Peds Heme/Onc Flashcards
Neutrophilia with lots of bands (>700)
neonatal sepsis
kidney disease associated with HIV
FSGS - most common nephrotic syndrome in adults
Hep B kidney disease
Membranous nephropathy (nephrotic)
pre-adolescent kidney disease
minimal change disease
PSGN
nephritic
Blood transufsions what electrolyte abnormality
Fe overload
Reticulocyclopenia
from what infx
sudden arrest of erythropoesis
parvo B19
Hemophilia A &B inheritance patten
X-linked recessive
usually males
Parvo risk in sickle cell
aplastic anemia
Shield Chest
Diamond Blackfan,
Noonan
Turner Syndrome
ITP tx
glucocorticoids or IVIG
Wiskott Aldrich triad
X-linked disorder with
- thrombocytopenia
- eczema
- recurrent bacterial infx
ALL
Hepatospleenomegally
lymphadenopathy
petichiae
nasal obstruction with visible mass
bony errosion
epistaxis
Juvenile angiofibroma
Juvenile angiofibroma
nasal obstruction with visible mass
bony errosion
epistaxis
renal failure
hemolytic anemia
thrombocytopenia
s/p diarrhea
Hemolytic Anemia
Diamond Blackfan anemia vs. Megaloblastic
Both are Macrocytic
Diamond Blackfan results in no hypersegmentation of nucleus in neutrophils
Macrocytic Anemia with Congenital anomalies and low retic count
Diamond Blackfan anemia
Diamond Blackfan anemia tx
corticosteroids/ transfusions
Wiskott-Aldrich inheritence
X-linked
Eczema
Low Platelets
Hypgammaglobulinemia
Wiskott-Aldrich
Red Cell Aplasia
Transient Erythroblastopenia
Pancytopenia and Macrocytosis and
Cafe Au Lait spots, microcephaly, horshoe kidneys, no thumbs (not triphalangeal thumbs)
Fanconis
Fanconis
Pancytopenia and Macrocytosis and
Cafe Au Lait spots, microcephaly, horshoe kidneys, no thumbs (not triphalangeal thumbs)
Fanconi’s age
8 years
Diamond Blackfan anomalies
Sheild Chest, Triphalangeal thumbs, short with webbed neck and cleft lip
Heinz bodies
hemoglobin precipitates… found in G6PD deficiency
low Retic
Fe def, B12 def, chemo, infx, aplastic anemia
neonatal polycythemia
delayed clamping of umbilical cord
May cause respiratory distress, hypoglycemia
Hct>65%
Leukocytosis
Anemia
Thrombocytopenia
ALL
Pain insidious and worse at night
Pancytopenia after drugs or toxin exposure or viral infections
Aplastic Anemia
anemia hyperpigmentation on trunk and intertrigenous areas cafe au lait short stature hypogonads renal changes eyelid changes
Fanconis
Thrombocytopenia is first then neutropenia then anemia
Diamond Blackfan age
first 3 months of life
Transient Erythroblastopenia of Childhood (TEC)
acquired aplastic anemia
gradual pallor and tachycardia
normocytic normochromic anemia
prolonged aPTT but not PT in newborn
Factor 8 def (similar to vWD)
mucocutaneous bleeding
petechiae
normal PT, normal aPTT
uremia
aspirin/clopidogrel
Glanzmann throbasthenia congenital disorder
MCC inherited bleeding d/o
von Willebrand dz
may present similar to Factor 8 def
prolonged PT and aPTT in newborn
think Vitamin K def
hypochromic microcytic anemia with family hx
Alpha Thal
hypochromic microcytic anemia from 6-12 months
Beta Thal
Hemophilia A
Factor 8
Hemophilia B
Factor 9
Fe deficiency vs. spherocytosis
Fe deficiency has increased RDW
vitamin K clotting factors
2, 7, 9, 10, Protein C, Protein S
how to diagnose ALL
bone marrow biopsy
Anisocytosis
red blood cells of different size common in Fe def. anemia
what is normal level of reticulocytes
0.5% - 1.5%
low retic vs. high retic
low retic = leukemia or infection or aplastic anemia
high retic = hemolysis or maybe hemorrhage