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Drugs SEs Flashcards

1
Q 
CCB:
@HF/ObstOutflow 
-?
1. RL ?
2. DHP ?

Angina drug SEs = ?/?:

-? constipation/ankle swell

-?
Inc HA / HR-RR / Tolerance ; LowBP

-?=Inhibit ?
EyeSyx

-? - Inc QT, CCF, Under ?kg

-? - Anal ulcers
Sildenafil-HypoTN_HF=CI
_______

GTN SEs
-Hypotension + tachycardia + headache

A 
CCB:
@HF/ObstOutflow 
-Bblock>(DHP>RL) both still bad
1. RL 
[Verap-constip/Dilit]=[Dec HR/Contractility] -->
CI = 
-HB / HF/OverloadObstruction 
-HRlow/AF AFlutter/SickSinus
  1. DHP SA=reflex tachy*/LA-amlodipine
    * Airway suction @neonates = reflex bradycardia

Angina drug SEs = HA/Flushing:

-CCB constipation/ankle swell

-LAN IMononitrate-SR:
Inc HA / HR-RR / Tol ; LowBP

-Ivabradine=InhibitFunnyChannels
EyeVabradine

-Nolazine - Inc QT, CCF, Under 60kg

-Korandil - Anal ulcers
Sildenafil-HypoTN_HF=CI
_______

GTN SEs
-Hypotension + TACHY + headache

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2
Q

P- IMP -R/C
O- c>d -DMPH

PONV ?
______________

ICP high
Motion-labrynthine / MECH Bowel Obst
Preg

RT/Cancer = ?
______________

Cytotoxics - ?

Opiod - ?
______________

OCDMPH?

what for high ICP?
what for metabolic stuff = high Ca / RF?
Funct V Mechan Bowel Obst?

A

PONV - Ondan5HT3/Ginger
@Medulla
______________

ICP high
Motion-labrynthine / MECH Bowel Obst
Preg
-AntiHist > DopBlock

RT/Cancer = DopBlock
_______________

Ondan5HT=CYTOTOXICS=DopBlock

  • Nabilone=cannabinoid
  • Rolapitant-NK1 blocker

Opiod - OCD
-Ondan5HT/Antihis/DopBlocker
-ChemoreceptorTrigger zone - CT-zone
________________

Ondan5HTron - 5HeroTotinin3 blocker
-medulla

CycliZINE - antihistaMINE
-ZINES - promethazine NOT prochlorperazine
FOR HIGH ICP!!!!!!!!!!!

DopBlockr: Domp
MetocloProkinetic
Prochlorperazine
Haloperidol - METABOLIC stuff ?highCa/RF

Funct - metoclop / Mech - Cyclizine

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3
Q

Osmo - give 3
-@stool ?

Stim: give 3
-@stool ?

Softener ?

Co-danthramer = ??

Which laxative stains WEE red?

What to give in anorexia/reduced appetite? #cancerpts

A

Osmo:

  • @stool HARD - to put water in it
  • Macrogol=Movicol/Laxido
  • Lactulose
  • Phosphate enema

Stim: Senna, Glyc supp, Picosulfate
-@stool soft

Softener - docusate

Co-danthramer = osmo/senna = stains urine RED!!

PREDNISOLONE!

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4
Q

Depression @

  • obese pt
  • not respond to SSRI
  • least drug interactions
A

Depression @

  • obese pt = fluoxetine
  • not respond to SSRI - venlafaxine
  • least drug interactions - citalopram
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5
Q 
Anti Diabetics:
Which causes SIADH?
Which causes Hypos?
Which causes cholestasis?
Which causes weight gain?

Which causes fluid retention?
Which causes bladder cancer?

Which causes pemphigoid?!

What to give to DM + Fat ppl?
-Gliptins/Flozins

Metformin
Pioglitazone - ThioZolid
Sulfonylureas
SGLTFlozin
GlipDD4i
GLP-1 agonists
A

SUs

Pioglit

GlipDD4tins pemphigoid

What to give to DM + Fat ppl?
-Gliptins/Flozins

MetAMPK = biguanide 
- GFR<45 = reduce dose, stop @<30
Inc Peripheral util of BM
Inc insulin sensitivity
Dec GlucoNeoGenesis
Pio-PPARalphaAgonist-Periph resistance:
-BF-BOI
BMI + ?LFT
Fluid retention
Bladder Ca
OP risk + Hb low
Insulin sensitivity

SU=insulin=Stim Beta-islets

  • close Katp = Inc Ca -> depol
  • high BMI + ALT = Cholestasis
  • low BM + Na = SIADHypo

SGLTFlozin = reduce PCT BM absorption
-Fourniere’s, UTI, DKA

GlipDD4i:

  • Dec Glucagon,
  • Inc Incretins (GIP/GLP) = satiety feel full -> eat less so WL
  • Pancreatitis/Pemphigoid bullous

GLP-1 agonists:

  • meal/high BM -Lcell @bowel->
  • GLP-1 release -incretin effect->
  • Dec Glucagon/Gastric-empty/appetite
  • Inc Insulin
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6
Q 
DM+CVD = ?Atorva
DM-CVD = ?Atorva*

*20 Atorva @DM1/DM2:
-DM1:
CAND MTRM
___________

-DM2**:
8? y/o INDGP

Multiple BBdaily -fail-> ?
NPH - SA @HbA1c ?/+

A 
DM+CVD = 80 Atorva
DM-CVD = 20 Atorva*

*20 Atorva @DM1/DM2:
-DM1:
CVD established
Age >40
Nephropathy
DM >10yrs

Inuslin:
Multiple BBdaily -fail-> cont SC @12+ y/o
Twice daily Detemir basal
RA b4 meals
Metformin @BMI 25/+
\_\_\_\_\_\_\_\_\_\_\_

-DM2**:
84/- + Q10+
85/+

Insulin:
NPH - SA @HbA1c 75/+
Detemir
Glargine
Pre-mixed w/ SA
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7
Q

MTX

Leflunamide

Sulfasalazine

HOHchloroquine hydroxychloroquine

Penicllamine/gold

A 
MTX
Mucositis
MyeLosupp
       LF/Lung dx
FA 1/wk IM/PO - @diff-times
Avoid Trimeth

Leflunamide
LF + HTN
Lung dx

SulfaSperm motility
         SJS-rash
Heinz body Hb low 
Avoid Asp/Sulfonamides
Lung dx

HOHchloroquine - eyes

Penicllamine/gold
ProtUria |-> MGravis

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8
Q

Which TB drug? Mechanism?
-flu-like / orange secretions

  • B3Pellagra=Dementia/Diarrhoea/Dermatitis
  • AGRANulocytosis
  • Neuroooooopathy=GBS
  • SL3-histone Antibody

Gout/Arthralgia

OpticNeuritis

-Isonozid causes most of the shit basically #BANS

A

RIPE-RMFA
-RNA polym, Mycolic acid, FA, Arab-transferase

Rifamp = stop RNA polym -> stop mRNA synth
-flu-like / orange secretions

Isonoazid (+ Pyridox) = Mycolic Acid synth stop

  • B3Pellagra=Dementia/Diarrhoea/Dermatitis
  • Agranulocytosis
  • Neuropathy=GBS
  • SL3-histone

Pyridox = stop FA synth
Gout/Arthralgia

Ethambutol - Eye dx #OpticNeuritis
-stop arab-transferase

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9
Q

Parasaitemia = 999+PHE:

> 2% - severe/cx?

> 10% ?

<2% non-severe/UnCx:
-?* > ?

ACT =

  • ?
  • ?

Non-falciparum
-?

-Tx vivax/ovale -> dormant HYPNOZOITES @Liver?

Avoid what drugs with following:

  • HA - ?
  • Seizures - ?
  • GI dx - ?
  • Folate dx - ?
  • Psych dx - ?
A

Parasaitemia = 999+PHE:

> 2% - severe/cx
-IV Artesunate > Quinine

> 10% - exchange transfusion

<2% non-severe/UnCx:
-ACT* >
Atovaquone-proguanil
Doxy-Quinine

ACT = AL-ArM:

  • ArteMether+Lume
  • ARteSunate+Mefloquine

Non-falciparum
-oral ACT / Chloroquine

-Tx vivax/ovale -> dormant HYPNOZOITES @Liver?
Primaquine-G6PD beware

Avoid what drugs with following:

  • HA - chloroquine
  • Seizures - Chloroquine/Mefloquine
  • GI dx - proguanil
  • Folate dx - proguanil
  • Psych dx - Mefloquine
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10
Q

Random shit

Viagra CI - MiNiS

Avoid what drug at Azo? - ?

aHTN drug -> impotence ?

Amiodarone 4 things?

A

Random shit

Viagra CI:
MI, Nitrates/Nikorandil, Stroke

Avoid what drug at Azo? - Allopurinol

aHTN drug -> impotence #Thiazide

Amiodarone:
pul fibrosis, corneal deposits, grey-man, LF

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11
Q

TICS MATCH RALPH FBD-apo
1. Microcytic:

  1. Normocytic:
  2. Macrocytic:
    Non-megalo?

Megalo?

P450 inducers = INR low or high?

P450 inhibitors - INR low or high?

A

TICS MATCH RALPH FBD

  1. Microcytic:
    - Thalassaemia, Iron Def, ChrDx, Sidero
  2. Normocytic:
    - Marrow dx
    - Acute blood loss
    - Thyroid LOW
    - ChrDx early / CKD
    - Hemolytic
3. Macrocytic:
Non-megalo = NOOOO hypersegmented 
Neutrophils 
-Myelo-prolif/dysp/mm
-Reticulocytosis
-Alco XS - GGT CDT high MCV
-LF
-Preg
-HypoT

Megalo = hypersegmented neutrophils
-Folate, B12, Drugs (allop/phenyt/OHcarbimide)

P450 inducers = INR low

  • Phenytoin
  • Carbemazapine
  • Barbituates
  • Rifampicin
  • Alco
  • SUs

P450 inhibitors - INR HIGH

  • PPI/grapefruit
  • LF
  • Allopurinol
  • NSAID
  • Cranberry
  • DISULFIRAM
  • Erythromycin
  • Valproate
  • Isoniazid
  • Cipro/Ketocon
  • Ethanol
  • Sulfonamides
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12
Q

Organophosphates
Heparin

Ethylene glycol*
Methanol*

Salicylates
Lithium* tremor HYPERreflexia ataxia

TCA-wide QRS, tachy
Cyanide*

Digoxin: bradycardia, reverse tick t-wave inversion, eye syx green/yellow vision
Lead/Arsenic*

A

Organophosphates - atropine
Heparin - protamine sulfate

Ethylene glycol - Fomepizole/ Ethanol / Dialysis
Methanol - Fomepizole>Ethanol / Dialysis

Salicylates - IV Bicarb/dialysis
Lithium - IVF/dialysis

TCA - IV Bicarb
Cyanide - OH-cobalamin

Digoxin - Dig-specific Antibodies
Lead/Arsenic*- dimercaperol / edetate

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13
Q

Parkinson’s tx?

A

Levo/carbi

  • Motor improve/cx increase
  • ADLs improve
  • Adverse rxns decrease (hallucinations/impulse/sleep)
  • Time inc = effectiveness decrease

AMANTADINE/DBS
Selegeline MAOi - Tyramine foods, Off-time
Entacapone - COMTi - off-time reduce
Ropinirole/CabergolineCardiacFibrosis - hallucinations/impulse/sleep
DBS

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14
Q

Codeine to PO morphine

PO morphine = to…

SC moprhine /?
OXYCOD PO /?

SC diamorphine /?
IV moprhine /?

OXYCOD SC /?

Alcohol units?

A

Codeine to PO morphine /10

PO morphine = to…

SC moprhine /2
OXYCOD PO /2

SC diamorphine/3
IV moprhine /3

OXYCOD SC /4

Alcohol units:
-%.mls / 1000

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15
Q

Statins SEs

If cancer causing nerve compression, what give??
________

POP cons: i-WOAH

  1. Irreg periods,
  2. Weight gain, Obesity, Acne, Headache

Depot cons:

  • delayed return 2 fertility
  • obesity
  • BMD low

HRT cons
-Breast/Endomet/VTE/incFIBROIDsize

Tamoxifen cons?
LF/Hypertriglyc, Endomet dx, VTE

A

Myositis
Gallstones/Pancreatitis
LFTs dx
Interstitial Lung Dx

Cancer nerve compression = DEXAMETHASONE!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
_________________

POP cons: i-WOAH

  1. Irreg periods,
  2. Weight gain, Obesity, Acne, Headache

Depot cons:

  • delayed return 2 fertility
  • obesity
  • BMD low

HRT cons
-Breast/Endomet/VTE/incFIBROIDsize

Tamoxifen cons?
LF/Hypertriglyc, Endomet dx, VTE

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16
Q

Preg:

ACEi ?

Cocaine ?

Valproate/Carbemaz = ?
-? MOST teratogenic

Phenytoin = ?
-? MOST teratogenic

Warfarin courmarins = ?

Di-Ethyl-Stil-BESTROL @mum = ?

Isotret = ?

Misoprostol = ?

Thalidomide - ?

A

Preg:

ACEi = iuGR, iuRenal-Insuff, Oligohydramnios

Cocaine = Small brain, Limb dx, Urine-tract dx

  • mum = PreEcl / Pl.Abruption
  • kid = Prem / Abstinence-syndrome

Valproate/Carbemaz = NTDs

  • valproate MOST teratogenic
  • heart dx

Phenytoin = Hydantoin Syndrome = craniofacial dx
-valproate MOST teratogenic

Warfarin courmarins = skeletal dx

Di-Ethyl-Stil-BESTROL @mum = vaginal adenocarcinoma in kid 14 yrs later

Isotret = CNS/Craniofacial/Cardiac dx

Misoprostol = Moebius Syndrome - cranial nerve dx

Thalidomide - limb dx

17
Q

ACAG / POAG tx

A

Mydriatics

  • AntiMuscs = CycloPlegicPentate / Atropine
  • Adr = PhenylEphrine
  • ->

Surg: Laser Iridotomy / Trabeculo -plasty -ectomy -shunt
Meds: ALBAMA

AIM = Inc UveoScleralFlow + Lower Aqueous Production

-Lantoprost = Inc USF #BrownPigmentation #Blepharitis #LashLengthen
-Beta-Timolol - Lower AP - Asthma/HB CI
_________
Alpha AGONIST - Brimonidine = FOVL / Inflamm - itch/Red / TCA-MAOi CI
-inc USF + lower AP

Musc AGONIST - Pilocarpine = HA / Blurry / Ciliary Constriction Spasm
-inc USF
_________________
-Acetazmol - lower AP = sulfa-like rxns

18
Q 
MetAMPK = biguanide 
- GFR< ? = reduce dose, stop @< ?
Inc Peripheral util of ?
Inc insulin ?
Dec ?
\_\_\_\_\_\_\_\_

Pio-PPARalphaAgonist- ?

SU=insulin=Stim Beta-islets
-close Katp = Inc Ca -> depol
________
For the fat people:

SGLTFlozin = ?

GlipDD4i:
-Dec ?,
-Inc ? (GIP/GLP) = satiety feel ? -> eat less so ?
________

GLP-1 agonists:

  • meal/high BM -?cell @?->
  • GLP-1 release -? effect->

-Dec Glucagon/ Inc Insulin
-Dec Gastric-empty/ Appetite
____________
____________
____________
____________

Lactic Acidosis/ GI Dx
________

BMI incr + ?LFT fuck up
Fluid retention
Bladder Ca

OP risk + Anaemia Hb low

-high BMI + ALT = Cholestasis
-low BM + Na = SIADHypo
________
For the fat people:

  • Fourniere’s, UTI, DKA, WLoss
  • Pancreatitis/ Pemphigoid bullous
A 
MetAMPK = biguanide 
- GFR<45 = reduce dose, stop @<30
Inc Peripheral util of BM
Inc insulin sensitivity
Dec GlucoNeoGenesis

Pio-PPARalphaAgonist-Periph resistance Reduce

SU=insulin=Stim Beta-islets
-close Katp = Inc Ca -> depol

SGLTFlozin = reduce PCT BM absorption

GlipDD4i:

  • Dec Glucagon,
  • Inc Incretins (GIP/GLP) = satiety feel full -> eat less so WL

GLP-1 agonists:

  • meal/high BM -Lcell @bowel->
  • GLP-1 release -incretin effect->

-Dec Glucagon/Gastric-empty/appetite
-Inc Insulin
____________
____________
____________
____________

Lactic Acidosis/ GI Dx = Metformin
________

BMI incr + ?LFT fuck up
Fluid retention
Bladder Ca
-Pio-ThioZolid

OP risk + Anaemia Hb low = Pio-ThioZolid

-high BMI + ALT = Cholestasis
-low BM + Na = SIADHypo
—–SulfonylUreas
________
For the fat people:

  • Fourniere’s, UTI, DKA, WLoss = SGLTFlozin
  • Pancreatitis/Pemphigoid bullous = GlipDPPtins

GI (22 decks)

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