat

  1. -none
  2. -visible
  3. <35mm / Unruptured
  4. > 35mm / Ruptured
  5. WW2d / MTX
  6. Salpingectomy/Salpingostomy
    ___________

Hemorrhagic Dx of Newborn
-Vit K def
_________

Preg:

ACEi = iuGR, iuRenal-Insuff, Oligohydramnios

Cocaine = Small brain, Limb dx, Urine-tract dx

  • mum = PreEcl / Pl.Abruption
  • kid = Prem / Abstinence-syndrome

Valproate/Carbemaz = NTDs
-valproate MOST teratogenic
-heart dx
______

Phenytoin = Hydantoin Syndrome = craniofacial dx
-valproate MOST teratogenic

Warfarin courmarins = skeletal dx

Thalidomide - limb dx
______

Di-Ethyl-Stil-BESTROL @mum
-vaginal adenocarcinoma in kid 14 yrs later

Isotret
-CNS/Cranio-Facial/Cardiac dx

Misoprostol = Moebius Syndrome
-cranial nerve dx

_______

Downs 21 - AVSD
Noonan = Pul Stenosis
William 7 = Supravalvular Aortic Stenosis
Turner 45XO = Coarcation
DiGeorge 22q11 = Truncal dx = TOF/TGA/PulAtr-VSD
_____

MIFEProgRecepBlocker ONLY USED IN Abortion BASTARD

MISCARRIAGE: WMVE

WMVE

WW < 2w

  • (d/c with f/u in ? week)
  • BYPASS WW –> straight to Med/Surg Mx @:
  • -Haemorrhage (late T1/blood dx)
  • -Infection
  • -Prev preg dx

MED:
Vag MMMisoProstaGlandin - > Ut Contract
-Moebius Synd= Cranial Nerve dx

SURG:
OP: VVVacuum Asp Suction Curettage
IP: Theatre EEEEEvacuation

_____________
ABORTION: MMSE

< 9 w: MM
0hrs: MifeProg-ReceptorBlocker

48 hours: MisoProstaGlandin=

  • stim ut contract
  • Moebius Synd= Cranial Nerve dx

< 13 w: DS
Surg dilation + Suction

> 15-24 weeks: DE
Surg dilation and Evac
medical abortion = ‘mini-labour’

> 24 - ILLEGAL MURDERRRRRRRRR
_____

ovarian FIGO

  1. inside ovary
  2. outside ovary i.e. @pelvis
  3. abdomen
  4. distant mets
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2
Q

Storage syx? ax?

Void syx? ax?

Noct Polyuria ax?

Stress Incontinence Ax? Tx?
-Relax, Retain, Awareness-decrease, Produce?

Stress Incontinence Tx?
-Refer when?

Urge Incont?

-PSymp -> bladder contract -> piss
–AntiMuscs = block Musc Receptor,
hence
stop PS -> retain

Botox = stop Ach release from Pre-Synap neurone

A
STORAGE FUNDHS-COUNTS: 
Freq Urg Noct Dys Haemat Suprapub:
-CANCER
-Overactive
-UTI/STI
-Neuro
-TInfection - UTI/STI
-Stones
VOID/Rentention = SHWD-CANS: 
Strain/Hesitancy/WeakStream/Dribble-postmic:
-CANCER/BPH
-Antimusc/Opiods
-Neuropathy
-SSC: 
stricture-stones-constipation/ 
stone-sloughed-papillae-clotsVTE

Noct Polyuria - NERD

  • Endocrine (HyperCalc/DM-DI/Addison)
  • Renal dx
  • Drugs: CCB/SSRI
Stress Incontinence: DIP
Drugs/Injury/Prostatectomy
-Relax - alpha blockers
-Retain - SympathoMimetics/AntiMuscs/Opiods
-Awareness -reduce - Benzos
-Production

Stress incont tx:

  1. ACES
  2. Kegel 3m - - > ArupBCD

Alco/Caff/Fizzy
Constipation ALLOW
Ex/Diet
Sweeteners/Smoke ALLOW

Kegel 3m - - > ArupBCD
-ARtificial sphincter 
-AUtologous rectus sling 
-APpliance sheath 
-Bulk/urethral slings 
-Catheter/Colposuppression 
-Diversion 
-->
Duloxetene 
-Refer if NOT had prostatectomy...

Urge Incont:

  • Bladder Retrain 1.5m
  • Oxybutinin/solefenacin/tolderodine
  • MiraBegron
  • Botox/ Cystoplasty
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3
Q

Pain=central abdomen –> localising to RIF
Anorexia
CRP + WCC high

Fever, Tachycardia

Sign: more pain in RIF than LIF when palpating LIF?
Sign: press in but pain mild -> let go -> THEN pain develops
___________

MID cycle pain.

  • sharp onset
  • mild SUPRA-pubic .

May have recurrent episodes.
Usually settles over 24-48 hours.
__________

FEVER;
dysuria / dyspareunia
Pelvic pain + vag discharge = ?SMELLY
-period irregular

Cervical excitation may be found on examination

Mycoplasma genitalium?

Gon high risk?
Gon low risk?
____________

abdominal pain, b/c/d 6 MONTHSSSSSSSSSSSSS
lethargy/ nausea,

BACKache and BLADDER-FUNDHS
__________

Rash - ?
Arthralgia
Serositis - MAPLe?
Haem - ?

Oral - ?
Renal - ?

PS?
ANA
IC - T? HSR
Neuro dx

  1. Ddx - inflammatory markers?
  2. AB v AutoAG = ImmComplexes
    - T?HSR
  3. Tx?
    - which legit in PREG?
  4. RUDEASH* DlE
    *TEACH
    ___________
Clots, 
Livido-Rash?, 
Obstetric cx - ? 
TCP/APTT ?
5. Ddx-antibodies?

ThromboProph Tx?
-APLS + NO prev VTE = ?

-APLS + Prev VTE = ?

-APLS + pregnancy =
? + ?(stop after w?)

  • APLS + Prev VTE WHILST on AC =
  • –? lifelong + ? lifelong
  • –? @Preg + ? lifelong

-APLS + ArtTE = ?

-INR ?-? @initial
-INR ?-? @ArtTE
-INR ?-? @recurrent
________

yellow/green
-strawberry cervix
-smelly 
Dx? Tx?
\_\_\_\_\_\_\_\_
Cda-Gcc
Chlamydia Tx?
Refer for:
-GUM
-Repeat infection @?/+y/o = high p(re-infection)
-Avoid sex till when?
-STD screen/ Safe sex
-Sex-abuse < ?yrs 

Gonorrhoea Tx:

  • UnCx:
  • anogenital gon = ?
  • anogenital/ pharyngeal gon + antimicrobial susceptibility known = ?
  • needle phobia = ?
  • Asyx = ?Ix ?/+w after ABx end
  • Syx = ?Ix ?/+d after ABx end

Syx men = C+T:

  • all partners < ?w
  • most recent partner if >?w

The rest i.e. Asyx men /Women
- C+T all partners < ?m
_____

A

appendicitis

Rovsing: more pain in RIF than LIF when palpating LIF
Blumberg Rebound Tenderness
_____________

Mittelschmerz
___________

Pelvic inflammatory disease
PID:

Mycoplasma genitalium
-moxifloxacin / ceftriax -> Azithro

Gon high risk = Ceftriax+Doxy+Metro
Gon low risk = Ceftriax/Oflox
________

IBS ABC!!!!!!!!!
ABDO PAIN
BCD
__________

Rash - malar/discoid
Arthralgia
Serositis - MAPLe
-Myocard/Alveolitis/Pericarditis/LibmanEndocarditis
Haem - ANT

Oral - NP ulcers
Renal - GNephritis

PhotoSensitivity
ANA
IC - T3 HSR
Neuro dx

  1. sl3
    S HIGH AF
    cRp~norm
  2. AB v AutoAG = ImmComplexes
    - T3HSR
3. Tx: 
HOH, mycophenolate
Mild: csteds
Mod: DMARDs
Severe, Ritux, Cyclophosphamide, Sted HD
-maintenance: NSAID, Azo, MTX, bElumimab
-lupus nephritis = ACEi @BP high

PREG: AZOTHIOPRINE

4.
RhF, U1 rnp, Ds-dna, Ena
Ana, Smith, Histone* @drugs
Ds-dna, low c3/4 -> high C3d/4d, Esr high-CRP~

*
TNFi-TB/cancer
Tetracyclines - mino
Epileptics - Phenytoin
AntiArryhtmics - Procainimide
Chlorpromazine
Hydralazine
\_\_\_\_\_\_\_\_\_\_\_\_\_\_
  1. APLS:
    - Cardiolipin/Coagulant
    - gp12b

Clots,
Livido-Retic,
Obstetric cx - miscarriage
TCP/APTT high paradoxical

ThromboProph Tx?
-APLS + NO prev VTE = Asp lifelong

-APLS + Prev VTE = Warf lifelong

-APLS + pregnancy =
Asp + LMWH(stop after w34)

  • APLS + Prev VTE WHILST on AC =
  • –Warf lifelong + Aspirin lifelong
  • –LMWH @Preg + Aspirin lifelong
  • APLS + ArtTE = Warf LIFElong
  • INR 2-3 @initial/ ArtTE
  • INR 3-4 @recurrent

ArtTE = Art ThromboEmbolism
___________

yellow/green
-strawberry cervix
-smelly
Dx? Trichomoniasis Tx? Metro

Chlamydia=
Doxy /Azithro
7d//////2d, respectively 
Refer for:
-GUM
-Repeat infection @25/+ y/o = high p(re-infection)
-Avoid sex after ABx end/Azithro +7d
-STD screen/ Safe sex
-Sex-abuse < 18yrs 

Gonorrhoea

  • UnCx:
  • anogenital gon = IM Ceft
  • anogenital/ pharyngeal gon + antimicrobial susceptibility known = Cipro
  • needle phobia = Cefix+Azithro
  • Asyx = NAAT 2/+w after ABx end
  • Syx = C+S 3/+d after ABx end

Syx men = C+T:

  • all partners < 2w
  • most recent partner if >2w

The rest i.e. Asyx men /Women
- C+T all partners <3m
_______

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4
Q

Breast cancer 2ww
__________

Ovarian cancer cancer 2ww guideline:
Ovarian Cancer Tx? 
All stages? 
Stagaes 2-4?  
\_\_\_\_\_\_\_\_\_\_

Endomet cancer 2ww:

Endomet Cancer Ix:
?scan -> ?biopsy
–inconclusive-biopsy–>
?ix + ?sampling (?d+c)

Endomet Cancer Tx:
-localised disease =
?surg –Hrisk–> post-op ?

Endomet Cancer Tx
@Frail elderly women + NOT suitable for surg ?

?Ix for PMB
__________________

Dyskaryosis - CIN:

When are smears done?

?test

  • strains?
  • ->
  1. HPV POS = ?
    + = ? (what’s positive cytology-wise?)
    - = ?
  2. HPV NEG = ?
  3. HPV inadequate?
    ___________

Old guideline
? /? = HPV test:
-POS = Colpo w
-NEG =?

CIN?/CIN? /? = Colpo w -> ?
Inadequate x? = Colpo w
Preg/PP12w = Colpo w -> ?

-Cerv cancer + St IA tumour + Gold standard tx =
?surg ± ? clearance

-Cerv cancer + St IA tumour + MAINTAIN FERTILITY =
?procedure 2 maintain fertility + ? margins

Cervi Cancer + stage IB /+ =
-? + ?

A

Breast Cancer Screen: 47-73=mamogram / 3yrs

LUMP:
30/+ lump 
50/+ unilat nipple d/c / syx
-Mass @Axillary 30/+
-Peau/ Skin changes in ANY age
FHx - DJCOMBS
Dx <40
JEWS
Childhood cancer
Ovarian cancer
Male BC / paternal fhx 2/+
B/L Breast cancer <50
Sarcoma <45

1 FDR/SDR w/ Ovarian Cancer
+
1FDR/SDR w/ Breast Cancer

2FDR/ 1FDR+1SDR = BC
3FDR/SDR = BC
__________

Ovarian cancer cancer 2ww guideline:

50/+ w/ 
Syx x12/m = LAIDS* -> 
CA125 - 35/+ -> 
USS-AP
-sinister = refer

-O/E Ascites / A-P mass = refer

*

  • LUTS -A-P pain -IBS syx
  • Distended -SATIETY

Ovarian Cancer Tx?
All stages = LaparoTOMY tumour excision
Stagaes 2-4 = Chemo
_______________

Endomet cancer 2ww:

-55/+ w/ …
PMB = 2ww

vag d/c / HUria
-HUria      -Hb low
-1st time
HIGH Plts/BM
--> TVUSS

Endomet Cancer Ix = TVUSS, Pipelle, Hystero+Sample
TVUSS -> Pipelle biopsy
–inconclusive–>
Hysteroscopy + directed sampling (dilation + curettage)

Endomet Cancer Tx @ localised disease =
TAH + B/L Sooph –Hrisk–> post-op RT

Endomet Cancer Tx
@Frail elderly women + NOT suitable for surg =
—Progestogen tx

Endometrial biopsy for PMB
_____________

Dyskaryosis:

When are smears done?

  • 25/+ / 3yrs
  • 50/+ / 5yrs
  • 65/+ ask

HPV high risk test
16 18 31 33
–>

1. HPV POS = Cytology:
\+ = Coloposcopy
-borderline
-mild = LG
-mod/severe = HG
-invasive/glandular 
  • = HPV @12m
    a. @+ = HPV @12m AGAIN -> @+ = Colpo / @- = d/c

b. @- = d/c

  1. HPV NEG = DTFU=DownToF***U
    -d/c unless
    -TOC path @6m
    -f/u @ incomp excision @borderline/
    CGIN-SMILE/CC
    -Untx CIN 1

3.
HPV inadequate:
- repeat <3m -> inadequate 2ice = COLPO

-Cerv cancer + St IA tumour + Gold standard tx =
TAH ± Node clearance

-Cerv cancer + St IA tumour + MAINTAIN FERTILITY =
Cone biopsy + Neg margins

Cervi Cancer + stage IB /+ =
-RT + Chemo
_______________

Old guideline
borderline/mild CIN 1 = HPV test:
-POS = Colpo <8w
-NEG = d/c - 25/+ /3yrs ; 50/+ /5yrs

CIN2/CIN3/invasive = Colpo <2w -> smear @6m=TOC
Inadequate x3 = Colpo <8w
Preg/PP12w = Colpo <2w -> smear @6m=TOC
_____________

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5
Q

3 innocent murmurs

PMS tx

a ?-generation COCP may be helpful
- ?‐containing COC taken cont/cyclical?

  • ?Antidepressant

Specific lifestyle changes to manage PMS:

  • ? hourly
  • ?size balanced meals
  • rich in ?

(Remeber ? diet @epileptic kids + ? @IBS)
__________________

Infertility in PCOS - clomifene V metformin - which one suprior?????
-NORMAL FSH
-NORMAL LH
-NORMAL Estradiol 
\_\_\_\_\_\_\_\_\_\_\_\_\_

Hyperemesis gravidarum, diagnostic criteria triad:

Tx?
Reassure < ?w = NORMAL / Rest
-Avoid ?
-B?
-Cold ?
-Drink=? +? # ?spice
-EMETIC -
1.  #anti-?
2. #5ht3-blocker # ?brain
-FLUIDS - Refer for ? @DEHYDRATION 

Scoring system in H.Gravidarum?
________

S1-2 sounds?
-Soft -Loud

Wide split ??

Paradox split??
Fixed split??

S4-3 sounds?

HTN fucking has S2 + S4 sound !!!!
____________

Causes of 1st and 2nd degree HB KIMBAD

Causes of 3rd degree complete HB i-FASC
____________

Pericardial rub - ??
Pleural rub - ??
Pericardial knock - ??
____________

Causes of LBBB

RBBB causes?
________

AD - long QT + NO sensorineural deafness

AR - long QT + sensorineural deafness

AD Asian men 
pseudoRBBB + 
ST elevation (downsloping mostly V1-3ish)
T-invert
Risk? Tx? Gene? 

Antiarryhtmics causing long QT?
Others?
Electrolytes?

? = Long QT + J waves
? = Short QT + J waves
_________

Aspirin

Clopidogrel

Enoxaparin/Fonda

Bivalirudin Reversible

Abciximab, eptifibatide, tirofiban ???

TxA2, ADP plt receptor, aAT3 stop f10a, DTi, gp2b3a blocker
_________

Soft, Systolic-ejection

  • Short , S1+2 ok, SymptomLESS,
  • Standing-Sitting varies w/ position

_______
1.
Short BUZZZZZ @Aorta, OR
Soft BLOWWW @Pul

  1. Continuous blowing = BELOW the clavicles
  2. Low-pitched sound @LLSE
A

3 innocent murmurs

PMS tx:

a NEW-generation COCP may be helpful

  • Dros-pire-none‐containing COC taken CONITNUOULSY?
  • SSRI

Specific lifestyle changes to manage PMS:

  • 2-3 hourly
  • small balanced meals
  • rich in COMPLEX carbohydrates

(Remeber Ketogenic diet @epileptic kids + FODMAP @IBS)

__________________

Infertility in PCOS - clomifene > metformin
-NORMAL FSH
-NORMAL LH
-NORMAL Estradiol 
\_\_\_\_\_\_\_\_\_\_\_\_\_
HGravidarum Triad = WED 
-WL 5% PRE-preg - large 4 dates uterus
-Electrolyte imbalance - ketones
-Dehydration 
(not the latter bits like large 4 dates/ketones - just there to help you remember features)
Tx:
Reassure < 20w = NORMAL / Rest
-Avoid triggers
-Biscuit
-Cold meals
-Drink=little +often #GINGER
-EMETIC - 
1. cyclizine/promethazine #anti-hist
2. Metoclop #dop-blocker/Ondan5HT3ron #5ht 3-blocker #medulla
-FLUIDS - Refer for IVF @DEHYDRATION 

Scoring system in H.Gravidarum?
-PUQE N+V score
_________

S1 = AV valves mitral/tricuspid closing
soft @Regurg
loud @MS

S2 = Aortic/pul closing 
soft @ASten
Loud @ 
-HTN, Hyperdymamic states,
-ASD-PulHtn

Wide s2-
delay RV empty
-(PS; PAH{MRegurg severe}; RBBB)

Paradox s2
-WPW-b, AS/LBBB, RVPacing, PDA

Fixed s2 - ASD

S4 = atria contract against STIFF ventricle
HOCM/HTN
ASten

S3 = diastolic filling of ventricle 
Const pericarditis - pericard knock, X+Y, X ✔️; 
Dilated CM, 
MRegug
NORMAL<30y

HTN fucking has S2 + S4 sound !!!!
____________

1st and 2nd degree:
K+low; IHD; myocarditis;
Beta-blockers; Athletes; Digoxin

3rd degree complete block:
iHD/ Fibrosis; AS; Surg/Trauma; Congen
____________

Pericardial rub - pericarditis
Pleural rub - pneumonia/PE
Pericardial knock - C. Pericarditis
____________

LBBB=CM, HTN, AS, IHD

RBBB=PE, ASD, Normal
_________

Romano Ward, KCN(Q1+H2) fucked K channels

Jervell Nielsen

Brugada = tachy-arrhythmias, sudden cardiac death. ICD!! Gene SCN5A mutation -> fucked Na Channel

Not FAPS

  • SSRI/TCA; APsych; Li
  • ABx = MACROLIDES
  • Low Mg K Ca/ Low Temp HypoThermia
  • Typ»»Atyp

HypoThermia = Long QT + J waves
HyperCalc = Short QT + J waves
________

Aspirin Antiplatelet -
inhibits thromboxane A2 production

Clopidogrel Antiplatelet -
inhibits ADP + plt receptor binding

Enox/fonda = Activates AT3 ->
-stop f8-12a

Bivalirudin Reversible DTi

Abciximab, eptifibatide, tirofiban
GP2b/3a receptor blockers
______

1-Ejections* - turb OUTFLOW tract

2-Venous - turb INFLOW venous tract

3- stiLLSe - LLSE low pitched
_________

*EJECTION:
Pulmonary=soft blowing/Aortic=short Buzzing
-Assoc w/Valsalva

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6
Q

Chronic CYCLICAL pelvic pain
Dysmenorrhoea/Dyspareunia-deep
Infertility

NOOOOOOOO MENORRHAGIA!!!!! DONT GET CONFUSED!!!!!

Dyschezia/Dysuria

Dx? Ix? gold-standard ix!?
Tx?
? used before Myomectomy!!
_________

Dyspareunia types?

A

Endometriosis NCG

Ultrasound- may show free fluid
LAPARASCOPY GOLD STANDRD

NSAID/Paracet
COCP/POP –> Refer
GnRH Ag / Lap Surg

Goserelin used before Myomectomy!!
__________

Dyspareunia

  • superficial
  • deep
  • orgasmic
  • post-coital
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7
Q

InterMenstrual Bleed Ax?
_______

Explain eisenmenger

Sx?

Ax?
____________

ASD:
-RBBB+RAD - Dx? Risk?
-RBBB+LAD - Dx?
___________

Man/Turner’s girl

  • HTN in arms
  • R-F delay
  • E-MSys @ LUSE through to BACK!!
  • CXR = notched ribs cos of?

Dx? Anatomy? HTN in which vessels?
_______

MITRAL AREA:

S3: Pansystolic = blowing high pitched ->
Radiate to AXILLA

Pansystolic + EMSyst click

Diastolic @Exp -> opening snap + Rumbling
_______

Collapsing pulse = ? 
Wide Pulse Pressure = ? 
Narrow Pulse Pressure = ? 
Slow-rising pulse
\_\_\_\_\_\_\_

Pansystolic @LLSE
- louder @insp #incrVenReturn #carcinoid
- harsh?
__________

_________

—EJECTION Mid-Systoic Murmurs
Andy:
-ASten/Sclerosis

Pandy:

  • Syst: innocent/ PS(carcinoid-noonan)/ ASD/ ToF/ HOCM
  • Diast: AR / PR
PDA = continous machine, wide/collapsing below clavicle
Coarctation = Turner, EMSyst to back 
Carcinoid = TR/PS

—PANSYSTOLIC murmurs
Teddy:
-Syst: TR carcinoid-ivdu / VSD harsh
-Diast: TSten

Me:
-Syst: MRegurg(high-pitch)/ MVP(EMS click)
-Diast: MSten(Rumbling)
_______

_________

—EJECTION Mid-Systoic Murmurs
Andy:
-ASten/Sclerosis

Pandy:

  • Syst: innocent/ PS(carcinoid-noonan)/ ASD/ ToF/ HOCM
  • Diast: AR / PR
PDA = continous machine, wide/collapsing below clavicle
Coarctation = Turner, EMSyst to back 
Carcinoid = TR/PS

—PANSYSTOLIC murmurs
Teddy:
-Syst: TR carcinoid-ivdu / VSD harsh
-Diast: TSten

Me:
-Syst: MRegurg(high-pitch)/ MVP(EMS click)
-Diast: MSten(Rumbling)
__________

Diastolic murmur @ LUSE
PR - ? murmur HighPitched
AR - ? Flint Murmur = Rumbling/Sit forward!!!

MADCAT PAQ

A

ectropion/polyps/cancer

COCP UNDERdosing = breathrough bleed
Depot / IuD / POP
________

If persists #uncorrected, you get:
L->R shunt -> PAH + RVH -> 
R->L shunt @Eisenmenger REVERSAL SHUNT--> 
-murmur = DISAPPEARS --> 
infant = CYANOTIC #not shocked

CCPP:

  • cyanosis clubbing
  • polycythemia PAH

Ax = VSD, ASD, PDA.
_____________

ASD:

RBBB+RAD = secundum dx
-EMBOLUS SHOOT OFF -> STROKE!!!!!!

RBBB+LAD = primum dx
-prime lad
__________

Coarctation
-Aorta NARROW near PDA -> 
-HTN in Bracioceph + LSubclavian 
-CXR = collats eroding ribs -> notched ribs
\_\_\_\_\_\_\_\_

MR
- Pansys blowing high pitched -> Axilla

MVP = Pansys + EMSyst click

MS
-opening snap + Rumbling
________

Collapsing pulse = AR/PDA/ Incr requirement
Wide Pulse Pressure = AR/PDA/ 3rdHB
-Narrow Pulse Pressure = ASten
-Slow-rising pulse = ASten
\_\_\_\_\_\_\_\_\_

Pansystolic @LLSE
- louder @insp #incrVenReturn=TR
- harsh=VSD
________

Diastolic murmur @ LUSE
PR - Graham Steel murmur HighPitched
AR - Austin Flint Rumbling/Sit forward

Musset nodding, Austin Flint, Dariosz Fem

Corrigan carotid, Traube PISTOL Fem

Pulse = collapsing/wide split;
Apex displaced;
Quincke nail bed hemorrhage

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8
Q
SUDDEN
UNI-LAT lower abdo pain
#RIF #LIF
  • Recent EXERCISE.
  • N+V

O/E: Unilat, tender adnexal mass

WCC NORMAL!!!!!!! SO NOT APPENDICITIS

Uss = ?sign
______________________

  • DULLache=intermittent @SEXX/exercise!!
  • Unilat
  • DysPAREunia
  • IF Large -> BLOAT / FUNDHS #bladder

Differentiate from other shit!!!

  • No menorrhagia/dysmenorrhoea = r/o?
  • No Adnexal tenderness.. = r/o?
  • No N+V.. = r/o?

Repeat USS when?
_______________________

Cancer likely in simple or complex cyst?

Common types of ovarian cysts?

Intermenstrual bleed Ax?
_____________

Woman going through

GnRH/hCG due to
IVF treatment….

Abdomen distended, abdo pain

Can eventually get Olig/Anuria, VTE, Ascites, ARDS…

A

Ovarian torsion
-sudden (unlike cyst)

Ultrasound- may show free fluid
LAPARASCOPY GOLD STANDRD

Uss = whirlpool sign
_________________

Ovarian cyst = RUPTURED
-dull-ache=intermittent (unlike torsion)

  • No menorrhagia(i.e. NOT fibroid) / dysmenorrhoea (i.e. NOT endometriosis!!!)
  • No Adnexal tenderness.. not PID/Ectopic
  • No N+V.. - not Preg/PID/Ectopic

Repeat USS = 8-12 weeks
__________________

Cancer @ complex cyst

FOLLICULAR > Corpus luteum

InterMenstrual Bleed =
-Ectopic/ Polyp/ Cancer
-COCP underdose breakthrough bleed / Depot / IuD - POP
____________

Ovarian hyperstimulation

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9
Q

Seen in OLDER women
Sensation of pressure, heaviness, ‘bearing-down’
Urinary symptoms: incontinence, frequency, urgency
________

PPHemorrhage tx
_________________________

Premature labour tx?

After W?
symphysis-fundal
height in cm = ??
________

Oligohydramnios definition
< ?ml @ T3
AFI < ?th centile
-Ax?

Shoulder dystocia tx?

A

UVP
_______

-BOE-CAB
Bimanual uterine compression
Oxytocin - stim ut contract
Ergotamine(
-5HT/Alpha-adr/Dop=vasc SM constrict -> reduce Uterus BF = less bleed)

Carboprost
Atony = Balloon tamponade
B-lynch UA/Iliac ligation/TAH
________________________

Premature labour:
Admit
Tocolytics and Steds

After W20, S-F height i=
-g.WEEKS +/- 2cm
_______

Oligohydramnios
< 500ml @ T3
AFI < 5th centile

Ax:
Renal agenesis / ACEi
IUGR
PROM/Pre-Ecl/Post-term>42w

Shoulder dystocia: MESZ
McRoberts’ - flexion and abduct
Episiotomy, Symphysiotomy,
Zavanelli / Rubin Wood’s Corkscrew

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10
Q

menorrhagia
infertility
pelvic pain/mass = bulky -> distended/distorted anatomy

?BLACK

  • bloating
  • cramping abdo pain @period
  • FUNDHS/pressure syx @larger ones

Ix? When to refer for fibroids?

Wtf is red degeneration? Worsened when?
_________________

Low p(CHAF) - Mx?

  • ?Bloods dx
  • ? @Submucosal fibroid/Polyp/Endomet dx
  • ? @fibroid,
  • ? @adenomyosis

Fibroid <3cm + ? / ? - Mx?

Fibroid >3cm - Mx?
-what can increase fibroid size?

Fibroid distorted + want contraception?

  • Risky @ ?
  • Rest = legit - ?

__________

PAIN + BLEED

  • Dysmenorrhoea
  • Menorrhagia

Enlarged, tender/boggy Uterus

Ix??

A

FIBROID
-A/PUSS + TVUSS

When to refer for fibroids?

  • Size >3cm/12cm
  • Comp syx
  • Infertility
  • Malignancy
  • Palpable

Wtf is red degeneration? Worsened when?
-growth > blood supply
-worse at preggers
_________________

Low p(cavity dx, histologic dx, adenomyosis, fibroid)
OR
Fibroid <3cm NOT distorted/Adenomyosis:

A) MIRENA iUS
-dct->

B)
NH = TXA/NSAID(mefenamic)
H = Combo/POP
-dct-> IPS

C)
1. Ix - 
-FBC/Bleed-clotting dx 
-Hysteroscope @Submucosal fibroid/Polyp/Endomet dx 
-USS-TA/TV @fibroid, 
-TVUSS @adenomyosis (MRI best on passmed..)
2. Pharm - NH/H
3. Surg:
-T-C Resection
-Hysterectomy yes
-EAblation 2ndary yes
-Myomectomy
-B/L Sooph
-UAEmbol
-MRI guided USS ablation 
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

Fibroid >3cm - Mx?

  • REFER + TXA/NSAID(mefenemic) -> IPS-HUM
  • HRT increases fibroid size

Fibroid distorted + want contraception?
-Risky @iUS/iUD
-Rest = legit - barrier/ sterilize/ combo-pop
____________

Adenomyosis

TVUSS > A/PUSS/MRI

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11
Q

Infertility

40+F 5m Hx of Amenorrhoea
Abdo mass!!!! Dx?

How long they gotta try for and how often sex?
-? % conceive @Y1
-? % conceive @Y2
________________

When to refer for infertility?
Mid-luteal Prog-d ??????????
S? - 2ndary*
C?/ C?- ?agonists

G?/ G? Pulsatile 
I-suv
S?
Tubal ?
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

When fail, how to Ix?
___________

@Endometriosis/Fibroid/adenomyosis, which surg is recommended for fertility??

  • Myomectomy
  • Endometrial ablation
  • Uterine artery embolisation
A

40+F 5m Hx of Amenorrhoea
Abdo mass!!!! Dx = PREGNANCY!!!!!!!

UPSI / 2-3days - 1 year
-84% conceive @Y1
-92% conceive @Y2
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
GAS MSC GIST:
Genital dx
Amenorrhoea/Varicocele
STI/Surg/Systemic dx
Women 36/+ yrs
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

MSC GIST:
d21 d21 d21 d21 d21 d21 d21 d21 d21 d21
-length of period - 7 !!!!!

Mid-luteal Prog-d21!!!
SHeeP-GOAT - 2ndary*/ Sperm count
Chlamydia/Clomifene-Dop agonists

Gonadotrophins/GnRH Pulsatile
ISCI-UInsem-IVF
Surg
Tubal patency

*Stress
HCG - preggers
Excess Exercise
Prolactin

Gonadotrophins - MP/POF;Asherman;PID;Sheehan
Oestradiol - MP/POF
Androgen - PCOS
TFT
\_\_\_\_\_\_\_\_\_\_\_\_

Myomectomy RETAIN lady’s fertility

Endometrial ablation destroys the endometrial lining, therefore meaning that an embryo would NOT implant.

Uterine artery embolisation is NOT RECOMMENDED if trying to conceive as it cuts down the blood supply to the uterus significantly, therefore meaning that the fetus would be unable to implant and grow.

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12
Q

Preg woman A/W with:
?sudden Abdo pain and Circ collapse
-evidence of rupture OR impending rupture

  • Preg sx - Gestation EVIDENCE #999
  • LMP 10wk i.e. AGES ago

Some vag DISCHARGE is common.

There is usually adnexal tenderness.

Dx?
-most useful next Ix = may demonstrate ????

Types:
?
-os ? #Light-Bleed
-ALIVE -others=?

?
-os ? #HEAVY-bleed

Missed
-os ?
-gestational sac is > ? mm and 
-no ?
#'? ovum' #'? pregnancy'

Incomplete

  • os ?
  • ? left

Complete

  • os ?
  • ? uterus

Miscarriage tx?

  • @WW, when d/c + f/u in ? week
  • BYPASS WW when?!
A

Dx: miscarriage
-TVUS which may demonstrate NO fetal heart

Threatened

  • os Closed #Light-Bleed
  • ALIVE -others=dead

Inevitable
-os open #HEAVY-bleed

Missed
-os Closed
-gestational sac is > 25 mm and 
-no embryonic/fetal part 
#'blighted ovum' #'anembryonic pregnancy'

Incomplete

  • os open
  • clots and material left

Complete
-os Closed
-empty uterus
________

WMVE

WW < 2w

  • (d/c with f/u in ? week)
  • BYPASS WW –> straight to Med/Surg Mx @:
  • -Haemorrhage (late T1/blood dx)
  • -Infection
  • -Prev preg dx

MisoProstGlandins - Moebius Synd
Vacuum Asp Suc Curettage - OP tx
Evac @Theatre - iP tx

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13
Q

PainLESS nodue @Thyroid
-cervical LNopathy
-YOUNG
____________

Solitary thyroid nodule
-Encapsulated

Invades vascular
___________

Calcitonin raised
-diarrhoea+flushing
-hard upper lobe
____________

OOOOLD woman
-dysphagia, hoarseness, SOBOE
-hard mass @unilateral lobe
-cervical LNopathy
\_\_\_\_\_\_\_\_\_\_

Parathyroid/Pit/Panc
-insulinoma gastrinoma

Parathyroid/pheochromocytoma
MED THYROID CANC

Pheochromocytoma
-Marfanoid - Neuroma
MED THRYOID CANC

A

Papillary cancer

  • –papillary projections
  • –pale empty nuclei
  • –NOT encapsulated

LN mets common
________

follicular adenoma

Follicular carcinoma
________

Medullary carcinoma
-Lymphatic and haematogenous metastasis
-Poor prognosis
_______

Anaplastic - ANNA the old woman

________

MEN 1

MEN 2a RET

Men 2b RET

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14
Q

leaking small amounts when coughing or laughing
_________

detrusor overactivity
__________

BPH -> bladder outlet obstruction #blocking!
-similar concept to constipation……

A

Stress incontinence
________

OAB/urge
__________

overflow incontinence

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15
Q

Urge Tx?
________

Codeine to PO morphine

PO morphine = to…

SC moprhine /?
OXYCOD PO /?

SC diamorphine /?
IV moprhine /?

OXYCOD SC /?

  • SP—SI–S
  • MO-DM-O
  • 22—33–4

Alcohol units?
-AST > ALT (ratio usually> 2:1)
-toAST
________

Monoplegia -?
Hemiplegia -?
Quadriplegic -?
-Paraplegia -?

ACA–MCA–PCA*

*PCA - midbrain Weber
________________

Amaurosis fugax - which vessel?
Locked in syndrome - which vessel?
__________

  • Absent < – > horizontal eye-move
  • Miosis
  • Paralysis=Quadriplegia
  • Same FACE: PD/PT (paralysis/deaf // pain/temp)
  • Opp limb
  • Nystagmus
  • Ataxia
  • Same FACE: PD/PT (pain/temp)
  • Opp limb
  • Nystagmus
  • Ataxia

__________

  • Unilat sensory/motor FAL
  • Cog dx - VisuoSpatial/Dysphasia
  • HomoHNopia
1 of:
-Sensory
-AtaxicHemiParesis
-Motor
PURELY + HTN

CN dx + CONTRALAR motor/sensory dx
Conjugate EYE dx
CEREbellar dx - ataxia/nystag/vertigo
HomoHNopia

4-6-4 H:
CN4 present?
CN3 present?
CN6 present?

________

Nystagmus: central v peripheral?
-B/?
-Assoc with ? syx
-Direction = ? / purely ?
\_\_\_\_\_\_
Brainstem Death:
C? unknown Ax
R? ax excluded
S? X
E? fine
B? stim -> no cough
Response to ? / ?
? Reflex absent
? Reflex absent
Disconnect ventilator 5-mins -> ?

_________

Delirium > Dementia
________

?vessel lesions (dominant side - i.e. most ppl are ?-handed so ?-sided MCA fucked):

Lesion -> SPEECH = FLUENT  
sentences that make Sense
-Repetition = FUCKED
-AWARE of Errors making 
Comprehension is NORM 
Lesion -> SPEECH = FLUENT 
sentences that make NO Sense
-word substitution / neologisms  #word-salad
Comprehension FUCKED
Repetition NORM 
Lesion -> SPEECH = NON-FLUENT
sentences that make Sense
-Laboured + Halting 
-Repetition = FUCKED
Comprehension NORM 
\_\_\_\_\_\_\_\_\_\_
-Can't read/calculate/recognise #RCR
alexia(cant read)
acalculia(can't calculate)
finger agnosia (can't to recognize objects)
-RIGHT-LEFT disorientation 
-?

? involuntary, irregular, non-rhythmic movements of UNILATERAL side of the body

? involuntary, flinging, violent movements of UNILATERAL side of the body
_______

PONV -?
@Medulla
______________

ICP high
Motion-labrynthine / MECH Bowel Obst
Preg
?

RT/Cancer = ?
_______________

?=CYTOTOXICS=?

  • ?=cannabinoid
  • ?-NK1 blocker

Opiod -?
________________

OCDMPH:
Ondan5HTron - 5HeroTotinin3 blocker
-medulla

CycliZINE - antihistaMINE
-ZINES - promethazine NOT prochlorperazine
FOR HIGH ICP!!!!!!!!!!!

DopBlockr: 
Domp = NOT cross BBB so can use in Parkinson's
MetocloProkinetic
Prochlorperazine
Haloperidol - METABOLIC stuff ?highCa/RF

Funct - metoclop / Mech - Cyclizine

A

Alco/Caff/Fizzy
Constipation ALLOW
Ex/Diet
Sweeteners/Smoke ALLOW

Bladder retrain 1.5m
Oxybutinin/tolterodine #AMusc
Mirabegron
Botox/Cystoplasty
\_\_\_\_\_\_\_\_\_

Codeine to PO morphine /10

PO morphine = to…

SC moprhine /2
OXYCOD PO /2

SC diamorphine/3
IV moprhine /3

OXYCOD SC /4

Alcohol units = %.mls / 1000
-make a toAST with alcohol > ALT. 2>1

_________

Monoplegia - 1 limb
Hemiplegia - Unilat 2 limbs
Quadriplegic - 4 limbs
-Paraplegia - Bilat LOWER limbs

ACA MCA PCA*
L>UL ; UL>L

< – HemiParesis
……..Aphasia – > Agnosia
……..Sensory
….HomoHAnopia – > Mac-Sparing

*PCA - Weber Midbrain
-Same CN3, opp HemiParesis
-Agnosia
-Macular sparing HomoHNopia
________________

Amaurosis fugax - Retinal/Ophthalmic Artery
Locked in syndrome - Basilar Artery
____________

Pontine bleed: PAMP

  • Absent < – > horizontal eye-move
  • Miosis
  • Paralysis=Quadriplegia

AICA: Lat Pont

  • Same FACE: PD/PT
  • ——(paralysis/deaf // pain/temp)
  • Opp limb
  • Nystagmus
  • Ataxia

PICA: Lat Med Wallenburg

  • Same FACE: PD/PT (pain/temp)
  • Opp limb
  • Nystagmus
  • Ataxia

______________

Anterior Circulation Stroke:

3=TotalACS
2=PartialACS
-UCH

  • Unilat sensory/motor FAL
  • Cog dx - VisuoSpatial/Dysphasia
  • HomoHNopia
LacACS = L-SAMP 
1 of:
-Sensory
-AtaxicHemiParesis
-Motor
PURELY + HTN

POstCS
_________

4-6-4 H:
CN4 vertical nystagmus
CN3 Ptosis, Dilated, Vertical nystagmus
CN6 horizontal nystagmus

Nystagmus: Central v Periph:
central is:

  • B/L
  • Assoc sens/motor dx
  • Direction = multi / purely uni or rotatory
Brainstem Death:
Coma unknown Ax
Reversible ax excluded
Sedation X
Electrolytes fine
Bronchial stim -> no cough
Response to sound/Supra-Orb Pressure
Occ-Vestib Reflex absent
Corneal Reflex absent
Disconnect ventilator 5-mins -> no resp support
\_\_\_\_\_\_\_

-Emotions = fear, agitation
-Fluct Syx = worse @night, normal periods
-GCS impaired
-Hallucinations/Illusions/Delusions #perception
_________
MCA lesions (dominant side - i.e. most ppl are right-handed so left-sided MCA fucked):

Conduction aphasia

  • Arcuate Fasciculus
  • Fluent + Sense + Comp NORM
  • Repetition fucked

Wernicke Receptive

  • SUP Temp gyrus
  • Fluent + NO Sense + Comp FUCKED
  • Repetition NORM
Broca Expressive
-INF Frontal gyrus
-NON-Fluent + Sense + Comp NORM
-Repetition fucked 
\_\_\_\_\_\_\_\_\_\_

alexia, acalculia, finger agnosia
RIGHT-LEFT disorientation
-Gerstman’s

hemichorea: involuntary, irregular, non-rhythmic movements of one side of the body

hemiBALLismus: involuntary, flinging, violent movements of one side of the body

PONV - Ondan5HT3/Ginger
@Medulla
______________

ICP high
Motion-labrynthine / MECH Bowel Obst
Preg
-AntiHist > DopBlock

RT/Cancer = DopBlock
_______________

Ondan5HT=CYTOTOXICS=DopBlock

  • Nabilone=cannabinoid
  • Rolapitant-NK1 blocker

Opiod - OCD
-Ondan5HT/Antihis/DopBlocker
-ChemoreceptorTrigger zone - CT-zone
________________

OCDMPH:
Ondan5HTron - 5HeroTotinin3 blocker
-medulla

CycliZINE - antihistaMINE
-ZINES - promethazine NOT prochlorperazine
FOR HIGH ICP!!!!!!!!!!!

DopBlockr: Domp
MetocloProkinetic
Prochlorperazine
Haloperidol - METABOLIC stuff ?highCa/RF

Funct - metoclop / Mech - Cyclizine

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16
Q

Stress tx

A

Alco/Caff/Fizzy
Constipation ALLOW
Ex/Diet
Sweeteners/Smoke ALLOW

Kegel 3m - - > ArupBCD
-ARtificial sphincter 
-AUtologous rectus sling 
-APpliance sheath 
-Bulk/urethral slings 
-Catheter/Colposuppression 
-Diversion 
-->
Duloxetene 
-Refer if NOT had prostatectomy...

surgical procedures: e.g. retropubic mid-urethral tape procedures

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17
Q

Testicle: Painless lump and non-tender (Onset is chronic, but the lump may have only just been discovered) or there may be a DRAGGING sensation in the scrotum.

Most common in men 20–40 years of age, but can occur in older men, when it is usually a lymphoma.
Usually presents with testicular enlargement.
On palpation, there is a solid, firm swelling involving all or part of testis
-CAN’T be separated from testes

back or flank pain, SOB , supraclavicular nodes, abdominal mass (enlarged para-aortic lymph nodes),

WEIGHT LOSS, BOOOBS!!!!!!! , epididymo-orchitis, or a hydrocele.

Pain is present in ?% of people with testicular cancer.

  1. Germ 20-30
    -NSemi
    Choriocarc-Tropho
    Embryonic
    Teratoma
    Yolk Sac

-Semi 40+

  1. Non-Germ = Sex Cord
    Leydig/Lymphoma ;
    Sertoli/Sarcoma

50+

RFs?
Ix?

AFP( ?%) / LDH( ?%) is elevated
in around ? cell tumours

Seminomas: hCG may be
elevated in around ?%

-Non-semi=Choriocarc.Embryonic.Teratoma.Yolk-sac #germ
-Seminoma #germ
-Non-germ=Leydig-Lymohoma.Sertoli-Sarcoma
_______________

Germ = NSemi+Semi
-AFP( ?%) / LDH( ?%) is elevated
in around ? cell tumours

-Seminomas: hCG may be
elevated in around ?%

……..(NSemi……Semi)….NGerm

AFP/ hcg: high/low?
…………………

Age: …..(20-30……40)…….50

Prognosis:…………good)

FHx
Undesc
Crypto-Orchid
Kleinfelter
Infertility
TIN 
--> size/shape/texture change = 2WW + USS TESTES !!!
A

Testicular cancer

Pain is present in 20–27% of people with testicular cancer.

GERM 95% > Non-Germ-SexCord
1. Germ 20-30
-NSemi
Choriocarc-Tropho
Embryonic
Teratoma
Yolk Sac

-Semi 40+
hCG may be elevated in around 20%

  1. Non-Germ = Sex Cord
    Leydig/Lymphoma ;
    Sertoli/Sarcoma

50+

FHx, Undesc, Crypto, Kleinfelt, Infertility, TIN
Ix = USS

AFP(60%) / LDH(40%) is elevated
in around GERM cell tumours

Seminomas: hCG may be
elevated in around 20%

-Non-semi=Choriocarc.Embryonic.Teratoma.Yolk-sac #germ
-Seminoma #germ
-Non-germ=Leydig-Lymohoma.Sertoli-Sarcoma
_______________

Germ = NSemi+Semi
-AFP(60%) / LDH(40%) is elevated
in around GERM cell tumours

-Seminomas: hCG may be
elevated in around 20%

……..(NSemi……Semi)….NGerm

AFP/ hcg: high
…………………

Age: …..(20-30……40)…….50

Prognosis:…………good)

FHx
Undesc
Crypto-Orchid
Kleinfelter
Infertility
TIN 
--> size/shape/texture change = 2WW + USS TESTES !!!
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18
Q

PAIN = Sudden <6hrs,
Severe, Unilateral, N+V

@neonatal / puberty.

Hx of severe, SELF-LIMITING PAIN

CREMASTER = ABSENT
Testis is ELEVATED #TRANSverse lie.

Neonatal = scrotal swelling + discoloration (similar to scrotal haematoma).

Hx of previous trauma
___________

PAIN = SUDDEN/GRADUAL over a few days.
-HEAD of the testis/epididymis

Nooooooooo N+V

O/E: Early NODULE @UPPER testis/epididymis –> scrotal OEDEMA.

Torson V Appendage-torsion = hard 2 diff
But @appendage, testis =
mobile + normal size,
-CREMASTER = PRESENT.

Infarcted appendage = seen through the skin (the ‘BLUE DOT sign’).

A
Testicular torsion (torsion of spermatic CORD)
\_\_\_\_\_\_\_\_\_\_

Torsion of appendix testis or appendix epididymis

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19
Q

T1/2 bleed causes?
T3 bleed causes?

  • Bleeding @T1/earlyT2
  • exaggerated syx e.g. HyperEmesis.
  • LARGE 4 dates uterus
  • hCG = high AF!!! = HYPERthyroid
  • ? @USS

Tx????????

Complete V Partial mole?

? % = develop choriocarcinoma
___________

Delayed 3rd stage labour
Pt w/ prev
-PMH: PID
-PSH: c.section / p.praevia

?-types - what invades what?

Tx: ?
_______________

@preggers
•shock OUT OF KEEPING w/ visible loss

•tender, tense, hard woody uterus #CONSTANT-pain

  • lie /presentation - NORM
  • fetal heart: absent/distressed
  • coag dx=DIC / pre-eclampsia
  1. NO fetal distress + <3? w
  2. NO fetal distress + >3? w
  3. Fetal distress - tx?
    ___________

@preggers
•shock IN PROPORTION to visible loss
•painLESS

  • lie /presentation - ABnormal
  • fetal heart: FINE
  • coag dx=none..

Ix? - what to avoid?!

  1. If low-lying placenta @16-20 week scan
    - rescan at ?weeks
  2. If still present @ ?-weeks and
    grade 1/2 then ?
  3. If high presenting at ?weeks then ?
  4. If high abnormal lie at ?weeks then ?
    _____________

Rupture of membranes –>

  • immediately get vaginal bleeding
  • Fetal BRADYcardia #classically seen
A

T1/2 = Ectopic / Miscarriage-Molar preg
T3 = Praevia / Abruption
_________________

Complete HyDatiDiForm Mole (MOLAR)
Tx = EVAC -> CONTRACEP 12m

COMPLETE=46 XX/XY
-EMPTY egg + 1 sperm –> DNA duplicates –>
ALL 23x2 male genes
-Honeycomb/Grapes/SNOWstorm @USS

PARTIAL=69 XXX/XXXY

  • haploid egg (23) + 2 sperm (23x2)
  • partial fetal parts

Around 2-3% = develop choriocarcinoma
___________

Accreta

  • delayed labour #3rdstage
  • prev c-sec/praevia/PID

3-types = chorionic villi:-

  • invade PPerimetrium #PPercreta
  • IInvade myometrium #IIncreta
  • AAttach* 2 myometrium #AAccreta

*-instead of decidua basalis #accreta

Tx: hysterectomy w/ placenta left in-situ
___________

P.Abruption - PainFUL PV bleed
-OUT OF KEEPING w/ visible loss
- feta heart fucked + DIC/Pre-Ecl
____________

  1. NO fetal distress + <36w
    - observe+steroids
    - ?adjust delivery threshold
  2. NO fetal distress + >36w
    - vag delivery
  3. Fetal distress - tx?
    -immediate c-section
    _____________

P.Praevia - PainLESS PV bleed

  • IN PROPORTION to visible loss
  • Lie = abnormal

Ix? - what to avoid?!
-TV-USS - avoid PV exam till praevia excluded!!
LLP @W-16-20 = Rescan @w34
-34 + G1/2 = TVUSS/2w
-37 = high-presenting-part/abnormal life = C-SECTION

  1. If low-lying placenta at 16-20 week scan
    - rescan at 34 weeks
  2. If still present at 34 weeks and grade 1/2 then
    - scan every 2 weeks
  3. If high presenting part at 37 weeks then
    - C-section
  4. If abnormal lie at 37 weeks then
    -C-section
    _______________

Vasa praevia
-ROM - >PVbleed + BradyBaby

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20
Q

Onset is usually GRADUAL over hours to days.

Usually painful and tender. Relieved @ ELEVATE testis = Prehn sign

?palpable swelling, erythema, oedema, hydrocele

?Urethral discharge, UTI Syx, parotid swelling (mumps orchitis usually occurs 4–8 days after parotitis), or vomiting.

-Dx? Organism? Tx?
3 causes:
-? - (anal sex/ catheter) -> ? 
-? - (Age <35) -> ? 
-? - (supportive) - ? 

–f/u?w->

f/u =? + Refer ?

2ww:
45/+ vHU
45/+ vHU + (UTI + Tx fail)

60/+ nvHU +
-dysuria/WCC
-Recurrence/Persistence
__________

@?, the epididymis = HARD, IRREG surface, the spermatic CORD is THICK, and the vas deferens feels hard and irregular (like a string of beads)

Painless and non-tender if tuberculous.
________

Fever
Storage: FUNDHS
Sterile Pyuria (puss in piss)
-INfertility

O/E: testic swelling, perianal SINUS, ulcers
________

When to USS testicle?
_________

Varicocele - Refer:
_________

When 2 refer for Urology:
_________

Fluid AROUND testicle
#CANNOT FEEL testes
-TRANSILLUMINATES
Dx?

For CONGEN hydrocele:
-when 2 reassure - @?yrs

-when 2 refer for paeds?
Hydrocele @?
Hernia = ?

For non-CONGEN hydrocele?
__________

Varicoceles - how 2 manage:
-G1/subclin = ?

-@G2/3
Symmetrical - ?
Asymm = ?

Syx OR Abnormal semen = ?
Asyx AND Normal semen = ?

Most are on the left,
left varicocele = RCC cos left testicular vein drains into left renal vein
_________

Lump in INGUINAL groin area
Reducible disappears when laying flat scrotum fine

<6w - surg < ?
<6m - surg < ?
<6y - surg < ?
__________

BLACK kid
symmetrical bulge
@UMBILICUS

Dx? Tx? Resolve by?
Assoc w/?
-If syx/ large = Surg @ ? -? yr
-If Asyx+Small = ?Surg @ ? -? yr

A

E-Orchitis

3 causes:

  • E.coli - (anal sex/ catheter) -> Cipro
  • STD - (Age <35) -> Ceft+Doxy /Cipro
  • Mumps - (supportive) - MSU/dipstix

–f/u2w->

f/u =
?ABx change + Refer @UTI/ GUM-STI/ Fail

45/+ vHU
45/+ vHU + (UTI + Tx fail)

60/+ nvHU +
-dysuria/WCC
-Recurrence/Persistence
___________

Tuberculous E-Orchitis
______

GUTB
-genito-urinary-TB

Sterile Pyuria:
Partially/Recently Tx UTI
Chlamydia
Tumours - renal/bladder
TB/Schisto/AppendicitisDivertic-ureter irritation
Cystoscopy
RT/Drugs
Atrophic vaginitis
Preg
InterstitialNephritis/ATN
\_\_\_\_\_\_\_\_\_
When to USS testicle?
Hematocele @non-trauma
-if < x3 V contralat = chill
Hx of pain/ persistent/ trauma
Hydrocele = 20-35
Uncertain ddx
Testicle = ETvTesticle ?
\_\_\_\_\_\_\_\_\_
Varicocele - Refer:
-Sudden pain 
-Not drain @supine
-R-sided varicocele
-TGA = low volume
\_\_\_\_\_\_\_\_\_
When 2 refer for Urology:
-Torsion
-AEOrchitis
-StrangHernia
-Hematocele TRAUMA
\_\_\_\_\_\_\_\_\_
Dx = Hydrocele 

For CONGEN hydrocele:
-Reassure < 2yrs

-when 2 refer for paeds:
Hydrocele @SCord /Abdo-Scrotal Hernia
Hernia = Inguinal /Strang

For non-CONGEN hydrocele:
-Surg/Sclero/Asp
__________

Varicoceles - how 2 manage:
G1/subclin
-Reassure, Analgesia, Infertile 33.3%, Supportive underwear

-@G2/3
Symmetrical - Annual exam
Asymm = Urology ref

Syx OR Abnormal semen = Urology ref
Asyx AND Normal semen = Semen analysis
__________

Congenital inguinal hernia – paediatric surgery ASAP incarceration risk
<6w - surg <2d
<6m - surg <2w
<6y - surg <2m 
\_\_\_\_\_\_\_\_\_\_\_\_\_
Infanta UMBILICAL hernia
No tx - resolve <3yrs
-Assoc with HypoT !!!
If Syx/ Large = Surg @2-3yr
-If Asyx+Small = ?Surg @4-5yr
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21
Q

painless, non-tender, soft, fluctuant, smooth, round nodule in the epididymis. It is usually small

Onset is chronic.
__________

Pain onset may be sudden / chronic.

Does NOT transilluminate as well as a hydrocele.

Usually caused by trauma/cancer –>?testicular rupture
__________

Not possible to ‘get above’ the swelling or feel spermatic cord

Onset may be acute or chronic.

Dull dragging

Often painless but pain may be present, particularly if the hernia is incarcerated or strangulated.

May enlarge with Valsalva-type manoeuvres, and disappear on lying down (if reducible).

Positive cough impulse.

A

Epididymal cyst or spermatocele
______

Haematocele
_______

Indirect inguinal hernia

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22
Q

Dysmenorrhoea, - PAIN
Menorrhagia - BLEED
Enlarged, tender/boggy Uterus

Dx ? Ix?

A

Adenomyosis

TVUSS

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23
Q

Intermenstrual bleeding ONLY = ??

Intermenstrual bleeding
Postcoital bleeding
Pelvic pain 
-dx? 
\_\_\_\_\_\_\_\_\_\_\_\_

Menorrhagia

  • NO underlying pathology i.e.
  • -no masses felt i.e. No..?
    • scans all normal so no cancer
  • -ALL Ix all frikn normal bastard
A

Endometrial polyps
-Ectropion/Polyp/CC

Endometrial hyperplasia / carcinoma
_______

Dysfunctional uterine bleeding

  • -no masses felt i.e. No FIBROID
  • MORE COMMON THAN FIBROIDS
  • MOST common cause of heavy bleed
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24
Q

Risk factors of cancers:

Ovarian ELN-B

ENDO ELN-DOH+ht

Cervical

young woman
post-coital bleed
o/e friable, oedematous lesion
move side-2-side

A

Early menarche, Nulliparity, Late menopause
BRCA

Early menarche, Nulliparity, Late menopause
DOH+ht : DM/Obesity/HNPCC Lynch + HRT/Tamoxif

Cervical: literally all bad things…

Cervicitis

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25
Q

PCOS

Hirsutism and acne
Tx - ?? –> ?? and what else??

Infertility Tx -
? —> (? > ?)

Amenorrhoea tx?

-TVUSS - Endomet thickness
(THICK = ?action … due to ? )
(NORM = ?hormonals )

A

Hirsutism and acne -
Dianette/COCP –>
-Eflornithine +
-Flutamide/Finasteride/Spiro

Infertility -
WL –> (CLOMIFENE #refer > metformin)

Amenorrhoea:

  • Cyclical Prog = Medroxyprog = NOT contracep dose !!!
  • COCP (not @fatso/UKMEC3-4)
  • Levonorgest-iuS= fat+need contracep

-TVUSS - Endomet thickness
(THICK = refer ?hyperplasia/cancer)

(NORM = MMC
mirena / medroxy-prog cyc-prog / cocp)

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26
Q

Aside from ovarian cancer, what else can CA125 be rasied in? C-OPE

Ovarian cancer types:
MOST COMMON CAUSE OF OVARAN:
-CANCER = ? cancer
-BENIGN tumour < 25y = ?
-ENLARAGEment @reproductive age = ?

Epithelium
Germ-cell
Sex-cord

Type of Ovarian Cyst
-Follicular > Corpus luteum
Complex cyst = ?dx = Mx?

Ovarian teratoma –>
Psych dx, memory dx, encephalitis, seizures, dyskinesias, autonomic dx, language dx = Anti-?

A

CA125

  • Ovarian Cancer/Cysts,
  • Periods,
  • Endometriosis
Ovarian cancer types:
MOST COMMON CAUSE OF OVARAN:
-CANCER = SEROUS cancer
-BENIGN tumour < 25y = DERMOID Teratoma
-ENLARAGEment @reproductive age = FOLLICULAR cyst

-Epithelium - sero / mucinous –>
(@rupt = pseudomyx peritonei)
MUCIN IN ABDO!!!!! BLUERGH

-Germ-cell
ChorioTropho/
Embryonic/
Terotoma-dermoid/
YolkSac/
Dysgerminoma 

-Sex-cord = Granulosa / Thecoma / Leydig-Sertoli

Type of Ovarian Cyst
-Follicular > Corpus luteum
Complex cyst = cancer = REFER

Ovarian teratoma –>
Psych dx, memory dx, encephalitis, seizures, dyskinesias, autonomic dx, language dx = Anti-NMDA

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27
Q

________________HRT*
_____________Cycli ¦ Contin
Predictible______ ? ¦ ?
bleed_________@? ¦ @?

LMB _________?yr / >?yr
@?

*HRT = Endomet? (Y = ? / N = ?)
O+P (?=protect against Endo cancer)

Vasomotor syx tx?

Atophic vag?

A

________________HRT*
_____________Cycli ¦ Contin
Predictible______ Y ¦ N
bleed_____i.e.@peri-mp ¦ i.e.@mp

LBP _________<1yr ¦ >1yr / >2yr
@POF

HRT = Endomet? (Y = O+P / N = O)
O+P*(P=protect against Endo cancer)
__________

Vasomotor syx tx?

  • Clonidine - NH
  • SSRI - NH
  • SNRI - NH
  • HRT = hormonal

Atophic vag -
top oest ± Lubricants and moisturisers

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28
Q

@MenoPause - Bleed Stopped:

LMB-age ¦ contraception until…

  • –<50 ¦ ?
  • –>50 ¦ ?

@STILL bleed >40yr
____Age ¦ COCP/Combo ¦ Depot
—<50 ¦ ?
—>50 ¦ ?

@STILL bleed >40yr
____Age ¦ IuS/POP//Implant
—<50 ¦ ?
—>50 ¦ ? / check ?pattern ->

test what pit test?:

  • check if stop b4 when?
  • > 30 = cont ? for how long?
A

@MP - Bleed Stopped:

LMB-age ¦ contraception until…

  • –<50 ¦ 2yr AFTER LMB
  • –>50 ¦ 1yr AFTER LMB

@STILL bleed >40yr
____Age ¦ COCP/Combo ¦ Depot
—<50 ¦ cont till 50
—>50 ¦ NH/ius-pop-implant

@STILL bleed >40yr
____Age ¦ IuS/POP//Implant
—<50 ¦ cont till 55
—>50 ¦ cont till 55/check bleed pattern ->

FSH:

  • check if stop b4 55
  • > 30 = cont ius-pop-implant for 1 year
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29
Q

OCP-BV : BEVif
Pros and cons of OCP (ocp bv)
__________________

Cons of HRT - BEVif the biddy comes in for HRT
___________

hot flushes,
vaginal dryness / atrophy,
sleep dx / irritability.

POF: Premature Ovarian Failure =
? syx + ? FSH/LH < ?yrs
—— ?% women

menopause =
?? months of amenorrhoea
AFTER the LMB

FHx
Chemo/Radio
Autoimmune

Avg age women MP = ?

A
Pros: OCP
Cancer: 
OOOvarian, EEEndo, 
COLORECTAL
Periods: heavy=fibroids / pain-endomet

Cons: BV
BBBreast/CCCervical*
VTE
*(Ectropion) (ECTZ column cells - Cold Coag)

__________________

Cons of HRT: BEVi
Breast (prog increases this)
Endomet (prog reduces this)
VTE / IHD (Transdermal HRT reduces this)
iNC Fibroid size 
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

Ovarian Failure - MP

Premature ovarian failure =
MP syx + high FSH/LH < 40yrs
—— 1% women.

menopause =
12 months of amenorrhoea
AFTER the LMB

Avg age women MP = 51

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30
Q

-Primary CMFT
-Secondary SHeeP GOATmaps
causes of amenorrhoea

Anorxia b4 puberty - primary or secondary amenorrhoea?
____________________________

Infertility in men?
VINDICATE
________

pros and cons of OCP

A
PRIMARY: CMFT
Anorexia B444* puberty!!! #PRE-pubertal
CAH/5alphaReduct, 
Malformation, 
Feminisation-AndInsensSynd, 
Turner + genetic dx

*GnRH release will be delayed, hence PRIMARY - otherwise Anorexia generally = SECONDARY

SECONDARY:
SHeePGOAT

Stress
HCG - preggers
Excess Exercise
Prolactin

Gonadotrophins - MP/POF;Asherman;PID;Sheehan
Oestradiol - MP/POF
Androgen - PCOS
TFT

________________________________

Infertility in men?

V - HF/LF/RN
I - orchitis (STI/mumps)
Neoplasm
D - saulfasal/infliximab
I - Trauma/Surg/WARM BALLS
C - Cryptoorchid
Ai Thyroid dx
T - Trauma/Surg/WARM BALLS 
E: DM / HYPERTHERMIA
\_\_\_\_\_\_\_

pros:
Ov/Endo cancer prevent
Colo cancer prevent
Periods lighten(fibroid)/pain ease (endometriosis)

cons:
breast/ cervical cancer
VTE

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31
Q

25 F =5 months AFTER dilation+curettage for a miscarriage.

Since procedure = not had period.

HCG negative.
Hysteroscopy reveals diagnosis.

A

Asherman’s syndrome

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32
Q

gestational sac >25mm
contains a dead fetus

BEFORE 20 weeks
NOOOOOOOO expulsion sign/symptom

AKA ‘blighted ovum’ or ‘anembryonic pregnancy’

The most useful next ?, may demonstrate ????

A

Missed miscarriage

-TVUS = no fetal heart.

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33
Q

H

A

H

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34
Q

Pain typically starts JUSTTTT/HOURS before period

Pain appears within 1-2 years after menarche
-YOUNG PERSON w/ DYSMENORRHOEA

DYSSSSmenorrhoea

Tx??????????????????
________________

primary AAAAAMENorrhoea
(failure to ?? menses
by the age of ?? years)

________________

Premature ovarian failure????

_________________

Primary Infertility =
couples who have ??? conceived.

A

Primary Dysmenorrhoea

Nsaid/paracetamol
Cocp/pop
Gnrh agonists/surg

________________

primary AMENorrhoea
(failure to START menses
by the age of 16 years)

_________________

POF =
MP syx
+
high FSH/LH < 40yrs —— 1% women.

___________________

Primary Infertility = couples
who HAVE NEVER conceived.

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35
Q

Pain occurs 1-2 DAAAAAYS B4 period

Pain started YEEEEEEARS after the menarche
-Older PERSON w/ DYSMENORRHOEA

DYSSSSmenorrhoea dyspareunia

Tx??????????? Ax?????????

________________

Secondary AMENorrhoea =
bleeding previously ? - - >
now stopped for at least ? months

________________

Secondary Infertility in couples who ?? ?? conceived.

A

Secondary DYSSSmenorrhoea

REFER TO GYNAE ASAP!!! UNDERLYING PATHOLOGY

C-CHAF:

  • Cancer-Cavity dx(PID/IuD/Polyp) ,
  • Histolog dx,
  • Adenomyosis,
  • Fibroid,
  • Endometriosis)

REMEMBER menorrhagia=CHAF/Dysmen=Endometriosis but for this condition it all could cause Dysmenorrhoea so Ix for both 🤷🏽‍♂️🤦🏽‍♂️
________________

Secondary AMENorrhoea =
bleeding PREVIOUSLY occurred - - >
now stopped for at least 666666666666666 months
________________

Secondary Infertility in couples who
HAVE PREVIOUSLY conceived.

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36
Q

Menstruation:
MFOL? - follicles?

Physiologic changes @preggers
-rises: ?
-drops: ?
______________

  1. MENSTRUATION d ? - ? - >
    mucus = ? + forms what where?
2. FOLLICULAR phase (Endomet ? phase) d5-13
a.
-FSH peak = ? - - > 
-oestradiol peak = ? - - > 
-LH peak - - > ? 

b.
mucus = ? , ? , low ? , ‘stretchy’ ?
just b4 ovulation

  1. OVULATION d ?
    - Tertiary follicle - - > ?
  2. LUTEAL phase (Endomet ? phase)
    a.
    Corpus Luteum secrete ? ->
    Body temp ? after ovulation
b.
If fertilisation NOT occur, 
-what happens to corpus luteum? and 
-what happens to prog lvl?)    d15-28
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

Oestrgoen secreted -> so body temp ?? B4/after ovulation

Prog secreted by the corpus luteum -> so body temp ?? B4/after ovulation

BASICALLY, temp @period + BP @preg = U-wave relationship bro FFS remember that shit

A

MFOL

  • Menstruation d1-5
  • Follicular - Endomet PROLIF phase
  • Ovulation d14
  • Luteal - Endomet SECRETORY phase

Follicles: primordial, primary, secondary, tertiary

Physiologic changes @preggers
-rises: everything else
-drops: Hb + BP
______________

  1. MENSTRUATION d1-4 - >
    mucus = THICK + forms a PLUG @EXT OS
  2. FOLLICULAR phase (endomet prolif phase) d5-13
    a.
    -FSH peak = follicle development - - >
    -oestradiol peak = body temp falls - - >
    -LH peak - - > ovulation

b.
mucus = clear, acellular, low viscosity, ‘stretchy’ spinnbarkeit just b4 ovulation

  1. OVULATION d14
    -Tertiary follicle - - > corpus LAD
    #Luteum, Albicans, Degraded.
  2. LUTEAL phase (Endomet SECRETORY phase)
    a.
    Corpus Luteum secrete Prog ->
    Body temp RISES after ovulation

b.
If fertilisation NOT occur, corpus luteum degenerate and prog lvl fall) d15-28”

___________________

Oestrgoen secreted -> so body
TEMP FALL B4
Ovulation

Prog secreted by the Corpus Luteum -> so body
TEMP RISE After
Ovulation

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37
Q

Vulval ?? are commonly
@labium ?
ULCERATED
-Melanomas = usually ?.

Vulval ?? tend to be
WHITE/PLAQUE-like
NOTTTTT ulcerate

A

Vulval carcinoma = commonly
@labium MAJORA.
ULCERATED
Melanomas = usually PIGMENTED.

VIN =
WHITE/PLAQUE-like
NOTTTTT ulcerate

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38
Q

When to give anti-D @rhesusNEG mums:

If mum had Acne Rosacea, tx?

Preg + Pit.Versicolor, tx?

A
Abortion/Miscarriage >12w
TransPlacentalHaemorrhageRisk(procedures)
-procedures/abdo trauma/iuDeath
Ectopic
Evac after miscarriage
  • I AM DE
    Acne Rosacea tx = 8-12 weeks
    mild/mod - ltd pap/pust =
    -TOP: Ivermectin / Azelaic/Metro @preg/BFeed

mod/severe - ext pap/pust ± plaques
-PO Doxy / Erythro @preg/BFeed
______

Pityriasis versicolor 
Ix: skin scraping MCS
@preg/BFeed = give Ketoncon 
Preg/BFeed CI: Selenium / Flucon/Itracon 
Tx: ASKIF
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39
Q

When to give anti-D to mum?

A. Booking visit

B. 11 - 13 weeks

C. 28 wks –> 34wks

D. 36 wks

Positive serum AFP/Prev NTD ->
USS ->
Amniocentesis for AFP/AChi w12 16-20

@HIV, mum viral load < 50 @ w?
-what delivery recommended?

-what should be started 4 hrs b4 c-section?

After birth:
-mum CD4 < 50, what administered to neonate?

-mum CD4 > 50, what administered to neonate?
_______

BF advantages?

MMR CI

A
Abortion/Miscarriage >12w
TransPlacentalHaemorrhageRisk(procedures)
-procedures/abdo trauma/iuDeath
Ectopic
Evac after miscarriage

A. 8-12 wks -

  • Booking
  • overlap w/ Down’s nuchal scan
B. 11-13 
-Down's + Nuchal scan 
-overlap w/ booking
\_\_\_\_\_\_\_\_\_\_
C. 
28 wks
- 1st dose of anti-D prophylaxis @RhNEG 
- 2nd Anemia/AlloAB test @28w
34 wks: 2nd dose of anti-D prophylaxis @RhNEG
\_\_\_\_\_\_\_\_\_\_
D. 36 wks:
-BFeed / Blues
-ECV ?Presentation legit
-Vit K 
@viral load < 50 @ w36: VAG > C-section 
- IF c-section, then b4 c-section: IV zidovudine
After birth:
< 50: PO zidovudine @neonate
> 50: Triple ART @neonate
\_\_\_\_\_\_\_\_

Mother:

  • BabyBond
  • Reduce BreastCancer / PPH-risk

Kid: i-AIRD

  • Infections
  • Allergy/ IBD / RA / DM 1
MMR CI
Live vaccine <4w
Ig tx / 3m 
Preg avoid @MMR<4w
Preg avoid @MMR<4w
IC 
Neomycin allergy

Influenza vacc = egg allergy?

40
Q

Bradycardia < 100

Tachycardia > 100
_______________

Early Decel

Late Decel
____________

Variable decel

Loss of baseline variablity

A

Bradycardia < 100
-Beta-blocker / vagal tone

Tachycardia > 100
-Infection / Prematurity
___________

Early Decel
-head compression #normal

Late Decel
-asphyxia/placent insuff #hypoxia ->
DO FETAL BLOOD SAMPLING -> ?c-section
___________

Variable decel
-cord comp

Loss of baseline variablity
-Prematurity / Hypoxia

41
Q

SGA: small for gest age = < ?th centile

Down’s babies generally ?size - have own chart

Macrosomia - Cx

iuGR - CVD / DM

iuGR -> ‘stressed’ generally -> ? release -> lung MATuration -> LESS RDS @iuGR

small mum = ?size baby
______

Antidepressants in preg/BFeeding:

  • ? @preg
  • ?@BFeed

@preg, serum hcg detected in 98% ppl when?!

@conception, OTC preg test positive after how many days?

@preg, serum hcg detected in 98% ppl when?!

Gravidity? Parity?
_______

Woman becomes preggers
Somehow develops unilateral facial nerve palsy
APTT fine, no sign of APLS or any other bleed dx…
Dx?

A

SGA: small for gest age = <10th centile

Down’s babies generally smaller - have own chart

Macrosomia - hypoglyc / obstructed labour /disticia

iuGR - CVD / DM

iuGR -> ‘stressed’ generally -> cortisol release -> lung MATuration -> LESS RDS @iuGR

small mum = small baby
_______

Antidepressants in preg/BFeeding?

  • Sertraline + Fluoxetine @preg
  • Sertraline @BFeed

OTC->HCG:
OTC preg test positive @day 10
serum HCG detected by day 11

G=total pregnancies

P:
x- births >24w
\+
y=pregnancies <24w losses
\_\_\_\_\_\_\_

Preg -> BELL’S palsy

42
Q

Sexual intercourse

  • snapping sound
  • lateral bending of erect dick
EGGPLANT deformity
\+/-
blood @meatus, 
haematuria, 
dysuria, retention--> 
piss extravasation

Dx?

Which layer damaged?

Where does urethral damage occcur most likely in terms of fracture anatomy?

Ix @urethral injury?

Ix for the actual dick?

Tx:
_______

SUSTAIN pelvic fracture -> 
cystogram = extraperitoneal 
urine extravasation
-NO blood @meatus
\_\_\_\_\_\_\_

Phimosis:

if dont clean under foreskin, 2 issues?

Tx?
________

straddle injury e.g. bicycles

triad:
- perineal haematoma
- retention
- blood at the meatus

pelvic fracture ->
-Penile/Perineal oedema/hematoma
-O/E: PROSTATE displaced UPWARDS
_________

Pelvic fracture + inability to void

  • haematuria/suprapubic pain
  • UNABLE to retrieve ALL fluid used to irrigate bladder through a Foley catheter
A

Penile fracture

Which layer damaged?
-tunica albuginea

Urethral dx most likely @
-both corporsa cavernosum

Ix @urethral injury?
–Retrograde/Asc urethrogram -> SPC

Ix for the actual dick?

  • caverno-sography
  • MRI
Tx:
-Hematoma evac
-Fix T.Albuginea + Urethra
-SPC
\_\_\_\_\_\_\_\_

Bladder rupture:
- Tx = Conservative Foley urinary catheter
- LAPARATOMY @intraperitoneal
__________

Phimosis:

if dont clean under foreskin, 2 issues?

  • stones @pre-putial sac
  • penile cancer

Conservative
Med: Steriods
Surg: Circumcision
______

Bulbar rupture
–Retrograde/Asc urethrogram -> SPC

Membranous rupture
–Retrograde/Asc urethrogram -> SPC
__________

Bladder/urethral rupture

  • IVUrogram or Cystogram
  • intraperitoneal = LAPARATOMY
  • extraperitoneal = Conservative + Foley Catheter
43
Q

Tight white ring + phimosis @foreskin tip

Flat-PAP #ulcerate @foreskin = ?

Red-velvet plaque = ?

Orange/ red/ pinpoint = ?

Reactive Arthiritis -> red plaque , ragged white border = ?
_________

BPH tx:

  • Conservative?
  • Med?
  • Surg: ? -> Cx due to #? #?electrolyte-dx

Finasteride take how long before results?
_________

…… ……(NSemi……Semi)….NGerm

AFP/ hcg: highorlow
………………..

Age: ………(? -? ……….? )……….?

Prognosis:……………..? )

GERM: AFP ?% ; LDH ?%
-hcg ?% @seminomatous

RFs?
–> size/shape/texture change = ?

A

Tight white ring + phimosis @foreskin tip
-BXO-LSclerosis

Flat-pap #ulcerate @foreskin = SqCC

Red-velvet plaque = EoQ SqCC-IS

Orange/ red/ pinpoint = Zoon’s balanitis

Reactive Arthiritis -> red plaque , ragged white border = Circinate balanitis
________

BPH tx:

Conservative:

  • Alco/Caffeine/Fizzy drinks
  • Constipation
  • Ex/diet
  • Sweeteners/Smoke stop

Med:

  • alpha-blocker Tamsulosin = post hypoTN
  • 5alphaReduct-i = Finasteride
  • Finasteride take 6 months before results

Surg: TURP -> TURP syndrome #glycine #HYPOnatraemia
__________

-Non-semi=Choriocarc.Embryonic.Teratoma.Yolk-sac #germ
-Seminoma #germ
-Non-germ=Leydig-Lymohoma.Sertoli-Sarcoma
_______________

……..(NSemi……Semi)….NGerm

AFP/ hcg: high
…………………

Age: …..(20-30……40)…….50

Prognosis:…………good)

GERM: AFP 60% ; LDH 40%
-hcg 20% @seminomatous

FHx
Undesc
Crypto-Orchid
Kleinfelter
Infertility
TIN 
--> size/shape/texture change = 2WW + USS TESTES !!!
44
Q

When to USS testicle?
_________

Varicocele - Refer:
_________

When 2 refer for Urology:
_________

Fluid AROUND testicle
#CANNOT FEEL testes
-TRANSILLUMINATES
Dx?

For CONGEN hydrocele:
-when 2 reassure - @?yrs

-when 2 refer for paeds?
Hydrocele @?
Hernia = ?

For non-CONGEN hydrocele?
__________

Varicoceles - how 2 manage:
-G1/subclin = ?

-@G2/3
Symmetrical - ?
Asymm = ?

Syx OR Abnormal semen = ?
Asyx AND Normal semen = ?

Most are on the left,
left varicocele = RCC cos left testicular vein drains into left renal vein
_________

Lump in INGUINAL groin area
Reducible disappears when laying flat scrotum fine

<6w - surg < ?
<6m - surg < ?
<6y - surg < ?
__________

BLACK kid
symmetrical bulge
@UMBILICUS

Dx? Tx? Resolve by?
Assoc w/?
-If syx/ large = Surg @ ? -? yr
-If Asyx+Small = ?Surg @ ? -? yr

A
When to USS testicle?
Hematocele @non-trauma
-if < x3 V contralat = chill
Hx of pain/ persistent/ trauma
Hydrocele = 20-35
Uncertain ddx
Testicle = ETvTesticle ?
\_\_\_\_\_\_\_\_\_
Varicocele - Refer:
-Sudden pain 
-Not drain @supine
-R-sided varicocele
-TGA = low volume
\_\_\_\_\_\_\_\_\_
When 2 refer for Urology:
-Torsion
-AEOrchitis
-StrangHernia
-Hematocele TRAUMA
\_\_\_\_\_\_\_\_\_
Dx = Hydrocele 

For CONGEN hydrocele:
-Reassure < 2yrs

-when 2 refer for paeds:
Hydrocele @SCord /Abdo-Scrotal Hernia
Hernia = Inguinal /Strang

For non-CONGEN hydrocele:
-Surg/Sclero/Asp
__________

Varicoceles - how 2 manage:
G1/subclin
-Reassure, Analgesia, Infertile 33.3%, Supportive underwear

-@G2/3
Symmetrical - Annual exam
Asymm = Urology ref

Syx OR Abnormal semen = Urology ref
Asyx AND Normal semen = Semen analysis
__________

Congenital inguinal hernia – paediatric surgery ASAP incarceration risk
<6w - surg <2d
<6m - surg <2w
<6y - surg <2m 
\_\_\_\_\_\_\_\_\_\_\_\_\_
Infanta UMBILICAL hernia
No tx - resolve <3yrs
-Assoc with HypoT !!!
If Syx/ Large = Surg @2-3yr
-If Asyx+Small = ?Surg @4-5yr
45
Q
yellow/green
-strawberry cervix
-smelly 
Dx? Tx?
\_\_\_\_\_\_\_\_
Cda-Gcc
Chlamydia Tx?
Refer for:
-GUM
-Repeat infection @?/+y/o = high p(re-infection)
-Avoid sex till when?
-STD screen/ Safe sex
-Sex-abuse < ?yrs 

Gonorrhoea Tx?

  • Asyx = ?Ix ?/+w after ABx end
  • Syx = ?Ix ?/+d after ABx end

Syx men = C+T:

  • all partners < ?w
  • most recent partner if >?w

The rest i.e. Asyx men /Women
- C+T all partners < ?m
_____

PID:

Mycoplasma genitalium?

Gon high risk?
Gon low risk?

A

yellow/green
-strawberry cervix
-smelly
Dx? Trichomoniasis Tx? Metro

Chlamydia=
Doxy /Azithro
7d//////2d, respectively 
Refer for:
-GUM
-Repeat infection @25/+ y/o = high p(re-infection)
-Avoid sex after ABx end/Azithro +7d
-STD screen/ Safe sex
-Sex-abuse < 18yrs 

Gonorrhoea=Ceftriax IM /Cipro

  • Asyx = NAAT 2/+w after ABx end
  • Syx = C+S 3/+d after ABx end

Syx men = C+T:

  • all partners < 2w
  • most recent partner if >2w

The rest i.e. Asyx men /Women
- C+T all partners <3m
_______

PID:

Mycoplasma genitalium
-moxifloxacin / ceftriax -> Azithro

Gon high risk = Ceftriax+Doxy+Metro
Gon low risk = Ceftriax/Oflox

46
Q

EOrchitis

3 causes:

  • ? - anal sex/ catheter -> Tx?
  • ? - Age < ? -> Tx?
  • ? - supportive - Tx?

–f/u ?w->

f/u = ? + Refer @?
\_\_\_\_\_\_\_\_\_\_\_
UTI tx?
-Cath change @?/+d
-A
-M
-Preg = Tx when? ; ? @GBS-agalactae

Refer: SA RC AS TIC

  • S+F dx
  • Atyp org
  • Recurrence/Persistence
  • CATHETER
  • Atyp org
  • S+F dx

-TwoWW@
?/+ and ?HU:
-w/ ?
-w/out ?

?/+ and ?HU +

  • ? / ?
  • ? / ?

-IC/ Urology dx @prostatitis = ?
-Acute = ? + ? –f/u=?d->
? d/w @f/u
-?
-? @STD

Chronic = ?
_______

?: UTI + incr p(Cx e.g. Persistent/Recurrent infection, Tx failure)
-Cx UTI RFs = S+F dx, catheters, virulent/atypical organisms and co-morbidities (DM or IC)

Recurrent = Relapse/Reinfeciton

  • UTI 2/+ / ? m
  • UTI 3/+ /? m
  • ? — same strain infection
  • ? — different strain infection
A

EOrchitis

3 causes:

  • E.coli - (anal sex/ catheter) -> Cipro
  • STD - (Age <35) -> Ceft+Doxy /Cipro
  • Mumps - (supportive) - MSU/dipstix

–f/u2w->

f/u = ?ABx change + Refer @UTI/ STI/ Fail
\_\_\_\_\_\_\_\_\_\_\_
UTI tx?
-Cath change @7/+d
-ABx/Analgesia
-MSU/ Dipstix
-Preg = Tx NOW; ANC @GBS-agalactae

Refer:

  • S+F dx
  • Atyp org
  • Recurrence/Persistence
  • CATHETER
  • Atyp org
  • S+F dx

-TwoWW@
45/+ + vHU
45/+ + vHU + (UTI + Tx fail)

60/+ nvHU +

  • dysuria / inc WCC
  • recurrent/persistence
IC/ Urology dx @prostatitis = REFER
-Acute = cipro+CS --f/u=2d-> 
C+S result d/w @f/u
-ABx accordingly
-GUM @STD

Chronic =
-Lactulose @pain-poo, Alpha-blocker, CBT/ADep, Trimeth
________

45/+ + vHU:
-w/ UTI + Tx fail
-w/out UTI
________

Cx UTI — UTI + incr p(Cx e.g. Persistent/Recurrent infection, Tx failure)
-Cx UTI RFs = S+F dx, catheters, virulent/atypical organisms and co-morbidities (DM or IC)
Recurrent = Relapse/Reinfeciton
-UTI 2/+ / 6 m
-UTI 3/+ /12m

  • Relapse — same strain infection
  • Reinfection — different strain infection
47
Q

LVH: deep S @V1-2; tall R @V5-6

  • Pulse = slow rising/narrow pressure
  • Apex = thrill
  • S4

Tx for:

  • Asyx?
  • Asyx >40/50mmHg + LV sys dx?
  • Syx?
Common Ax @ 
<65 ?
>65 ?
iNFECTION?
\_\_\_\_\_\_\_\_\_\_\_\_\_
For bioprosthetic valve for OLDER
Inc risk of?? 
>age? get aortic one
>age? get mitral one
AC needed? give what antithrombotic Tx? 

For mechanical valve for YOUNGER
Inc risk of??
AC needed? And what else if IHD??
____________

S1-2 sounds?
-Soft -Loud

Wide split ??

Paradox split??
Fixed split??

S4-3 sounds?
____________

Causes of 1st and 2nd degree HB KIMBAD

Causes of 3rd degree complete HB iFASC
____________

Pericardial rub - ??
Pleural rub - ??
Pericardial knock - ??
____________

Causes of LBBB

RBBB causes?
____________

Ax LAD

Ax RAD
_______
ECG signs:

Tall R @V5+6
Inverted T @V5+6, 1, VL
LBBB+LAD

R tall @V1
Inverted T @V1+2,
RBBB+RAD

Bifid/Broad P-mitrale +/- AF = ?
(what letter does Bifid P look like? 🤔)

Peaked P-pulmonale = ?
____________

Pulses paradoxes? PAH
Slow rising/plateau?
_________

COLLAPSING? API
Pulsus alternans?
_________

Bisfriens pulse - DOUBLE systolic beat
Jerky
_________

J wave Osborn
Widespread/SADDLE ST elevation
_________

PR depression?!
pericardial knock
_______

  • Collapsing pulse = ?
  • Wide Pulse Pressure = ?
  • Narrow Pulse Pressure = ?
  • slow rising pulse =?
A

AStenosis
-S4=HOCM/HTN/ASten
Asyx = OBSERVE

Asyx >40/50mmHg + LV sys dx = SURG

Syx = valve replacement -> balloon valvuloplasty

Ax Aortic stenosis:
<65 - bicuspid aortic valve #TURNER
>65 - calcification
Rheumatic Fever ________________

For bioprosthetic valve for OLDER
Inc risk of calcification 
>65 get aortic one
>70 get mitral one
Long term AC not needed, give aspirin

For mechanical valve for YOUNGER
Inc risk of thrombosis
Give warfarin + aspirin if IHD.
____________

S1 = AV valves mitral/tricuspid closing
soft @Regurg
loud @MS

S2 = Aortic/pul closing 
soft @ASten
Loud @ 
-HTN, Hyperdymamic states,
-ASD-PulHtn

Wide s2-
delay RV empty
-(PS; PAH{MRegurg severe}; RBBB)

Paradox s2
-WPW-b, AS/LBBB, RVPacing, PDA

Fixed s2 - ASD

S4 = atria contract against STIFF ventricle
HOCM/HTN
ASten

S3 = diastolic filling of ventricle 
Const pericarditis - pericard knock, X+Y, X ✔️; 
Dilated CM, 
MRegug
NORMAL<30y
\_\_\_\_\_\_\_\_\_\_\_\_

1st and 2nd degree:
K+low; IHD; myocarditis;
Beta-blockers; Athletes; Digoxin

3rd degree complete block:
iHD, Fibrosis; AS; Surg/Trauma; Congen
____________

Pericardial rub - pericarditis
Pleural rub - pneumonia/PE
Pericardial knock - C. Pericarditis
____________

LBBB=CM, HTN, AS, IHD

RBBB=PE, ASD, Normal
___________

RAD vs LAD

A(R>S @ V1) - WWPW - B (S»>R + Tinvert)+ VT
AAAArm switch/dextrocardia
RRRRVH - LVH
Lat (circumflex) - MMMMI - Inf (RCA)
TTTTall thin = RAD
Left post fasicle - HHHHemiblock - left ant fasicle/(bifasicular)

p176 ECG John Hampton book
\_\_\_\_\_\_\_
LVH:
R>25mm @V5+6
Inverted T @ V5+6, 1, VL
LBBB+LAD

RVH:
R tall @ V1
Inverted T @ V1+2,
RBBB+RAD

Bifid/Broad P-mitrale +/- AF = LAH
-MS -> LAH

Peaked P-pulmonale #RAH
-TS>RVH(PS/PAH)

As per John Hampton p112
____________

Tamponade/ Severe asthma:
- PAH, AR/ASD, High Left EDV

AS
_________

AR/PDA/ Incr requirement
LVF
_________

HOCM/Aortic valve Dx
HOCM
_________

J = hypothermia HyperCalcemia
Widespread ST elevate = pericarditis
_________

PR depression = most sensitive for pericarditis!!!!!

pericardial knock = constr pericard
_______.

  • Collapsing pulse = AR/PDA/ Incr requirement
  • Wide Pulse Pressure = AR/PDA/3rd HB
  • Narrow Pulse Pressure = ASten
  • slow rising pulse = ASten
48
Q

Catheter UTI = ? ?d
-what to do @ Asyx bacteria @catheterised pts

Recurrent UTI = ? (?? >?? ) proph SD @:

  • ?
  • ?

Preg:

  • Asyx BU == ? ?d
  • UTI @preg = ? ?d

Bog-standard UTI w/ no catheter/preg
-man = ? ?d
-woman = ? ?d
________

Kids:
1. UTI < 3m U or L-UTI = ?+?+?

  1. UTI > 3m = ?Ix ->
    - nitrite POS AND leukocyte POS = ?
    - nitrite POS + leukocyte NEG = ?
    - nitrite NEG + leukocyte POS = ?

–@infants and toddlers =
?type of sample –fail–> ?

Kids >3m Upper-UTI #fever + flank-pain
- Pyeloneph = ? / ?

Kids >3m Lower-UTI

  • ?
  • @recurrent?

Kids < 3m U or L-UTI = ?+?+?
_______

?Ix @:
Flow dx / Mass
Atyp org
Sepsis
Tx fail
Recurrence, USS-KUB @:
- acute infection if ?age @recurrent
- <6w if ?age @recurrent

Acute infection
@Recurrent /Atyp<3y
–? - ?m-> ?Ix #parenchymal dx

For reflux = ?
________

Recurrence:
x2 (L-UTI + U-UTI)
x1 (L-UTI + U-UTI) AND x1 (L-UTI)
_______

Recurrent = Relapse/Reinfeciton

  • UTI 2/+ / ? m
  • UTI 3/+ /? m
  • ? — same strain infection
  • ? — different strain infection
A

Catheter UTI = TANP 7d
-do NOT treat Asyx bacteria @catheterised pts

Recurrent UTI = TANC (TN>AC) proph SD @:

  • expose2trigger
  • ON

Preg:

  • Asyx BU == NAC 7d
  • UTI @preg = NAC 7d

Bog-standard UTI w/ no catheter/preg
-man = NT 7d
-woman = NT-PF 3d
_________

Kids:
1. UTI < 3m = 
Refer asap + 
ABx + 
C+S
  1. UTI > 3m = dipstick ->
    - nitrite POS AND leukocyte POS = ABx
    - nitrite POS + leukocyte NEG = ABx
    - nitrite NEG + leukocyte POS = UrineMCS

–@infants and toddlers, sample =
Clean Catch Urine -fail-> Suprapubic

Kids >3m Upper-UTI #fever + flank-pain
- Pyeloneph = Cefalexin/ Co-amox

Kids >3m Lower-UTI

  • TANC (TN>AC)
  • Even recurrent = -TANC (TN>AC) /6m-r/v

Kids < 3m U or L-UTI = Refer asap + ABx + C+S
_______

USS-KUB @:
Flow dx / Mass
Atyp org
Sepsis
Tx fail
Recurrence, USS-KUB@:
- acute infection if < 6m/o @recurrent
- <6w if > 6m/o @recurrent

Acute infection
@Recurrent /Atyp< 3y
–4-6m-> DMSA #parenchymal dx

For reflux = MCUG
______

Recurrence:
x2 (L-UTI + U-UTI)
x1 (L-UTI + U-UTI) AND x1 (L-UTI)

Recurrent = Relapse/Reinfeciton

  • UTI 2/+ /6 m
  • UTI 3/+ /12 m
  • Relapse — same strain infection
  • Reinfection — different strain infection
49
Q

GRADUAL reduction hearing #conductive
-not pain

SUDDEN hearing loss / Muffling. -assoc w/ pain or ache
-?ear bud /trauma hx
________

Earache/TUGGING/rubbing/crying/restlessness
ear reveals a BULGING tympanic membrane.
-most common pathogen?

SALT delay #hearing dx
behav/balance dx
@otoscope = 
effusion + air-fluid levels ?bubbles w/ 
normal/RETRACTEDDDDDDD tympanic membrane landmarks 
#conductive hearing loss. 

2 WEEKS!!!! = Persisssstent inflamm
PERF of the tymp membrane + discharge

mycoplasma/influ –>
@otoscopy = erythema/injection of tympanic membrane
_________

Otalgia, hearing loss, pre-AURICULAR nodes.
O/E: canal = red and inflamed, yellow debris
GP PULLS ON TRAGUS -> significant PAIN !!
-Dx? Refer when? Tx fail?

Eye gunk, PRE-AURICULAR nodes, malaise
_________

persistent, foul-smelling discharge
Crusting @attic PARS FLACCIDA!!
Conductive loss
Vertigo

grommet insertion -->
White appearance of 
FIBROTIC scarring 
@tympanic membrane
\_\_\_\_\_\_\_\_\_
Allergen exp -> B/L syx develop asap:
Sneezing, Discharge (rhinorrhoea)
-nasal CONGESTION / ITCH / Drip-postNasal
-Palate ITCH , Cough 
-Hayfever-Eye syx too 

Nasal CONGESTION features:
-Snoring, MOUTH breathing, and Halitosis.

PMH/FHx of atopy (asthma, eczema, or allergic rhinitis).

Fatigue, Sneeze, Post-nasal drip,
Eye-water
Itch posterior-pharynx

A

Ear wax imapction

Perf Tymp Memb
______

AOM: earache/TUGGING/rubbing/crying/restlessness
ear reveals a BULGING tympanic membrane
-H.Flu !!!

OME (glue ear) —
@otoscope =
effusion and air fluid levels/bubbles w/
normal/RETRACTED tympanic membrane landmarks
#conductive hearing loss.
speech and language delay, behavioural or balance problems

CSOM — 2 WEEKS!!!! persistent inflammation and PERF of the tympanic membrane with discharge

Myringitis-bullous
-mycoplasma
-erythema/injection of tymp memb
_________

Otitis Externa
1.
-Otomise ->
-Fluclox/Erythro

2.
-REFER + Cipro @malig otitis ext ->

3.
Tx fail = ?dermatitis/?fungal
-top c.sted/top a.fungal

Viral conjunctivitis
_________

Cholesteatoma
-pars FLACCIDA

Tympanosclerosis
_________

Allergic Rhinitis

50
Q

Earache/TUGGING/rub
O/E: BULGING tympanic memb

Admit @?

When to give ABx?

Tx:
Analgesia + ?/?- >
worsen but NO MUSIC = ?
\_\_\_\_\_\_
Sinusitis ?d Syx = Tx?

Sinusitis ? d Syx = Tx?

ABx only @ Cx?

Tx = ? -> ?/ ? @allergy
__________

FeverPANIC
-when give ABx?
_________

-Persistent OME IN BETWEEN episodes
-Persistent C.LNopathy
-Epistaxis
Tx?

If recurrent AOM @…

  • Unexplained
  • Adult
  • Downs/Cleft #Craniofacial dx

–> ?
________

  • SALT delay #hearing
  • Effusion + air-fluid levels
  • RETRACTED #conductive-loss

ASAP refer @ ?

WW < ? w (± ? @older kids):
-? PTAudio+Tympano-metries ? w apart

  • OM -> Perf = Tx?
  • H? @?OME (/Surg* @? )
  • Auto-inflation: CI @?
  • MGA?

Grommets usually stop functioning after ?m

CSOM >2w = Tx?

Cholesteatoma = Tx?
_______

Refer:
-AOMrefer=Down-Cleft/Adult/Unexplained

-OMEasap=Down/Cleft - Deafness - Cholesteatoma

A

AOM: MUSIC FBI PUNK

Admit @

  • Mastoiditis/Meningitis
  • Unwell systemically#<3m >38deg
  • Sinus Thrombosis
  • IC Abscess
  • CN 7 paralysis

ABx @:

  • Fail tx / 4/+ days
  • Bilat @<2yr
  • IC
  • Perf /Discharge
  • Unwell
  • Kidney liver heart etc dx

Tx:
Analgesia + Amox/Clari- >
worsen but NO MUSIC = Co-Amox
______

Sinusitis <10d Syx - NO ABx

Sinusitis >10d Syx:
-nasal c.sted

ABx only @ Cx:

  • Systemic dx
  • Peri-orbital/orbital cellulitis
  • Ophthalmoplegia
  • Sub-periosteal abscess
  • Meningitis

Tx = PMP-V -> Co-Amox/ Doxy @allergy
__________

  1. Fever > 38/ 3-14y
  2. Purulent exudate
    Admit <3d
  3. No cough/Coryza
    Inflamed tonsils
  4. C.LNopathy

FeverPAIN 4/5 = PMP-V
Centor 3/4 = PMP-V
________

-Persistent OME IN BETWEEN episodes
due to EUSTACHAIN BLOCKAGE
-Persistent C.LNopathy
-Epistaxis
Tx = 2ww NPCancer!!
If recurrent AOM @...
-Unexplained 
-Adult 
-Downs/Cleft #Craniofacial dx 
--> Refer
\_\_\_\_\_\_\_\_\_\_

OME:

ASAP refer
@Downs/Cleft / Cholesteatoma/ Hearing-loss

WW <12w (± Auto-inflation @older kids):
-2 PTAudio+Tympano-metries 12w apart

  • OM -> perf = Amox
  • Hearing-aid(/Surg* @Down’s/Cleft) @BILAT -OME
  • Auto-inflation: CI @URTI/pain
  • Myringotomy + grommet ± Addenoidectomy*

Grommets usually stop functioning after 10m

CSOM >2w = ENT
-Cleaning, ABx, Top c.steds

Cholesteatoma = ENT
-CT + Audiology

51
Q

Sinusitis ?d Syx = Tx?

Sinusitis ? d Syx = Tx?

ABx only @ Cx?

Tx = ? -> ?/ ? @allergy
__________

FeverPANIC
-when give ABx?
_________

Allergen exp -> B/L syx develop asap:
Sneezing, Discharge (rhinorrhoea)
-nasal CONGESTION / ITCH / Drip-postNasal
-Palate ITCH , Cough 
-Hayfever-Eye syx too 

Nasal CONGESTION features:
-Snoring, MOUTH breathing, and Halitosis.

PMH/FHx of atopy (asthma, eczema, or allergic rhinitis).

Fatigue, Sneeze, Post-nasal drip,
Eye-water
Itch posterior-pharynx

Tx mild-mod? Mod-severe?

-Chronic bilat rhino-sinusitis?
-Chronic UNILAT rhino-sinusitis?
________

-ALLyear?
-worse @spring/summer?*
-worse @work e.g. bakery?
________
1. House dust mites - ?
2. *Pollens:
-Tree = ?
-Grass = ?
-Weed = ?/?/?
3. Work

A

Sinusitis <10d Syx - NO ABx

Sinusitis >10d Syx:
-nasal c.sted

ABx only @ Cx:

  • Systemic dx
  • Peri-orbital/orbital cellulitis
  • Ophthalmoplegia
  • Sub-periosteal abscess
  • Meningitis

Tx = PMP-V -> Co-Amox/ Doxy @allergy
__________

  1. Fever > 38/ 3-14y
  2. Purulent exudate
    Admit <3d
  3. No cough/Coryza
    Inflamed tonsils
  4. C.LNopathy

FeverPAIN 4/5 = PMP-V
Centor 3/4 = PMP-V
________

Allergic Rhinitis:
Mild-Mod: AHist > MastCellStab
1. AHist:
- a. Intranasal Azelastine >
- b. Oral AHist > 
  1. MastCellStab-NaCromoGlic

Mod-Severe/ Mild fail:
-Intranasal Csted

Chronic Bilat rhino-sinusitis?
-saline nasal douches

-Chronic UNILAT rhino-sinusitis = 2WW!!!
________
-PERENNIAL all year - house dust mites

-seasonal hay-fever - spring/summer*

-Occupational
________

  1. House dust mites
    - all the time/ALLyear #PERENNIAL
  2. Pollens:*
    - Tree = spring
    - Grass = early summer
    - Weed = spring/summer/autumn
  3. Occupational
52
Q

Bastards:
APE TYME ORCS

Acoustic neuroma: #NF2
CN ? ? ? affected
-? reflex dx
-? palsy
-SVT?

Ix? -> Tx?
________

Most common salivary gland tumour 
- ? 80%
I--> most common paroid tumour = 
? > ?
\_\_\_\_\_\_\_\_\_\_
Recurrent unilat pain/swelling @EATING
-submandible = ?
-@face-side = ? @parotid
-infected = ? - ivdu floor of mouth dx
\_\_\_\_\_\_\_\_\_\_

Tonsilar SCC is associated with ? infection

Audiogram:
-if ONE ear low than other AND
-Bone > Air
Dx?

Bilateral HIGH-freq hearing loss. Air > bone

Bilat Conductive loss,

  • LOW frequencies
  • worse @preg
  • FHx: parent same issue

Low libido + ED -> ?Dx

Normal libido + ED -> ?Dx

ED Ix

B
P
P
V = ?direction nystag

Vestib = ?direction nystag nysag
-Still going on -> Tx?

Aspirin + NSAIDs taken in HIGH doses can cause ?

UTI ?
Biopsy ?
Ex ?
Ejac ?
DRE ?

Perf Tym Memb

  • NO infectoin
  • hx of barotrauma
  • ———-Tx?

Post-tonsillectomy haemorrhages tx?

Primary haemorrhage WITHIN HOURS hours after tonsillectomy = ?Tx

Haemorrhage 5-10 days AFTER tonsillectomy = Dx?
-Tx = ABx

AOM pathogen?

? neck mass:

  • benign, lateral, UNI-lateral neck mass
  • ABOVE SCMastoid
  • acellular CHOLESTEROL crystals

Top decongestants for prolonged periods = ?Cx

Prostate Cancer: RT risk = ? cancer

Fluid AROUND testicle
#CANNOT FEEL testes
-TRANSILLUMINATES

A

Bastards:

Acoustic neuroma: #NF2
CN 5 7 8 affected
-corneal reflex dx V1
-facial nerve palsy - CN4
-sensorineural vertigo tinnitus CN8

MRI cerebello-pont angle -> Surg
________

Most common salivary gland tumour
- parotid 80%
I–> most common paroid tumour = Pleomorphic Adenoma > Warthin’s tumour
__________

Recurrent unilat pain/swelling @EATING
-submandible = Wharton
-@face-side = Stenson @parotid
-infected = Ludwig angina - ivdu floor of mouth dx
\_\_\_\_\_\_\_\_\_\_\_

Tonsilar SCC is associated with HPV infection

Audiogram:
-if ONE ear low than other AND
-Bone > Air
Dx = MIXED hearing loss

Presbycusis

  • Sensori A>B
  • HIGH-freq -B/L

Otoscloersis

  • Conductive B>A
  • LOW-frew -B/L

Low libido + ED ->
Psycho-Somatic

ED Ix
-morning Testost > FSH/LH/Prolactin

Normal libido + ED ->
Organic cause… need to Ix (usualy vascular dx)

B
P
P
V = Vertical nystag

Vestib = horizontal nysag
-Still going on -> Vestib REHAB exercises!!!!

Aspirin + NSAIDs taken in HIGH doses can cause tinnitus

UTI 4w
Biopsy 6w
Ex 48hr
Ejac 48hr
DRE 7d

Perf Tym Memb
-NO infectoin
-hx of barotrauma
WW 6-8 weeks

Post-tonsillectomy haemorrhages should be assessed by ENT

Primary haemorrhage WITHIN HOURS hours after tonsillectomy =
immediate RETURN 2 theatre

Haemorrhage 5-10 days AFTER tonsillectomy =
Wound infection
-Tx = ABx

AOM pathogen = H. Flu

Branchial cyst:

  • benign, lateral, UNI-lateral neck mass
  • acellular CHOLESTEROL crystals

Top decongestants for prolonged periods = TachyPhylaxis

Prostate Cancer: RT risk = COLOrectal cancer

Fluid AROUND testicle
#CANNOT FEEL testes
-TRANSILLUMINATES
Dx = HYDROCELE

53
Q

A 31-year-old woman is diagnosed with a primary herpes infection at 35+2 weeks gestation. She does not have any other medical problems. She has had a normal pregnancy up to this point. A Caesarean section is planned for delivery at 39 weeks. What treatment should be initiated?
-? 400 mg tds until ?

Woman on OCP -> Bili + ALT goes up - jaundiced NO pain
The oral contraceptive pill is associated with
drug-induced ?

Helicobacter pylori infection is also associated with duodenal ? > gastric ?carcinoma + ? gastritis + ? lymphoma

?’s sign differentiates between
organic + non-organic
?weakness

Parkinsons disease should only be diagnosed, and management initiated, by a specialist with expertise in movement disorders

  • Don’t just start levodopa
  • Refer ?

In sickle-cell, acute painful vaso-occlusive THROMBOTIC crises should be diagnosed clinically #dactylitis #peripheries in pain – infarcts of bone etc

  • Oxygen, Hydration, Analgesia
  • ?Tx = PREVENTION of crises

?philia is a feature of ALLERGIC bronchopulmonary aspergillosis

Look at isoelectric lead -> find lead perp to isoelectric lead -> find direction of that perp lead

  • If positive = Axis in that lead direction
  • If negative = Axis in that lead OPP direction
  • If neither = perperndicular !!!

A 22-year-old man is referred to urology with ‘possible’ urinary retention.
-He is passing huge amounts of urine.
-Post void bladder ultrasound is NORMAL i.e. he aint fucking retaining !!!
-Dx?
This causes a lower bitemporal hemianopia.

A

A 31-year-old woman is diagnosed with a primary herpes infection at 35+2 weeks gestation. She does not have any other medical problems. She has had a normal pregnancy up to this point. A Caesarean section is planned for delivery at 39 weeks. What treatment should be initiated?

  • Oral Aciclovir 400 mg tds until DELIVERY
  • c-section

The oral contraceptive pill is associated with
drug-induced cholestasis

Helicobacter pylori infection is also associated with duodenal ulceration > gastric ADENOcarcinoma + atrophic gastritis + MALT lymphoma

Hoover’s sign differentiates between
organic and non-organic
lower leg weakness

Parkinsons disease should only be diagnosed, and management initiated, by a specialist with expertise in movement disorders

  • Don’t just start levodopa
  • Refer URGENTLY

In sickle-cell, acute painful vaso-occlusive THROMBOTIC crises should be diagnosed clinically #dactylitis #peripheries in pain – infarcts of bone etc

  • Oxygen, Hydration, Analgesia
  • HOHuria = PREVENTION of crises

Eosinophilia is a feature of ALLERGIC bronchopulmonary aspergillosis

Look at isoelectric lead -> find lead perp to isoelectric lead -> find direction of that perp lead

  • If positive = LAD
  • If negative = RAD
  • If neither = normal

A 22-year-old man is referred to urology with possible urinary retention. He is passing huge amounts of urine. Post void bladder ultrasound is normal.

  • Craniopharyngioma -> Diabetes insipidus
  • Bitemporal hemianopia.
54
Q

HYPERthyroidism = oligomennorhoea, or amennorhoea, whereas
HYPOthyroidism = menorrhagia
- patient has proximal muscle weakness (difficulty getting out of chair and combing hair) consistent with myopathy
- This type of myopathy can be due to drugs (glucocorticoids), connective tissue disease (e.g. polymyositis), neuromuscular (e.g. myasthenia gravis) disease or endocrine (e.g. hypo or hyperthyroidism).

FBC/ HbA1c/ Anti-TPO(# - graves 75%) / Lipids/ TgAB (#)-TSHrAB (graves)

Myelo? -> leading to ANT
Myelo? -> neutropaenia only ->
@early disease: spleen compensate for RBC + Plts production.
@dx progression: spleen production tapers off = RBC + Plts numbers begin to fall

\_\_\_\_\_Hb WCC Plt | Philadel JAK2
PRV=Hb high high high - JAK2
CML=WCC low high high - 9,22
ET=Plts ASP + HOHuria
MyeloFib=FibroBlasts low = HSM/Teardrop/Bone
-PRV / CML / ET / MyeloFib

Polycythemia - RBC mass:
-low = Relative:
Acute=Dehydration
Chronic=HTN/Alco/Obesity/

-high = Absolute
Pri = PRV*
2ndry = Altitude/ COPD/ EPO-OSAS

*(Abnormal bleed, SMeg, HTN/Hyperviscos, Itch @shower/ Plethoric)

ULTx @:

  • Two/+ attacks/yr // Tophi/joints
  • Urate stones
  • RF GFR <60
  • Proph @cytotoxics/diuretics/pyrazinamide

the British Society of Rheumatology Guidelines =
advocate offering ULT
to all patients after their
FIRST BASTARD attack of gout
-Offer allopurinol ? weeks AFTER attack with colchicine cover

Hyperacute TRANSPLANT rejection 
-MINUTES-HOURS
-is caused by pre-existing ? 
against 
? or  ? antigens

Acute GRAFT failure (< ? months) = mismatched HLA

  • ?-mediated (cytotoxic ? cells)
  • Tx?
Chronic GRAFT failure (> ? months) = 
both ? + ?-mediated mechanisms -> 
fibrosis to the transplanted kidney 
#chronic allograft ?
-get recurrence of original renal disease 
(?GlomeruloNephritis > IgA > FSGS)
Blood Transfusion
S-SSI-S
G=Stop+Steds
A=Stop+Saline
D=Stop+IVIg
N=Stop+Slow+Paracetamol

Blood transfusion -?
–PAINful MacPap Rash

Mandem w/ Ai PMH + join pain + RhF neg = ?gene dx

25-year-old male attends his GP with myalgia and flu-like symptoms.

  • Toxo IgM + IgG positive
  • NOT immunocomp = ?Tx
  • Immunocomp = ?Tx

? is a common trigger for cold sores

? palsy = fell -> 
pronated 
\+ 
medially rotated = 
brachial trunks ?nerve roots

? paralysis = slip, HUNG on -> weakness of the
-hand intrinsic muscles
+
-Horner’s = brachial trunks ?nerve roots

Confabulation/Apathy-AmnesiaRetro/Psychosis are features of ? psychosis

Which RTA dyou get renal stones in?! 
Type 1 renal tubular acidosis (distal) complication – RENAL stones
-Congen URO dx
-RHEUM dx
-Amphoterocin
-Painkillers – NSAID

Fever on alternating days, think ?infection

  • headache, myalgia, HMeg
  • history of foreign travel

Sexy-times

  • anorexia, nausea and
  • RUQ pain + tender HMeg
  • fever

-ROSE spot rash + Constipation
-BRADYcardia
-dry cough, fever, EPISTAXIS and malaise.
Ix?

Febrile phase (high ALT/ low Plts)) #saddleback

  • critical phase (abdo pain, vomiting and incr RR)
  • recovery phase.

Most neurologists now start antiepileptics following ? epileptic seizure.

Following a FIRST seizure
-anti-epileptic drug tx should only be started
B4 specialist review in exceptional circumstances including:
1. ? activity observed on EEG
2. Presence of a neurological ?
3. Presence of a ? brain abnormality
4. Patient, parent/carer considers the risk of a further seizure to be ?
- prescribe ? to use in the event of status epilepticus.

Positron Emission Tomography (PET) demonstrates ? uptake

dissecting aneurysm of the ascending aorta which originates at the aortic valve
-?Surg

Mandem when strokes his face/shaves/brushes care - gets tingling pain
- He’s UNDER ? years of age
- ? changes
- ? /ear problems
- Skin / Oral ? = ?spread peri?
- Pain @? division of the trigeminal (?, ?, ?)
- Optic ? / FHx of ?
—Tx = NOT ? straight away.. urgent referral
for specialist assessment rather than treatment.

Has had several episodes where she becomes suddenly tearful –>
-period of unresponsiveness:
-wanders the house = unaware of what she is doing
-sleeps for around 2 hours
Patients may display ? during a COMPLEX FOCAL seizure - ?LOBE?

Anterior MI -> Complete heart block
Tx = ?

inferior MI -> Complete heart block
Tx = ? i.e….
? an indication for ?

Nasal ? + ? for the skin

CT = ANT CIRC ischaemic stroke + LIMITED (I.E. not completely fucked !!) infarct CORE

  • ? in acute ischaemic stroke,
  • extended target time of 6-24 hours
  • CTperf/MRd-w =?SAVE brain tissue
A

HYPERthyroidism = oligomennorhoea, or amennorhoea, whereas
HYPOthyroidism = menorrhagia
- patient has proximal muscle weakness (difficulty getting out of chair and combing hair) consistent with myopathy
- This type of myopathy can be due to drugs (glucocorticoids), connective tissue disease (e.g. polymyositis), neuromuscular (e.g. myasthenia gravis) disease or endocrine (e.g. hypo or hyperthyroidism).

Myelodysplastic syndrome -> leading to ANT
Myelofibrosis neutropaenia, WITHOUT anaemia/TCP ->
@early disease: spleen compensate for RBC + Plts production.
@dx progression: spleen production tapers off = RBC + Plts numbers begin to fall

\_\_\_\_\_Hb WCC Plt | Philadel JAK2
Hb high high high - JAK2
WCC low high high - 9,22
Plts ASP + HOHuria
FibroBlasts low = HSM/Teardrop/Bone
-PRV / CML / ET / MyeloFib

Polycythemia - RBC mass:
-low = Relative:
Acute=Dehydration
Chronic=HTN/Alco/Obesity/

-high = Absolute
Pri = PRV*
2ndry = Altitude/ COPD/ EPO-OSAS

*(Abnormal bleed, SMeg, HTN/Hyperviscos, Itch @shower/ Plethoric)

ULTx @:

  • Two/+ attacks/yr // Tophi/joints
  • Urate stones
  • RF GFR <60
  • Proph @cytotoxics/diuretics/pyrazinamide

the British Society of Rheumatology Guidelines =
advocate offering ULT
to all patients after their
FIRST BASTARD attack of gout
-Offer allopurinol TWO weeks AFTER attack with colchicine cover

Hyperacute transplant rejection 
-minutes to hours
-is caused by pre-existing ABs 
against 
ABO or HLA antigens

Acute graft failure (< 6 months) = mismatched HLA

  • Cell-mediated (cytotoxic T cells)
  • Tx = steroids + immunosup

Chronic graft failure (> 6 months) = both AB + cell-mediated mechanisms ->
fibrosis to the transplanted kidney
#chronic allograft nephropathy
-get recurrence of original renal disease (MCGN* > IgA > FSGS)
-MesangioCap/MembProlif GN

S-SSI-S
G=Stop+Steds
A=Stop+Saline
D=Stop+IVIg
N=Stop+Slow+Paracetamol

Acute GvH stop + steds
–PAINful MacPap Rash

Mandem w/ Ai PMH + join pain + RhF neg = ?HLA-B27 dx

25-year-old male attends his GP with myalgia and flu-like symptoms.

  • Toxo IgM + IgG positive
  • NOT immunocomp = DON’T TREAT
  • Immunocomp = Pyrimethamine and sulphadiazine

Sunlight is a common trigger for cold sores

Erb's palsy = fell (waiters TIP)-> 
pronated 
\+ 
medially rotated = brachial trunks C5-6
-ERB'S HAS 4 LETTERS but just add one FFS...
Klumpke's paralysis = slip, hung on -> 
weakness of the 
hand intrinsic muscles 
\+ 
Horner’s = brachial trunks C8-T1
-KULMPKE'S HAS 8 LETTERS

Confabulation/Apathy-AmnesiaRetro/Psychosis are features of Korsakoff’s psychosis

Which RTA dyou get renal stones in?! 
Type 1 renal tubular acidosis (distal) complication – RENAL stones
Congen URO dx
RHEUM dx
Amphoterocin
Painkillers – NSAID

Fever on alternating days, think MALARIA

  • headache, myalgia, HMeg
  • history of foreign travel

Acute hepatitis B

  • anorexia, nausea and
  • RUQ pain + tender HMeg
  • fever

Typhoid fever classically presents with 4 phases.

  • ROSE spot rash + Constipation
  • BRADYcardia
  • dry cough, fever, EPISTAXIS and malaise
  • Ix = CULTURES

Dengue fever (high ALT/ low Plts)

  • Febrile phase
  • critical phase (abdo pain, vomiting and incr RR)
  • recovery phase.

Viral haemorrhagic fever can also present with fever and non-specific flu-like symptoms. However, it does not typically cause hepatomegaly and does not cause this pattern of fever.

Most neurologists now start antiepileptics following a SECOND epileptic seizure.

Following a FIRST seizure, anti-epileptic drug treatment should only be started before specialist review in exceptional circumstances including: SDSU

  1. SEIZURE activity observed on EEG
  2. Presence of a neurological DEFICIT
  3. Presence of a STRUCTURAL brain abnormality
  4. Patient, parent or carer considers the risk of a further seizure to be UNACCEPTABLE
    - prescribe LORAZEPAM to use in the event of status epilepticus.

Positron Emission Tomography (PET) demonstrates Glucose uptake

dissecting aneurysm of the ascending aorta which originates at the aortic valve
-Aortic root replacement

Mandem when strokes his face/shaves/brushes care - gets tingling pain
- He’s < 40 years of age
- Sensory changes
- Deafness ear problems
- Skin / Oral LESIONS = ?spread perineurally
- Pain @OPHTHALMIC V1 division of the trigeminal (socket, forehead, nose)
- Optic neuritis / FHx of MS
—Tx? NOT carbemazapine straight away..
URGENT REFERRAL for specialist assessment rather than treatment.

Has had several episodes where she becomes suddenly tearful –>
-period of unresponsiveness:
-wanders the house = unaware of what she is doing
-sleeps for around 2 hours
Patients may display AUTOMATISM during a
COMPLEX FOCAL SEIZURE #TEMPORAL lobe

Anterior MI -> Complete heart block
Tx = pacing

inferior MI -> Complete heart block
NOT an indication for pacing

Nasal mupirocin + chlorhexidine for the skin

CT = ANT CIRC ischaemic stroke + LIMITED (I.E. not completely fucked !!) infarct CORE

  • thrombectomy in acute ischaemic stroke,
  • extended target time of 6-24 hours
  • CTperf/MRd-w =?SAVE brain tissue
55
Q

IV ?Tx should be used in patients who are found to have Fe deficiency anaemia prior to surgery where

  • oral iron either can’t be tolerated or the
  • time interval is too short

? is recommended in the treatment of Turner’s syndrome

? is associated with a firm, smooth, tender and PULSATILE liver edge

Paraneoplastics:

  • ? cell: ? cells = SAL*
  • ? = PTHrP
  • ? = GynaecomAstiA
  • ? = hcg
  • SIADH, ACTH, Lambert-Eaton

Lung cancer in NOn-smoker - ?
Lung cancer in SSSmoker - ?

? rejection is caused by pre-existing antibodies against ABO or HLA antigens
-minutes to hours

?/ ? such as bisoprolol are common precipitants of myasthenic crises.

? reduce hypoglycaemic awareness

? may cause insomnia

Bile-acid malabsorption may be treated with ?

? typically causes an early diastolic murmur

A late diastolic murmur is associated with ?.

Charcot-Marie-Tooth disease
(hereditary sensorimotor neuropathy type I) is an autosomal ?

NOT FUCKING RHEUMATOID ARTHITIR SYOU FUCKONG PIECE OF FUCKING SHI !!!!!!!!!!!
Upper zone?
Mid Zone?
Lower Zone?

Arnold-Chiari malformation can cause

  • ? hydrocephalus
  • assoc w/ ?

Status epilepticus: rule out hypo? and hypo? before thinking of other causes: LLPR

orlistat = Pancreatic ? inhibitor

MTX ?m AFTER tx #preg

CN3 palsy:
Motor(down+out, ptosis), PSymp(dilated), ?vertical nystagmus
-iCUMP Ax?

COCP use + FHx of VTE + Severe HEADACHE = more insidiously than a ‘thunderclap headache’, with ?subtle neurology
-?Ix is the gold standard test for diagnosing ?Dx

Cavernous sinus syndrome 2 Ax = 
-Cavernous Sinus Tumours, OR
-NPC = invades Cavernous Sinus -> 
Corneal Reflex Absent ?Anatomy
Horner ?Anatomy
Opthalmoplegia ?Anatomy
Pain, Proptosis #mass-effect
-max sens low ?Anatomy
-CN 3 ?
-CN 4 ?
-CN 5- (V1=?Reflex, V2=?sensation)
-CN 6 ? + ICA (?) + Symp trunk (?)

-Motor:(down+out, ptosis),
-PSymp(dilated),
-?vertical nystagmus
Ax ?

PAINFUL third nerve palsy = r/o ?

Ulcerative colitis - ? is the most common site affected
-Diverticu = ? most affected (dont get mixed up !!!)

low-grade temperature.

  • painful ulceration of his mouth and gums.
    37. 4ºC submandibular lymphadenopathy.
  • ? !!!

Sudden weight loss + NAFLD

  • MANDEM got roux-en-y, gastric bypass, lost 30kg. Suddenly got jaundice
  • ?

IgA nephropathy develops 1-2 ? after URTI
PSGN develops 1-2 ? after URTI.

A

IV iron should be used in patients who are found to have iron deficiency anaemia prior to surgery where

  • oral iron either can’t be tolerated or the
  • time interval is too short

Growth hormone is recommended in the treatment of Turner’s syndrome

Right heart failure is associated with a firm, smooth, tender and PULSATILE liver edge

Paraneoplastics:

  • Small cell: Kulchitksy cells = SAL*
  • Squamous = PTHrP
  • Adeno = GynaecomAstiA
  • Large = hcg
  • SIADH, ACTH, Lambert-Eaton

Lung cancer in NOn-smoker - AdeNO
Lung cancer in SSSmoker - SSSquamous

HYPERACUTE rejection is caused by pre-existing antibodies against ABO or HLA antigens
-minutes to hours

Beta-blockers/ CCB-RL such as bisoprolol are common precipitants of myasthenic crises.

Beta-blockers reduce hypoglycaemic awareness

Beta-blockers may cause insomnia

Bile-acid malabsorption may be treated with cholestyramine

Aortic regurgitation typically causes an early diastolic murmur

A late diastolic murmur is associated with mitral stenosis.

Charcot-Marie-Tooth disease (hereditary
sensorimotor neuropathy type I) is an autosomal dominant

NOT FUCKING RHEUMATOID ARTHITIR SYOU FUCKONG PIECE OF FUCKING SHI !!!!!!!!!!!
Upper zone
-PMF-coal/beryliosis
HSRpneumonitisAKAExtAllAlveolitis, 
AnkSpond, RTherapy !!!!!!!!!!!!!! , TB

Mid Zone

  • Sarcoid
  • Silicosis-EGGSHELL/Caplan@RA
  • Histoplasmosis

Lower Zone

  • IdiopathPF
  • Asbestosis
  • Amiodarone/Bleomycin/MTX/Nitro

Arnold-Chiari malformation can cause

  • non-comm hydrocephalus #OBSTRUCTIVE
  • assoc w/ Syringomyelia

Status epilepticus: rule out hypoxia and hypoglycaemia before thinking of other causes: LLPR but fucking choose BM man

orlistat = Pancreatic lipase inhibitor

MTX 6m AFTER tx #preg

CN3 palsy:
Motor(down+out, ptosis), PSymp(dilated), ?vertical nystagmus
-isch, CavSinThrom, UncalHerniate/trans-tentorial, MidbrainWeber, PComAneurysm

COCP use + FHx of VTE + Severe HEADACHE = more insidiously than a ‘thunderclap headache’, with ?subtle neurology
-MR Venogram is the gold standard test for diagnosing venous sinus thrombosis

Cavernous sinus syndrome Ax =
Cavernous sinus tumours, OR
NPC = locally invades cavernous sinus. ->
Corneal Reflex Absent,
Horner,
Opthalmoplegia
Pain, Proptosis #mass-effect
-CN 3 Opthalmoplegia (ptosis/diplopia)
-CN 4 Opthalmoplegia
-CN 5- (V1=Corneal Reflex Absent, V2=low max sens)
-CN 6 Opthalmoplegia + ICA (thrombosis) + Symp trunk (Horner’s)

CN3 palsy:
Motor(down+out, ptosis), PSymp(dilated), ?vertical nystagmus
-isch, CavSinThrom, UncalHerniate/trans-tentorial, MidbrainWeber, PComAneurysm

PAINFUL third nerve palsy = posterior communicating artery aneurysm

Ulcerative colitis - the rectum is the most common site affected
-Diverticu = sigmoid most affected (dont get mixed up !!!)

low-grade temperature.extensive painful ulceration of his mouth and gums. 37.4ºC submandibular lymphadenopathy.
-HSV 1 !!!

Sudden weight loss is associated with non-alcoholic fatty liver disease

  • MANDEM got roux-en-y, gastric bypass, lost 30kg. Suddenly got jaundice
  • Acute on chronic NAFLD !!!

IgA nephropathy develops 1-2 days after URTI
PSGN develops 1-2 weeks after URTI.

56
Q

Intention tremor @ ?dx
? - over/undershooting @ MS/ALS

ET v Parkinsons =
NICE recommend ?

Levo/carbi

  • Motor ? /cx ?
  • ADLs ?
  • Adverse rxns ? (#HIS)
  • Time inc = ? decrease

Ropinirole/CabergolineCardiacFibrosis -
?HIS

Mandem = NA 154 
serum osmo >300
urine osmo < 600
Ax? - Binge alco/ DM/ MDMA/ Polydipsia/ SIADH
Mechanism?
Absence of BETA-chains
F2T HSM Micro-TICS
-HbA2 + HbF high 
-HbA ABSENT
----Dx? 2 Tx?

? are used in the management of Severe ALCO hepatitis

Alco+Met Acidosis+NORMAL BMs
-Dx? is managed with an infusion of ? + ?
___________

*PRAD: Pyrexia, Rigidity (high ?BLOODS), Autonomic syx, Delirium - ORP

SSRI/MAOi/Ecstasy –>
RAPID onset PRAD*
HYPOOOreflexia NOOORMAL pupils
-ALL low - onset time, reflexes, pupils

  1. Dx? Tx?

Antipsychotic/ Parkinson-med stop –>
SLOW onset PRAD* ORP
HYPERreflexia, DILATED pupils
-ALL HIGH - onset time, reflexes, pupils

  1. Dx? Tx?
    __________________
Paraesthesia
UNSTEADiness
Restless + SLEEP dx, 
SWEATing
-Mood change
? = HIGHER incidence of 
DISCONTINUATION syx 
than other SSRI
\_\_\_\_\_\_\_\_\_\_\_
low AF BP
BICUSPID aortic valve
MarfanEhlers/Turner's and Noonan
-Preg/syph
-> Chest pain radiate 2 back
Tx?

DVT 1/- 2/+ ; PE 4/- 5/+

30-d mortality - ?OutPt tx? = ?VTE score?

SUSPECT PE?

  • ? criteria to r/o PE
  • ? the criteria must be ABSENT to have NEG PERC to rule-out PE
  • this should be done when you think there is a LOW PRE-TEST probability of PE, but want more REASSURANCE that it isn’t the diagnosis
  • this low probability is defined as < ?%

Pearly penile papules - Tx?

Bone pain + Deformity (which 2 met bone dx cause this…) -> X-ray
generalised osteopenia,
erosion of the terminal phalyngeal tufts (acro-osteolysis) and
sub-periosteal resorption of bone
particularly the radial aspects of
2nd + 3rd middle phalanges.
-Dx?

STEPWISE progression of symptoms in dementia - think ? dementia

A

Intention tremor @ cerebellar dx
Dysmetria - over/undershooting @ MS/ALS

ET v Parkinsons =
NICE recommend 123I‑FP‑CIT SPECT

Levo/carbi

  • Motor improve/cx increase
  • ADLs improve
  • Adverse rxns decrease (hallucinations/impulse/sleep)
  • Time inc = effectiveness decrease

Ropinirole/CabergolineCardiacFibrosis - hallucinations/impulse/sleep

Mandem = NA 154
serum osmo >300
urine osmo < 600
Ax? - Binge alco/ DM/ MDMA/ Polydipsia/ SIADH
-Tx: BINGE ALCO = suppress ADH @post-pit -> polyuria

Beta thalassaemia long term tx?

  • Life-long blood transfusions
  • desferrioxamine chelation -> prevent iron overload

Corticosteroids are used in the management of severe ALCOHOLIC hepatitis

Alco+Met Acidosis+NORMAL BMs
Alcoholic ketoacidosis is managed with an infusion of SALINE + Thiamine
__________________

*PRAD: Pyrexia, Rigidity (high CK), Autonomic syx, Delirium - ORP

PRAD - ORP

  1. SeRAPIDtotonin Serotonin Syndrome
    - CyproPhetadine/Chlorpromazine
2. NMS: Anti-pSLOOOOOOOOWcotic
Stop APsych/Start Parkinson-meds, 
IVF, 
-Dantrolene/?DopAgonists - bromocriptine
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

SSRI Discontinuation Syx

Paroxetine = HIGHER incidence of
DISCONTINUATION syx
than other SSRI
______________________

SSRI Discontinuation Syx

Paroxetine = HIGHER incidence of
DISCONTINUATION syx
than other SSRI

______________________

Aortic dissection 
BICUSPID aortic valve
MarfanEhlers/Turner's and Noonan
-Preg/syph
-> Chest pain radiate 2 back
THORACIC AORTIC DISSECTion
-Aortic Root Valve Replacement
\_\_\_\_\_\_\_\_\_\_

DVT 1/- 2/+ ; PE 4/- 5/+
1/- = Dimer (POS = PLSDoppler <4hr / PLS <24hr + Tx DOAC ; NEG = d/c)

2/+ = PLSDoppler <4hr 
POS = Tx DOAC ; 
NEG = Dimer (Pos dimer = Repeat PLS <6-8d + Tx DOAC ; Neg dimer = d/c)
Pos Repeat PLS = Tx DOAC
Neg Repeat PLS = d/c

30-d mortality - ?OP tx? = PESI

SUSPECT PE?

  • PERC criteria to r/o PE
  • ALL the criteria must be ABSENT to have NEG PERC to rule-out PE
  • this should be done when you think there is a LOW PRE-TEST probability of PE, but want more REASSURANCE that it isn’t the diagnosis
  • this low probability is defined as < 15%

Pearly penile papules are not a cause for concern and do not require intervention

Bone pain + Deformity (OM / Paget..) -> X-rayX-ray
generalised osteopenia,
erosion of the terminal phalyngeal tufts (acro-osteolysis) and
sub-periosteal resorption of bone
particularly the radial aspects of
2nd + 3rd middle phalanges.
-Hyperparathyroidism.

STEPWISE progression of symptoms in dementia - think vascular dementia

57
Q

The investigation of choice for narcolepsy is ?

I and aVL, and in V5+V6 ?

Over the past seven days pt has received
TPN + adequate Calcium replacement.
DESPITE THIS, she remained HYPOcalcaemic.
Patients with malabsorption may develop ? deficiency

? / ? tablets can reduce the absorption of levothyroxine - should be given 4 hours apart

Gilbert’s syndrome is a benign condition causing a mild rise in bilirubin - Tx?

  • Streptococcus ? - classically linked to poor dental hygiene or following a dental procedure
    2 - Streptococcus ? - most commonly linked with colorectal cancer
    3 - ? - causes Q fever = infection caught most commonly from farm animals #farmer or abattoir worker.
    5 - ?ococcus ? - most commonly associated with patients who have undergone previous PROSTETIC VALVE surgery / Peritoneal Dialysis

Farmer, fever, transaminitis high ALT

Fever +

  • Headache + Photophobia + neck stiffness. #meningitis
  • seizure -> Recovers within 2 minutes + more tired than before #encephalitis
  • altered mental status #encephalitis

Dx: Encephalitis = Tx?
-meningitis = ?virus; -encephalitis = ?virus

HYPOdense collection #?
around the convexity of the brain #?dural
that is NOT limited to suture lines

dysphagia + glossitis + iron-def anaemia
-Dx?

Conjunct Pallor
Angular cheilosis + Atrophic glossitis
koilonychia spoon-nails
-? Def Anemia

Neuro shit
Angular cheilosis + Glossitis (red smooth + shiny tongue, ? ulcers)
Lemon skin
-? def Anemia

CT confirms numerous bilateral calculi.
Investigations urgently?
-?Bloods #OBSTRUCTION BASTARD

Arteriovenous fistulas are the preferred method of access for haemodialysis

A 17-year-old girl presents with a six week history of nausea and abdominal discomfort. Routine blood tests reveal the following. ALP 262 high AF !!!
-Preg V PBC?
-PREGGERS!!!!
Pbc = middle aged IgM etc

commonly due to aspiration/alco
sputum appears red and jelly-like pneumonia - upper lobe

Complete heart block following a MI? - ?vessel

The concurrent use of MTX + Trimeth containing antibiotics may cause
?suppression -> ?cytopaenia

Azo + Allopurinol = ? too…

Acute ?
in the immunocompetent pt
can mimic acute EBV
(low-grade fever, generalised LNopathy, prominent cervical lymph nodes, malaise)
-should be suspected with NEGATIVE EBV serology.
-VCA neg – EBNA neg i.e. EBV antigens

For thrombectomy in acute ischaemic stroke, an EXTENDED target time of ?-? hours may be considered if there is the potential to salvage brain tissue, as shown by imaging such as CT perfusion or diffusion-weighted MRI sequences showing limited infarct core volume

A 28-year-old man develops nausea and a severe headache whilst trekking in Nepal. Within the next hour he becomes ataxic and confused. A diagnosis of high altitude cerebral oedema is suspected. Other than descent and oxygen, what is the most important treatment?

  • ? is used more in the PREVENTION of high altitude cerebral oedema,
  • ? used in TREATMENT of cerebral oedema

? + ?@diarrhoea

  • Octreotide is a ? analogue used to treat the symptoms of carcinoid syndrome
  • urine ?/ plasma ?

Whilst using an inhaler, you should ideally hold your breath for ? seconds AFTER PRESSING down on the canister

When using an inhaler, for a second dose you should wait for approximately ? seconds B4 REPEATING

A

The investigation of choice for narcolepsy is
multiple sleep latency EEG

I and aVL, and slightly in V5+V6 LEFT circumflex

Over the past seven days pt has received
TPN + adequate Calcium replacement.
DESPITE THIS, she remained HYPOcalcaemic.
Patients with malabsorption may develop MAGNESIUM deficiency

Iron / calcium carbonate tablets can reduce the absorption of levothyroxine - should be given 4 hours apart

Gilbert’s syndrome is a benign condition causing a mild rise in bilirubin - NO treatment needed

  • Streptococcus viridans - classically linked to poor dental hygiene or following a dental procedure
    2 - Streptococcus bovis - most commonly linked with colorectal cancer
    3 - Coxiella burnetti - causes Q fever, an infection caught most commonly from farm animals. So, consider in any farmer or abattoir worker.
    5 - Staphylococcus epidermis - most commonly associated with patients who have undergone previous PROSTETIC VALVE surgery / Peritoneal Dialysis

Farmer, fever, transaminitis ?Q fever
-Coxiella

Fever +

  • Headache + Photophobia + neck stiffness. #meningitis
  • seizure -> Recovers within 2 minutes + more tired than before #encephalitis
  • altered mental status #encephalitis

Dx: Encephalitis = IV (Aciclovir + ABx)
-meningitis = enterovirus; -encephalitis = HSV1

Hypodense collection #chronic
around the convexity of the brain #subdural
that is not limited to suture lines

dysphagia + glossitis + iron-def anaemia
-Plummer Vinson

Conjunct Pallor
Angular cheilosis + Atrophic glossitis
koilonychia spoon-nails
-Iron Def Anemia

Neuro shit
Angular cheilosis + Glossitis (red smooth + shiny tongue, ? ulcers)
Lemon skin
-B12 def

CT confirms numerous bilateral calculi.
Investigations urgently?
-U+E #OBSTRUCTION BASTARD

Arteriovenous fistulas are the preferred method of access for haemodialysis

A 17-year-old girl presents with a six week history of nausea and abdominal discomfort. Routine blood tests reveal the following. ALP 262 high AF !!!
-Preg V PBC?
-PREGGERS!!!!
Pbc = middle aged IgM etc

sputum appears red and jelly-like.
KLEBSIELLA pneumonia-> commonly due to aspiration

Complete heart block following a MI? -
right coronary artery lesion = AVN

The concurrent use of MTX + Trimeth containing antibiotics may cause
bone marrow suppression -> pancytopaenia

Azo + Allopurinol = Myelo too…

Acute toxoplasmosis
in the immunocompetent pt
can mimic acute EBV
(low-grade fever, generalised LNopathy, prominent cervical lymph nodes, malaise)
-should be suspected with NEGATIVE EBV serology.
-VCA neg – EBNA neg i.e. EBG antigens

For thrombectomy in acute ischaemic stroke, an extended target time of 6-24 hours may be considered if there is the potential to salvage brain tissue, as shown by imaging such as CT perfusion or diffusion-weighted MRI sequences showing limited infarct core volume

A 28-year-old man develops nausea and a severe headache whilst trekking in Nepal. Within the next hour he becomes ataxic and confused. A diagnosis of high altitude cerebral oedema is suspected. Other than descent and oxygen, what is the most important treatment?

  • Acetazolamide is used more in the PREVENTION of high altitude cerebral oedema,
  • Dexamethasone used in TREATMENT of cerebral oedema

Octreotide + cyprophetadine@diarrhoea

  • Octreotide is a somatostatin analogue used to treat the symptoms of carcinoid syndrome
  • urine 5hiaa/ plasma chromogranin

Whilst using an inhaler, you should ideally hold your breath for 10 seconds AFTER PRESSING down on the canister

When using an inhaler, for a second dose you should wait for approximately 30 seconds B4 REPEATING

58
Q

Isolated TCP + Rash
in a WELL pt –> ?Dx

MAHA + AKI + TCP#Rash = ?Dx

Alpha1-antitrypsin deficiency can be diagnosed ?

  • Chorionic villus sampling @? weeks gestation
  • Amniocentesis = ?w
PCP:
•  ?ABx
•  IV ? @ severe cases
•  ? pentamidine is an alternative Tx for PCP but is LESS effective with a risk of ?
•  ? if hypoxic 

muscle wasting @hands,
numbness + tingling,
?autonomic syx

pain, cold sensitivities
poor circulation @hands + extremeties

Subdural haemorrhage is caused by damage to bridging veins between
cortex + ?

In trauma, to test if the fluid draining from the nose or ear is CSF, check for ?

35M pain occurs
AFTER he has walked for 10 mins
-relieved when he sits
-toes turn white, then blue and red during the COLD #Raynaud
-smoking 3 - 4 PACKS of cigs/ day for 10yrs
i.e. Raynaud’s + extremity ischaemia + SMOKING
- ?Dx
-large/med/small vessel vasculitis?

SLE + proteinuria = consider ?

LP –> A low pressure headache
- Tx: ? and ?

Consider the use of pain management clinics in resistant diabetic neuropathy

If MSCC is suspected, 
?
should be given ?
WHILST AWAITINGGGG
?

Isoniazid can cause drug-induced ?
-iTEACH

Woman with bone metastases- most likely to originate in the ?
In order of frequency: 
Breast
Bronchus
Brostate
Bridney
Bryroid

The Levine Scale:
•Grade 4 = palpable THRILL
•Grade 5 - palpable THRILL + steth EDGE
•Grade 6 – heard WITHOUT STETH

? hemisphere
?vessel strokes -> aphasia

STOPPING of anti-epileptic drugs (AED):

  • If seizure free for > ? years +
  • with AEDs being stopped over ?months

‘high-stepping’ gait - he tends to excessively flex his knees to ensure the feet ‘clear’ the ground when walking.
Dx: Peripheral neuropathy
-high-stepping gait develops to compensate for ?

Atorvastatin ?mg is a high-intensity statin and should be started as primary prevention against cardiovascular disease

HNPCC is ?woman cancer + ?HPB cancer

Overnight dexamethasone suppression testing was performed, which revealed no change in cortisol levels i.e. FUCKING SYNDROME !!!
-high urinary cortisol + LOW ACTH i.e. sutin suppressing pituitary (pituitary isn’t obvs making any XS ACTH so cant be pit adenoma bastard). Likely ? making loads of cortisol -> suppress ACTH @pit #CT-Abdo

suspected stroke. unable to speak BUT able to follow instructions

  • do not know the handedness of the patient
  • Percentage of right (90% )and left (60%) handed individuals
  • making the LEFT BRAIN always > most likely affected side
  • ? on dominant side supplies both Wernicke’s (? ? Gyrus) + Broca’s (? ? Gyrus) areas
  • which are responsible for understanding and production of speech.

Just ask what are the insulin regimes for DM1 + DM2:
Insulin DM1: MTRM
-multiple daily Basal-Bolus -fail-> cont SC ins @12/+ yr
-twice daily Detemir basal
-RA analog b4 meals
-metformin @BMI 25/+

  1. Insulin DM2: INDGP
    NPH=SA @HbA1c 75/+
    Detemir/Glargine
    Pre-mixed w/ SA analogue

man TChol of 6.2 (i.e. < 7.5)
Q-risk score to be 23%.
10 cigarettes a day
His father died of a heart attack aged 50.
Tx: Atorva 20 or Atorva 80?
-ATORVA 20 !!!!!! HES NOT HIMSELF HAD A FUCKING MI
-If non-HDL NOT drop by 40%/+ -> Titrate up provided GFR > 30

A

Isolated TCP + Rash
in a WELL pt –> ITP

MAHA + AKI + TCP#Rash = TTP

Amniocentesis

Alpha1-antitrypsin deficiency can be diagnosed prenatally.

  • Chorionic villus sampling is usually performed between 11 to 14 weeks gestation
  • amniocentesis @15 to 20 weeks gestation
PCP:
•  co-trimoxazole
•  IV pentamidine @ severe cases
•  aerosolized pentamidine is an alternative Tx for PCP but is LESS effective with a risk of Pneumothorax
•  steroids if hypoxic 

Neurogenic Thoracic Outlet Syndrome -muscle wasting @hands,

  • numbness + tingling,
  • ?autonomic syx

Arterial Thoracic Outlet Syndrome

  • least common subtype of thoracic outlet syndrome
  • pain, cold sensitivities + poor circulation @hands + extremeties

Subdural haemorrhage is caused by damage to bridging veins between
cortex + venous sinuses

In trauma, to test if the fluid draining from the nose or ear is CSF, check for glucose

35M pain occurs
AFTER he has walked for 10 mins
-relieved when he sits
-toes turn white, then blue and red during the COLD #Raynaud
-smoking 3 - 4 PACKS of cigs/ day for 10yrs
i.e. Raynaud’s + extremity ischaemia + SMOKING = Buerger’s Thromboangiitis obliterans Dx
-medium vessel vasculitis

SLE + proteinuria = consider lupus nephritis

LP –> A low pressure headache
- Tx: Caffeine and fluids

Consider the use of pain management clinics in resistant diabetic neuropathy

If MSCC is suspected, 
high-dose oral Dexamethasone 
should be given ASAP
WHILST AWAITINGGGG 
Whole spine MRI

Isoniazid can cause drug-induced lupus
-iTEACH

Woman with bone metastases- most likely to originate in the breast
In order of frequency: 
Breast
Bronchus
Brostate
Bridney
Bryroid

The Levine Scale:
•Grade 4 = palpable THRILL
•Grade 5 - palpable THRILL + steth EDGE
•Grade 6 – heard WITHOUT STETH

Dominant hemisphere
MCA strokes cause aphasia

stopping of anti-epileptic drugs (AED) is most correct?

  • If seizure free for > 2 years, +
  • AEDs being stopped over 2-3 months

‘high-stepping’ gait - he tends to excessively flex his knees to ensure the feet ‘clear’ the ground when walking.
Dx: Peripheral neuropathy
-high-stepping gait develops to compensate for foot drop

Atorvastatin 20mg is a high-intensity statin and should be started as primary prevention against cardiovascular disease

HNPCC is endometrial cancer + pancreatic cancer

Overnight dexamethasone suppression testing was performed, which revealed no change in cortisol levels i.e. FUCKING SYNDROME !!! high urinary cortisol + LOW ACTH i.e. sutin suppressing pituitary (pituitary isn’t obvs making any XS ACTH so cant be pit adenoma bastard). Likely Adrenal Adenoma making loads of cortisol -> suppress ACTH @pit #CT-Abdo

suspected stroke. unable to speak BUT able to follow instructions

  • do not know the handedness of the patient
  • Percentage of right (90% )and left (60%) handed individuals
  • making the LEFT BRAIN always > most likely affected side
  • MCA on dominant side supplies both Wernicke’s (sup Temp Gyrus) + Broca’s (inf Frontal Gyrus) areas
  • which are responsible for understanding and production of speech.

Insulin DM1: MTRM

  • multiple daily Basal-Bolus -fail-> cont SC ins @12/+ yr
  • twice daily Detemir basal
  • RA analog b4 meals
  • metformin @BMI 25/+
  1. Insulin DM2: INDGP
    NPH=SA @HbA1c 75/+
    Detemir/Glargine
    Pre-mixed w/ SA analogue

man TChol of 6.2
Q-risk score to be 23%.
10 cigarettes a day
His father died of a heart attack aged 50.
Tx: Atorva 20 or Atorva 80?
-ATORVA 20 !!!!!! HES NOT HIMSELF HAD A FUCKING MI
-If non-HDL NOT drop by 40%/+ -> Titrate up provided GFR > 30

59
Q

Chondrocalcinosis helps to distinguish ? from ?

Acromegaly can develop what rheum dx?
-see what in Fluid microscopy?

HyperParathyroidism is a risk factor for Pseudogout/gout?
-whereas HYPOcalcaemia = ?

Gout = ?-shape ? birefringent

CT scan was performed = 1.5cm nodule – adrenal gland = a lipid rich core
-Dx?

TXA = ? followed by ?

upper ? /3 oesophagus = ?histology
lower ? /3 = ?histology

The incubation period of Ebola virus is ? days

CKD-mineral bone disease = 
Correct hyperPHOSPHataemia first
-start with ? changes...
 (eduction in foods like chocolate, nuts, shellfish and cola)
BEFORE STARTING...
-starting a ? = ?mer and ?anum

Patient with CKD taking
calcium-based binders (?)
can have problems ->
?calcaemia + vascular ?

?Tx for Lyme disease in Asyx patients bitten by a tick

Pt a/w swelling of face arms trunk. 
PMH: this happened b4. 
No allergy/anaphylaxis signs or history. 
Serum C4 = LOW AF. 
Dx: ?
Tx: ? / ?

MS: ? can be used in the management of acute relapse

If patients treated with PCI for MI are experiencing pain or haemodynamic instability post PCI, urgent ? is recommended

TRALI is the specific name given for ARDS occurring within ? hours of a transfusion

? can only be diagnosed in the
ABSENCE of a cardiac cause
for pulmonary oedema
(i.e. the pulmonary capillary wedge pressure must not be raised)

Pulmonary capillary wedge pressure NOT raised = ?

Pulmonary capillary wedge pressure raised = ?

In suspected spinal epidural abscess,
a ?Ix is required
to search for ?

Intramuscular vitamin B12 -> start oral folic acid when vitamin B12 levels are NORMAL to avoid precipitating subacute combined degeneration of the cord.

74M viral gastroenteritis 1 week ago 
-3 days of D+V
-Sx settled
-Ongoing nausea. 
-Vision = more blurry + felt dizzy -> falls
HR 54/min + irregular pulse
BP 119/68 mmHg 
PMH: IHD, HTN, AF and T2DM.
-ECG: ST depression + T-invert  bradycardia
-Dx?

Kaposi’s sarcoma - caused by ? (
human herpes virus ?)

-Red man syndrome
? vancomycin infusion
until symptoms ?
re-starting at ?

? is a cause of Torsades de pointes

pseudohypertrophy calf muscles
use his arms to help stand up from the floor #Gower-Sign
?Dx is a less severe form of dystrophinopathy
that presents at ?

71F presents with 2w SOB and haemoptysis
O/E: reveals a loud S1 = diastolic murmur + new-onset AF
-Dx? Why hemoptysis?
-It aint gna be AR cos AR has ? sound remember!!!!

A/w PE for the past week
she has been taking 4mg of warfarin
and her INR four days ago was 2.2.
Her INR has been checked today and is 1.3.
i.e. woman on warfarin has INR < 2 i.e. sub-therapeutic
-? warf dose
-cover ? in meantime i.e. short-acting
-monitor INR
-LMWH ?discont/cont when has adequate INR

Reduction in GCS + vomiting > 1 are sinister signs in headache: ? is indicated

ECG is performed that shows a

  • bradycardia with
  • intermittently non-conducted P waves
  • no sign of PR elongation / shortening of the waves that are conducted
  • Dx? is an indication for a ?

Oxycodone V morphine in palliative patients with mild-moderate renal impairment

IV infusion of ? is
commonly used to treat acute
hypophosphataemia in adults
@refeed syndrome

Indications for corticosteroid treatment for sarcoidosis are:

  • ?
  • ?
  • NOT ? alone
emergency splenectomy. 
takes PMP-V on a daily basis. 
Which organism is he particularly susceptible to? 
Since he already on PMP-V, then ? is covered. So ? would be risky!!!
Please SHiNE my SKiS
-Pseudomonas
-S.pneu, H.flu, Neisseria, Ecoli 
-S.agalact-gbs, Klebsiella, Sally

Temporarily lost GCS 20 secs
-states feeling lightheaded this AM.
-shake her limbs for a few secs
-NOT bite her tongue/incontinence
-she came around, she was PALE,
-took few minutes B4 she felt orientated again…..#post-ictal !!!
-This was the FIRST TIME this has happened.
LIKE THAT FAINTING GIRL IN ANATOMY 1ST YEAR
Dx: ?

  • SHORT post-ictal period in comparison to a tonic-clonic seizure.
  • Syncopal episodes = rapid recovery + short post-ictal period
  • Seizures are associated with a far greater post-ictal period

Psychogenic Pseudoseizures FACTOrs:

  • F?
  • A?
  • C? after seizure
  • T?
  • Onset = ?

Favour true epilep seizures:
- T?
- P?
__________

There is NO role for ABx in the Tx of HUS unless indicated by preceding ?
-Tx?

Trimethoprim --> HANDA ROTS
?Dx = leading to 
-?KALaemia and 
-increased ?
-decreased ? 
-? in both of her legs
CCD: remember....
low Aldost:
-Heparin
-ACE/ARB
-NSAID
-DM Renin
-Addison

Resistance

  • Obst Uropathy
  • TMP-SMX
  • Spiro/Amiloride
A

Chondrocalcinosis helps to distinguish pseudogout from gout

Acromegaly can develop POS BIREFRINGENT
-RHOMBOID - PseudoGout

HyperParathyroidism is a risk factor for Pseudogout
- whereas HYPOcalcaemia = cataracts

Gout = needle-shape NEG birefringent

CT scan was performed 1.5cm nodule – adrenal gland = a lipid rich core
-Benign Incidental Adenoma

TXA = IV bolus followed by slow infusion

upper 2/3 oesophagus – SqCC
lower 1/3 = adenoCC

The incubation period of Ebola virus is 2-21 days

CKD-mineral bone disease =
Correct hyperPHOSPHataemia first
-start with Dietary changes before
(eduction in foods like chocolate, nuts, shellfish and cola)
BEFORE STARTING…
-starting a phosphate binder = Sevelamer and Lanthanum

Patient with CKD taking
calcium-based binders (Calcium acetate)
can have problems ->
-Hypercalcaemia + Vascular calcification

There is no need for prophylactic antibiotics for Lyme disease in asymptomatic patients bitten by a tick

Pt a/w swelling of face arms trunk. 
PMH: this happened b4. 
No allergy/anaphylaxis signs or history. 
Serum C4 = LOW AF. 
Dx: Hereditary angioedema: 
Tx: IV C1-inhibitor concentrate / FFP

MS: high dose steroids can be used in the management of acute relapse

If patients treated with PCI for MI are experiencing pain or haemodynamic instability post PCI, urgent coronary artery bypass graft (CABG) is recommended

TRALI is the specific name given for ARDS occurring within 6 hours of a transfusion.

ARDS can only be diagnosed in the
ABSENCE of a cardiac cause
for pulmonary oedema
(i.e. the pulmonary capillary wedge pressure must not be raised)

Pulmonary capillary wedge pressure NOT raised = ARDS

Pulmonary capillary wedge pressure raised = Pul Oed #cardiac

In suspected spinal epidural abscess,
a full spine MRI is required
to search for skip lesions

Intramuscular vitamin B12 -> start oral folic acid when vitamin B12 levels are NORMAL to avoid precipitating subacute combined degeneration of the cord.

74M viral gastroenteritis 1 week ago 
-3 days of D+V
-Sx settled
-Ongoing nausea. 
-Vision = more blurry + felt dizzy -> falls
HR 54/min + irregular pulse
BP 119/68 mmHg 
PMH: IHD, HTN, AF and T2DM.
-ECG: ST depression + T-invert  bradycardia
-Digoxin

Kaposi’s sarcoma - caused by HHV-8
(human herpes virus 8)

-Red man syndrome: stop, resolve, slower
Stop vancomycin infusion
until symptoms resolve
re-starting a slower rate

Hypothermia/K low or high/Alco is a cause of Torsades de pointes

pseudohypertrophy calf muscles
use his arms to help stand up from the floor #Gower-Sign
Becker’s muscular dystrophy is a less severe form of dystrophinopathy that presents at a later age

71F presents with 2w SOB and haemoptysis
O/E: reveals a loud S1 = diastolic murmur + new-onset AF
Mitral Stenosis -> raised left atrial pressure –> rupture of Bronchial Veins –> Haemoptysis i
-It aint gna be AR cos AR has S3 sound remember!!!!

Woman on warfarin has INR < 2 i.e. sub-therapeutic

  • inc warf dose
  • cover LMWH in meantime i.e. short-acting
  • monitor INR
  • LMWH discontinued when has adequate INR

Reduction in GCS + vomiting > 1 are sinister signs in headache: urgent CT head is indicated

ECG is performed that shows a

  • bradycardia with
  • intermittently non-conducted P waves
  • no sign of PR elongation / shortening of the waves that are conducted
  • Mobitz II is an indication for a pacemaker

Oxycodone > morphine in palliative patients with mild-moderate renal impairment

IV infusion of phosphate polyfusor is
commonly used to treat acute
hypophosphataemia in adults
@refeed syndrome

Indications for corticosteroid treatment for sarcoidosis are:

  • Systemic Dx
  • HYPERcalcaemia
  • NOT BHL alone

emergency splenectomy.
takes PMP-V on a daily basis.
Which organism is he particularly susceptible to?
Since he already on PMP-V, then strep pneu is covered. So H.Flu would be risky!!!

Temporarily lost GCS 20 secs
-states feeling lightheaded this AM. 
-shake her limbs for a few secs 
-NOT bite her tongue/incontinence 
-she came around, she was PALE, 
-took few minutes B4 she felt orientated again.
-This was the FIRST TIME this has happened
Dx: Vasovagal syncope
  • SHORT post-ictal period in comparison to a tonic-clonic seizure.
  • Syncopal episodes = rapid recovery + short post-ictal period
  • Seizures are associated with a far greater post-ictal period

Psychogenic Pseudoseizures FACTOrs:

  • FHx epilepsy/Females
  • ALONE = don’t occur
  • CRYING after seizure
  • Thrusting pelvic
  • Onset = GRADUAL

Favour true epilep seizures:
- Tongue biting
- PROLACTIN
__________

There is NO role for ABx in the Tx of HUS unless indicated by preceding diarrhoeal infection
- Only supportive treatment e.g. fluids and dialysis as required

Trimethoprim --> HANDA ROTS
RTA4 !!! = leading to 
-HyperKALaemia and 
-increased Creatinine
-decreased urine output, and 
-swelling in both of her legs
CCD: remember....
low Aldost:
-Heparin
-ACE/ARB
-NSAID
-DM Renin
-Addison

Resistance

  • Obst Uropathy
  • TMP-SMX
  • Spiro/Amiloride
60
Q

Colchicine = SE?

LP for meningitis: wcc high, BM low, prot high AF - TB/Cryto?
-Check CD4 count - Cryto usually at LOW AF CD4 in the <300 range

?studies can help in the diagnosis of Guillain-Barre
-plasmapharesis, IVIg, Nerve Conduction studies, DVT proph FFS

? involvement in Grave’s disease indicates severe eye pathology

Child Pugh:
A - ?
B - ?
C - ?
D - ? (ascites)
E - ?
-ALT/AST IS ?!!!!

Lymphoma + Alcohol = painful node = HODGKINs/NHL?
-MIRROR image nuclei?

Type 1 Ai Hepatitis = ANA SMA
Type 2 = ?antibody in kids - ?Freya Dulson FY1?

Stains inhibit HMG-CoA = DECR chol ?

Phaeo = alpha block + beta block (?)

  • CHOOSE ? SELECTIVE BB = propr #periph
  • cardio selective eg atenolol/ bisop NOT legit @Phaeo

Gram + Catalase + Coag + = STAPH aureus
Gram + Catalase + Coag NEG = STAPH epidermis
Gram + Catalase NEG = Strep

HOCM = sudden cardiac death from ?

AIHA Hemolysis Ix? = ? Coombs + ? Haptoglobin
Rhesus hemolytic dx of ? = ? Coombs

Lipophilic statins = ?/ ? -> ?Cx #CK-high
Hydrophilic = ? give when lipophilic fucks muscles up

SUDDEN SYNCOPE
Pt = bradycardia + …
-loads of Ps + and few QRS = don’t match up..
-WIDE + DEEEEEP inverted T waves = ?Dx

Lung cancer surgery CI

  • FEV < ?
  • ? pleural effusion
  • Vocal Cord ?
  • ?

Acoustic neuroma = ? SVT
Menieres = ? of SVT + aural fullness

Parkinon’s TRAPS =
-Asymmetric/Symmetric?, pill-rolling @?,
-? with voluntary movement
(Rememer Back 2 the Future guy ice skating?!)

Tremor = WORSENS as reaches out to examiner’s finger
-? tremor = ? dx

?-pointing - pointing BEYOND the finger
@finger-nose test = ? dx
# ?

Tremor = worsens @OUTstetched arms = ? Dx
-bi/unilateral? + worsens/improve? with action

Low plts + high Fibrin Degradation Products = ?haem dx

COPD = XS O2 lose ? drive -> retain ? ->
-? Acid + ? Compensation

for ABG Acidosis questions, if BE is high and CO2 is high i.e. ‘?’ ->

  • look at pH
  • then CO2 (in keeping @?, norm/NOT in keeping @?)
  • THEN bicarb (low in ?, high in ?)

Glomerulonephritis + VTE = ? loss from piss!! #VTE

Orthostatic HTN = 20/10 drop after
? fucking minutes

Carotid Sinus HSR ->

  • Vent pause > ?s
  • SystBP drop by ?mmHg/+

Unilat headache + meningism (bend head back) + NO fever = ?

GLOBAL T-wave inversion = ?
-?HInjury

Causes of HF - ROCIA SH
(Rocio always tells us to sshhh in the teaching ffs 😂)
Preload high, Pump failure, Afterload high
-High output

A

Colchicine = diarrhoea

Patients don’t typically tend to get Cryptococcal infection with a CD4 count that high, you would start to suspect it in the <300 range

Nerve conduction studies can help in the diagnosis of Guillain-Barre syndrome
-plasmapharesis, IVIg, Nerve Conduction studies, DVT proph FFS

CORNEAL involvement in Grave’s disease indicates severe eye pathology

Child Pugh:
A - albumin
B - bilirubin
C - clotting
D - distention (ascites)
E - encephalopathy
-ALT/AST IS SHIT !!!!

Lymphoma + Alcohol = painful node = HODGKINs
–MIRROR image nuclei = Reed Sternberg

Stains inhibit HMG-CoA = DECR chol SYNTH

Phaeo = alpha block + beta block (propranlol/ labetalol)

  • CHOOSE NON-CARDIO SELECTIVE BB = propr #periph
  • cardio selective eg atenolol/ bisop NOT legit @Phaeo

Gram + Catalase + Coag + = ?
Gram + Catalase + Coag NEG = ?
Gram + Catalase NEG = ?

HOCM = sudden cardiac death from vent arrythmia

AIHA Hemolysis Ix? = Direct Coombs + LOW Haptoglobin
Rhesus hemolytic dx of NEWBORN = INdirect Coombs

Lipophilic statins = Simva/ Atorva -> Prox-myopathy #CK-high

Hydrophilic = Rosouva/ Prava/ Fluva give when lipophilic fucks muscles up

SUDDEN SYNCOPE
Pt = bradycardia + …
-loads of Ps + and few QRS = don’t match up = 3rd HB
-WIDE + DEEEEEP inverted T waves = Stokes-Adams attacks

Lung cancer surgery CI

  • FEV < 1.5 L
  • Exudate MALIG pleural effusion
  • Vocal Cord paralysis
  • SVCO

Acoustic neuroma = PROGressive SVT
Menieres = Intermittent attacks of SVT + aural fullness

Parkinon’s TRAPS =
-Asymmetric, pill-rolling @rest,
-IMPROVE with voluntary MOVEMENT
(Rememer Back 2 the Future guy ice skating?!)

Tremor = WORSENS as reaches out to examiner’s finger
-Intention tremor = cerebellar dx

past-pointing - pointing BEYOND the finger
@finger-nose test = cerebellar dx
#Dysmetria

Tremor = worsens @OUTstetched arms = essential tremor
-BIlateral + WORSEN with action

Low plts + high Fibrin Degradation Products = DIC

COPD = XS O2 lose hypoxic drive -> retain co2 ->
-Resp Acid + Met Compensation

for ABG Acidosis questions, if BE is high and CO2 is high i.e. ‘mixed’ ->

  • look at pH
  • then CO2 (in keeping @resp, norm/NOT in keeping @met)
  • THEN bicarb (low in acid, high in alk)

Glomerulonephritis + VTE = AT3 loss from piss!! #VTE

Orthostatic HTN = 20/10 drop after
3 fucking minutes

Carotid Sinus HSR ->

  • Vent pause > 3s
  • SystBP drop by 50mmHg/+

Unilat headache + meningism (bend head back) + NO fever = SAH

-Preload high -
Regurg/VSD
Overload -meds (Nsaid/Pioglit/Steds) -IVF

-Pump failure -
CM/CPericard;
IHD/Ionotrope neg (CCB/AntiArrythmicFlecanide)
Arrhythmia

-Afterload high -
Stenosis (any valve)
HTN(periph/pul-corpulmonale)

-High output - Preg/Anemia/Thyrotoxicosis

61
Q

Acute Mesenteric Ischaemia
-emboli @Endocard/Cancer –> block SMA

?Ix FIRST
CT –> URGENT Surg
____________________

Isch. Colitis
-cocaine

mucosal OED/HAEMORRH –>
- AXR = ? –> ? Tx
______

? / ? such as bisoprolol are common precipitants of myasthenic crises.

? reduce hypoglycaemic awareness

? may cause insomnia

Suspected neoplastic spinal cord compression should have an urgent MRI of the WHOLE/Lumbar Spine

maximum recommended rate of potassium infusion via a peripheral line is ? mmol/hour
-40 mmol bag over ?hrs

IVDU + DESCending paralysis + diplopia + bulbar palsy = ?infection

Phenytoin infusion = ? monitoring is required due to the ? effects

Ig? @ breast milk iAIRED

? @kids =
- present w/ only generalised LNopathy #lymphoma

Coeliac disease is associated with

  • iron, -folate , -vitamin B12 deficiency
  • ?MCV = micro + macro #Asplenia

Swallowing of saliva is often more difficult @?
-solids + liquids are fine though

Non-small Lung cancer = chemo/RT #immune-checkpoint inhibitor. ? for SOLID tumours

Headache triggered by coughing ->
legit?
-@suspected head cancer = ?Ix

@hypothermia –> cardiac arrest

  • ? is SHIT
  • only ? shocks should be administered
  • b4 the patient is rewarmed to ? degrees

Prog worsening headache + higher cognitive function dx = ?Ix
-@suspected head cancer

Disproportionate MICROCYTIC Anemia
= ? I.e. MCV of like 60

Hyaline casts @urine = ?

? are used in the management of Severe ALCO hepatitis

Alcoholic ketoacidosis is managed with an infusion of ? + ?

COPD:
-LTOT improve ?
-Becky = Improve: ?, ? / Reduces freq ?
_________

Short attacks with stereotyped movement +
QUICK RECOVERY = ? seizures

-impaired consciousness AND feels knackered/weakness after…..

Focal ? would involve rigidity + writhing

  • relapses of new / worsening symptoms
  • periods of remission
  • NO worsening symptoms
Relapse-remitting MS --> 
-deteriorate 
-develop WORSEning symptoms 
-NO obvious flares/ attacks
Dx?

MS =

  • Worsening symptoms
  • NO periods of remission
  • Elderly population
severe headache 
-nausea
-difficulty in finding the right words. 
-cocp
-FHx: mother had an unprovoked DVT in her 30s
Dx: ?
Ix: ?

The interossei are supplied by the ? nerve.

Vision worse going down stairs? Think ? nerve palsy
-?!!!!

Triceps - Bradchioradialis/Biceps/Brachialis, Extensors/ Anconeus/ Supinator/ Triceps

Ulnar: MAIF
M-LOAF-DIGITI MINMI
ADdP
Interossei
FCU / FDP

Median = LP
LLOAF
Pronator Quad,
—FDS / FDP

basically FDP = Median + Ulnar

A

Acute Mesenteric Ischaemia
-emboli @Endocard/Cancer –> block SMA

LACTATE FIRST
CT –> URGENT Surg
____________________

Isch. Colitis
-cocaine

mucosal OED/HAEMORRH –>
- AXR = THUMBPRINTING –> SUPPORTIVE Tx
______

Beta-blockers/ CCB-RL such as bisoprolol are common precipitants of myasthenic crises.

Beta-blockers reduce hypoglycaemic awareness
-and autonomic neuropathy

Beta-blockers may cause insomnia

suspected neoplastic spinal cord compression should have an urgent MRI of the WHOLE Spine

maximum recommended rate of potassium infusion via a peripheral line is 10 mmol/hour
-40 mmol bag over 4hrs

IVDU + DESCending paralysis + diplopia + bulbar palsy = Clostridium botulinum

Phenytoin infusion = cardiac monitoring is required due to the pro-arrhythmogenic effects

IgA @ breast milk iAIRED

Kaposi’s sarcoma @kids = with only generalised lymphadenopathy #lymphoma

Coeliac disease is associated with

  • iron, -folate , -vitamin B12 deficiency
  • normocytic = micro + macro #Asplenia

Swallowing of saliva is often more difficult @globus pharyngis
-solids + liquids are fine though

Lung cancer = chemo/RT #immune-checkpoint inhibitor. Nivolumab for SOLID tumours

Headache triggered by coughing ->
legit? NO #investigate further
-@suspected head cancer = Standard Struct MRI

@hypothermia –> cardiac arrest

  • defibrillation is SHIT
  • only 3 shocks should be administered
  • b4 the patient is rewarmed to 30 degrees

Progressively worsening headache with higher cognitive function impaired =
URGENT imaging required
—–Standard Struct MRI
-@suspected head cancer

Disproportionate MICROCYTIC Anemia
= thallaemia I.e. MCV of like 60

Hyaline casts @urine = furosemide

Corticosteroids are used in the management of severe ALCOHOLIC hepatitis

Alcoholic ketoacidosis is managed with an infusion of SALINE + Thiamine

COPD:
-LTOT improve survival
-Becky = Improve: QoL, FEV1 / Reduces freq exac
_________

Short attacks with stereotyped movement +
QUICK RECOVERY = focal aware seizures

Focal seizures + impaired awareness
-impaired consciousness AND post-ictal state

Focal dystonia would involve rigidity + writhing

Relapse-Remit

Secondary progressive MS
-usually have relapse-remit anyway..

MS = 
-Worsening symptoms 
-NO periods of remission 
-Elderly population
PRImary progressive
severe headache 
-nausea
-difficulty in finding the right words. 
-cocp
-FHx: mother had an unprovoked DVT in her 30s
Dx: Venous Sinus Thrombosis
Ix: MR Venogram

The interossei are supplied by the ulnar nerve.

Vision worse going down stairs? Think 4th nerve palsy
-TROCHLEAR!!!!

62
Q

EIA -> TPPA -> RPR
The EIA = acute/chronic? Ig? to syphilis
- it may be NEGATIVE in reinfection.

The T-pallidum particle agglutination (TPPA) test is a specific test for syphilis and often remains ? in patients who have been PREVIOUSLY infected.

The rapid plasma reagin (RPR)

  • useful to monitor disease activity and reinfection.
  • 1 in 2 means it needs to be diluted twice,
  • 1 in 32 means it needs to be diluted 32 times (meaning disease activity is higher in the latter).
  • A rise by x ? or more in a previously infected patient = no treatment response/ reinfection.

Following treatment for syphilis:
TPHA remains positive, VDRL becomes ?
_______

SAICA - Admit / Follow-up
-BEST -MAST -BEANCO

Keeping them in 24hrs:
Bi?
ED access ?
Asthma ?
Night/ ?/ Unable 2 ?
Continuing ? 
Onset = ?
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

____________MAP=CO.SVR HR PAP
Hypovol______low . low………………low
Cardiogen___ _low . low
Anaphyl/Sepsis_low………..low……….low
Neurogen_____low . low.low

\_\_\_\_\_\_\_\_\_\_\_\_MAP=CO.SVR HR PAP
Hypovol\_\_\_\_\_\_low . low.........high.low
Cardiogen\_\_\_ _low . low.........high
Anaphyl/Sepsis_low...........low.high..low
Neurogen\_\_\_\_\_low . low.low

______Fe . TFsats . Ferritin . TIBC
..Fe…….low . low …………………….high
.ChrDx.low . low ……..high………low
.HChr…high . high ……high………low
Sidero.high . high ……high………low

Wells 1 2 4 5 
-------DVT
1/- = Dimer -> 
-POS=PLS<4hr/<24hr+Tx DOAC
-NEG=d/c ddx

2/+ = PLS <4hr ->

  • POS=Tx DOAC
  • NEG=Dimer–>
  • -POSdimer=stop AC + PLS 6-8d*
  • -NEGdimer=d/c ddx
  • —POSpls6-8d = Tx DOAC
  • —NEGpls6-8d = d/c ddx

——-PE
4/- = Dimer
-POS=CTPA
-NEG=d/c ddx

5/+ = CTPA

  • POS=Tx
  • Neg=d/c ddx
Syx + IlioFem DVT
-Cath Directed Thrombolysis
Funct status ?
low p(?)
LE > ? yr
Sx < ?d 

30-d mortality
suitability of ? tx
-use of the ?score

SUSPECT PE?
-PERC criteria to r/o PE
-ALL the criteria must be ABSENT to have NEG PERC to rule-out PE
-this should be done when you think there is a LOW PRE-TEST probability of PE, but want more REASSURANCE that it isn’t the diagnosis
-this low probability is defined as < 15%
________
COPD -Atopy, Macrolide, Roflumilast, SPFJC, Surg
2. LABA + ARafe:
A?/ Resp2?
(? / ? / ? ) –>

Y=Becky –(? / ? / ?)->
N=LAMA–>
_______________
STAMM DR

MACROLIDE* ?mg x? /wk

  • N?
  • O?
  • S?
Before *Macrolide:
-? / ? C+S
-CT-?/Chest-?
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
Roflumilast
-E? ?+/yr
-FEV < ?%
-? / ? 
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
1sev/2mod exac/yr
Sputum+Exac @Macrolide
Exac-2+/yr @Roflumilast
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
SpO2 < ?
P? / P? Oed
FEV< ?%
JVP ?
C?

SBOT @ severe =
evidence of resp2prevTx
-dont smoke = FUCKING explosion

LTOT @Pao2: ABG-x? / ?w-apart
<7.3 + ?
7.3-8.0 + ...
- ?
- ?
- ?
- ?
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

Surg:
?Syx+CT Bulla ?HT = ?

Transplant:
FEV1< ?+low ?
NON-?
FINISH ?

LungVolRed consider**:
FEV1< ?+low ?
NON-?
FINISH - ? - ?

after ** ‘‘consider’’ –> ‘actually do’ LungVolRed @:
- ?Ix = shows what?
-CT = ?
________

Ix for asthma? Order in adults + kids
Fuck's Sake BP - (Adult Ix - Kid Ix)
1-3-FeNO >? / >? @ ?-?yrs ppb
2-1-Spiro FEV/FVC < ? obstr
3-2-BD Inc ?% in ?WHAT @ ?ml ?/?
4-4-PEFR inc ?% ? in 2-4w @BD monitoring
5-5-Methacholine Histamine Test PC? @?mg/ml FEV drop

CC50M:
control=reduce maintenance after ?m
check: ? @Steds
50+ = Syx/HD?/ ?exac requiring ? /year –>

MACROLIDE ?mg x? / wk ?m

  • ECG-QTc = ?m ?m
  • LFT ?m ?m ?m

StopSteds=reduce by ?% / /m
______

Pneumothorax
-Age >? + ? Hx
-Lung dx @? or ?
Y = ?
N = ?

-N i.e. (Air Rim<2cm AND no SOB)=d/c+OPD r/v ->
1. Stop ?
2. ? offer
3. Fly > ?w/ > ?w AFTER ? AND ? @trauma/spont
_________
CCF:
? @QRS<150 - LBBB+NYC ?/-
? @QRS 120-150 + LBBB+NYC ?/+
? @QRS 120-150 - LBBB+NYC ?

Surgery?

  • PVent = ?heartDx type, ?Which diseases
  • -Aim?
A

The EIA = Acute IgM to syphilis
- it may be NEGATIVE in reinfection.

The T-pallidum particle agglutination (TPPA) test is a specific test for syphilis and often remains POSITIVE in patients who have been PREVIOUSLY infected.

The rapid plasma reagin (RPR)

  • useful to monitor disease activity and reinfection.
  • 1 in 2 means it needs to be diluted twice,
  • 1 in 32 means it needs to be diluted 32 times (meaning disease activity is higher in the latter).
  • A rise by x 4 or more in a previously infected patient = no treatment response/ reinfection.

Following treatment for syphilis:
TPHA remains positive, VDRL becomes negative
___________

SAICA - Admit / Follow-up
-BEST -MAST

BP
ECG
SpO2
Tryptase

Medic-alert
ACH
Skin Prick
Teach Ant Lat Thigh

Keeping them in 24hrs:
Biphasic
ED access difficult
Asthma severe
Night/ Eve/ Unable 2 respond
Continuing absoprtion 
Onset = slow/severe
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

____________MAP=CO.SVR HR PAP
Hypovol______low . low………………low
Cardiogen___ _low . low
Anaphyl/Sepsis_low………..low……….low
Neurogen_____low . low.low
-Distributive = anaphl/seps/neurogenic

\_\_\_\_\_\_\_\_\_\_\_\_MAP=CO.SVR HR PAP
Hypovol\_\_\_\_\_\_low . low.........high.low
Cardiogen\_\_\_ _low . low.........high
Anaphyl/Sepsis_low...........low.high..low
Neurogen\_\_\_\_\_low . low.low

______Fe . TFsats . Ferritin . TIBC
..Fe…….low . low …………………….high
.ChrDx.low . low ……..high………low
.HChr…high . high ……high………low
Sidero.high . high ……high………low

Syx + IlioFem DVT
-Cath Directed Thrombolysis
Funct status legit
low p(bleed)
LE >1 yr
Sx < 14d 

30-d mortality
suitability of OP tx
-use of the Pulmonary Embolism Severity Index (PESI) score

SUSPECT PE?
-PERC criteria to r/o PE
-ALL the criteria must be ABSENT to have NEG PERC to rule-out PE
-this should be done when you think there is a LOW PRE-TEST probability of PE, but want more REASSURANCE that it isn’t the diagnosis
-this low probability is defined as < 15%
________

COPD:
2. LABA + ARave:
Asthma/Resp2steds
(atopy/ variable diurnal/FEV/ eosinophilia –>

Y=Becky --(Sx-lowQol/1severe/2mod exac/yr)-> 
N=LAMA-->
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
STAMM DR
MACROLIDE* 250mg x3/wk
-Non-smoker
-Optimum-meds
-Sputum+Exac
Before *Macrolide:
-Sputum/TB C+S
-CT-Thorax/Chest-physio
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
Roflumilast
-Exac 2+/yr
-FEV<50%
-COPD/Bronchitis
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
1sev/2mod exac/yr
Sputum+Exac @Macrolide
Exac-2+/yr @Roflumilast
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
SpO2 < 92
PolyCythemia / PeriphOed
FEV< 30%
JVP high
Cyanosis

SBOT @ severe =
evidence of resp2prevTx
-dont smoke = FUCKING explosion

LTOT @Pao2: ABG-x2/3w-apart
<7.3 + stable
7.3-8.0 + ...
-P.Cythemia
-P.HTN-pul
-P.Oed-periph
-PNoct Hypoxia
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

Surg:
SOB+CT Bulla 1/3HT = Bullectomy

Transplant:
FEV1<50+lowQoL
NON-smoker
FINISH -ChestPhysio

LungVolRed consider**:
FEV1<50+lowQoL
NON-smoker
FINISH -ChestPhysio -140m6minWalk

after ** ‘‘consider’’ –> ‘actually do’ LungVolRed @:
-Plethysmography = HyperInflation
-CT = Emphysema
__________

Adults - Kids: Ix for asthma?
1 - 3-FeNO >40 / >35 @ 5-16yrs ppb
2 - 1-Spiro FEV/FVC < 70 obstr
3 - 2-BD Inc 12% FEV @ 200ml SABA/Becky
4 - 4-PEFR inc 20% VARIABILITY in 2-4w @BD monitoring
5 - 5-Methacholine Histamine Test PC20 @8mg/ml FEV drop

CC50M:
@control=reduce maintenance after 3m
check: BP BM-hba1c BMD; Chol Cataracts @Steds
50+ = Syx/HDsteds/1exac requiring PO steds/year –>

MACROLIDE 500mg x3/wk 6-12m

  • ECG-QTc = 0m 1m
  • LFT 0m 1m 6m
StopSteds=reduce by 25-50%/3m
\_\_\_\_\_\_\_\_\_\_
Pneumothorax
-Age >50 + smoking Hx
-Lung dx @O/E or CXR
Y = 2ndary
N = 1rimary

-N i.e. (Air Rim<2cm AIR no SOB)=d/c+OPD r/v ->
1. Stop smoke
2. Pluorodesis offer
3. Fly >2w/>1w AFTER drain AND no residual air @trauma/spont
__________________
CCF:
ICD @QRS<150 - LBBB+NYC 3/-
CRT @QRS 120-150 + LBBB+NYC 2/+
CRT @QRS 120-150 - LBBB+NYC 4

Surgery: CPT
a. CResync 
b. Partial Ventriculectomy @non-IHD=
-Chagas/CMyopathy/Valve-dx
-Aim=reduce:EDV->LVstrain-> 
optimiseLVFunction
c. Transplant
63
Q

The most common causes of VIRAL MENINGITIS in Adults are ?
-meningism: photophobia, nuchal rigidity etc..

? is the commonest cause of viral ENCEPHALITIS in the adult population
-personality changes, confused, seizures etc

Insulin -> sliding scale
Li ? 
AC = ? 
COCP ? 
\_\_\_\_
K spare = ? 
Oral hypoglyc = nbm + sliding scale
PRILs = ? 
-Spiro + Rampiril = ?

HIV needlestick PEP=
Refer to ?
+
oral ? therapy for ? weeks

CK-MB remains elevated for 3 to 4 days following infarction.
Troponin remains elevated for 10 days.
AFTER 4 to 10 days, CK-MB = useful for detecting re-infarction AFTER 4-10 days

HBsssssssAg: acute/chronic > ?m dx — ALTTTT@ ACTIVE #CARRIER/INFECTIOUS HBsAg

Anti-HBc ?/ ? — Ig? @ ACUTE –> Ig? CHRONIC
HBV-DNA acute/chronic (high lvls assoc with ?)
HBeeeeAg ? marker –> anti HBeeeee @ ?

anti-HBsss POS only ?

anti-HBsss POS, anti-HBccccc/eee POS

anti-HBc only

> 100 ?
10 - 100 ?
< 10 ?

Over-replacement with thyroxine increases the risk for ?bone dx

Baclofen and ? are first-line for spasticity in multiple sclerosis

Diplopia is not common in Parkinson’s disease and may suggest an alternative cause of parkinsonism such as ?

Miliary TB is due to the spread of the bacteria through pulmonary venous/arterial system?
-gain entry into the pulmonary ? system via damaged ? epithelium -> gain access to the lymphatic system using ?

Patients with focal seizures may experience post-ictal weakness (what’s this called?)

If there is clubbing with ?thyroidism, think ? disease
__________

  • BMI < ?;
  • unintentional WL > ?% @last 3-6 months; or
  • BMI < ? + unintentional WL > ?% @last 3-6 months

? = WL 10% / 6m (any faster = worsen fibrosis)

WL 5% pre-preg Weight, Electrolyte dx, Dehydration
__________

Mandem had accident -> Cord injury @above T6 
-> HTN + Bradycardia + ...
-Flushed + Sweating #Red ABOVE shoulders
-PALE BELOW shoulders 
Ax of HTN?

Mandem in accident
-HTN and Bradycardia
-flushed above shoulders, pale below
?Dx can only occur if the spinal cord injury occurs above WHERE?

? are the most common triggers of autonomic dysreflexia

? is a life-threatening event associated with autonomic dysreflexia

Patients with a GCS < ? should be considered for both

i) review by an anaesthetist
ii) intubation and ventilation

Coagulase-? Staphylococcus is the most common cause of peritonitis secondary to peritoneal dialysis - Staphylococcus ?

Multiple myeloma + Paget's disease are typically associated with osteoLYTIC lesions 
- Mets =Sclerotic
\_\_\_\_\_\_\_\_\_\_
Pregnant:
- Raised ALP 

Jaundice, N+V, headache, and hypoGLYCaemia
-ALT would typically be raised

Pruritis + raised bilirubin
_________

NICE = ?Ix for someone presenting with

  • non-cardiac chest pain +
  • resting ECG shows ischaemia = Q wave abnormality, ST-T wave changes

Fever, weight loss, malaise, headache.

  • palpable-purpura
  • HUria -jaundice…..
  • no URT/LRT/lung dx…
A

The most common causes of VIRAL meningitis in Adults are ENTEROviruses
-Coxsackie B virus (CMV/Cryptococc/Arbovirus/Mumps/EnterooooooCoxsackie)

Herpes simplex virus is the commonest cause of viral ENCEPHALITIS in the adult population
-iv aciclovir = cross B-B barrier

Insulin -> sliding scale
Li 4 days b4
AC = 5 days b4
COCP 1m
\_\_\_\_
K spare = day of surgery
Oral hypoglyc = nbm + sliding scale
PRILs = day of surgery
-Spiro + Rampiril = day of surgery

HIV needlestick PEP=
Refer to Emergency Department
+
oral antiRETROviral therapy for 4 weeks

The Creatine Kinase (CK-MB) remains elevated for 3 to 4 days following infarction. Troponin remains elevated for 10 days. This makes CK-MB useful for detecting re-infarction in the window of 4 to 10 days after the initial insult

HBsssssssAg: acute/chronic>6m dx — ALTTTT@ ACTIVE #CARRIER/INFECTIOUS HBsAg

Anti-HBc: prev/current — IgM @ ACUTE -> IgG CHRONIC
HBV-DNA: acute/chronic>6m (high lvls assoc with HCC)
HBeeeeAg infectivity marker –> anti HBeeeee @ resolving

anti-HBsss POS only
-IMMUNE - vaccine

anti-HBsss POS, anti-HBccc/eee POS
-IMMUNE prev hep B

anti-HBc only: Resolved/Acute resolving/Chronic low level / False positive

BITHE
> 100 Booster at 5 years
10 - 100 - 1 more vaccine dose + test @immunocomp
< 10 Non-responder
-testing SCDE + HBIg @fail + 3 doses again

Over-replacement with thyroxine = HYPERThyr increases the risk for osteoporosis

Baclofen and gabapentin are first-line for spasticity in multiple sclerosis

Diplopia is not common in Parkinson’s disease and may suggest an alternative cause of parkinsonism such as progressive supranuclear palsy

Miliary TB is due to the spread of the bacteria through pulmonary venous system
-gain entry into the pulmonary venous system via damaged alveolar squamous epithelium -> gain access to the lymphatic system using macrophages.

Patients with focal seizures may experience post-ictal weakness (Todd’s paresis)

If there is clubbing with hyperthyroidism, think Graves’ disease ACROPACHY
__________

  • BMI < 18.5;
  • unintentional WL > 10% @last 3-6 months; or
  • BMI < 20 + unintentional WL > 5% @last 3-6 months

NAFLD = WL 10% / 6m (any faster = worsen fibrosis)

WL 5% pre-preg Weight, Electrolyte dx, Dehydration
__________

Mandem had accident -> Cord injury @above T6 
-> HTN + Bradycardia + ...
-Flushed + Sweating #Red ABOVE shoulders
-PALE BELOW shoulders 
Ax of HTN = Autonomic Dysreflexia

Mandem in accident
-HTN and Bradycardia
-flushed above shoulders, pale below
Autonomic dysreflexia can only occur if the spinal cord injury occurs above the T6 level

Faecal impaction / urinary retention are the most common triggers of autonomic dysreflexia

Stroke is a life-threatening event associated with autonomic dysreflexia

Patients with a GCS below 8 should be considered for both i) review by an anaesthetist and ii) intubation and ventilation

Coagulase-negative Staphylococcus is the most common cause of peritonitis secondary to PERITONEAL dialysis - Staphylococcus epidermis

Multiple myeloma + Paget's disease are typically associated with osteoLYTIC lesions 
- Mets =Sclerotic
\_\_\_\_\_\_\_
Pregnant:
- Raised ALP = NORMAL

Acute fatty liver of pregnancy =

  • jaundice, N+V, headache, and hypoGLYCaemia
  • ALT would typically be raised

Obstetric cholestasis = pruritis + raised bilirubin
_________

NICE = contrast-enhanced CT coronary angiogram for someone presenting with
-non-cardiac chest pain +
-resting ECG shows ischaemia = Q wave abnormality, ST-T wave changes
NEVER EVER CHOOSE EXERCISE ECG FOR ANYTHING FFS

Fever, weight loss, malaise, headache.

  • palpable-purpura
  • HUria -jaundice…..
  • no URT/LRT/lung dx…
  • —Polyarteritis Nodosa = Hep B
64
Q

? is not recommended in the diagnosis of type 1 diabetes
-do ? @DM1 to confirm

DM2 + HTN. What ANTI-HTN? ARB or ACEi?
-?

DM2 + HTN + Black. What ANTI-HTN?

  • ARB or ACEi?
  • ?!!!!!!!!

Teen, STD = MCS show obligate intracellular bacterium. Dx?
- ? Gram Neg Intracellular Bact

Age > 55 + HTN + Systemic Sclerosis + MAHA @severeSS.
Tx - ACE/CCB?
-?

Alpha1-antitrypsin deficiency can be diagnosed ?
-W11-14 - cHORIONIC VILLOUS SAMPLING
W15-30 - AmnioCentesis

Mandem in accident
-HTN and Bradycardia
-flushed above shoulders, pale below
?Dx can only occur if the spinal cord injury occurs above WHERE?

Light microscopy = ground-glass hepatocytes = Chronic/Acute hepatitis B infection?

? + ? can be used to prevent pathological fractures in bone metastases. If the eGFR < 30, ? is preferred

RAPD = CN? dx

diplopia when asked to look laterally = CN?
-LR6 SO4 R3

occupation asthma is suspected. Most appropriate diagnostic investigation?
Ix? and where?

1 pack year is defined as ?

Mandem got CP SOBOE Syncope, narrow pulse pressure, slow rising pulse. How to tx Syx?
- ?
? are contraindicated in aortic stenosis

Swabs for chlamydia and gonorrhoea in women should be taken from the ? area (introitus)

pt a/w
abdo pain/constipation + neuropsych syx + Anaemia
-O/E: blue lines @gum margin. legs become WEAK in the past few days.
?Basophilic stippling #NOiron
-Dx? is often ?

Mycoplasma + GBS

ventilation -> Sudden deterioration
-suggests ?

Myelodysplasia into ?
CLL = Richter into ?

? are given prior to appendicectomy

? can be safely used during pregnancy in rheumatoid arthritis/SLE

? can be safely used during pregnancy in Smoking Cessation

? = NDRI+NB

  • Norepinephrine and dopamine reuptake inhibitor, and
  • Nicotinic ?

VareNICline = NICtonic ?

Men who have sex with men should be offered immunisation against hepatitis ?

-ECG shows new widening QRS complexes and a
-NOTCHED morphology of the QRS complexes
in the lateral leads = ?

RSR complex = ?

CKD-mineral bone disease = 
Correct hyperPHOSPHataemia first
-start with ? changes...
 (eduction in foods like chocolate, nuts, shellfish and cola)
BEFORE STARTING...
-starting a ? = ?mer and ?anum

High phosphate levels in CKD
‘drags’ calcium from the bones,
resulting in osteomalacia
-Tx = ?

Patient with CKD taking
calcium-based binders (?)
can have problems ->
?calcaemia + vascular ?

Metastatic bone pain:
-Simpson’s character…..
Metastatic Spinal Cord Compression
-?

bumetanide mechanism

A

HbA1c is not recommended in the diagnosis of type 1 diabetes
-do FPG @DM1 to confirm

DM2 + HTN. What ANTI-HTN? ARB or ACEi?
-ACEi

DM2 + HTN + Black. What ANTI-HTN?

  • ARB or ACEi?
  • ARB!!!!!!!! - losartan

Teen, STD = MCS show obligate intracellular bacterium. Dx?
-Chlamydia Gram Neg Intracellular Bact

Systemic Sclerosis + HTN + Age > 55 + MAHA @severeSS.
Tx - ACE/CCB?
-ACEi

Alpha1-antitrypsin deficiency can be diagnosed prenatally

Mandem in accident
-HTN and Bradycardia
-flushed above shoulders, pale below
Autonomic dysreflexia can only occur if the spinal cord injury occurs above the T6 level

Light microscopy = ground-glass hepatocytes = CHRONIC hepatitis B infection

Bisphosphonates and denosumab can be used to prevent pathological fractures in bone metastases. If the eGFR < 30, denosumab is preferred

RAPD = CN2

diplopia when asked to look laterally = CN6
-LR6 SO4 R3

occupation asthma is suspected. Most appropriate diagnostic investigation?
-Serial peak flow measurements
@work + home

1 pack year is defined as
20 cigs/day for 1 year

Mandem got CP SOBOE Syncope, narrow pulse pressure, slow rising pulse. How to tx Syx?
-Furosemide
Nitrates are contraindicated in aortic stenosis

Swabs for chlamydia and gonorrhoea in women should be taken from the vulvo-vaginal area (introitus)

pt a/w
abdo pain/constipation + neuropsych syx + Anaemia
-O/E: blue lines @gum margin. legs become WEAK in the past few days.
?Basophilic stippling #NOiron
-Lead poisoning is often occupational

ventilation -> Sudden deterioration
-suggests TPx

Myelodysplasia into AML
CLL = Richter into NHL

Prophylactic IV antibiotics are given prior to appendicectomy

Hydroxychloroquine can be safely used during pregnancy in Rheumatoid Arthritis

Nictonic Replacement Therapy can be safely used during pregnancy in Smoking Cessation

Bupropion =
NorAdr + Dopamine reuptake inhibitor, and Nicotinic BLOCKER (Blocker… Bupropion)

VareNICline = NICtonic agonist

Men who have sex with men should be offered immunisation against hepatitis A

-ECG shows new widening QRS complexes and a
-NOTCHED morphology of the QRS complexes
in the lateral leads = LBBB

RSR complex = RBBB

CKD-mineral bone disease =
Correct hyperPHOSPHataemia first
-start with dietary changes before
(eduction in foods like chocolate, nuts, shellfish and cola)
BEFORE STARTING…
-starting a phosphate binder = Sevelamer and lanthanum

High phosphate levels in CKD 
'drags' calcium from the bones, 
resulting in osteomalacia
-Tx = Bisphosphonates 
(but not under GFR< 30)

Patient with CKD taking
calcium-based binders (Calcium acetate)
can have problems ->
hypercalcaemia + vascular calcification

Metastatic bone pain:
-bisphosphonates, analgesia, or RT
Metastatic Spinal Cord Compression
-Dexamethasone

bumetanide = LOOPS Ascending loop of Henle

65
Q

Loin mass, loin pain, HUria

  • PUO - left varicocele: left gonadal vein drain into left renal vein
  • Paraneo: EPO? PTHrH? ACTH?
Tx:
-Surgery? 
-TyK = ? > superior efficacy IFN-alpha
-IFN-alpha, IL2 reduce tumour size + mets
\_\_\_\_\_\_\_\_\_
TCP - Inc p(bact infect) = ROOM TEMP:
<10 + ? 
<30 + ? 
<50 + ? 
<100 + ? 

No major hamorrhage:

  • PT/APTT > ? / ?
  • —-? = contents?
  • Fibrinogen < ? / ?
  • —-? = contents?
- WARFARIN 
Stop ? 
Vit K  route? @minor bleed > ? 
Vit K route? @NO bleed > ? 
Restart @ < ? 
No bleed + 5-8 = ? 
-bleed @ therapeutic lvl? Ix cause..?renal/gastro dx
Major Haemorrhage MHP
- PTC warfarin reversal emergency 
- < ? hr
-SPF
- @ ?
\_\_\_\_\_\_\_\_\_\_\_\_
Bone pain (?which dx?)
Deformity (?which dx?)
\+
HSM (?which dx?)
-OMRicKIDS Tx: ?
-OPetrosis:Tx: ?
-Pagets:Tx: ?
\_\_\_\_\_\_\_\_\_\_\_\_

Bone pain+Deformity:
-OMRicKIDS
My?

RicKIDS - ? NOT fused
V?
O?
L?
T?
X-ray sign? - LOOSERs Pseudo#
Tx: ?
\_\_\_\_\_\_\_\_\_\_\_\_\_\_
Bone pain, Deformity + HSM:
-Dx?:
PathPhys?
Tx?
\_\_\_\_\_\_\_\_\_\_\_\_\_\_
Bone pain+Deformity:
PathPhys? Tx?
-Skull, Spine, Pelvis 
-Long bones = femur/tibia
\_\_\_\_\_\_\_

Ca/VitD , PO4, PTH, ALP:

OM low low high high
OPet low/high ALP
Paget high ALP

Pri PTH = OFC high low high high

2ndry PTH = CKD / PseudoHypoPTH
-low high high high

3rtiary PTH = CKD
- high low high high

A
RCC
-Paraneo: 
EPO Polycythemia, 
PTHrH HyperCalcemia, 
ACTH cushings syndrome

-RCC+cholestasis/HSM
-paraneoplastic
hepatic dysfunction syndrome
AKA Stauffer syndrome
#increased IL-6

Tx:
-Partial/Total nephrectomy
-IFN-alpha, IL2 reduce tumour size + mets
-TyK = Sunitinib/sorafenib > superior efficacy IFN-alpha
__________

TCP - Inc p(bact infect) = ROOM TEMP:
<10 + no (bleed/surg / TCP dx)
<30 + bleed
<50 + surg 
<100 + CNS-bleed/procedure 

No major hamorrhage:

  • PT/APTT >1.5 / Surg
  • —-Fibrinogen = clot/plasma prots
  • Fibrinogen <1.5 / Surg 1.0
  • —-Cryo = f8+13 / fibrinogen + vWF
  • WARFARIN
    Stop warfarin
    Vit K IV @minor bleed >5
    Vit K PO @NO bleed >8
    Restart @< 5.0
    No bleed + 5-8 = withhold dose, reduce dose
    -bleed @ therapeutic lvl? Ix cause..?renal/gastro dx
Major Haemorrhage MHP
- PTC warfarin reversal emergency 
- <1 hr
-Stop warf / PTC + vit K / FFP @unavail
- @HI / ICH
\_\_\_\_\_\_\_\_\_\_\_
Bone pain (all 3 bone dx - OM/OPet/Paget)
Deformity  (all 3 bone dx - OM/OPet/Paget)
\+
HSM - (JUST Petrosis)
-OMRicKIDS Tx: Ca+Vit D
-OPetrosis:Tx: BMT, alpha-IFN, EPO
-Pagets:Tx: Bisphosphonates
\_\_\_\_\_\_\_\_\_\_\_

Bone pain+Deformity:
-OMRicKIDS
Myopathy/Myalgia

RicKIDS - apophysis NOT fused
Vit D resistance
OsteoDystrophy
LF
Tumour

X-ray sign? - LOOSERs Pseudo#
Tx: Ca+Vit D
______________

Bone pain, Deformity + HSM:
-OPetrosis:
OC dx -> bone expands = BM narrow ->
ExtraMedHematopoeisis
                HSM
Tx?
BMT, alpha-IFN, EPO
\_\_\_\_\_\_\_\_\_\_\_\_\_\_

Pagets:
XS OB/C activity -> Pain+deformity
Tx: Bisphosphonates
______

Ca/VitD , PO4, PTH, ALP:

OM low low high high
OPet low/high ALP
Paget high ALP

Pri PTH = OFC high low high high

2ndry PTH = CKD / PseudoHypoPTH
-low high high high

3rtiary PTH = CKD
- high low high high

66
Q

Cluster headache =
SBOT + ? sumatriptan
-@Migraine = ? sumatriptan can be used

DKA can present with an ‘?’
BM + confusion + abdominal pain

coarctation of the aorta = assoc w/ ? aortic valve

Hodgkin’s lymphoma: signs of poor prognosis: B-symptoms, ?INC/dec age, ? sex, stage ? disease and lymphocyte depleted subtype

does not undergo angioplasty
DVLA advice post MI - cannot drive for ? weeks

Raised ALP + normal LFT's = raise suspicion of ? 
#bone cancer/ metastases

British National Formulary recommends giving the vaccine at least ? B4/AFTER Elective splenectomy

? = (clonic movements travelling PROXIMALLY) indicates
? LOBE epilepsy

HCC + nausea W/OUT vomiting
-jaundice ascites bloated +
BNO 2 days, but PASSING WIND
-Dx = ? BO -> Tx?

CKD + potassium > 6mmol/L
should prompt ? of ACE inhibitors
(once other agents that promote hyperkalemia have been stopped)

? + ? have been shown to reduce mortality in stable heart failure

Beck’s triad of falling BP, rising JVP and muffled heart sound. What is the most appropriate diagnostic Ix for this man’s condition?
________

Small + Delayed puberty ?

Normal/Tall + Delayed puberty ?

GIRL + Amenorrhoea
-High FSH/LH

Tits + small balls + Tall
-High FSH /LH + low testosterone

Anosmia + Undescended balls + Tall
-FSH/LH lowwwww + low Testost

Low FSH/LH + High Testost

-High FSH/LH + norm/high Testost
XLr THEREFORE what gender? -> overall RESISTANCE to testosterone
-Male karyotype (46XY)
-External female PHENOtype
i.e. Man with External female genitalia
-breasts may develop at puberty, #testost -> oestradiol
-NO internal female organs,
-testicles IN ABDOMEN #groin swelling
-If not identified at birth, it can present with primary amenorrhoea.
______________

Syringomyelia classically presents with cape-like loss of pain and temperature sensation due to compression of the ? tract fibres decussating in the anterior white commissure of the spine

COCP use + FHx of VTE + Severe headache = more insidiously than a ‘thunderclap headache’, with ?subtle neurology
-?Ix is the gold standard test for diagnosing ?dx

CLL is associated with ? AIHA

A ? coronary infarct
supplies the ? node
so can cause arrhythmias after infarction

? are the treatment of choice for
ABPA
allergic bronchopulmonary aspergillosis
#eosiniphils #hyphae

sudden onset hypotension, fever and dyspnoea is suggestive of
?-incompatibility h
-Acute Haemolytic transfusion reaction.

GvH < / >100d , Hemolytic Rxns < few hours

Bacterial contamination of blood products can result in a transfusion reaction, which typically develops over ?duration

An INR > ? is a relative contraindication for chest drain insertion

Clostridium difficile antigen positivity only shows exposure to the bacteria, rather than current infection
- Tx?

  • raised purple plaque of indurated skin that affects the tip of her nose and the skin around the right nostril
    Rash? - Dx?

Pubic lice infestation = Tx?

The ? is the most likely area to be affected by ischaemic colitis

Diagnosis of a mesothelioma is made on histology, following a ?

If a patient with ulcerative colitis has had a severe relapse or >=2 exacerbations in the past year they should be given ?

? - weakly positively birefringent ?-shaped crystals

When managing patients with COPD, once the pCO2 is known to be NORMAL the target oxygen saturations should be ? %.
-if dont know + COPD = assume ? for now until CO2 known

absolute contraindication to thrombolysis?

? helps to distinguish pseudogout from gout

The osteoporosis guidelines state if a PMP woman has a Fracture she should be put on bisphosphonates (there is no need for ?).

Hepatocellular carcinoma
• hepatitis ? most common cause worldwide
• hepatitis ? most common cause in Europe

Cisplatin is associated with ?electrolyte dx

Nephrotic syndrome is associated with a hypercoagulable state due to loss of ? via the kidneys

Restless leg syndrome - management includes ?

  • ? measures
  • treat any ? def
  • ? > ?

The ? vaccine should be offered to patients with chronic hepatitis

Sickle cell patients should receive the
? polysaccharide vaccine every 5 years

Which of the following combinations of vaccinations are routinely offered to pregnant women in the UK?
? and ?

pt w/ T2DM + BPH = burning pain in his feet. Tx?
- WTF WOULD YOU AVOID, BASTARD?!

In a patient with suspected anaemia of chronic disease secondary to CKD, ? status should be checked prior to commencing EPO

Statin: LFTs ?

Spinal cord compression - ? is the earliest and most common symptom

High calcium, PROTEIN in urine, old person #back-pain -> fucking ?!

DM 1 check other Ai dx ?

A

Cluster headache =
SBOT + SubCut sumatriptan
–@Migraine = Intranasal sumatriptan can be used

DKA can present with an ‘unrecordable’
BM + confusion + abdominal pain

coarctation of the aorta = assoc w/ Bicuspid aortic valve

Hodgkin’s lymphoma: signs of poor prognosis: B-symptoms, increasing age, male sex, stage IV disease and lymphocyte depleted subtype

does not undergo angioplasty
DVLA advice post MI - cannot drive for 4 weeks

Raised ALP + normal LFT’s = raise suspicion of malignancy #bone cancer/ metastases

British National Formulary recommends giving the vaccine at least 2 weeks B4 Elective splenectomy

Jacksonian march (clonic movements travelling proximally) indicates 
Frontal LOBE epilepsy

HCC + nausea W/OUT vomiting
-jaundice ascites bloated +
BNO 2 days, but PASSING WIND
-Dx = Functional BO -> metoclopramide

CKD + potassium > 6mmol/L
should prompt Cessation of ACE inhibitors
(once other agents that promote hyperkalemia have been stopped)

Carvedilol + Bisoprolol have been shown to reduce mortality in stable heart failure

Beck’s triad of falling BP, rising JVP and muffled heart sound. What is the most appropriate diagnostic test for this man’s condition?
-Echocardiogram
_______

Small + Delayed puberty: Turner/Noonan/Prader/GH def

Normal/Tall + Delayed puberty: Kline/Kallowman/AIS

GIRL + Amenorrhoea = Turner 45 XO
-High FSH/LH

KlineFortySeven 47 XXY
-High FSH /LH + Low testosterone
KlineFelHerTits = Pri Hypogonadism

KallowwwmanOSMIA Xr

  • FSH/LH lowwwww + low Testost
  • Hypogonadotrophic(low FSH/LH) hypogonadism(low Testost)

Low FSH/LH + High Testost
-Testost secreting tumour

AIS: -High FSH/LH + norm/high Testost
XLr so MALE, bastard!! -> overall RESISTANCE to testosterone
-Male karyotype (46XY)
-External female PHENOtype
i.e. Man with External female genitalia
-breasts may develop at puberty, #testost -> oestradiol
-NO internal female organs,
-testicles IN ABDOMEN #groin swelling
-If not identified at birth, it can present with primary amenorrhoea.
—ANDROGEN INSENSITIVITY SYNDROME
______________

Syringomyelia classically presents with cape-like loss of pain and temperature sensation due to compression of the SPINOTHALAMIC tract fibres decussating in the ANTERIOR white COMISSURE of the spine

COCP use + FHx of VTE + Severe headache = more insidiously than a ‘thunderclap headache’, with ?subtle neurology
-MR Venogram is the gold standard test for diagnosing venous sinus thrombosis

CLL is associated with warm AIHA

A right coronary infarct
supplies the AV node
so can cause arrhythmias after infarction

Oral glucocorticoids are the treatment of choice for allergic bronchopulmonary aspergillosis

sudden onset hypotension, fever and dyspnoea is suggestive of
ABO-incompatibility
Acute haemolytic transfusion reaction.

Bacterial contamination of blood products can result in a transfusion reaction, which typically develops over HOURS

An INR >1.3 is a relative contraindication for chest drain insertion

Clostridium difficile antigen positivity only shows exposure to the bacteria, rather than current infection
- Reassure and continue monitoring bowel motions

Lupus pernio = sarcoidosis
- raised purple plaque of indurated skin that affects the tip of her nose and the skin around the right nostril

Pubic lice infestation = MALATHION

The SPLENIC FLEXURE is the most likely area to be affected by ischaemic colitis

Diagnosis of a mesothelioma is made on HISTOLOGY, following a THORACOSCOPY

If a patient with ulcerative colitis has had a severe relapse or >=2 exacerbations in the past year they should be given either PO Azo/MCP = to maintain remission

Pseudogout - weakly positively birefringent RHOMBOID-shaped crystals

When managing patients with COPD, once the pCO2 is known to be NORMAL the target oxygen saturations should be 94-98%.
-if dont know + COPD = assume 88-92 for now until CO2 known

absolute contraindication to thrombolysis?
-Known intracranial neoplasm (VINDICATE)

Chondrocalcinosis helps to distinguish pseudogout from gout

The osteoporosis guidelines state if a postmenopausal woman has a fracture she should be put on bisphosphonates (there is no need for a DEXA scan).

Hepatocellular carcinoma
• hepatitis B most common cause worldwide
• hepatitis C most common cause in Europe

Cisplatin is associated with hypomagnesaemia

Nephrotic syndrome is associated with a hypercoagulable state due to loss of AT3 via the kidneys

Restless leg syndrome - management includes

  • simple measures,
  • Tx Fe def,
  • Ropinirole > Benzo/gabapentin

The pneumococcal vaccine should be offered to patients with chronic hepatitis

Sickle cell patients should receive the pneumococcal polysaccharide vaccine every 5 years

Which of the following combinations of vaccinations are routinely offered to pregnant women in the UK?
Influenza and pertussis

pt w/ T2DM + BPH = burning pain in his feet. Tx?
- DAG (if URINARY RETENTION, then NO AMITRIPTYLINE, BASTARD)

In a patient with suspected
anaemia of chronic disease
secondary to CKD,
Fe status should be checked prior to commencing EPO

Statin: LFTs at 0m, 3 months and 12 months

Spinal cord compression - BACK PAIN is the
earliest and most common symptom

High calcium, PROTEIN in urine, old person #back-pain -> fucking - MM

DM 1 check other Ai dx
-Thyroid + Coeliac/Addison Pernicious

67
Q

HBC SHLD

painful genital ulcers - HBC
-painFUL Unilat Ing NODE sharply defined, ragged, undermined border - ddx? organism?

______________

painless gential ulcers - SHLD

  • warts: plantar , common , anal
  • –Tx @single wart @multiple wart?
  • painLESS ulcer, painFUL Ing nodes, ProctoColitis- ALTERED bowel habits - ddx? organism?
  • painLESS ulcer, “beefy-red ulcer” + characteristic ROLLED edge of granulation tissue - ddx? organism?

CHD, LGC, DGIK
_________

Which 2 beta blockers = shown to reduce mortality in stable HF

An ultrasound is required in the investigation of all patients presenting with an AKI of unknown aetiology

Patients with an uncertain tetanus vaccination history should be given ? unless the wound is very minor and < 6 hours old

Asyx + HIV exp -> HIV test after ?wks

HIV needlestick PEP= 
Refer to ?
\+ 
?med
< ?hrs max?
for how long?

Neg Antibody test after ? =
UNlikely HIV infection

gonorrhoea + scared of needles = ?
___________

1.

  • fooooot EEEEEEVersion (i.e. inversion FINE!)
  • sensory loss in 1st web space
  • dorsiflexion / toe extension

2.
-Ankle EEEEEVersion (i.e. inversion FINE!)
- sensory loss @ANT-LAT lower leg + foot-DORSUM
(NOTTTTTT the 1ST web space).

  1. -> ? -> ?
    @lat thigh, lower leg, foot-dorsum, 1ST WEB SPACE
    - foot INversion + EVersion BOTH fucked
    - hip abduction
    - pain and sensory loss
    - Common peroneal fucked too (as above)

4.
-weak PLANTARflex + low sensation @LAT malleolus

A

PAINFUL ulcers
-Herpes painful nodes (oral aciclovir / @preg=oral ciclovir till delivery -> c-section)

-Behcet - uveitis VTE and painful ulcer

-Chancroid-HDucreyi=
painFUL Unilat Ing NODE sharply defined, ragged, undermined border.
______________

PAINLESS ulcers
-Syphilis=painLESS Ing node

  • HPV 1+2=plantar, 4=common, 6+11-anus;
  • solitary-cryo, multiple-podophyllum

-LGC: LymphoGranulomaChlamydia=
painFUL Ing nodes, ProctoColitis B/C/D

-DGiK: Donovanosis Granuloma Inguinale Klebsiella
-Azith Cipro Gent
__________

Which 2 beta blockers = shown to reduce mortality in stable HF? Bisop / Cardev

AKI w/ UNKNOWN pathology? FUCKING USS THEM !!!!

Patients with an uncertain tetanus vaccination history should be given a BOOSTER vaccine + Tet Ig, unless the wound is very minor and < 6 hours old

Testing for HIV in Asyx pts should be done at 4 weeks after possible exposure

HIV needlestick PEP= 
Refer to Emergency Department 
\+ 
oral antiretroviral therapy
< 72hrs
for 4 weeks

Neg Antibody test after 3 months =
UNlikely HIV infection

gonorrhoea + scared of needles = oral cefixime + oral azithromycin #refuses IM ceftriaxone
___________

Deep peroneal nerve-failed:

  • fooooot EEEEEEVersion (i.e. inversion FINE!!!)
  • sensory loss in 1st web space
  • dorsiflexion / toe extension

Superficial peroneal nerve-failed:
-Ankle EEEEEVersion (i.e. inversion FINE!!!)
- sensory loss @ANT-LAT lower leg + foot-DORSUM
(NOTTTTTT the 1ST web space).

L5 nerve root –> sciatic –> CPeron = S/D
@lat thigh, lower leg, foot-dorsum, 1ST WEB SPACE
- foot INversion + EVersion BOTH fucked
- hip abduction
- pain and sensory loss
- Common peroneal fucked too (as above)

S1 nerve root dx
-weak PLANTARflex + low sensation @LAT malleolus

68
Q

TCA use + dementia = ? cognitive impairment

? saline is usually indicated in patients with SEVERE hyponatraemia (< 120 mmol/L)

GTN SEs = ‘3 H’s’

What criteria should be used to determine whether patients who are having an excerbation of COPD require antibiotics?

ST elevation Ax?

ST depression AX? VICD

T wave inversion Ax? DRILb

ST elevation
ST dep + T invert =
T invert

short PR interval (<120ms),
wide QRS complex (>120ms),
upsloping delta wave.
-Dx?

  • low k+ high sodium; high BP; high renin = RAS / other 2ndary dx
  • low k+ high sodium; high BP; low renin = Conn’s/Cushings

> 80 with >150/90 clinic + ABPM < 145/85 = ?

> 80 with >150/90 clinic + ABPM > 145/85 = ?

? (due to hypogammaglobulinaemia) are a complication of CLL

Bog standard UTI MEN ? FUCKING DAYS!!!!!!!!!!!!!!!!
-women = ?

Azithromycin prophylaxis is recommended in COPD patients who meet certain criteria and who continue to have exacerbations
-reduce his exacerbation frequency

Acoustic neuroma Syx progressively getting worse
-Stroke e.g. VertebroBasilar Insuff / POCS = sudden onset @old person+RFs

Vision worse going down stairs? Think ? nerve palsy

BHL = ? / ?

Breast lump + firn NON-tender (so not abscess or cyst)
-stopped BF recently
-USS = well-circumscribed lesion -> white fluid
Dx = ?
____

A

TCA use + dementia = worsening cognitive impairment

Hypertonic is usually indicated in patients with SEVERE hyponatraemia (< 120 mmol/L)

GTN SEs = ‘3 H’s’

  1. Headache
  2. Hypotensive
  3. HR increase

What criteria should be used to determine whether patients who are having an excerbation of COPD require antibiotics?
-Purulent sputum OR clinical signs of pneumonia

ST elevation
-MI / Pericarditis / brugada

ST dep
-isch, CVD, VH (left or right), Digoxin

T-invert
-isch/old, Brugada, VH (left or right), Digoxin

short PR interval (<120ms), 
wide QRS complex (>120ms) 
upsloping delta wave.
-WPW
-PR 120-200ms; QRS <120ms
  • low k+ high sodium; high BP; high renin = RAS / other 2ndary dx
  • low k+ high sodium; high BP; low renin = Conn’s/Cushings

> 80 with >150/90 clinic + ABPM < 145/85 = lifestyle

> 80 with >150/90 clinic + ABPM > 145/85 = lifestyle + consider tx

Recurrent infections (due to hypogammaglobulinaemia) are a complication of CLL

Bog standard UTI MEN 7 FUCKING DAYS!!!!!!!!!!!!!!!!
-women = 3

Acoustic neuroma Syx progressively getting worse
-Stroke e.g. VertebroBasilar Insuff / POCS = sudden onset @old person+RFs

Vision worse going down stairs? Think 4th nerve palsy
-TROCHLEAR!!!!

BHL = sarcoid / TB

Breast lump + firn NON-tender (so not abscess or cyst)
-stopped BF recently
-USS = well-circumscribed lesion -> white fluid
Dx = Galactocele

69
Q

Bradycardia < 100
Tachycardia > 100
_______________

Early Decel
Late Decel
____________

Variable decel
Loss of baseline variablity
_________

When to give anti-D to mum?

A. Booking visit

B. 11 - 13 weeks

C. 28 wks –> 34wks

D. 36 wks

Positive serum AFP/Prev NTD ->
USS ->
Amniocentesis for AFP/AChi w12 16-20

@HIV, mum viral load < 50 @ w?
-what delivery recommended?

-what should be started 4 hrs b4 c-section?

After birth:
-mum CD4 < 50, what administered to neonate?

-mum CD4 > 50, what administered to neonate?
_______

BF advantages?

A

Bradycardia < 100
-Beta-blocker / vagal tone

Tachycardia > 100
-Infection / Prematurity
___________

Early Decel
-head compression #normal

Late Decel
-asphyxia/placent insuff #hypoxia ->
DO FETAL BLOOD SAMPLING -> ?c-section
___________

Variable decel
-cord comp

Loss of baseline variablity
-Prematurity / Hypoxia
\_\_\_\_\_\_\_\_\_\_
-Anti D @Rh neg ATE ME:
Abortion
TransPlacentalHaemorrhageRisk(procedures)
-procedures/abdo trauma/iuDeath
Ectopic

Miscarriage >12w
Evac after miscarriage
___________

A. 8-12 wks -

  • Booking
  • overlap w/ Down’s nuchal scan
B. 11-13 
-Down's + Nuchal scan 
-overlap w/ booking
\_\_\_\_\_\_\_\_\_\_
C. 
28 wks
- 1st dose of anti-D prophylaxis @RhNEG 
- 2nd Anemia/AlloAB test @28w
34 wks: 2nd dose of anti-D prophylaxis @RhNEG
\_\_\_\_\_\_\_\_\_\_
D. 36 wks:
-BFeed / Blues
-ECV ?Presentation legit
-Vit K 
@viral load < 50 @ w36: VAG > C-section 
- IF c-section, then b4 c-section: IV zidovudine
After birth:
< 50: PO zidovudine @neonate
> 50: Triple ART @neonate
\_\_\_\_\_\_\_\_

Mother:

  • BabyBond
  • Reduce BreastCancer / PPH-risk

Kid: i-AIRD

  • Infections
  • Allergy/ IBD / RA / DM 1
70
Q

The definition of a TIA is now ?-based #imaging
-NOT Syx DURATION RELATED!

Hyperventilation -> reduce CO2 ->
? of the cerebral arteries -> reduced ICP

Sweating, Pallor, N+V -> transient LOC
-Suggestive of ? syncope AKA ? mediated syncope

The ‘double duct’ sign may be seen in ?

COCP use + FHx of VTE + Severe HEADACHE = more insidiously than a ‘thunderclap headache’, with ?subtle neurology
-?Ix is the gold standard test for diagnosing ?Dx

Cavernous sinus syndrome 2 Ax = 
-Cavernous Sinus Tumours, OR
-NPC = invades Cavernous Sinus -> 
Corneal Reflex Absent ?Anatomy
Horner ?Anatomy
Opthalmoplegia ?Anatomy
Pain, Proptosis #mass-effect
-max sens low ?Anatomy
-CN 3 ?
-CN 4 ?
-CN 5- (V1=?Reflex, V2=?sensation)
-CN 6 ? + ICA (?) + Symp trunk (?)

-Motor:(down+out, ptosis),
-PSymp(dilated),
-?vertical nystagmus
Ax ?

PAINFUL third nerve palsy = r/o posterior communicating artery aneurysm

Rectal diazepam ? mg

Syncope. QRS duration is 110 ms, PR interval is 180ms and corrected QT interval is 500ms. ?cause for the abnormality seen on the ECG?

Behcet’s syndrome is associated with ?rash

? is contraindicated in patients with Parkinson’s disease

Anti-psychotics should be avoided in delirious patients with a background of Parkinson’s disease

xanthelasma secondary to ?

‘Young’ stroke blood tests include ? screening
-performed in those < ? with no obvious cause of a stroke

Which one of the following is the most common symptom of Crohn’s disease in children?

T2DM blood pressure targets and non-T2DM targets?

Pepper pot = multiple tiny well-defined lucencies in the calvaria caused by resorption of trabecular bone (looks like sand) #?Dx

Raindrop = multiple, well-defined lytic lesions (punched out lesions) of various size scattered throughout the skull #?

STEMI: Aspirin + ticagrelor + IV heparin + immediate percutaneous coronary intervention

IV ? is used to treat torsades de pointes

? is the commonest association for aortic dissection

diarrhoea + hypoglycaemia = ?

Atrial fibrillation + NO struct heart dx = pharm cardioversion: ?

Atrial fibrillation + struct heart dx = pharm cardioversion: ?
__________

most common form of brain tumours – ?

solid tumours = central necrosis + contrast enhancing rim; B-BBarrier dx -> vasogenic oedema.

tumour arising from falx cerebri -> pushing on the brain.

  • Well-defined border between the tumour + brain
  • ? typicallydevelop from the ? mater

Preg woman should be offered the flu vaccination during ?

Pharyngeal pouch requires surgical treatment

What shown to confer a survival benefit in motor neuron disease?

? optimal treatment in HNF1A-MODY

Acute Hemolytic Rxn – do ? test to confirm!!!
_____________

Pleomorphic tumour cells border necrotic areas = ?

Spindle cellspsammoma bodies = ?

Rosenthal fibres (corkscrew eosinophilic = ?

fried egg appearance = ?

perivascular pseudorosettes = ?

foam cells and high vascularity = ?

A

The definition of a TIA is now TISSUE-based #imaging
-NOT Syx DURATION RELATED!!

Hyperventilation -> reduce CO2 ->
vasoCONSTRICTion of the cerebral arteries -> reduced ICP

Sweating, Pallor and N+V -> transient LOC
-Suggestive of REFLEX syncope AKA neurally mediated syncope

The ‘double duct’ sign may be seen in PANCREATIC cancer

COCP use + FHx of VTE + Severe HEADACHE = more insidiously than a ‘thunderclap headache’, with ?subtle neurology
-MR Venogram is the gold standard test for diagnosing venous sinus thrombosis

Cavernous sinus syndrome Ax =
Cavernous sinus tumours, OR
NPC = locally invades cavernous sinus. ->
Corneal Reflex Absent,
Horner,
Opthalmoplegia
Pain, Proptosis #mass-effect
-CN 3 Opthalmoplegia (ptosis/diplopia)
-CN 4 Opthalmoplegia
-CN 5- (V1=Corneal Reflex Absent, V2=low max sens)
-CN 6 Opthalmoplegia + ICA (thrombosis) + Symp trunk (Horner’s)

CN3 palsy:
Motor(down+out, ptosis), PSymp(dilated), ?vertical nystagmus
-isch, CavSinThrom, UncalHerniate/trans-tentorial, MidbrainWeber, PComAneurysm

PAINFUL third nerve palsy = posterior communicating artery aneurysm

Rectal diazepam 10 mg

Syncope. QRS duration is 110 ms, PR interval is 180ms and corrected QT interval is 500ms.what is the cause for the abnormality seen on the ECG?
-Hypo-Mg/Ca/Kal (ssri/tca, abx-macrolide, Li low MgCaK, Typs)

Behcet’s syndrome is associated with erythema nodosum

Haloperidol is contraindicated in patients with Parkinson’s disease

Anti-psychotics should be avoided in delirious patients with a background of Parkinson’s disease

xanthelasma secondary to hyperCHOLesterolaemia.

‘Young’ stroke blood tests include thrombophilia and autoimmune screening
-performed in those <55 with no obvious cause of a stroke

Which one of the following is the most common symptom of Crohn’s disease in children? Abdominal pain

T2DM blood pressure targets are the SAME as non-T2DM. If < 80 years:

Pepper pot = multiple tiny well-defined lucencies in the calvaria caused by resorption of trabecular bone (looks like sand) #hyperparathyroidism

Raindrop = multiple, well-defined lytic lesions (punched out lesions) of various size scattered throughout the skull #MM

STEMI: Aspirin + ticagrelor + IV heparin + immediate percutaneous coronary intervention

IV magnesium sulfate is used to treat torsades de pointes

Hypertension is the commonest association for aortic dissection

diarrhoea + hypoglycaemia = Cholera

Atrial fibrillation + NO struct heart dx - cardioversion: amiodarone + flecainide

Atrial fibrillation + struct heart dx - cardioversion: amiodarone (AAAmiodarone @FFFUCKED Heart - AF)
___________

most common form of brain tumours – metastases

solid tumours = central necrosis + contrast enhancing rim; B-BBarrier dx -> vasogenic oedema.
-most common PRIMARY brain tumours – GLIOBLASTOMA #poor prognosis

tumour arising from falx cerebri -> pushing on the brain.

  • Well-defined border between the tumour + brain
  • Meningiomas develop from the DURA mater

She should be offered the flu vaccination during flu season (October to January)

What shown to confer a survival benefit in motor neuron disease? Riluzole

Sulfonylureas (e.g. gliclazide) are the optimal treatment in HNF1A-MODY

Acute Hemolytic Rxn – do Coombs test to confirm!!!
_____________

Pleomorphic tumour cells border necrotic areas = Glioblast

Spindle cellspsammoma bodies = Meningioma

Rosenthal fibres (corkscrew eosinophilic

  • Pilocytic astrocytoma
  • most common PRI brain tumour in kids

fried egg appearance = OOOligodendroma

perivascular pseudorosettes = Ependymoma

foam cells and high vascularity = HemangioBlastoma

71
Q

T1/2 bleed causes?
T3 bleed causes?

  • Bleeding @T1/earlyT2
  • exaggerated syx e.g. HyperEmesis.
  • LARGE 4 dates uterus
  • hCG = high AF!!! = HYPERthyroid
  • ? @USS

Tx????????

Complete V Partial mole?

? % = develop choriocarcinoma
___________

Delayed 3rd stage labour
Pt w/ prev
-PMH: PID
-PSH: c.section / p.praevia

?-types - what invades what?

Tx: ?
_______________

@preggers
•shock OUT OF KEEPING w/ visible loss

•tender, tense, hard woody uterus #CONSTANT-pain

  • lie /presentation - NORM
  • fetal heart: absent/distressed
  • coag dx=DIC / pre-eclampsia
  1. NO fetal distress + <3? w
  2. NO fetal distress + >3? w
  3. Fetal distress - tx?
    ___________

@preggers
•shock IN PROPORTION to visible loss
•painLESS

  • lie /presentation - ABnormal
  • fetal heart: FINE
  • coag dx=none..

Ix? - what to avoid?!

  1. If low-lying placenta @16-20 week scan
    - rescan at ?weeks
  2. If still present @ ?-weeks and
    grade 1/2 then ?
  3. If high presenting at ?weeks then ?
  4. If high abnormal lie at ?weeks then ?
    _____________

Rupture of membranes –>

  • immediately get vaginal bleeding
  • Fetal BRADYcardia #classically seen
A

T1/2 = Ectopic / Miscarriage-Molar preg
T3 = Praevia / Abruption
_________________

Complete HyDatiDiForm Mole (MOLAR)
Tx = EVAC -> CONTRACEP 12m

COMPLETE=46 XX/XY
-EMPTY egg + 1 sperm –> DNA duplicates –>
ALL 23x2 male genes
-Honeycomb/Grapes/SNOWstorm @USS

PARTIAL=69 XXX/XXXY

  • haploid egg (23) + 2 sperm (23x2)
  • partial fetal parts

Around 2-3% = develop choriocarcinoma
___________

Accreta

  • delayed labour #3rdstage
  • prev c-sec/praevia/PID

3-types = chorionic villi:-

  • invade PPerimetrium #PPercreta
  • IInvade myometrium #IIncreta
  • AAttach* 2 myometrium #AAccreta

*-instead of decidua basalis #accreta

Tx: hysterectomy w/ placenta left in-situ
___________

P.Abruption - PainFUL PV bleed
-OUT OF KEEPING w/ visible loss
- feta heart fucked + DIC/Pre-Ecl
____________

  1. NO fetal distress + <36w
    - observe+steroids
    - ?adjust delivery threshold
  2. NO fetal distress + >36w
    - vag delivery
  3. Fetal distress - tx?
    -immediate c-section
    _____________

P.Praevia - PainLESS PV bleed

  • IN PROPORTION to visible loss
  • Lie = abnormal

Ix? - what to avoid?!
-TV-USS - avoid PV exam till praevia excluded!!
LLP @W-16-20 = Rescan @w34
-34 + G1/2 = TVUSS/2w
-37 = high-presenting-part/abnormal life = C-SECTION

  1. If low-lying placenta at 16-20 week scan
    - rescan at 34 weeks
  2. If still present at 34 weeks and grade 1/2 then
    - scan every 2 weeks
  3. If high presenting part at 37 weeks then
    - C-section
  4. If abnormal lie at 37 weeks then
    -C-section
    _______________

Vasa praevia
-ROM - >PVbleed + BradyBaby

72
Q

PPHemorrhage tx
_________________________

Premature labour tx?

After W?
symphysis-fundal
height in cm = ??
________

Oligohydramnios definition
< ?ml @ T3
AFI < ?th centile
-Ax?

Shoulder dystocia tx?
________

MIFEPRISTONE ONLY USED IN WHAT BASTARD?!

Miscarriage Tx

When do Med/Surg Mx?

(remember miscarriage = WMVE, abortion = MMSE 9 13 15)
___________

Abortion tx < 24w
9 13 15 
MM SE
DS 
DE

(Remember
miscarriage WMVE,
Abortion MMSE 9 13 15)

A
-BOE-CAB
Bimanual uterine compression
Oxytocin - stim ut contract
Ergotamine(
-5HT/Alpha-adr/Dop=vasc SM constrict -> reduce Uterus BF = less bleed)

Carboprost
Atony = Balloon tamponade
B-lynch UA/Iliac ligation/TAH
________________________

Premature labour:
Admit
Tocolytics and Steds

After W20, S-F height i=
-g.WEEKS +/- 2cm
_______

Oligohydramnios
< 500ml @ T3
AFI < 5th centile

Ax:
Renal agenesis / ACEi
IUGR
PROM/Pre-Ecl/Post-term>42w

Shoulder dystocia: MESZ
McRoberts' - flexion and abduct
Episiotomy, Symphysiotomy,
Zavanelli / Rubin Wood's Corkscrew
\_\_\_\_\_\_\_\_\_\_\_

MIFEProgRecepBlocker ONLY USED IN Abortion BASTARD

MISCARRIAGE: WMVE

WW < 2w
 (d/c with f/u in ? week) 
Med/Surg Mx @:
-Haemorrhage (late T1/blood dx) 
-Infection
-Prev preg dx

MED:
Vag MMMisoProstaGlandin - > Ut Contract
-Moebius Synd= Cranial Nerve dx

SURG:
OP: VVVacuum Asp Suction Curettage
IP: Theatre EEEEEvacuation
\_\_\_\_\_\_\_\_\_\_\_\_\_
ABORTION: MMSE

< 9 w: MM

0hrs: MifeProg-ReceptorBlocker
- Moebius Synd= Cranial Nerve dx

48 hours: MisoProstaGlandin= stim ut contract

< 13 w: DS
Surg dilation + Suction

> 15-24 weeks: DE
Surg dilation and Evac
medical abortion = ‘mini-labour’

> 24 - ILLEGAL MURDERRRRRRRRR

73
Q

Thoracic ADiss:
Type A/1+2 = Tx?
Type B/3 = Tx?

Diabetes sick-day rules for insulin:

  • dose?
  • frequency of checking?

MI #transmural -> chest pain

  • worse @inspiration/lying
  • relief @lean-forward
  • ?Dx @first 48 hours following MI
  • ?Dx @2-6 weeks following a MI
  • Tx = ?

Pt w/ stroke + already on AC = Ix?

Adrenaline dose @

  • > 12y, 6-12yr, 6m-6yr, <6m
  • Cardiac arrest = ?

Coeliac/Hyplori -> haem cancers:

  • coeliac = Enteropathy T-cell Lymphoma
  • pylori - MALT lymphoma #erad tx

Orthostatic HypoTN = 20/10 drop after
? fucking minutes

Carotid Sinus HSR ->

  • Vent pause > ?s
  • SystBP drop by ?mmHg/+

Chondrocalcinosis helps to distinguish ? from ?

Acromegaly can develop ? BIREFRINGENT
-?shape - PseudoGout

HyperParathyroidism is a risk factor for pseudogout/gout? #Calcium ?
- whereas HYPOcalcaemia = ?

Gout = ?-shape NEG birefringent

Mandem = AF + chadsvasc 0:

  • Tx?
  • Ix? - why?

Factor V leiden = AKA ?
-aProtC –x? more Slowly ?–> f?

Tonsilitis -> did not finish the ABx course

  • CXR = bilateral infiltrates
  • CT chest = multiple SEPTIC EMBOLI
  • CT neck w/ contrast = thrombus @int jugular vein.
A

Thoracic ADiss: Stanford/DeBakey
A / 1+2) Asc = SURG + Labetall

B)/3 Desc i.e. distal to L Subcl =
TLC = Labetalol + BP 100-110 maintain

Diabetes sick-day rules for insulin:
-normal dose BUT more frequent checking

MI #transmural -> PR dep / Saddle ST elevation:

  • Pericarditis @first 48 hours following MI
  • Dressler’s syndrome @2-6 weeks following a MI t
  • Tx = NSAIDs + Colchicine

Pt w/ stroke + already on AC
-EMERGENCY ED imaging !!!

Adrenaline dose @
>12y=0.5mg, 6-12yr=0.3mg, 6m-6yr=0.15mg, <6m=0.15mg
- Cardiac arrest = 1mg

Coeliac/Hyplori -> haem cancers:

  • coeliac = Enteropathy T-cell Lymphoma
  • pylori - MALT lymphoma #erad tx

Orthostatic HTN = 20/10 drop after
3 fucking minutes

Carotid Sinus HSR ->

  • Vent pause >3s
  • SystBP drop by 50mmHg/+

Chondrocalcinosis helps to distinguish pseudogout from gout

Acromegaly can develop POS BIREFRINGENT
-RHOMBOID - PseudoGout

HyperParathyroidism is a risk factor for Pseudogout

  • # Calcium PyroPhosphate
  • whereas HYPOcalcaemia = cataracts

Gout = needle-shape NEG birefringent

Mandem = AF + chadsvasc 0:

  • no AC
  • do Echo!!!! exclude valvular dx
  • -remember pulse, ecg, echo 2 excl valve dx

Factor V leiden = AKA
Activated Prot C RESISSSSSSSSSSSSSSSSTANCE
-aProtC –x10 more Slowly INactivates–> f5a

Oropharyngeal infection
+
Internal Jug Vein Thrombophlebitis
-> Lemiere Syndrome

74
Q

Mandem takes MTX + wants a baby
-how long should he wait?

Atypical Lymphocytes?

Paget bones?

1ml of insulin syringe = how many inuslin units?

Venous cutdown of ankle veins - which vein?

OSAS can lead to what CV dx?

ThromboProph Tx?
-APLS + NO prev VTE = ?

-APLS + Prev VTE = ?

-APLS + pregnancy:
? + ?(stop after w?)

  • APLS + Prev VTE WHILST on AC =
  • –? lifelong + ? lifelong
  • –? @Preg + ? lifelong

-APLS + ArtTE = ?

  • INR ?-? @initial
  • INR ?-? @ArtTE
  • INR ?-? @recurrent

Warfarin

  • NOT legit in pregnancy but
  • legit for breastfeeding
  • @APLS + PREG ± prev VTEs= Tx?
  • -@APLS + prev VTEs = Tx?
  • –@APLS + VTEs whilst ON AC= Tx?

Type 2 Nec Fasc organism?
-Type 1 ?

Acute RA flare tx?

childhood with bone fractures and deformities,
BLUE sclera + hearing/visual problems
-Osteogenesis Imperfecta bloods?

Pneumothorax BTS main top bit ffs
- 2 fucking things

flu-like syx, subconjunctival haemorrhages, HMeg
-Dx Ix?

Leptospirosis Ix = ?

  • lepto = ?
  • sally = ?
  • legion = ? antigens
  • mycoplasma/s.pneu - ? antigens

Pt with chest infection + TNFi use for rheum dx ->
ABx failed -> ITU
-?Ix + BAL = Dx?

Away Towards - THEM CHP

AF questions + ?cardioversion -> look at ? !!!!

  • IF HD unstable THEN legit
  • offer ? or ? control if the onset of the arrhythmia is < than 48 hours,
  • and start ? control if it is > than 48 hours or is uncertain -> 3wk AC elec>pharm cardiovert
  • Amiod 4w if struct HD + for elec cardioversion

-Urticarial Rashes/Fever
-U+E fucked
AND
-High Urine: WCC, IgE, Eosinophils
Dx? #new ABx use…

A

Mandem takes MTX + wants a baby
- >6m AFTER stopping tx

Atypical Lymphocytes = EBV!

Paget bones = Skull, Spine, Pelvis, Long bones

1ml of insulin syringe = 100 inuslin units?

Venous cutdown of ankle veins - Long Saphenous
-ant to medial malleolus

OSAS can lead to what CV dx? HTN !!!

ThromboProph Tx?
-APLS + NO prev VTE = Aspirin lifelong

-APLS + Prev VTE = Warf lifelong

-APLS + pregnancy:
Aspirin + LMWH(stop after w34)

  • APLS + Prev VTE WHILST on AC =
  • –Warf lifelong + Aspirin lifelong
  • –LMWH @Preg + Aspirin lifelong

-APLS + ArtTE = Warf LIFElong

  • INR 2-3 @initial/ ArtTE
  • INR 3-4 @recurrent

ArtTE = Art ThromboEmbolism

Warfarin

  • NOT legit in pregnancy but
  • legit for breastfeeding
  • @APLS + PREG ± prev VTEs = Asp + LMWH
  • -@APLS + prev VTEs = Warf
  • –@APLS + VTEs whilst ON AC= Asp + Warf

Type 2 Nec Fasc organism = GAS Pyogenes
-Type 1 = post-surg + aerobes/anaerobes + DM

Acute RA flare tx = IM MethylPred

Osteogenesis imperfecta childhood with bone fractures and deformities
BLUE sclera + hearing/visual problems
Osteo Imperfecta = ALL BONE PROFILE BLOODS FKN NORMAL!!!!!

Px:

  • Age >50 + Sig Smoke Hx
  • Lung dx O/E or CXR

Leptospirosis Ix = Serology

  • lepto = serology
  • sally = cultures
  • legion = urinary antigens
  • mycoplasma/s.pneu - serum antigens

Pt with chest infection + TNFi use for rheum dx ->
ABx failed -> ITU
-Bronchoscopy + BAL = Invasive Aspergillosis

Away: TPx, Hernia, Effusion, Mass
Towards: Collpase, Hypoplasia, Pneumonectomy

AF questions + ?cardioversion -> look at ? !!!!

  • IF HD unstable THEN legit
  • offer rate or rhythm control if the onset of the arrhythmia is < than 48 hours,
  • and start rate control if it is > than 48 hours or is uncertain -> 3wk AC elec>pharm cardiovert

-Urticarial Rashes/Fever
-U+E fucked
AND
-High Urine: WCC, IgE, Eosinophils
Dx = Acute Interstitial Nephritis #Penicillins

75
Q

Ruptured AAA - ?units ?blood product

> 80 with ABPM >145/85
-Dx? Tx?

Person with LF gets RF - Dx?

  • develops < 2 weeks?
  • develops >2 weeks?
Mandem had accident -> Cord injury @above T6 
-> HTN + Bradycardia + ...
-Flushed + Sweating #Red ABOVE shoulders
-PALE BELOW shoulders 
Ax of HTN?

Mandem in accident
-HTN and Bradycardia
-flushed above shoulders, pale below
?Dx can only occur if the spinal cord injury occurs above WHERE?

? are the most common triggers of autonomic dysreflexia

SB bacterial overgrowth syndrome - Tx?

Mandem w/ cancer -> Chemo -> U+E:

  • what 3 things high?
  • 2 Cx @heart/brain
  • whats low
  • Dx? Tx?

Absent corneal reflex, CN7 palsy, SVT #CN578
___________

P Painless retention
E Eversion of FOOT = weak
N No ankle/knee jerk
I Impotence
S Saddle anaesthesia
-Anatomy of compression?

Upper Motor signs @ level
LMN signs below level…

Cancer + NEW back pain - Ix?
___________

Pt had stroke - what score used to predict disability?

A

Ruptured AAA - ?blood products?
-6 units CROSSMATCH RBC

> 80 with ABPM >145/85
-St1 HTN = lifestyle changes + ?Tx

HepatoRenal Syndrome

  • develops < 2 weeks - Type 1
  • develops >2 weeks - Type 2
Mandem had accident -> Cord injury @above T6 
-> HTN + Bradycardia + ...
-Flushed + Sweating #Red ABOVE shoulders
-PALE BELOW shoulders 
Ax of HTN = Autonomic Dysreflexia

Mandem in accident
-HTN and Bradycardia
-flushed above shoulders, pale below
Autonomic dysreflexia can only occur if the spinal cord injury occurs above the T6 level

Faecal impaction / urinary retention are the most common triggers of autonomic dysreflexia

SB bacterial overgrowth syndrome = RIFAXIMIN

Mandem w/ cancer -> Chemo -> U+E:

  • hyperrrKALaemia, -hyperrrPHOSPHataemia
  • HIGH creatine
  • Seizure/arrythmia

-LOWW Calcium
TLS - Allopurinol
#Tumour lysis syndrome

Absent corneal reflex, CN7 palsy, SVT #CN578
-Acoustic Neuroma
_________

Cauda Equina

Spinal Cord Compression

Cancer + NEW back pain = MRI whole spine #spinal-mets
_________

Stroke disability score prediction
-BARTHEL index

76
Q

Questions about POP - If: miss

  • Cerazette-desogestrel > ? hrs late
  • The rest > ? hrs late

WTF to do?
_____________________
Cocp pros + cos

POP cons?

Depot cons?

HRT cons?
Cons of HRT: BEVi
Breast (prog ? this)
Endomet (prog ? this)
VTE / IHD (? HRT reduces this)
iNC Fibroid size 

Tamoxifen cons?
___________________

Young people - LARC iDIP
Long Acting Reversible Contracep
_________

For breast cancer past/current, what UKMEC + contraceptive legit?

For young, what Long-Acting Reversible Contraceptive is legit? - iDIP

Contraceptives UNNNNNNNNNN
NNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNN
NNNAffected by Enzyme-Inducing Drugs?

Despite prog preps leading to obesity,
which prog prep
legit for obesity?
__________

Contraceptive mechanisms
Inhibit ovulation > Thicken cervical mucus < Endomet proliferation

Inhibit ovulation > Thicken cervical mucus
- ?

Endomet proflif > Thicken cervical mucus
- ?

Inhibit ovulation:
- ?
__________________

Copper-IuD mechanism?

Condom latex allergy?

Young people - LARC i-DIP
Long Acting Reversible Contracep
________

Post-pill amenorrhoea stop when?

Contraceptions UNaffected by enzyme inducing drugs?

Contraceptions that work #Time2Action:

  • Now
  • 2d
  • 7d

-How long it lasts
Nex = ?yrs
Mirena = ?yrs
Copper iuD = ?yrs

Contraception for obese ppl?

Sterilisation failure rate:
Female (on top hehe giggity..)
Male
_________

3 Emegency contracep | UPSI | CI? - LIE

@Post-partum - when is emergency contracpetive NOT needed IF have UPSI?

EMERGENCY Contrapception
? most EFFECTIVE <3d <5d generally?
? not affected by BMI

Levonelle (double the standard 1.5 mg dose)
-i.e. 3mg levonorgestrel
BMI > ? / weight > ?kg

Ella1 = CI asthma / BF wait 1 week

CuiuD = not recommended in patients with
?

seeking emergency contraception
-UPSI = 80 hours ago (i.e. between 3-5 days)
-On day 20 of her menstrual cycle.
-Took ellaOne ulipristal was prescribed to this patient 10 days ago for a similar episode (i.e. in same cycle).
Which of the following is a suitable method of emergency contraception in this case?
-Can give ? TWICE in a cycle
-Can give ? too <5d/ after d14/ FATsooos

Woman vomits < 3 hours of taking
Levonorgestrel OR Ella1Ullipristal,
prescribe a ? dose of emergency hormonal contraception ASAP
____________

COCP
UKMEC 3 –> 4

  • Age > ? + Smoke stop< ?yr/ < ?perday –> > ?/day
  • BMI > ?
  • B?/Prev ? –> Current ?
  • Clots ? FDR (< ?/?) –> VTE ?/ ?/ ?
  • Controlled ?/ >?/90 –> Uncontrolled >?/100 / ? dx
  • Current ? dx –> major surg IMMOBILE = switch to ?
Other COCP UKMEC 4s:
UKMEC 4 BMI -slva -carl
-BFeed < 6w pp = cos it reduces ?
-Migraine w/ ? = stroke
-I? / L? / S? -? dx/ ?
-----Cx / ? / ?-?VFail
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

BF/PP UKMEC 4/3s?

  • BFeed < ?w PP = ?UKMEC
  • PP < ?d + ? RFs = Y(?UKMEC) N(?UKMEC)
  • PP > ?d + ? RFs = ?UKMEC
  • PP 2d - 4w = ?UKMEC @ IuS/D

COCP legit
@PP d21 + NOT BFeed
___________

POP UKMEC 3 + 4

A

Cerazette > 12 hrs late
The rest > 3 hrs late

POP miss = 2UP TC
-2d condom + 
-UPSI < 2-3 days = Emerg contracept 
-Preg Test
-take last pill (even if taking 2 pills)
-cont pills OD
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
COCP:
pros = 
-ovarian/endomet cancer protect
-colo cancer protect
-periods = lighten (fibroid) / less pain (endmetr)

cons =

  • breast/ cervical cancer
  • vte

POP cons: i-WOAH

  1. Irreg periods,
  2. Weight gain, Obesity, Acne, Headache

Depot cons: DOB

  • delayed return 2 fertility
  • obesity
  • BMD low
Cons of HRT: BEVi
Breast (prog increases this)
Endomet (prog reduces this)
VTE / IHD (Transdermal HRT reduces this)
iNC Fibroid size 

Tamoxifen cons? LEV
LF/Hypertriglyc, Endomet dx, VTE

______________________

yLARC - Implant > Depot / IuS / POP = Low BMD!!
_____________

BC past = 3, current = 4
-Barrier/Copper only

yLARC - Implant > Depot / IuS / POP = Low BMD

Contracept UNaffected by Enzyme-Ind Drugs?
E I D:
IuS - Depot
IuD - Depot

Obesity - POP
_________

Contraceptive mechanisms:

Inhibit ovulation > Thicken cervical mucus < Endomet proliferation

Inhibit ovulation > Thicken cervical mucus
- Depot/Implant/POP

Endomet proflif > Thicken cervical mucus
- IuS

Inhibit ovulation:
- Levonorgestrel / Ella1Ullipristal (CI: BF 1wk wait, Asthma) / COCP
_______________________

Cu-IuD -
Sperm motility / Implantation / TOXIC

Latex allergy - PolyUreThane

yLARC - Implant > Depot / IuS / POP = Low BMD!!
Depot - weight gain / delayed return 2 fertility
____________

Post-pill amenorrhoea - periods return about 6m

Depot
IuS/D

Contraceptions that work:
Now - IuD
2d - POP
7d - COCP / Depot / IuS Implant

-How long it lasts
Nex = 3yrs
Mirena = 5yrs
Copper iuD = 10yrs

Contraception for obese ppl?
-POP

Sterilisation failure rate:
Female - 1/200
Male - 1/2000
_________

  1. Levenorgestrel - < 3d UPSI
  2. IuD - < 5d UPSI / AFTER ovulation / FATSOs
    - IuD > EllaOneUllipristal!!!!!
  3. EllaOneUllipristal - < 5d UPSI

EllaOneUllipristal
BFeed 1 week WAIT
CI = Asthma

< 21d PP - - > UPSI - - >
Not need emerg contra if

EMERGENCY Contrapception

  • Cu-iuD most effective <3d <5d generally
  • Cu-iuD not affected by BMI

Levonelle (double the standard 1.5 mg dose)
-i.e. 3mg levonorgestrel
BMI >26 / weight > 70kg

Ella1 = CI asthma / BF wait 1 week

Cu-iuD = not recommended in patients with
distortion of the uterine cavity
e.g. fibroids.

seeking emergency contraception
-UPSI = 80 hours ago (i.e. between 3-5 days)
-On day 20 of her menstrual cycle.
-Took ellaOne ulipristal was prescribed to this patient 10 days ago for a similar episode (i.e. in same cycle).
Which of the following is a suitable method of emergency contraception in this case?
-Can give Ella1Ullipristal TWICE in a cycle
-Can give CuiUD too <5d/ after d14/ FATsos

Woman vomits < 3 hours of taking 
Levonorgestrel OR Ella1Ullipristal, 
prescribe a SECOND dose of emergency hormonal contraception ASAP
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

Age > 35 + Smoke stop< 1yr/<15perday –> >15/day
BMI > 35
BRCA/Prev BC –> Current BC
Clots VTE FDR (< 45/immobile) –> VTE Current/Past/Dx
Controlled HTN/>140/90 –> Uncontrolled >160/100 / VASC dx
Current GB dx –> major surg IMMOBILE = switch to POP

UKMEC 4 BMI -slva -carl
-BFeed < 6w pp = cos it reduces milk
-Migraine w/ aura = stroke
-IHD / LF / Stroke -vasc dc/APLS
-----Cx / AF / L-RVFail
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
BFeed < 6w PP = 4
PP < 21d + VTE RFs = Y(4) N(3)
PP >21d + VTE RFs = 3
PP 2d - 4w = 3 @ IuS/D
\_\_\_\_\_\_\_\_\_\_\_

POP UKMEC 3 + 4

  • Stroke/IHD/BC past/LF = 3
  • BC current = 4
77
Q

GDM - booking appt:

PUBB-G:

  • Prev
    1. ?
    2. GDM -> ?Ix/ ?Ix @booking
  • -ifNormal–> ? @ w?

-Urine BM ? /+ x?

-BMI > ? +
Birth < ?w recommended +
Anesthetic r/v @? / ? +
? @fetal lung mat

  • B? /GDM in who?
  • -> do what Ix?:

FPG ? OR OGTT ?
- ? + ?blood-test < ?wks / ?-? wks

FPG 6.1-6.9 =

  1. ? -2wk/fail->
  2. ?
    a. –cant tol-> ? alone
    b. –CAN tol but BM control fail-> + ?
    c. -Insulin –can’t tol/fail-> Gliben (?discontinued)

FPG 7.0/+ OR ?/? + 6.1-6.9 = ? ± ? + ?

measure:
- ? @DM2/GDM = NOT@multiple daily injections

  • ? @DM2/GDM @multiple daily injections
  • ? @DM1 @multiple daily injections
cap BM target:
-Fasting ?, AND
-1hr Post Meal ?
-2hr Post Meal ?
Hba1c 48/+ = ?
\_\_\_\_\_\_\_\_\_\_\_\_\_
Pre-Existing DM @preg
1a. Renal Assx: 
Creat > ? 
Urine Alb:Creat > ?  -->   >? #?proph
TProt > ? g/d -> ? g/d #?proph

1b. Retinal Assx:
digital image w/ ? w/ ?
@1stANC –DiabRetinopath–> w? –> w?

  1. Anomaly scan @w? + ?Ix =
    w?-? // USS/?wk
  2. WL @BMI >?/+
4. 
Birth @?w recommended 
Anaesthetic r/v @?
Steds @?
-FPG @?w post-natal check
A

GDM - booking appt:

  • Prev
    1. macrosomia 4.5kg /+
    2. GDM -> selfBM/OGTT @booking
  • -ifNormal–> OGTT @w24-28

-Urine BM ++ / + x2

-BMI >30 + 
Birth <40+6w recommended + 
Anesthetic r/v @obesity/auto neuropathy + 
steds/tocolysis @fetal lung mat
-BAME/GDM FDR

–> do 2hr-OGTT:

FPG 5.6/+ OR OGTT 7.8/+
-GDM ANC + HbA1c <1wk / 1-2wks

FPG 6.1-6.9 =

  1. Lifestyle d/e -2wk/fail->
  2. Metformin
    a. –cant tol-> Insulin alone
    b. –CAN tol but BM control fail-> + Insulin
    c. -Insulin –can’t tol/fail-> Gliben (?discontinued)

FPG 7.0/+ // PolyHydramnios/Macrosomia+6.1-6.9 =
INSULIN ± Metformin + d/e

measure:
-Fasting + Post Meal-1hr
@DM2/GDM NOTTTTTT@multiple daily injections

-Fasting, Pre + Post Meal-1hr, Bedtime
@DM1 / DM2/GDM @multiple daily injections

cap BM target:
-Fasting 5.3, AND
-1hr Post Meal 7.8
-2hr Post Meal 6.4
Hba1c 48/+ = HRisk
\_\_\_\_\_\_\_\_\_\_\_\_\_
Pre-Existing DM @preg
1a. Renal Assx: 
Creat > 120 
Urine A:C >30 -->  >220 #VTEproph
TProt >0.5g/d -> 5g/d #VTEproph

1b. Retinal Assx: 16, 28
digital image w/ mydriasis w/ procainimide
@1stANC–DiabRetinopath–> w16-20 –> w28

  1. Anomaly scan @w20 + 4-chamber heart view = 28
    w28-36 / USS/4wk
  2. WL @BMI >28/+
4. 
Birth @37 - 38+6w recommended 
Anaesthetic r/v @obesity/auto neuropath
Steds/Tocolysis @fetal-lung-mat
-FPG @6w post-natal check (6-13 w PP)
78
Q
woman 
short-lasting UNILAT side of 
face = behind eye. 
UNILAT-sided tearing + nasal congestion
-no photophobia
-Several times/day 
Tx: indomethacin -> attacks stopped
Dx? Tx?
\_\_\_\_\_\_\_\_\_
Lesion -> SPEECH = FLUENT  
sentences that make Sense
-Poor REPETITION 
-AWARE of Errors making 
Pt Comprehension NORMAL 
Lesion -> SPEECH = FLUENT 
sentences that make NO Sense
-word sub / neologisms #word-salad
-Normal REPETITION
Pt Comprehension FUCKED
Lesion -> SPEECH = NON-FLUENT
sentences that make Sense
-Laboured + Halting 
-Poor REPETITION
Pt Comprehension NORMAL
\_\_\_\_\_\_\_\_

? @Oed from tumour
? @Raised ICP
? @SAH to reduce vasospasm
__________

Gait ataxia = ?

? = finger-nose ataxia

? - Hypokinetic (e.g. Parkinsonism) or hyperkinetic (e.g. Huntington’s)

? - sensory symptoms

? - dyLEXia, dysGRAPHia

? - motor symptoms

? expressive aphasia

? - disinhibition
________

suspected stroke. unable to speak BUT able to follow instructions

  • do not know the handedness of the patient
  • percentage of right and left handed individuals
  • with a dominant left hemisphere is 90% and 60% respectively,
  • making the ? always the most likely affected side
  • ? on dominant side supplies both Wernicke’s (sup Temp Gyrus) and Broca’s (inf Frontal Gyrus) areas
  • which are responsible for understanding and production of speech.
A

Paroxysmal HemiCrania
-Indomethacin
__________

Conduction aphasia

  • Arcuate Fasciculus
  • Fluent + Sense + Comp NORM
  • Repetition fucked

Wernicke Receptive

  • SUP Temp gyrus
  • Fluent + NO Sense + Comp FUCKED
  • Repetition NORM
Broca Expressive
-INF Frontal gyrus
-NON-Fluent + Sense + Comp NORM
-Repetition fucked 
\_\_\_\_\_\_

Dexa @Oed from tumour
Mannitol @Raised ICP
Nimodipine @SAH to reduce vasospasm
______

Gait ataxia = cerebellar vermis lesions
-Vermillion Gate

Cerebellar hemisphere = finger-nose past-pointing ataxia
-hemisPhere=PastPoint

Basal ganglia - Hypokinetic (e.g. Parkinsonism) or hyperkinetic (e.g. Huntington’s)

Parietal lobe - sensory symptoms, dyslexia, dysgraphia

Frontal lobe - motor symptoms, expressive aphasia #BrocaInfFrontGyrus, disinhibition
________

suspected stroke. unable to speak BUT able to follow instructions

  • do not know the handedness of the patient
  • percentage of RIGHT-HANDED > Left-Handed handed
  • therefore dominant LEFTTT hemisphere is 90% and 60% respectively,
  • making the left always the most likely affected side
  • MCA on dominant side supplies both Wernicke’s (sup Temp Gyrus) and Broca’s (inf Frontal Gyrus) areas
  • which are responsible for understanding and production of speech.
79
Q

Sarcoidosis can cause a false negative Mantoux test

  • Causes of false-negative Mantoux test
  • Sarcoid
  • ImmunoComp
  • Lymphoma
  • Old ppl
  • -Fever/Low Alb-Hb

OH-CUM?

<5mm = ?
>5mm = ?
>15mm = ?

Impaired hypoglycaemia awareness occurs due to neuropathy of parts of the ? nervous system
-beta blockers too

Thyrotoxic storm is treated with ?

Glucocorticoid treatment can induce neutro?

? is a life-threatening event associated with autonomic dysreflexia

An ICD/pacemaker? can be inserted
to reduce the risk of
sudden cardiac death in HOCM

classically 
worse on standing + IMPROVE when lying flat CHILLING -->
Low CSF headaches can occur due to
?
(not necessarily post-?) 

Yellow fever is present in Kenya but you would expect more significant jaundice and ?

1/3 of patients have infrequent relapses and
1/3 of patients have frequent relapses a majority
(2/3) will have later recurrent episodes
#MCD

HSP = full ? !!!

DEXA scans: the Z score is adjusted for
? (similar to MDRD CAGE..)

Headache linked to Valsalva manoeuvres =
e.g. coughing or lying down etc =
? until proven otherwise
so ? is contraindicated

Persistent ST elevation following recent MI,
NO chest pain
?pitting oedema to both ankles + slight distension of the neck veins.
-Dx?

Sickle cell patients should receive the
pneumococcal polysaccharide vaccine every ? years

Adrenal Insuff
In the UK the commonest cause is ?
Worldwide, however, the most common cause is ? (typically ?).

Severe sepsis may result in neutro?
Steroids may result in neutro?

Dysplasia on biopsy in Barrett’s oesophagus requires an ?

In the treatment of anaphylaxis, you can repeat adrenaline every ? minutes

Barrett’s oesophagus tx?
-The metaplastic mucosa needs to be monitored on a regular basis to check for ?/ ?

deranged LFTs 
\+
secondary amenorrhoea 
@young female strongly suggest 
-?Dx

?ABx can cause black hairy tongue

? disease is an indication for surgery in bronchiectasis

? CELL lung cancer is associated with LAMBERT EATON syndrome, a rare paraneoplastic syndrome, which features autonomic symptoms, limb-girdle weakness (manifesting as a WADDLING gait), and hyporeflexia.

Old person
painful frontal headaches
-pale oedematous optic disc.
-Dx? Eye issue?

*Domperidone does NOT cross the ? and therefore does NOT cause ? !

A low dose dexamethasone suppression test showed a lack of appropriate suppression of plasma cortisol. However, cortisol was suppressed during a high dose dexamethasone suppression test. Plasma ACTH was elevated. A pituitary MRI was normal.
-What is the most likely diagnosis?

MTX + Trimeth = ?
Azathioprine + Allopurinol = ?

bony growth extending from the C7 vertebrae unilaterally.
A cervical rib is a common cause of thoracic outlet syndrome

amiodarone
Is a common cause of ?
HENCE should ideally be given into
central/periph veins

IV adenosine needs to be infused via a large/small?-calibre vein OR ? route

Pseudo Pelger-Huet cells arise in ? #9,22

If a pleural effusion is drained too quickly,
a rare but important complication
that can develop is
?

Sudden onset
abdominal Pain, Ascites, tender HMeg
-BG: Polycythaemia vera

Specific lifestyle changes to manage premenstrual syndrome include

  • ? hourly
  • ?size balanced meals
  • rich in ?
A

Sarcoidosis can cause a false negative Mantoux test

  • Causes of false-negative Mantoux test
  • Sarcoid
  • ImmunoComp
  • Lymphoma
  • Old ppl
  • -Fever/Low Alb-Hb
0-12m, 
HR area, 
Contacts of smear + , 
Unvacc (35/-) / (36/+ + HCW)
Mantoux/ IFN/ Tuberculin NEG
<5mm = UNvaccinated
>5mm = past TB / BCG
>15mm = current TB infection

Impaired hypoglycaemia awareness occurs due to neuropathy of parts of the autonomous nervous system

Thyrotoxic storm is treated with
beta blockers + PTU + hydrocortisone

Glucocorticoid treatment can induce neutrophilia

Stroke is a life-threatening event associated with autonomic dysreflexia

An ICD can be inserted
to reduce the risk of
sudden cardiac death in HOCM

classically 
worse on standing + IMPROVE when lying flat CHILLING -->
Low CSF headaches =
Spontaneous Intracranial Hypoootension 
(not necessarily post-LP)

Yellow fever is present in Kenya but you would expect more significant jaundice and bleeding

1/3 of patients have infrequent relapses and
1/3 of patients have frequent relapses a majority
(2/3) will have later recurrent episodes
#MCD

HSP = full recovery !!!

DEXA scans: the Z score is adjusted for age, gender and ethnic factors

Headache linked to Valsalva manoeuvres =
e.g. coughing or lying down etc
raised ICP until proven otherwise
so LP is contraindicated

Persistent ST elevation following recent MI,
NO chest pain
?pitting oedema to both ankles + slight distension of the neck veins.
-LV Aneurysm

Sickle cell patients should receive the
pneumococcal polysaccharide vaccine every 5 years

In the UK the commonest cause is autoimmunity. Worldwide, however, the most common cause is infection (typically tuberculosis).

Severe sepsis may result in neutropenia
Steroids may result in neutrophilia

Dysplasia on biopsy in Barrett’s oesophagus requires an endoscopic intervention

In the treatment of anaphylaxis, you can repeat adrenaline every 5 minutes

Barrett’s oesophagus:
High dose PPI + endoscopic surveillance.
-The metaplastic mucosa needs to be monitored on a regular basis to check for dysplasia/ malignancy

deranged LFTs 
\+
secondary amenorrhoea 
@young female strongly suggest 
autoimmune hepatitis

Tetracyclines can cause black hairy tongue

Localised disease is an indication for surgery in bronchiectasis

SMALL CELL lung cancer is associated with LAMBERT EATON syndrome, a rare paraneoplastic syndrome, which features autonomic symptoms, limb-girdle weakness (manifesting as a WADDLING gait), and hyporeflexia.

Old person
painful frontal headaches
-pale oedematous optic disc
Dx: Temp Arteritis + AION

*Domperidone does NOT cross the blood-brain barrier and therefore does NOT cause EPSEs !

A low dose dexamethasone suppression test showed a lack of appropriate suppression of plasma cortisol. However, cortisol was suppressed during a high dose dexamethasone suppression test. Plasma ACTH was elevated. A pituitary MRI was normal.

  • What is the most likely diagnosis?
  • Cushing’s disease (i.e. still frickn PIT ADENOMA BUT @Pit MRI = TOO SMALL TO BE PICKED UP !!!!!!!!!!!)

MTX + Trimeth = MyeloSup
Azathioprine + Allopurinol = MyeloSup

amiodarone
Is a common cause of thrombophlebitis
HENCE should ideally be given into
CENTRAL veins

IV adenosine needs to be infused via a large-calibre vein or central route

Pseudo Pelger-Huet cells arise in CML #9,22

If a pleural effusion is drained too quickly,
a rare but important complication
that can develop is
REPO: Re-Expansion Pul Oedema

Budd-Chiari syndrome presents with the triad of sudden onset abdominal pain, ascites, and tender hepatomegaly
BG: Polycythaemia vera

Specific lifestyle changes to manage premenstrual syndrome include

  • 2-3 hourly
  • small balanced meals
  • rich in complex carbohydrates
80
Q

Syringomyelia is associated with the ? malformation

?type CT for stroke BASTARD!!!!

Klebsiella can cause ?formation

shaft of the humerus = ?nerve dx

Supracondylar fracture of humerus = ?nerve damage.

Proximal humerus Fracture = ?nerve damage.

3 month history of numbness and paraesthesia in his feet. On examination there is widespread numbness of both feet which does not fit a dermatomal distribution.
A recent gamma-glutamyl transpeptidase (gamma GT) is 4 times the upper limit of normal.
-What is the most likely diagnosis?

? is recommended to start early in the course of COPD, as soon as patients start feeling shortness of breath with regular activity

The AST/ALT ratio in alcoholic hepatitis is ?

number of features in keeping with a diagnosis of ARDS
-?onset within the past day, on the background of a known risk factor (e.g. pneumonia)
-? pulmonary oedema (crackles, x-ray changes)
-?heard (in collapse/atelectasis, don’t get crackles)
-?oxygen therapy = hypoxia
Low cap Wedge pressure

Central pontine myelinolysis
is a complication of ?
?electrolyte dx
too rapidly

COPD:

  • ?/ ? = improve survival
  • Becky = Improve: ?, ? / Reduces ?

? is the
most effective intervention
-to slow FEV1 decrease in COPD
-to improve survival

Septic arthritis - most common organism ?

Patients with sickle cell disease are at increased risk of ? spp septic arthritis.

Dermatomyositis is associated with ?Abody

Another clue is the fact that the patient is a retired sushi-chef and is likely to have consumed a fair quantity of fish which is known to be high in nitrosamines - a known carcinogen #?cancer

4-year-old son to you the GP. She says her son has not been growing relative to his peers in school.
-Axillary freckles are indicative of ?

? should be stopped in Clostridium difficile infections

A positive ?nerve stretch test may indicate referred ?spine pain as a cause of hip pain

productive cough = worsening / 6 months.
IVDU + multiple episodes of pneumonia in the past.
O/E conjunctival pallor and bilateral wheezing
-lots of eosiniphils
-Sputum CS: Eosinophils and fungal hyphae
Dx = ? –Tx = ?

Reactive arthritis is not typically acute -
it can develop up to 4 weeks after precipitating infection and can run a relapsing-remitting course over several months
- ? is the correct answer.

? is the most common form of
renal replacement therapy.

The usual first line option for INDEPENDENT patients for renal replacement is a form of ? dialysis.

? is only used in the acute setting, often only being available in critical care departments for very sick patients.

Farmer, fever, transaminitis ?

Levodopa and other antiparkinsons drugs are ‘critical’ medicines which should not be stopped on acute admissions and must be delivered on time
-Acute withdrawal of levodopa can precipitate ?

A

Syringomyelia is associated with the Arnold-Chiari malformation

Non-contrast CT for stroke BASTARD!!!!

Klebsiella can cause empyema formation

shaft of the humerus = radial nerve dx

Supracondylar fracture of humerus = ulnar nerve damage.

Proximal humerus Fracture = axillary nerve damage.

3 month history of numbness and paraesthesia in his feet. On examination there is widespread numbness of both feet which does not fit a dermatomal distribution.
A recent gamma-glutamyl transpeptidase (gamma GT) is 4 times the upper limit of normal.
-What is the most likely diagnosis?
-Alcoholic peripheral neuropathy

Pulmonary rehabilitation is recommended to start early in the course of COPD, as soon as patients start feeling shortness of breath with regular activity

The AST/ALT ratio in alcoholic hepatitis is 2:1

number of features in keeping with a diagnosis of ARDS

  • ACUTE onset within the past day, on the background of a known risk factor (e.g. pneumonia)
  • B/L pulmonary oedema (crackles, x-ray changes)
  • CRACKLES heard (in collapse/atelectasis, don’t get crackles)
  • DESPITE oxygen therapy = hypoxia

Central pontine myelinolysis
is a complication of
correcting hyponatraemia
too rapidly

COPD:

  • LTOT/Stop Smoking = improve survival
  • Becky = Improve: QoL, FEV1 / Reduces freq exac

Stopping smoking is the
most effective intervention
-to slow FEV1 decrease in COPD
-to improve survival

Septic arthritis - most common organism: Staphylococcus aureus

Patients with sickle cell disease are at increased risk of Salmonella spp septic arthritis.

Dermatomyositis is associated with ANA

Another clue is the fact that the patient is a retired sushi-chef and is likely to have consumed a fair quantity of fish which is known to be high in nitrosamines - a known carcinogen #oesophageal cancer

4-year-old son to you the GP. She says her son has not been growing relative to his peers in school.
-Axillary freckles are indicative of neurofibromatosis 1

Opioids should be stopped in Clostridium difficile infections

A positive femoral nerve stretch test may indicate referred lumbar spine pain as a cause of hip pain

productive cough = worsening / 6 months.
IVDU + multiple episodes of pneumonia in the past.
O/E conjunctival pallor and bilateral wheezing
-lots of eosiniphils
-Sputum CS: Eosinophils and fungal hyphae
Dx = ABPA –Tx=Steds

Reactive arthritis is not typically acute - it can develop up to 4 weeks after precipitating infection and can run a relapsing-remitting course over several months
-Oral prednisolone is the correct answer.

Haemodialysis is the most common form of renal replacement therapy.

The usual first line option for INDEPENDENT patients for renal replacement is a form of peritoneal dialysis.

Haemofiltration is only used in the acute setting, often only being available in critical care departments for very sick patients.

Farmer, fever, transaminitis ?Q fever - Coxiella

Levodopa and other antiparkinsons drugs are ‘critical’ medicines which should not be stopped on acute admissions and must be delivered on time
-Acute withdrawal of levodopa can precipitate neuroleptic malignant syndrome.

81
Q

First-line treatment for ITP is ?

Hepatitis E is spread by the faecal-oral route and is most commonly spread by undercooked ?meat

The neurologist decides to initiate treatment that will provide INITIAL symptomatic relief.
?
long/short-acting AChi temporarily improving symptoms of myasthenia gravis

C? is the ONLY cervical nerve root that comes out BELOW the vertebra

A ? test should be offered to all patients with TB

?Parkinson’s fucker
The postural hypotension and ataxia makes ? the most likely diagnosis.

Warfarin may rarely cause skin ?

The ? vaccine should be offered to patients with chronic hepatitis

Sickle cell patients should receive the
? polysaccharide vaccine every 5 years

Which of the following combinations of vaccinations are routinely offered to pregnant women in the UK?
-? and ?

In infective endocarditis,

  • ? valve is most COMMONLY affected
  • IVDUs get ?

Seizures are characteristically provoked by hyper/hypo-ventilation ?

Pt w/ Myasthenia Gravis is due for an elective abdominal hysterectomy.
Which commonly used anaesthetic agent would she most likely be resistant to?
-/

PMH: rheumatoid arthritis, is
-scheduled to have a laparoscopic cholecystectomy.
What imaging should be performed pre-operatively?
-? + ? + ? radiographs
-? is a rare complication of rheumatoid arthritis, but important as it can lead to ?
-goes to surgery in a ? and the neck is NOT HyperExtended on intubation.

Penicillamine can cause ?glomerulonephropathy in patients with Wilson’s disease

Which is the best assessment tool for differentiating between stroke and stroke mimics?

If a pituitary incidentaloma is found within the sellar, ? must be done to determine if it is functional or non-functional

?is commonly mistaken for being ‘drunk’ (high GGT/MCV) and so blood glucose measurement should always be part of initial assessment.

low HbA1c = ?/ ?/ ?
high HbA1c = ?/ ?

Ask her GP to repeat thyroid function tests (TFTs) in ? weeks
Sick euthyroid is common in unwell, elderly patients and often needs no treatment

?

  • wasting SMALL muscle hands
  • Pain + Temp FUCKED
  • ARNOLD CHIARI

Frontotemporal dementia is associated with ? neurone disease

The ?diet is a 
-high fat, 
-low carbohydrate, 
-controlled protein diet. 
It is an established treatment for children with epilepsy = hard to control + unresponsive to antiepileptic meds

? diet - This is used in treating irritable bowel syndrome (IBS)

Herpes + Preg =
?med until ?
and
?delivery

A

First-line treatment for ITP is oral prednisolone

Hepatitis E is spread by the faecal-oral route and is most commonly spread by undercooked pork

The neurologist decides to initiate treatment that will provide initial symptomatic relief.
Pyridostigmine
ong-acting acetylcholinesterase inhibitor emporarily improving symptoms of myasthenia gravis

C8 is the ONLY cervical nerve root that comes out BELOW the vertebra

A HIV test should be offered to all patients with TB

The postural hypotension and ataxia makes the Parkinson’s plus disorder progressive multi-system atrophy the most likely diagnosis.

Warfarin may rarely cause skin necrosis

The pneumococcal vaccine should be offered to patients with chronic hepatitis

Sickle cell patients should receive the pneumococcal polysaccharide vaccine every 5 years

Which of the following combinations of vaccinations are routinely offered to pregnant women in the UK?
Influenza and pertussis

In infective endocarditis,

  • Mitral valve is most commonly affected
  • IVDUs get Tricuspid regurg

Seizures are characteristically provoked by hyperventilation

Pt w/ myasthenia gravis is due for an elective abdominal hysterectomy.
Which commonly used anaesthetic agent would she most likely be resistant to?
-Suxamethonium

PMH: rheumatoid arthritis, is
-scheduled to have a laparoscopic cholecystectomy.
What imaging should be performed pre-operatively?
-Ant + Post + Lateral c-spine radiographs
-Atlanto-Axial subluxation is a rare complication of rheumatoid arthritis, but important as it can lead to cervical cord compression.
-goes to surgery in a C-spine collar and the neck is NOT HyperExtended on intubation.

Penicillamine can cause MEMBRANOUS glomerulonephropathy in patients with Wilson’s disease

Which is the best assessment tool for differentiating between stroke and stroke mimics?
ROSIER

If a pituitary incidentaloma is found within the sellar, laboratory investigation must be done to determine if it is functional or non-functional

Hypoglycaemia is commonly mistaken for being ‘drunk’ and so blood glucose measurement should always be part of initial assessment.

low HbA1c = Hemolysis / RF / WL
high HbA1c = Haematinics/ Splenectomy

Ask her GP to repeat thyroid function tests (TFTs) in 6 weeks
Sick euthyroid is common in unwell, elderly patients and often needs no treatment

Syringomyelia

  • wasting SMALL muscle hands
  • Pain + Temp FUCKED
  • ARNOLD CHIARI

Frontotemporal dementia is associated with motor neurone disease

The KETOGENIC diet is a 
-high fat, 
-low carbohydrate, 
-controlled protein diet. 
It is an established treatment for children with epilepsy = hard to control + unresponsive to antiepileptic meds

FODMAP diet - This is used in treating irritable bowel syndrome (IBS)

Herpes + Preg =
Oral aciclovir until delivery
and
delivery by caesarean section

82
Q

Women < 30 years, YOUNG

‘breast mice’ = discrete, non-tender, HIGHLY MOBILE lumps

What to do if <3cm? >3cm?
___________

Most common in MIDDLE-aged women
‘Lumpy’ breasts which may be PAINful.
-syx ?worsen prior to menstruation
_____________

hard, irregular lump.

There may be associated nipple inversion or skin tethering

Most common Brest cancer?
_____________

Reddening and thickening (may resemble eczematous changes) of the nipple/areola

nipple START -> spreads OUTWARD involving the areola
_______________

Breast anatomy

NLM TLS
_____________

70+M a/w
gradual loss of voice / 6 m

DDx?

Ax?

A

Fibroadenoma
-W+W < 3cm
-Surgical excision @ >3cm
_____________

Fibroadenosis
-FibroadenoSISSSSSS - SISters !!!
(fibrocystic disease, benign mammary dysplasia)
_______________

Breast cancer

Ductal No Special Type>
Lobular >
DCIS > LobCIS
___________

Paget’s disease of the breast - intraductal carcinoma
_________

FROM USMLE BOOK 2019 p635
-NLM TLS

Nipple,
LACTIFerous duct_Major duct = Paget, Abscess, Mastitis, IntraDuct-Papilloma=bloody

TERMinal duct_LOBular unit = Cancers - DCIS etc

Stroma = Fibroadenoma/Phyllodes tumour
_______________

Aphonia = inability to speak.

  • Ax:
    1. Recurrent Laryngeal Nerve palsy (TT/Tumour)
    2. PSYCHOgenic
83
Q
Green discharge 
Rupt -> plasma cell mastitis 
AREOLA lump = tender 
MenoPause #51

--- ?breast duct Dilatation 

____________

BLOOD stained discharge
-HyperPLASTIC lesions
@ large mammary ducts - NLM-TLS
___________

Obese women, LARGE breasts
-TRAUMA

Initial inflammatory response,
firm and round –> develop into a hard, IRREGULAR breast lump
___________

Lump
More common in LACTATING women
-Red, hot tender swelling
__________

HALO sign @ mammograms
MENSTRUAL cycle VARIATION
#pain #fluctuant

___________

Young SMOKER
-Mammillary duct FISTULA
__________

@BREASTFEEDING: 
bact enter skin-cracks -> 
RISK bacterial infection
Dx? Tx?
? is most common pathogen.
\_\_\_\_\_\_\_\_\_\_

TNM breast staging

What chemo you give to node +?
What chemo you give to node -?

I.e. If you just remember T2, T4c, T4d
__________

Preg woman >20w till 4w PP
w/ BP >140/90 has: HENPS (end organ dx)

HA
Eye dx
N+V
pain BELOW RIBS
Sudden SWELLING

Advice?
_______________

Intrahepatic cholestasis of preg increased risk of ??

Tx?

A

Mammary duct ectasia
-Dilatation of the LARGE breast ducts
__________

Duct papilloma
- NOT malignant or premalignant
_________

Fat necrosis

Rare and may mimic breast cancer so further investigation is always WARRANTED!!!!!!
__________

Breast abscess
-LACTATING women
-Fluclox + I+D
________

Breast cyst
-HALO sign @ mammograms

Excision > I+D
Needs excision to remove shell
- breast cancer risk !!!
__________

PERIDUCTAL mastitis
-ABx, I+Drain
___________

Lactational mastitis
-FLUCLOX and Cont BFeeding
-S Aureus
________

T1 <2cm
T2 2-5cm
T3 >5cm

T4a skin
T4b CW
T4c skin + CW

T4d INFLAMM

FEC-D chemo = for node +ve, and that

FEC chemo = for node -ve that requires chemo
______________

Hospital.

Refer @ 160/110 / ProtUria [2/+]
______________

Intrahepatic cholestasis of preg increased risk of PREMATURITY

Induce @ 37w +
USDA +
Vit K

84
Q

When contraceptive patch applied and not?

W1-2 patch delay <2d? TC
W1-2 patch delay >2d? 7UPTC

W3-end, patch removal DELAY? TC

W4 patch-FREE week END, delay new patch application? 7UPTC

If combined patch started after day 5?
____________
____________

If COCP started after day 5??
____________________

Pill-free week end –> take COCP –>
miss 9/+ days:
if UPSI during/after pill-free week

____________________

COCP taking options?
___________
If 1 COCP missed? TC
If 2 or more COCPs missed generally? 7UPTC

2 COCPs missed in week 1: 7UPTC

2 COCPs missed in week 2: C

2 COCPs missed in week 3: omit?
____________________

InterMenstrual Bleed Ax?

A

W1-3 patch ; W4 = patch free = bleed

W1-2 patch delay <2d TC
W1-2 patch delay >2d 7UP TC
-7d Barrier
-UPSI @ >2d delay/last 5 days = EMERG CONTRACEP
-Preg test
-Take off patch
-Change ASAP

@W3-end, patch removal DELAY?
-Take off patch
-Change patch @next cycle start
even if withdrawal bleeding

@W4 patch-FREE week END, delay new patch application?
7UPTC

If combined patch started after day 5??

-7UPTC
________
________

If COCP started after day 5 -
-7UPTC
____________________

Pill-free week end --> take COCP --> 
miss 9/+ days: 7UP TC
-7d condom
-UPSI @/after pill-free week - EMERG contra
-Preg test
-take last pill (even if taking 2 pills)
-cont COCP OD
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

COCP methods:
Tricycling 3 weeks 1 week off
-W1-3 pills ; W4 = pill free = bleed

No pill-free week
________

If 1 COCP missed: TC

  • take last pill (even if taking 2 pills)
  • cont COCPs OD

If 2 or more COCPs missed 7UPTC:

  • 7d condom
  • UPSI @/after pill-free-week –> EMERG contracep
  • Preg test
  • take last pill (even if taking 2 pills)
  • cont COCPs OD

@week 1: 7UP TC

@week 2: chill

@week 3: omit pill-free week
____________________

Ectropion/Polyps/Cancer
- COCP UNDERdosing = breakthrough bleed, Depot, IuD, POP

85
Q

If 2 or more COCPs missed generally:

2 COCPs missed in week 1:

2 COCPs missed in week 2:

2 COCPs missed in week 3:
____________________

7 consecutive COCPs missed in any week of pill-taking

A

If 2 or more COCPs missed generally:

  • 7d condom +
  • take last pill (even if taking 2 pills)
  • cont COCPs OD

@week 1:

  • UPSI during/after pill-free-week –> EMERG contracep
  • Preg test

@week 2: chill

@week 3: omit pill-free week
____________________

7 Concsecutive COCPs missed: RCP
-Restart COCP as new user
-7d condom + 
-preg test
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
86
Q

HR of pre-eclampsia (CHAD FFM10-35-40)
-1 of/2 of?
___________

Refer when?

Haemolysis (H) - polychromasia and schistocytes
Elevated liver enzymes (EL),
Low Platelets (LP).

Preggers/PP<4w:
A/W - Clonus/HYPERreflexia >160/110
-HA
-Eye dx
-N+V
-pain BELOW RIBS
-Sudden SWELLING
Dx? Tx?
\_\_\_\_\_\_\_\_\_\_
  1. Mx @Pre Eclampsia HR
  2. @booking 8-12w + HR Pre-Ecl, do what?
  3. Refer when?
    __________

What at each ANC?

If dipstix prot 1/+ - - >??

A
1 of:
CKD
HTN pre-existing
AImmune
DM

2 of: FFM 10 35 40
FHx/First/multiple
10yr interval / BMI 35/+ 40/+yrs
______________

Refer @

  • 160/110 / ProtUria [2+]
  • A:CR >8 / P:CR >30 = significant –> Refer obst

HELP syndrome - IV MgSO4

Preggers/PP<4w = HENPS
-Dx: Pre-Eclampsia -> Tx: 999
___________

@ Pre-Eclampsia HR:
1. Consultant-led @ PrEcl HR (1CHAD/2FFM10/35/40)

  1. @booking 8-12w
    - Asp 75mg W12 –> birth @ HR Pre-Ecl
  2. Refer @ (dipstix/BP @each ANC)
    - 160/110 / ProtUria [2+]
    -A:CR >8 / P:CR >30 = significant –> Refer obst
    __________

Dipstix/BP @ each ANC

If dipstix prot 1/+ –> Renal Assx:

A:CR >8 /
P:CR >30 =
Significant –> Refer obst

Refer @ 160/110/ ProtUria [2/+]

87
Q

gHTN VS
Pre-Eclampsia VS
Eclampsia?

MgSO4 induced respiratory depression?

____________________

Ix @ each ANC?

Tx?
_______

Pre-existing HTN - stop which antihypertensives?

Anti-HTN TX is not necessary if BP..??

Preg + chronic HTN >? + NOT taking aHTN tx =
Start on which meds? TARGET?

METHYLDOPA during preg
stopped within ? days of birth
cos of ?

physiological dropORrise in BP
@EARLY pregnancy??

Ix + Tx after w12?
\_\_\_\_\_\_\_\_\_\_\_\_\_
Physiologic changes @preggers
-rises?
-drops?
A

gHTN
—– >20 weeks w/ >140/90

Pre-Eclampsia :
----- >20 weeks w/ >140/90 
and 
----- 1/+: ProtUria OR Organ dx 
(Neuro/
LF/RF/
UtPlacent dx/
TCP)
---HbA1c/HUria-uACR/U+E-Fundoscope-ECG

Eclampsia: as above + seizures –> Magnesium sulphate

CaGluconate @ MgSO4 induced respiratory depression?
____________________

Ix: Dipstix/BP @ each ANC

@ Pre-Eclampsia HR:
1. Consultant-led @ PrEcl HR (1CHAD/2FFM10/35/40)

  1. @booking 8-12w
    - Asp 75mg W12 –> birth @ HR Pre-Ecl
  2. Refer @:
    - 160/110 / ProtUria [2+]
    -A:CR >8 / P:CR >30 = significant –> Refer obst
    _____________

ACE/ARB/ THIAZIDEEEEEEEEEE

Stop anti-HTN tx if
BP < 110/70/ Syx @low BP

chronic HTN >140/90 + NOT taking aHTN tx = LNM<135/85
–labetalol > nifedipine > methyldopa –> Target < 135/85

METHYLDOPA during preg
stopped < 2 days of birth
cos of DEPRESSION

physiological DROP in BP
@EARLY pregnancy??

Ix: Dipstix/BP @ each ANC

@ Pre-Eclampsia HR:

  1. Consultant-led @ PrEcl HR (1CHAD/2FFM10/35/40)
    - PRE-EXISTING PART OF CHAD mnemonic
  2. @booking 8-12w
    - Asp 75mg W12 –> birth @ HR Pre-Ecl
  3. Refer @:
    - 160/110 / ProtUria [2+]
    -A:CR >8 / P:CR >30 = significant –> Refer obst
    _____________

Physiologic changes @preggers

  • rises: everything else
  • drops: Hb + BP
88
Q

SALANA…

  1. If >20w + NEW ProtUria + no HTN =
    Ddx? Ix? F/u? ABx?
  2. @PP:
    had pre-Ecl + NOT had anti-HTN tx =
    BP measured ?d after birth
  3. @PP:
    had pre-Ecl + HAD anti-HTN tx =
    -BP check/ < ?d after birth
    -for ?weeks
  4. @PP BP > ? start anti-HTN tx
Remember @preg = ?Tx < ?Target
POSTnatal period:
- NOT BREASTfeed = ?HTN tx 
- BREASTfeed = ?HTN tx:
1. ? / ? @black
2. ? + ?  
3. ? + ? ± ?
gHTN/chrHTN = BP check:
check 
-day ?
-day ?
-days ?
R/V BP meds @ ? wks postnatally
Postnatal review ? weeks
-Preg + chronic HTN >140/90 + NOT taking aHTN tx = 
?Tx < ?target
---Target BP Postnatally: ? 
\_\_\_\_\_\_\_\_\_
\_\_\_\_\_\_\_\_\_
\_\_\_\_\_\_\_\_\_

St 1: 140/90 -ABPM-> 135/85
St 2: 160/100 -ABPM-> 150/95
St 3: 180/120
________

180/120/+ w/ PapOed/RetHaem/LT syx*
*Confusion/ChestPain-CCF/AKI

NO = 
-CVD RF - Lipid profile/Q10
-Lifestyle
-EODx Assx = 
HUria/HbA1c, Urine ACR/U+E, Fundoscopy, ECG:
Y = Tx-ABPM
N = BP 7d repeat

YES = 1. 999 Malig Acc HTN 2. Suspected Phaemo:
- 1. Rest, Atenolol, Nitroprusside/Labetalol, DBP drop <100/12-24hrs

- 2. Suspected Phaemo:
HA/HTN, Anxiety, Sweat 
\+
pHoresis, pALlor/pALp, pOst HypoTN
\_\_\_\_\_\_\_\_

160/110 / 2/+ PUria = refer @preg
-@PPartum BP > 150/100 start anti-HTN tx =
E/NAm ENAtLab

160/100 -ABPM-> 150/90 = St 2
160/90 = Isol Syst HTN
150/90 -ABPM-> 145/85 St 1 >80y

140/90 = gHTN/PreEcl
140/90 -ABPM-> 135/85 St 1 <80y
140/90 CKD + ACR <70

130/80 CKD + ACR >70
130/80 DM = AlbuminUria + 2/+ WTHG
___________________

BP tx when?

  1. <40 = 2ndary cause find*
  2. <60 + Q10/-
  3. <80 +
    - CVD established
    - DM
    - EODx
    - Renal dx
    - Q10/+ = 20mg Atorva
  4. > 80 >150/90
*Ix:
CVD - Coarc/RAS
Renal dx = LUMP*
Eye dx Keith Wagner
ECG
Endo - Thyroid/Acromeg/GFR** dx
Drugs
*
Lump - RCC
Urine: PUria/AlbUria = DM / HUria = g.nephritis
Mass = obst uropathy/RCC @loin
Pyelo
**G(Ald:Renin/synACTHen)
F(DexaSuppTest)
R
Catechol (urine metaneph/CT-AP/meta-IBG)
\_\_\_\_\_\_\_\_\_\_\_\_\_

Age<55/DM Age>55/Black

  1. ACE/ARB C/D @ccb-CI e.g.CCF
  2. A+C > A+D
  3. A+C+D
  4. K 4.5/- = Spiro / 4.51/+ = alpha/beta-block
  5. Refer specialist
A
  1. probable UTI –> MSU –>
    f/u 1wk + Cephalex/ Amoxi/ Pivmecillinam
  2. @PP:
    had pre-Ecl + NOT had anti-HTN tx =
    BP check 3–5d after birth
  3. @PP:
    had pre-Ecl + HAD anti-HTN tx =
    - BP check/1-2d after birth
    - for 2 weeks
  4. @PP BP > 150/100 start anti-HTN tx
Remember @preg = LNM<135/85
POSTnatal period:
- not BREASTfeed = normal HTN tx 
- BREASTfeed
1. A/C*
2. A+C
3. A+C±B**
  • SALANA = SA/LA = Nifed/Amlod
  • *+/- atenolol/labetalol
gHTN/chrHTN = BP check:
check 
-day 1 
-day 2
-days 3–5 (x1)

R/V BP meds @ 2wks postnatally
Postnatal review 6-8 weeks
chronic HTN >140/90 + NOT taking aHTN tx = LNM<135/85***
—Target BP Postnatally: 140/90

***labetalol > nifedipine > methyldopa –> Target < 135/85
_________
_________
_________

St 1: 140/90 -ABPM-> 135/85
St 2: 160/100 -ABPM-> 150/95
St 3: 180/120
________

180/120/+ w/ PapOed/RetHaem/LT syx*
*Confusion/ChestPain-CCF/AKI

NO = 
-CVD RF - Lipid profile/Q10
-Lifestyle
-EODx Assx = 
HUria/HbA1c, Urine ACR/U+E, Fundoscopy, ECG:
Y = Tx-ABPM
N = BP 7d repeat

YES = 1. 999 Malig Acc HTN 2. Suspected Phaemo:
- 1. Rest, Atenolol, Nitroprusside/Labetalol, DBP drop <100/12-24hrs

- 2. Suspected Phaemo:
HA/HTN, Anxiety, Sweat 
\+
pHoresis, pALlor/pALp, pOst HypoTN
\_\_\_\_\_\_\_\_

160/110 / 2/+ PUria = refer @preg
-@PPartum BP > 150/100 start anti-HTN tx =
E/NAm ENAtLab

160/100 -ABPM-> 150/95 = St 2
160/90 = Isol Syst HTN
150/90 -ABPM-> 145/85 St 1 >80y

140/90 = gHTN/PreEcl
140/90 -ABPM-> 135/85 St 1 <80y
140/90 CKD + ACR <70

130/80 CKD + ACR >70
130/80 DM = AlbuminUria + 2/+ WTHG
___________________

BP tx when?

  1. <40 = 2ndary cause find*
  2. <60 + Q10/-
  3. <80 +
    - CVD established
    - DM
    - EODx
    - Renal dx
    - Q10/+ = 20mg Atorva
  4. > 80 >150/90
*Ix:
CVD - Coarc/RAS
Renal dx = LUMP*
Eye dx Keith Wagner
ECG
Endo - Thyroid/Acromeg/GFR** dx
Drugs
*
Lump - RCC
Urine: PUria/AlbUria = DM / HUria = g.nephritis
Mass = obst uropathy/RCC @loin
Pyelo
**G(Ald:Renin/synACTHen)
F(DexaSuppTest)
R
Catechol (urine metaneph/CT-AP/meta-IBG)
\_\_\_\_\_\_\_\_\_\_\_\_\_

Age<55/DM Age>55/Black

  1. ACE/ARB C/D @ccb-CI e.g.CCF
  2. A+C > A+D
  3. A+C+D
  4. K 4.5/- = Spiro / 4.51/+ = alpha/beta-block
  5. Refer specialist
89
Q

Vit D doses + Folate doses @ preg?

When take folic acid 5mg instead of 400 mic?

GBS tx?
______

Avoid which drugs @ breastfeed:

Post-term pregnancy definition? Mx?
- High Risk of?
_______

A nurse informs you
30F 38 weeks pregnant. BP 155/90
Prev BP 2 days ago was 152/85

24hr urinary prot excr of 0.7g / 24 hours

Tx?

Target DIASTOLIC BP?
___________________________

Temp > 38ºC <6w after delivery
-Dx? -Tx?
-Post-partum period = ?
___________________________

Breast-feeding 
Sore nipple
White discharge - candida 
Tx???
\_\_\_\_\_\_\_\_\_

T3 preggers

Pruritic ABDO Striae –> spread
____________________

Pruritic
Umb –> Spread-2-trunk
BLISTERINGGGG
________

Baby blues - anxious tearful < 1wk

Puerperal Psychosis - mood swings/auditory hallucinations < 2-3 wks

PNDepression tx? < 4-12 wks

Screenin tool measure?
________

If baby breech, by when till it turn spontaneously?

What to do if still not turn?

What to do if STILL not turn?

A

Vit D 10 micrograms once a day
Folic acid 400 micrograms OD

NTD pmh/fhx/prevpreg
BMI 30/+, Coeliac, DM, Epilepsy, Thalassaemia

INTRApartrum IV BenPenG
______

V - Aspirin/Amiodarone
I - chloramphen/Quinolone/Sulfonamide/Tetras/Fungals - selenium, flucon, itracon
N - MTX/Cytotoxics
D - LITHIUM/BENZOs
I - LITHIUM/BENZOs
C - LITHIUM/BENZOs
A - MTX/Carbimazole
TE - SUs
Post-term = beyond 42 w --> 
INDUCE > WW
-High Risk of Meconium Asp
-High Risk of Oligohydramnios
\_\_\_\_\_\_\_

Labetalol

Deliver < 48hrs

Target DIASTOLIC bp = 80-100
_________________

Puerperal pyrexia - admit IVAbx
-Post-partum period = <6wks

__________________

Continue breast feeding + Tx BOTH:
- Mum - Miconazole cream
- Baby - Nystatin
_________

Polymorphic - emollients, top/PO steroids
-Pruritic
-3rd trimester
-ABDO Striae --> spread
-ACE
\_\_\_\_\_\_\_\_\_\_\_

PemphigOOOOOid gestation - PO steds

O looks like fkn belly-button!!!
-and blisters too!!!
_________

RACE
Reassure - Blues < 1 wk

ADMIT - Psychosis < 2-3 wks

CBT + Sertraline/Parox V Fluox - PND < 4-12 wks

  • Sertraline + Fluoxetine @preg
  • Sertraline @BFeed

Edinburgh Scale is a screening tool for postnatal depression
________

< 36 w turn spontaneously

AFTER 36 w = ECV

C-section/Vaginal delivery

Summary: W36 spont -> ECV -> C-sec/Vag

90
Q
  1. Small: Brain, Eyes, Limbs
    ______
3. 
Brain CALCification/ small
-ChorioRetinitis (white + RED)
-SENSORI-neural deafness
-TCP -iuGR
  • Seizures -HSM
  • Blueberry muffin rash

________________

  1. Brain CALCification,
    -Chorioretinitis (white, overlying VIT inflamm)
    -HYDROcephalus
  • Seizures -HSM
  • Blueberry muffin rash

Tx?
__________

  1. EARRR): Sensorineural DEAF,

EYEEE): Smaaaall
CATARACT/ Glaucoma
——‘SALT-pepp’ CHORIOret

HEARTTT) - ?WHICH one?

-NOOOO Seizures -HSM
-Blueberry muffin rash
__________

sensorineural = ? + ?
brain calc = ? + ?
chorioret = 
-?(white+red) + 
-?(white overlying vitreous) + 
-?(salt+pepper)
\_\_\_\_\_\_\_\_\_\_

Preggers -Rubella IgG not detected - advice?

12 week PREG meet f2f >15 mins relative with shingles.
PMH: chickenpox

12 week PREG meet f2f >15 mins relative with shingles.
PMH: NOOOO chickenpox

pregnant woman develops chickenpox >20w

pregnant woman develops chickenpox <20w

A
  1. sBEL: Fetal Varicella
    -small brain eyes limbs
    LIKE A CHICKEN-(pox) lol
    -disabilities/microophthalmia/hypoplasia
    _______
  2. CMV

SEEEE-MV=Sensorineural

  • ganciclovir
    ________________
  1. Toxo
    -HydroCEPH
    ?erythema multiforme

-spiramycin
-pyrimethamine + sulfadiazine
_______

  1. Rubella
    -ears, eyes, heart - PDA
    _________
sensorineural = cmv + rubella
brain calc = cmv + toxo
chorioret = 
-cmv(white+red) + 
-toxo(white overlying vitreous) + 
-rubella(salt+pepper)
\_\_\_\_\_\_\_\_\_\_

Keep away from anyone w/ rubella
Advise risks
MMR PoooooST-NATALLY

Reassure her. No further action

check varicella ABs + VZIG

> 20 w = ORAL Aciclovir <24hr of rash

< 20 w = ?consider ORAL aciclovir

91
Q
Pt had DE stent put in, 
on aspirin and ticagrelor. 
Gets breathless. What to do? Why?
-Ticag = stops ? -> 
incr adenosine --> ? sx
-Sub ticag for ?
\_\_\_\_\_\_\_
iNITIAL Tx?

MONA? ?mg +

eligible for PCI:

  • -> ? = Asp + already on ?
  • Y = ? + ?
  • N = ? + ? / ? or ? @ ?Age/+ + HR of ?
For the poor fuckers 
NOT eligible 
for reperfusion therapy 
--> ? : ? + HR ?
Y = ? ± ? 
N = ? + ?
Can PCI be done < ?hr
when ?
COULD have been given?
- Y = ? = ?type @Syx <12hr
#Asp?- ?blood vessel > ?blood vessel 
#Syx >12hr = consider ?
@Cont?/?
  • N = ? + ?
    ECG < ? mins -> ?STEMI improve 50%
    NO = ?implication -> ?Tx

GPi bailout @PCI via

  • Radial = ?
  • Femoral = ?

STEMI + Multivessel dx + Cardiogen shock = ?

STEMI + Multivessel dx + NO Cardiogen shock = ?

B4 d/c:
-? testing in all NSTEMI/STEMI #Echo

(look at pictures on 18/1/21 for written notes)

A

-Ticag = stops adenosine clearance ->
incr adenosine –> SOB sx
-Sub ticag for clopi
________

iNITIAL Tx?

MONAsp 300mg + …

eligible for PCI:

  • -> DAPT: Asp + already on AC?
  • Y = Asp+ Clop
  • N = Asp + Prasugrel / Ticag or Clopi @75/+ + HR bleed
For the poor fuckers 
NOT eligible 
for reperfusion therapy 
--> DAPT: Asp + HR bleed?
Y = Asp ± Clopi 
N = Asp + Ticag
Can PCI be done < 2hr
when Fibrinolysis
COULD have been given?
- Y = Angio + PCI = DES @Syx <12hr
#AspThrombus-Radial>Fem
#Syx >12hr = consider Angio + PCI 
@ContIsch/CardioShock
  • N = Fibrinolysis#tPA + UFH/LMWH #AT
    ECG < 60-90 mins -> ?STEMI improve 50%
    NO = failed thrombolysis -> Refer for Angio + PCI

GPi bailout @PCI via

  • Radial = UFH (ruff ruff like a dog… )
  • Femoral = Bivilarudin

STEMI + Multivessel dx + Cardiogen shock =
-Culprit Vessel Revasc

STEMI + Multivessel dx + NO Cardiogen shock =
-COMPLETE Vessel Revasc

B4 d/c:
-LVF testing in all NSTEMI/STEMI #Echo

(look at pictures on 18/1/21 for written notes)

92
Q

NSTEMI:

MONAsp ?mg
? \_\_\_\_ \ ? @
@angio  \ Creat >265
ASAP
--> 

GRACE ?m mortality

  • Bloods ?
  • ?
  • ?

Angio ± PCI + ? @cardiac cath lab = DES @
1)-?

2)-Stable AND GRACE 1.5 - 3% #Low Risk
AND ? / ?

3)-Stable AND GRACE >3% #Inter/High Risk < ?

GRACE 1.5 - 3% #Low Risk 
For the poor fuckers 
NOT eligible 
for reperfusion therapy 
--> ?: ? + HR bleed?
Y = ? ± ? 
N = ? + ?

GRACE >3% #Inter/High Risk

  • ?: ? + already on AC?
  • Y = ? + ?
  • N = ? + ?/?

B4 d/c:

  • ? if conservative tx
  • ? testing in all NSTEMI/STEMI #Echo
A

NSTEMI:

MONAsp  300mg
Fonda  \ UFH @
@angio  \ Creat >265
ASAP
--> 

GRACE 6m mortality

  • Bloods: Trop I or T / FBC U+E BM
  • Hx / Ex
  • ECG

Angio ± PCI + UFH @cardiac cath lab = DES @
1)-HD UNSTABLE

2)-Stable AND GRACE 1.5 - 3% #Low Risk
AND Isch exp/demonstrate @testing

3)-Stable AND GRACE >3% #Inter/High Risk < 72hr

GRACE 1.5 - 3% #Low Risk 
For the poor fuckers 
NOT eligible 
for reperfusion therapy 
--> DAPT: Asp + HR bleed?
Y = Asp ± Clopi 
N = Asp + Ticag

GRACE >3% #Inter/High Risk

  • DAPT: Asp + already on AC?
  • Y = Asp+ Clop
  • N = Asp + Prasugrel / Ticag

B4 d/c:

  • isch testing if conservative tx @NSTEMI
  • LVF testing in all NSTEMI/STEMI #Echo
93
Q

WMVE: Expectant management (d/c with f/u in 1 week)
is generally the 1st line management for miscarriages
except if:
-H? HR (late T? i.e. w?ish / ? dx)
-i?
-PMH: ?

PROLONGED labour –> later woman continuous dribbling incontinence
Vesicovaginal fistula / Stress urinary?
-Ix = ? studies > IV ?
__________

-Cerv cancer + St IA tumour + Gold standard tx =
?surg ± ? clearance

-Cerv cancer + St IA tumour + MAINTAIN FERTILITY =
?procedure 2 maintain fertility + ? margins

Cervi Cancer + stage IB /+ = 
-? + ?
\_\_\_\_\_\_\_\_\_\_
Endomet Cancer Ix: 
?scan -> ?biopsy 
–inconclusive-biopsy--> 
?ix + ?sampling (?d+c)

Endomet Cancer Tx:
-localised disease =
?surg –Hrisk–> post-op ?

Endomet Cancer Tx
@Frail elderly women + NOT suitable for surg ?

?Ix for PMB
__________

Ovarian Cancer Tx?
All stages?
Stagaes 2-4?
__________

Endometriosis is a risk factor for ? pregnancy

What of the following risks is most common following a Termination of Pregnancy?

positive pregnancy test
+
abdo/ pelvic or cervical motion tenderness
?Tx

-The Nexplanon prog-only implant can be inserted
?when
ALTHOUGH contraception = NOT needed B4 day ? PP
-The POP can be started on or after day ? postpartum.
-Mirena + Copper iuD can be used from ? postpartum.

TRANS-Female (i.e. genetically a ?) 
In relationship with another woman 
-Has regular UPSI. 
-In the process of gender reassignment. 
-No surgery on meat’n’2veg. 
What is the most appropriate form of contraception to advise?
-Barrier = condoms

-GMC = that we should report
all known cases of FGM
in under-? to ?

FGM 1234: ?
-CLNP

Which of the following ovarian tumours
assoc w/ Endometrial HyperPlasia?
-Granulosa cell tumours

Atyp HyperPlasia of the endometrium is classified as a ? condition

Rokitansky’s protuberance = ?ovarian tumour

unknown location @uss
I.E they can’t see shit + hCG levels >1500 = ectopic

  • HCG
    1. < ?
    2. > ?

HBeat

    • ?
    • ?
  1. < ? / ?
  2. > ? / ?
  3. WW?d / ?Drug
  4. ? / ?
    ___________
    -How long it lasts
    Nexplanon = ?yrs
    Mirena = ?yrs
    CuID = ?yrs
suspicion of ovarian cancer 
but there is an abdo-pelvic mass/Ascites, 
? and ? 
can be BYPASSED and the 
patient directly REFERED to gynaecology
A

WMVE: Expectant management (d/c with f/u in 1 week)
is generally the 1st line management for miscarriages
except if:
-Haemorrhage HR (late T1 i.e. w13ish 39/3 / bleed dx)
-infection
-PMH: prev fucked preg

PROLONGED labour –> later woman continuous dribbling incontinence
-VESICO-VAG fistula #prolonged-labour
-Ix = Urinary dye studies > IV urogram/pyelogram
__________

-Cerv cancer + St IA tumour + Gold standard tx =
TAH ± Node clearance

-Cerv cancer + St IA tumour + MAINTAIN FERTILITY =
Cone biopsy + Neg margins

Cervi Cancer + stage IB /+ =
-RT + Chemo
__________
Endomet Cancer Ix = TVUSS, Pipelle, Hystero+Sample
TVUSS -> Pipelle biopsy
–inconclusive–>
Hysteroscopy + directed sampling (dilation + curettage)

Endomet Cancer Tx @ localised disease =
TAH + B/L Sooph –Hrisk–> post-op RT

Endomet Cancer Tx
@Frail elderly women + NOT suitable for surg =
—Progestogen tx

Endometrial biopsy for PMB
__________

Ovarian Cancer Tx?
All stages = LaparoTOMY tumour excision
Stagaes 2-4 = Chemo
__________

Endometriosis is a risk factor for ectopic pregnancy

Which of the following risks is most common following a Termination of Pregnancy?
-Infection

positive pregnancy test
+
abdo/ pelvic or cervical motion tenderness
Tx = Immediate Assx

-The Nexplanon prog-only implant can be inserted
at any time
ALTHOUGH contraception = NOT needed B4 day 21 postpartum.
-The POP can be started on or after day 21 postpartum.
-Mirena + Copper iuD can be used from 4w postpartum.

TRANS-Female (i.e. genetically a man) 
In relationship with another woman 
-Has regular UPSI. 
-In the process of gender reassignment. 
-No surgery on meat’n’2veg. 
What is the most appropriate form of contraception to advise?
-Barrier = condoms

GMC) state that we should report
all known cases of FGM
in under-18s to the POLICE

FGM 1234: Clitoris ± Labia ± Narrowed vag ± Procedures

Which of the following ovarian tumours
assoc w/ Endometrial HyperPlasia?
-Granulosa cell tumours

Atyp HyperPlasia of the endometrium is classified as a ? condition

Rokitansky’s protuberance = Teratoma (dermoid cyst) #Germ-cell

unknown location @uss
I.E they can’t see shit + hCG levels >1500 = ectopic

  • HCG
    1. <1500
    2. >1500

HBeat

  1. -none
  2. -visible
  3. <35mm / Unruptured
  4. > 35mm / Ruptured
  5. WW2d / MTX
  6. Salpingectomy/Salpingostomy
    ___________

-How long it lasts
Nexplanon = 3yrs
Mirena = 5yrs
CuID = 10yrs

suspicion of ovarian cancer 
but there is an abdo-pelvic mass/Ascites, 
CA125 and TVUSS 
can be BYPASSED and the 
patient directly REFERED to gynaecology
94
Q

POP use. As a general guide:
• 20% = ?
• 40% will have ? bleeding
• 40% will have ? bleeding

Suspected/PMH breast cancer/ BRCA
- ? = safest

diagnosed with a simple UTI -> prescribed a 3d Trimeth

  • Returns 2 weeks later = new onset VAG D/C
  • The patients vaginal discharge is most likely caused by a ? #reccent ABx Tx

Lactational amenorrhoea is a reliable method of contraception as long as …..

  • ?period
  • baby < ?duration/age AND
  • breastfeeding (> ?% breast milk feeds)
If BFeed < 85% + UPSI After PP day 21 = 
Mx?
\_\_\_\_\_\_\_\_\_\_\_\_\_
concerned as her daughter has NOT STARTED periods 
although suffers from NO pain. 
O/E: the daughter LOOKS WELL. 
Ddx?
concerned as her daughter has NOT STARTED periods 
although suffers from NO pain. 
O/E: the daughter looks FUCKED 
(no uterus + hypoplastic upper vag). 
Ddx?
concerned as her daughter has NOT STARTED periods  
although suffers CYLICAL PAIN. 
O/E: the daughter LOOKS WELL. 
Ddx?
\_\_\_\_\_\_\_\_\_\_\_\_\_

? is offered to women who has a tubal ectopic
UNLESSSS they have other RFs for infertility
eg. Contralat tube dx
—Otherwise, ? is offered as an alternative.

Incomplete/complete hydatidiform mole
-NO foetal parts present + snowstorm seen

Incomplete/complete hydatidiform mole
-Foetal parts present + snowstorm NOT seen

The best imaging technique for diagnosing 
ADENOMYOSIS is ?
\_\_\_\_\_\_\_\_\_\_\_\_\_
Pregnant women who are 
> 6 weeks gestation + vag bleeding = ?
< 6 weeks gestation + vag bleeding + no pain = 
manage ?
------return if 
-bleeding ? / experience ? 
-repeat a urine pregnancy test after ?d 
---negative pregnancy test means ?

Risk malignancy index (RMI) prognosis in
ovarian cancer is based on
? findings, ? status and ? levels

Good Medical Practice (2013) 
if YOU have a CONSCIENTIOUS OBJECTION 
to a particular procedure
You must tell them about 
-their right to ? 
-make sure they ?

Mirena = Initially ? bleeding -> light menses or amenorrhoea

Young/FAT + First/Multiple preg
assoc with
?

Pearl Index of the
COCP = 0.2:

?women = become PREG
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_  = ? year
1000 women 
using this form 
of contraception  
PMH of endometriosis 
\+ 
SUDDEN pain acute abdomen 
\+ 
FLUID in pelvis = 
---Ddx?

ruptured ectopic pregnancy =
Resuscitate + arrange for emergency ?

If a SEMEN Sample is abnormal,
? should be arranged,
ideally ?time later

To confirm ovulation #MSC-GIST
Take the serum mid-luteal prog level 
7 days BEFORE WHAT?
e.g. 28d cycle: 28-7 = d21, USUALLY
e.g. 35d cycle = 35-7 = d28 !!! 
(its not just d21, its Duration - 7 !!!)

Incontinence:
1-bladder diaries ?d –inconclusive–> ? studies
2-vag exam exclude ?
3-?UTI exclude ix?
4-Then ACES -> stress(Kegel ABDE dulox) / urge(BOMB)

A

POP use. As a general guide:
• 20% = amenorrhoeic
• 40% will have Regular bleeding
• 40% will have Erratic bleeding

Suspected/PMH breast cancer/ BRCA
- copper coil = safest

diagnosed with a simple UTI -> prescribed a 3d Trimeth

  • Returns 2 weeks later = new onset VAG D/C
  • The patients vaginal discharge is most likely caused by a FUNGAL infection #reccent ABx Tx

Lactational amenorrhoea is a reliable method of contraception as long as

  • AMENORRHOEIC
  • baby <6 months AND
  • breastfeeding (> 85% breast milk feeds)
If BFeed < 85% + UPSI After PP day 21= 
Preg Test + Contraception 
\_\_\_\_\_\_\_\_\_\_\_\_\_
concerned as her daughter has NOT STARTED periods 
although suffers from NO pain. 
O/E: the daughter LOOKS WELL. 
Ddx?
- Constitutional delay
concerned as her daughter has NOT STARTED periods 
although suffers from NO pain. 
O/E: the daughter looks FUCKED 
(no uterus + hypoplastic upper vag). 
Ddx?
- Mullergan Agenesis
concerned as her daughter has NOT STARTED periods  
although suffers CYLICAL PAIN. 
O/E: the daughter LOOKS WELL. 
Ddx?
-Imperforate hymen
\_\_\_\_\_\_\_\_\_\_\_\_\_

salpinGECTomy is offered to women who has a tubal ectopic
UNLESSSS they have other RFs for infertility
eg. Contralat tube dx
—Otherwise, salpinGOSTomy is offered as an alternative.

COMPLETE hydatidiform mole = 46 XX/XY
-NO foetal parts present + snowstorm seen

INCOMPLETE hydatidiform mole = 96 XXX/XXY

  • foetal parts present and
  • snowstorm NOT seen

The best imaging technique for diagnosing
ADENOMYOSIS is MRI
_____________
Pregnant women who are
> 6 weeks gestation + vag bleeding = Preg Assx Unit

< 6 weeks gestation + vaginal bleeding + no pain =
managed expectantly
——return if
-bleeding continues / pain
-repeat a urine pregnancy test after 7–10d
—-negative pregnancy test means MISCARRIAGE

Risk malignancy index (RMI) prognosis in
ovarian cancer is based on
US findings, menopausal status and CA125 levels

Good Medical Practice (2013) 
if YOU have a CONSCIENTIOUS OBJECTION 
to a particular procedure
You must tell them about 
-their right to SEE ANOTHER DOC
-make sure they HAVE ENOUGH INFO 
to exercise that right

Mirena = Initially IRREG bleeding –> light menses / amenorrhoea

Young/FAT + First/Multiple preg
assoc with
HyperEmesis

Pearl Failure Index of the
COCP = 0.2:

2 = become PREG
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_  = ONE year
1000 women 
using this form 
of contraception  
PMH of endometriosis 
\+ 
SUDDEN pain acute abdomen 
\+ 
FLUID in pelvis = 
---RUPTURED endometrioma

ruptured ectopic pregnancy = Resuscitate and arrange for emergency LaparOTOMY

If a SEMEN Sample is abnormal,
REPEAT TEST should be arranged,
ideally 3 months later

To confirm ovulation #MSC-GIST
Take the serum mid-luteal prog level 
7 days BEFORE expected next period
e.g. 28d cycle: 28-7 = d21, USUALLY
e.g. 35d cycle = 35-7 = d28 !!! 
(its not just d21, its Duration - 7 !!!)

Incontinence:
1-bladder diaries 3d –inconclusive–> urodynamic studies
2-vag exam exclude prolapse
3-dipstix/culture
4-Then ACES -> stress(Kegel ABDE dulox) / urge(BOMB)

95
Q

Most common cyst in reproductive woman?

NPMc = 0 3w 4w
-The Nexplanon prog-only implant can be inserted
?when
ALTHOUGH contraception = NOT needed B4 day ? PP

-The POP can be started on or after day ? postpartum 
#short-term contracep

-Mirena + Copper iuD can be used from ? postpartum.

Contraceptives NOT NOT NOT NOT NOT NOT NOT NOT NOT NOT NOT NOT NOT NOT NOT NOT NOT NOT NOT Affected
by Enzyme-Inducing Drugs?

? / ? due to
IVF treatment….
Ovarian Hyperstim

Cervical screening in PREGNANY
delayed until ? months post-partum
unless missed ? / prev ? smears

HIV positive = cervical cytology ?how often

Women who have been treated for CIN II 
should be offered what 2 THINGS?
- cervical screening at ? months 
\+
- ?

Vaginal vault prolapse tx
= sacro-colpo-plexy

Most common site of ectopic pregnancy is in the
? of fallopian tube
-most dangerous @ ?

Termination of pregnancy:
-A positive test < 4 weeks = NORMAL

-A positive test > 4 weeks =
? abortion / persistent ?

Common Cx following Myomectomy = ?

HRT:
adding a progestogen increases the risk of ? cancer
adding a progestogen decreases the risk of ? cancer

She is currently taking 
-carbamazepine for epilepsy #EID 
-BMI is 39 kg/m² 
-She has no other PMH 
Which of the following would be the most suitable contraceptive to offer her?

A diagnosis of hyperemesis gravidarum is made.
What other treatment should this patient receive?
ABCDE – IVF, electrolye correct + ?

48-year-old want contraception
-LMB 9 months ago

-convinced that she has ‘gone through the menopause’.
Most suitable form of contraception is:
COCP/Mirena/HRT/Barrier ?
Taking into account AGE (ukmec 3 @35/+) has to be …?

hyperemesis = Reassure @preg < ? w

Ovarian cancers which are stage 2-4, are treated primarily by ?

Atrophic vaginitis is a diagnosis of EXCLUSION,
and can only be made after ? OUT 1ST

A transvaginal ultrasound shows an endometrial thickness of 15mm. What would be the next appropriate line of investigation?

Stop the COCP ? weeks before surgery and
restart ? weeks after surgery

vaginal hysterectomy with
antero-posterior repair.
Which of the following is a long-term complication of this procedure?

infected miscarriage –> progressing to septic shock
Tx = ?

Heavy menstrual bleeding
\+
Severe period pain
-everything pretty much normal o/e
Mx?
\_\_\_\_\_\_\_\_\_

EMERGENCY Contrapception
? most EFFECTIVE <3d <5d generally?
? not affected by BMI

Levonelle (double the standard 1.5 mg dose)
-i.e. 3mg levonorgestrel
BMI > ? / weight > ?kg

Ella1 = CI asthma / BF wait 1 week

CuiuD = not recommended in patients with
?

seeking emergency contraception
-UPSI = 80 hours ago (i.e. between 3-5 days)
-On day 20 of her menstrual cycle.
-Took ellaOne ulipristal was prescribed to this patient 10 days ago for a similar episode (i.e. in same cycle).
Which of the following is a suitable method of emergency contraception in this case?
-Can give ? TWICE in a cycle
-Can give ? too <5d/ after d14/ FATsooos

Woman vomits < 3 hours of taking
Levonorgestrel OR Ella1Ullipristal,
prescribe a ? dose of emergency hormonal contraception ASAP
_________

Transdermal/Oral HRT
does not appear to increase the
risk of VTE ??

PCOS = increases the long-term risk of which of the following conditions?
-? cancer

For people with 
-unexplained/ male factor ?
-mild ?
who are having regular UPSI x2-3/wk
Don’t offer ? yet
Wait up to ? years in total for these ppl
A

FOLLICULAR > Corpus luteum

-The Nexplanon prog-only implant can be inserted
at any time
ALTHOUGH contraception = NOT needed B4 day 21 postpartum.

-The POP can be started on or after day 21 postpartum
#short-term contracep

-Mirena + Copper iuD can be used from 4w postpartum.

UNNNaffected EID: IuS IuD Depot

GnRH/hCG due to
IVF tx
—Ovarian Hyperstim

Cervical screening in PREGNANY
delayed until 3 months post-partum
unless missed screening / prev abnormal smears

HIV positive = ANNUAL cervical cytology

Women who have been treated for CIN 2
should be offered 
-cervical screening at 6 months 
\+
-HPV TOC

The treatment for vaginal vault prolapse is
sacro-colpo-plexy

Most common site of ectopic pregnancy is in the ampulla of fallopian tube
-most dangerous @isthmus #RUPTURE

TOP:
-A positive test < 4 weeks = NORMAL

-A positive test > 4 weeks =
INCOMPlete abortion / persistent Trophoblast

Common Cx following Myomectomy = Adhesions

HRT:
adding a progestogen INCreases the risk of BREAST cancer
adding a progestogen DECreases the risk of ENDOMET cancer

She is currently taking 
-carbamazepine for epilepsy #EID 
-BMI is 39 kg/m² 
-She has no other PMH 
Which of the following would be the most suitable contraceptive to offer her?
---ius iud Depot = NOT affected by EID

A diagnosis of hyperemesis gravidarum is made. What other treatment should this patient receive?
ABCDE – IVF, electrolye correct + IV Vit B/C pabrinex

48-year-old want contraception
-LMB 9 months ago
-convinced that she has ‘gone through the menopause’.
Most suitable form of contraception is:
COCP/Mirena/HRT/Barrier ?
Taking into account AGE (ukmec 3 @35/+) has to be …?
-The intrauterine system (IUS)

hyperemesis = Reassure @preg <20w

Ovarian cancers which are stage 2-4, are treated primarily by
tumour excision + CHEMO

Atrophic vaginitis is a diagnosis of exclusion, and can only be made after RULE SHIT OUT 1ST

A transvaginal ultrasound shows an endometrial thickness of 15mm.

A transvaginal ultrasound shows an endometrial thickness of 15mm. What would be the next appropriate line of investigation?
-Endometrial biopsy at hysteroscopy

Stop the pill 4 weeks before surgery and
restart 2 weeks after surgery

vaginal hysterectomy with antero-posterior repair. Which of the following is a long-term complication of this procedure? Vaginal vault PROLAPSE

infected miscarriage –> progressing to septic shock
Tx = evacuate the pregnancy ASAP

Heavy menstrual bleeding
\+
Severe period pain
-everything pretty much normal o/e
Mx?
----MENORRHAGIA IPS!!! 
---Ix = FBC/Clot, Hysterscope @SMF/Polyp/Endomet, USS tv/ta @fibroid, USS-TV @adenomyosis
---This bitch got menorrhagia AND dysmenorrhoea = TVUSS !!!!!!
\_\_\_\_\_\_\_\_\_

EMERGENCY Contrapception @FATSO
Cu-iuD most effective <3d <5d generally
Cu-iuD not affected by BMI

Levonelle (double the standard 1.5 mg dose)
-i.e. 3mg levonorgestrel
BMI >26 / weight > 70kg

Ella1 = CI asthma / BF wait 1 week

Cu-iuD = not recommended in patients with
distortion of the uterine cavity
e.g. fibroids.

seeking emergency contraception
-UPSI = 80 hours ago (i.e. between 3-5 days)
-On day 20 of her menstrual cycle.
-Took ellaOne ulipristal was prescribed to this patient 10 days ago for a similar episode (i.e. in same cycle).
Which of the following is a suitable method of emergency contraception in this case?
-Can give Ella1Ullipristal TWICE in a cycle
-Can give CuiUD too <5d/ after d14/ FATsos

Woman vomits < 3 hours of taking
Levonorgestrel OR Ella1Ullipristal,
prescribe a SECOND dose of emergency hormonal contraception ASAP
_________

Transdermal HRT
does not appear to increase the
risk of VTE ??

PCOS) increases the long-term risk of which of the following conditions?
-Endometrial cancer

For people with 
-unexplained/ male factor INFERTILITY
-mild ENDOMETRIOSIS
who are having regular UPSI x2-3/wk
Don’t offer IuInsemm yet
Wait up to 2 years in total for these ppl