ID Flashcards

1
Q

Farm animals/rodent urine

1.flulike
2.subconjunctival haemorrhage
3.CK high = myalgia
_________

Temp SPIKE/ TWICE daily

  • Ulcer @ lip
  • NasoPharynx involvement

-HSM-ANT
-South American
__________

Flulike syx

Worse Better worse

COUNCILmen inclusion bodies
________

Facial Flushing!!!! Classssssic

  • HIGH AF fever #Saddleback-fever
  • comes goes comeback

Low WCC
Low Plts

High ALT
________

Rose spot rash

SplenoMegaly+Bradycardia

CONSTIPATION=inflamed PeyerPatch
\_\_\_\_\_\_\_\_
a.
Dermatitis
Arthritis
Tino synovitis
b.
Perihepatitis
Endocarditis
Arthritis septic
\_\_\_\_\_\_\_

Meningitis/CN palsy

Erythema migrans

Heart block myocarditis

  1. E.Migrans+No other dx?
  2. NO E.Migrans
    - Syx+TickBiteHx?

Treatment? Treatment at disseminated?

A

Leptospirosis
-Doxy+Penicillin
_______

Leishmaniasis=Kala Azar 7-21d
-Similar to Histoplasmosis
________

Yellow fever 2 - 14 days
________

Dengue
-hemorrhagic manifestations
-4-10d
_______

Typhoid - culture

RRickettsii on the wRRists,
TTyphus on the TTrunk.
_______

a. Disseminated gonorrhoea infection
b. Fitzhugh Curtis
________

Lyme disease blood zero ology

E.Migrans+No other dx?

  • Doxy / Amoxi
  • Ceftriaxone disseminated
NO E.Migrans
-Syx+TickBiteHx?
Test antibodies:
\+ = Abx
- = Repeat+Refer
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Temp SPIKE/ TWICE daily

  • Ulcer @ lip
  • NasoPharynx involvement
  • HSM-ANT
  • South American
A

Leishmaniasis
-Kala Azar
7-21d

Similar to Histoplasmosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Flulike syx

Worse Better worse

COUNCILmen inclusion bodies

A

Yellow fever 2 - 14 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Facial Flushing!!!! Classssssic

Low WCC
Low Plts

High ALT

HIGH AF fever
Saddleback fever
-comes goes comeback

A

Dengue
-hemorrhagic manifestations

4-10d

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Rose spot rash

SplenoMegaly+Bradycardia

CONSTIPATION=inflamed PeyerPatch

A

Typhoid - culture

Rickettsii on the wRists,
Typhus on the Trunk.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Dermatitis
Arthritis
Tino synovitis

Perihepatitis
Endocarditis
Arthritis septic

A

Disseminated gonorrhoea infection

Fitzhugh Curtis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Meningitis/CN palsy

Erythema migrans

Heart block myocarditis

  1. E.Migrans+No other dx?
  2. NO E.Migrans
    - Syx+TickBiteHx?

Treatment? Treatment at disseminated?

A

Lyme disease blood zero ology

E.Migrans+No other dx?

  • Doxy / Amoxi
  • Ceftriaxone disseminated
NO E.Migrans
-Syx+TickBiteHx?
Test antibodies:
\+ = Abx
- = Repeat+Refer
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Gross loss of vision

A

Globe rupture of eye

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Mono ocular vision blur

Blood in ant chamber

Diagnosed on inspection apparently.. looool
_________

Difficulty opening mouth

NO visual changes
________

Blowout fracture of the orbit
________

Binocular vision + facial trauma

Step deformity @orbital margin
Depressed CHEEEEK contour

A

Hyphaema = Red

Hypopyon = pus
_______

Ramus fracture
______

Comminuted MAXillary fracture ->
maxillary ANTRUM rupture
______

Depressed zygomatic fracture

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Difficulty opening mouth

NO visual changes

A

Ramus fracture

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Blowout fracture of the orbit

A

Comminuted MAXillary fracture ->

maxillary ANTRUM rupture

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Binocular vision + facial trauma

Step deformity @orbital margin
Depressed CHEEEEK contour

A

Depressed zygomatic fracture

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Pupils:

Bilaterally constricted

Unilat const + preserved light response

Unilateral dilated?!

Pupil constrict mechanism?
____

  1. diabetic / prostitue

BILAT small pupils
Accomodate WELL,
NOT constrict to light
________________

  1. Light is SWUNG from
    UNaffected –> Affected eye
    pupils constrict LESS + appear to dilate
    ___________
3. 
Unilat dilated pupil = UNresponsive 2 light
oCCULOMOTOR compression IPSI-lat
Mass/tumour/Hematoma
\_\_\_\_\_\_\_\_\_
4. 
Tonically dilated pupil UNILAT
Absent knee/ankle jerk
VIRAL/BACT infection
\_\_\_
  1. Ptosis, Anhydrosis, Miosis-constricted
A

Bilat const=

  • Metabolic encephalopathy
  • Argyll Robertson
  • Pontine dx/opiates

Unilat const + preserved light response =
-Symp pathway dx

Unilateral dilated =
-Marcus Gunn RAPD = optic nerve dx

Light on retina -> CN2 -> LGNuc -> 
-PreTectal ->B/L EdWestPhal ->
-PSnerves+CN3 b/L -> 
-Ciliary Ganglion-Nerve -> 
-Pupil constrict
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
  1. Argyll-Robertson pupil
    ____
  2. Marcus-Gunn RAPD
    -AION/Optic Neuritis MS/DM/Syph
    ___
  3. Hutchinson sign
    _______
  4. Holmes-Adie Pupil
    ___
  5. Horner
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Fever (alternating/diurnal on - off between days),

HeadAche, myalgia,

Hepatomegaly + Foreign travel hx

Dx? Ix?
_____________

Parasaitemia = 999+PHE:

> 2% - severe/cx?

> 10% ?

<2% non-severe/UnCx:
-?* > ?

ACT =

  • ?
  • ?

Non-falciparum
-?

-Tx vivax/ovale -> dormant HYPNOZOITES @Liver?

Avoid what drugs with following:

  • HA - ?
  • Seizures - ?
  • GI dx - ?
  • Folate dx - ?
  • Psych dx - ?
A

Malaria!!!

Giesma thick and thin blood films
___________

Parasaitemia = 999+PHE:

> 2% - severe/cx
-IV Artesunate > Quinine

> 10% - exchange transfusion

<2% non-severe/UnCx:
-ACT* >
Atovaquone-proguanil
Doxy-Quinine

ACT = AL-ArM:

  • ArteMether+Lume
  • ARteSunate+Mefloquine

Non-falciparum
-oral ACT / Chloroquine

-Tx vivax/ovale -> dormant HYPNOZOITES @Liver?
Primaquine-G6PD beware

Avoid what drugs with following:

  • HA - chloroquine
  • Seizures - chloroquine/Mefloquine
  • GI dx - proguanil
  • Folate dx - proguanil
  • Psych dx - Mefloquine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q
Tet: Clean v TetProne v HRWound
??? : Non-penetrating <6hrs
??? : Puncture, Fract/FB, Burn/Bite
??? : Contaminated/FUCKED
Ask pts what?

5Vacc <10yr + Clean = ???
5Vacc <10yr + TetProne = ???
5Vacc <10yr + HRWound = ???
-5Vacc <10yr + any wound = ???

5Vacc >10yr + Clean = ???
5Vacc >10yr + TetProne = ???
5Vacc >10yr + HRWound = ???

?/Not vacc + Clean = ???
?/Not vacc + TetProne = ???
?/Not vacc + HRWound = ???
___________

bVacc @:

1a) ???
1b) ???

Tet Ig + bVacc @:

2a) ???
2b) ???
2c) ???

A
Tetanus:
Clean: non-penetrating <6hrs
TetProne: Puncture, Fract/FB, Burn/Bite
HRisk: Contaminated/FUCKED
Ask pts 
5vacc <10yrs OR 
5vacc >10yrs OR 
?/Not vacc ?

5Vacc <10yr + Clean = CLEAN+CHILL
5Vacc <10yr + TetProne = CLEAN+CHILL
5Vacc <10yr + HRWound = CLEAN+CHILL
-5Vacc <10yr + any wound = CLEAN+CHILL

5Vacc >10yr + Clean = CLEAN+CHILL
5Vacc >10yr + TetProne = bVacc
5Vacc >10yr + HRWound =
-bVacc + Tet Ig

?/Not vacc + Clean = bVacc
?/Not vacc + TetProne = 
-bVacc + Tet Ig
?/Not vacc + HRWound = 
-bVacc + Tet Ig
\_\_\_\_\_\_\_\_\_\_\_

bVacc @:

1a) Clean wound + ?/Not vacc
1b) TetProne + 5Vacc >10yr

bVacc + Tet Ig @:

2a) TetProne + ?/Not vacc
2b) HRWound + 5Vacc >10yr
2c) HRWound + ?/Not vacc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Toxoid inactivation toxins?

Inactivated preps?

Live attenuated

Rabies:
Animal in UK - ? risk =
-???

Animal bite elsewhere - ? risk = 
??? + ...
-Already immunised: ???
-Not prev immunised: ???
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

PEP:
Hep A: ?? / ??

Hep B - risk of needlestick transmission - ??????? %
look at source - ?? OR ??

  1. HBsAg Pos+ :
    - known responder = ???
    - non-responder = ???
    - being vacc = ???
  2. Unknown source:
    - known responders = ???
    - non-responders = ???
    - being vacc = ???

Hep C -
??? / monthly –>
@seroconversion = ???

Exp to Varicella @ preggers:

  • NOT had chickenpox = ???
  • IC = ???
A

Toxoid = DTaPertussis

Inactivated = R A-H IMflu
-Rabies/A-Hep/IMflu

Rest live attenuated

Rabies:
Animal in UK - NO risk =
-WASH + ?CoAmox

Animal bite elsewhere - HR = 
-WASH + ...
-Already immunised: 2 further doses
-NotPrevImmunised: HRIg+Fullcourse
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

PEP:
Hep A: HNIg / HepA vaccine

Hep B - risk of needlestick transmission - 20-30%
look at source - HBsAg Pos+ OR unknown?

  1. HBsAg Pos+ :
    - known responder = booster
    - non-responder = HBIg + vaccine
    - being vacc = HBIg + vaccine
  2. Unknown source:
    - known responders = booster
    - non-responders = HBIg + vaccine
    - being vacc = accHBV vaccine
  3. Booster @ known responders
  4. HBIg + Vacc:
    @non-responders+beingVaccHBsAgPOS
  5. AccHBV+Vacc:
    @unknown+beingVacc

Hep C -
PCR/monthly –>
@seroconversion = IFN +/- Ribavirin

Exp to Varicella @ preggers:

  • NOT had chickenpox = VZIg
  • IC = VZIg
17
Q

Fever, WL
RUQ pain
Blood diarrhoea
USS=liver ascessssss

Colon biopsy = Aask-shaped ulcers

Tx?
_________

Coxsackie/Polio/Rhino - ?

MeaslesMumps - ?

ParaInfluCroup - ?
Influenza - ?

Viral warts - HPV ?

Hepatits - ?

HIV - ?
-Riskiest way to get it?
______

Skin dx and periph Neuropathy

HypoEsthetic, Hairless skin plaques

  • low Bact load
  • Th 1-type response
  • high cell-mediated immunity

Lion-like Lethal

  • high Bact load
  • Th2 response
  • low cell-mediated immunity

Tx?
________

South Atlantic states - North Carolina.

Classic triad

  • headache,
  • fever,
  • rash - palms/soles(vasculitis).

You drive CARS using?

wRists ?
Trunk ?
___________

OroPharyngeal Ulcers
SMeg-ANT
Mid/Upper Zone pneumonia

LUNG inflamm dx ->

  • Skin = Verrucas -> SCC
  • Bone = Granulomatous Nodules

LUNG inflamm dx ->

  • Skin = Verrucas -> SCC
  • Bone = Granulomatous Nodules

-Males>Females

Meningitis
Arthralgia
Diss 2 BONE/Skin
ENodosum

A

Amoebiasis entamoeba histolytica
-fecal-oral

USS->CT

Metronidazole
______

Coxsackie/Polio/Rhino - Picorna

MeaslesMumps - ParaMyxo

CroupParaInflu - ParaMyxo
Influenza - OrthoMyxo

Viral warts - HPV Papova-Virus

Hepatits - Hepad-virus

HIV - retro
-receiving anal sex
________

  1. Tuberculoid
  2. Lepromatous

Tx:
-Dapsone + Rifampin @tuberculoid form;
- +CloFaziMine @lepromatous
_________

Rocky Mountain Ricketsia
-spotted fever

Palms and soles rash @:

  • CoxsackieA (hand, foot, mouth)
  • Rocky Mountain Ricketsia
  • Syphilis 2°

(you drive CARS using your palms and soles).

Rickettsii on the wRists,
Typhus on the Trunk.
________

Histo
-similar 2 leishmaniasis TWICE daily SPIKEs

Blasto

ParaCoccidio

Coccidio

18
Q

Coxsackie/Polio/Rhino - ?

MeaslesMumps - ?

ParaInfluCroup - ?
Influenza - ?

Viral warts - HPV ?

Hepatits - ?

HIV - ?
-Riskiest way to get it?

A

Coxsackie/Polio/Rhino - Picorna

MeaslesMumps - ParaMyxo

CroupParaInflu - ParaMyxo
Influenza - OrthoMyxo

Viral warts - HPV Papova-Virus

Hepatits - Hepad-virus

HIV - retro
-receiving anal sex

19
Q

FLAT pink and blotchy #vascular
Since BIRTH -> disappears by 2yr
-forehead/eyelids/neck nape
BLANCHES

Naevus ?
_____________

small BRIGHT Red LUMP 
NOT present @birth -->
develops @1st MONTH of life -->
Inc SIZE / VASC till 9 months
\_\_\_\_\_\_\_\_\_\_

Purple LUMP
Face as a purplish/red macule with irregular contours.
NOTTTTT resolve!!!!!

Assoc with intracranial vascular abnormalities like Sturge-Weber-Syndrome.

Naevus ?

A

Salmon Stork Patch
-Naevus Simplex

Marks on the neck may persist.
______________

Strawberry naevus
-capillary haemangioma
______________

Port wine stains
-Naevus FLAEMMUS - need cosmetics / laser therapy.

20
Q

Skin dx and periph Neuropathy

HypoEsthetic, Hairless skin plaques

  • low Bact load
  • Th 1-type response
  • high cell-mediated immunity

Lion-like Lethal

  • high Bact load
  • Th2 response
  • low cell-mediated immunity

Tx?

A
  1. Tuberculoid
  2. Lepromatous

Tx:

  • Dapsone + Rifampin @tuberculoid form;
  • +CloFaziMine @lepromatous
21
Q

South Atlantic states - North Carolina.

Classic triad

  • headache,
  • fever,
  • rash - palms/soles(vasculitis).

You drive CARS using?

wRists ?
Trunk ?

A

Rocky Mountain Ricketsia
-spotted fever

Palms and soles rash @:

  • CoxsackieA (hand, foot, mouth)
  • Rocky Mountain Ricketsia
  • Syphilis 2°

(you drive CARS using your palms and soles).

Rickettsii on the wRists,
Typhus on the Trunk.

22
Q

OroPharyngeal Ulcers
SMeg-ANT
Mid/Upper Zone pneumonia

LUNG inflamm dx ->

  • Skin = Verrucas -> SCC
  • Bone = Granulomatous Nodules

LUNG inflamm dx ->

  • Skin = Verrucas -> SCC
  • Bone = Granulomatous Nodules

-Males>Females

Meningitis
Arthralgia
Diss 2 BONE/Skin
ENodosum

A

Histo
-similar 2 leishmaniasis TWICE daily SPIKEs

Blasto

ParaCoccidio

Coccidio

23
Q

Bloating, flatulence,
FOUL-smelling,
FATTY diarrhea

Bloody diarrhoea - (dysentery),
USS liver abscess (“anchovy paste”),
RUQ pain;
Colon biopsy= Aask-shaped ulcers

Severe diarrhea in
AIDS

A

Giardiasis

Amoebiasis

Crytopsporidum

24
Q

Cat scratches -> area of skin’s LNodes swells
_________

Diarrhoea:

<6 hrs

<48 hrs

48-72 hrs

> 7 days

Which ones bloody? Except?
_________

Neg Antibody test after ?months =
UNlikely HIV infection

CD4 < 500 CHo

CD4 < 400 SL

CD4 < 350 BEN

  • ?ring-enhancing lesions @MRI
  • Thallium SPECT ?

CD4 < 200 - DK

  • ?ring-enhancing lesions @MRI
  • Thallium SPECT ?

CD4 < 100 DC

A

Bartonella - catch scratch dx
________

<6 hrs ABC
-Aureus/Bacillus/C.perfringens

<48 hrs
-Sally/E.coli

48-72 hrs
-Shiggy/Campy

> 7 days YAG
Yersinia/AmoebiasisAnchhovy/Giardiasis

All blood except
-ABC+Giardiasis
_________

Neg Antibody test after 3 months =
UNlikely HIV infection

CD4 < 500 - Cervical/HodgkinRScells

CD4 <  400 sweats/LNpathy
BF
-Bact
-Fungal = 
Candida-oral thrush SCRAPable
M.furfur-seborrh derm
CD4 < 350 Burkitt EBV NHL High Grade
SHEFCOT
1. Shingles
2. HSV
3. EBV HAIRY Leukoplakia UNscrapable
EBV->CNS lymphoma
-single-ring-enhancing lesions @MRI
-Thallium SPECT POS
4. Fungal-CoTrimox/Atovaquone/Pentamadine/Sted @hypoxia 

CD4 < 200 Diarrhoea Kaposi

  • Crypto Cocc-Meningitis / Sporid-Diarrhiea
  • Oesophageal Candidiasis
  • Toxo = brain abscess, MULT ring-enhancing lesions, Thallium SPECT neg
  • PyriMethAmine+SulfaDiaZine

CD4 < 100 Dementia, Cerebral Lymphoma

  • Atyp m.avium
  • CMV pneumonitis retinitis conjunctivitis encephalitis
  • PML JC virus
25
Neg Antibody test after ?months = UNlikely HIV infection CD4 < 500 CHo CD4 < 400 SL CD4 < 350 BEN - ?ring-enhancing lesions @MRI - Thallium SPECT ? CD4 < 200 - DK - ?ring-enhancing lesions @MRI - Thallium SPECT ? CD4 < 100 DC
Neg Antibody test after 3 months = UNlikely HIV infection CD4 < 500 - Cervical/HodgkinRScells ``` CD4 < 400 sweats/LNpathy BF -Bact -Fungal = Candida-oral thrush SCRAPable M.furfur-seborrh derm ``` ``` CD4 < 350 Burkitt EBV NHL High Grade SHEFCOT 1. Shingles 2. HSV 3. EBV HAIRY Leukoplakia UNscrapable EBV->CNS lymphoma -single-ring-enhancing lesions @MRI -Thallium SPECT POS 4. Fungal-CoTrimox/Atovaquone/Pentamadine/Sted @hypoxia ``` CD4 < 200 Diarrhoea Kaposi - Crypto Cocc-Meningitis / Sporid-Diarrhiea - Oesophageal Candidiasis - Toxo = brain abscess, MULT ring-enhancing lesions, Thallium SPECT neg - PyriMethAmine+SulfaDiaZine CD4 < 100 Dementia, Cerebral Lymphoma - Atyp m.avium - CMV pneumonitis retinitis conjunctivitis encephalitis - PML JC virus
26
Cat scratches -> area of skin's LNodes swells
Bartonella - catch scratch dx
27
3. Brain CALCification Sensorineural deafness ________________ ``` 4. Brain CALCification, Hydrocephalus Epilepsy Blueberry muffin rash ?erythema multiforme ```
1. CMV - SeeMV - Sensorineural 2. Toxo
28
Preggers -Rubella IgG not detected - advice? ____________________ 1. 12 week PREG meet f2f >15 mins relative with shingles. PMH: chickenpox 2. 12 week PREG meet f2f >15 mins relative with shingles. PMH: NOOOO chickenpox pregnant woman develops chickenpox >20w pregnant woman develops chickenpox <20w
-Keep away from anyone w/ rubella -Advise risks -MMR PoooooST-NATALLY _________________ 1. Reassure her. No further action 2. VZIG +*check varicella ABs > 20 w = ORAL Aciclovir <24hr of rash < 20 w = ?consider ORAL aciclovir
29
5Vacc <10yr + any wound = ? -Clean/TetProne/HRisk 5Vacc >10yr + Clean = ? 5Vacc >10yr + TetProne = ? 5Vacc >10yr + HRWound = - ? ?/Not vacc + Clean = ? ?/Not vacc + TetProne/HRWound = -? ______________ Hep B - risk of needlestick transmission -? % look at source - HBsAg Pos+ OR unknown? 1. HBsAg Pos+ : - known responder = ? - non-responder/being vacc = ? 2. Unknown source: -known responders = ? -non-responders = ? -being vacc = ? _________________ Rabies: Animal in UK - NO risk = -? Animal bite elsewhere - HR = - ? + ... - Already immunised: ? - NotPrevImmunised: ?
5Vacc <10yr + any wound -Clean/TetProne/HRisk = CLEAN+CHILL 5Vacc >10yr + Clean = CLEAN+CHILL 5Vacc >10yr + TetProne = bVacc 5Vacc >10yr + HRWound = -bVacc + Tet Ig ?/Not vacc + Clean = bVacc ?/Not vacc + TetProne/HRWound = -bVacc + Tet Ig ______________ Hep B - risk of needlestick transmission -20-30 % look at source - HBsAg Pos+ OR unknown? 1. HBsAg Pos+ : known responder = booster non-responder/being vacc: -HBIg + vaccine 2. Unknown source: -known responders = booster -non-responders = HBIg + vaccine -being vacc = accHBV vaccine _________________ Rabies: Animal in UK - NO risk = -WASH + ?CoAmox Animal bite elsewhere - HR = - WASH + ... - Already immunised: 2 vaccines - NotPrevImmunised: HRIg+FullCourse
30
Enlarged kidneys ax? G+ Bacilli? G+ Cocci G- Bacilli G- Cocci ___________ ABx affecting: FA synth = ? -SEs? ___________ Cell-wall synth: A-PeptidoGlyc synth: ? B-PeptidoGlyc cross-link ? 1. Beta-lactam SENS: ? 2. Beta-lactam RESIST: ? ___________ 30s ribosome = ? + SEs? 50s ribosomes = CCML? Gyrase = ? + SEs? mRNA synth ? DNA integrity?
Enlarged kidneys: PKD, HIV, Amyloidosis, DM G+ Bacilli? - Bacillus cereus - C.diff - Gardenella - List/ LactoBacillus/ TB G+ Cocci - Aureus - StaphyloCOCCUS - StreptoCOCCUS - EnteroCOCCUS G- Bacilli -Errrrrything else G- Cocci -Moraxella -Neisseria Men/Gon ___________ ABx affecting: FA synth = TMP SMX -Hematopoesis, Itch, PS -RTA 4 - resistance ___________ Cell-wall synth A-peptidoglyc synth: Vanc/Bacitracin B-peptidoglyc cross-link: Penicillins/Cephalos/Carbepenems: 1. Beta-lactam SENS: PMP-V, BenPenG, Amox 2. Beta-lactam RESIST: Fluclox #cholestasis ___________ ``` 30s ribosome = Aminoglycosides + Tetracyclines -Aminoglyc = Oto/Nephro toxics -Tetracyclines: PS, Oesophagitis, IIHTN, Not <12yrs Teeth discolour ``` ``` 50s ribosomes = Chloramp = Aplastic Anemia Clinda - C.diff Macrolide - P450i, long QT, Nausea Lizenolid ``` Gyrase = Quiolones P450i Seizure threshold lower Tendon dx mRNA synth: -Rifampicin DNA integrity - metronidazole = Alco rxn
31
Hep A tx? ____________ General Mx 4 hep b/c? Specific Hep B tx? Specific Hep C Ix? Tx? - Acute? - Chronic?
Hep A tx? -nothing -> f/u/2w LFTs/3m ____________ General Mx 4 hep b/c? Refer: -Gastro, -GUM 4 Sex-screen, -PHE=Cont-Trace Bloods + AFP-HCC Specific Hep B tx? -Peg IFN alpha > tenof/entac Specific Hep C Ix? Tx? - Acute? - 15-45% ppl resolve in 6m - Chronic? - DAAS=Direct-Acting AntiviralS
32
Latent TB screening? -> Tests? -> Tx?
Latent TB screening: - New NHS employees - IC / Immigrants - Contact w/ pul/laryngeal TB pt - CXR=TB scarring/Untx fibrotic changes -> Mantoux/IGRA -> - RIpyridox 3m @34/-/high LFTs - Ipyridox 6m @IC
33
Active TB: Ix? Tx: -? -> ? #?m-RIp #?m @TB-men -DOT @?
Active TB: Ix: - CXR - 3-sputum-MCS Tx: -2m RIpPE -> 4m RIp #6m-RIp #10m @TB-men -DOT @Homeless/Non-compliant/Prisoner