Pediatrics Flash Cards - Case 8 - NN Jaundice

Question 1

Crigler-Najjar and Gilbert’s are both caused by

Answer 1

deficient UDP-glucuronyl-transferase deficiency, w/ Gilbert’s being much milder

Question 2

Crigler-Najjar and Gilbert’s both caused (unconj)(conj)hyperbili?

Answer 2

unconj

Question 3

Dubin-Johnson and Rotor are caused by ? and result in?

Answer 3

deficient MRP2 proteins -> slowed dumping of conjbili into bile -> thus end up w/ conj hyperbili

Question 4

Breastfed infants may lose up to ??% of their birth weight during the first ?? days of life and typically regain birth weight by at least ?? age.

Answer 4

7%-10% ; the first 4 to 5 days of life ; at least 2 weeks of age.

Question 5

Kasai procedure?

Answer 5

tx for biliary atresia

Question 6

Voiding frequency over time in infants?

Answer 6

3-4 times a day by the third day, and at least 6-8 times a day by the sixth day

Question 7

By the 6th or 7th day, most newborns have ? to ? stools per day, although many infants pass stool with every feeding.

Answer 7

3 to 4

Question 8

Facial jaundice means bili of at least?

Answer 8

4-5 mg/dL (68-86 μmol/L)

Question 9

When jaundice has progressed from the head all the way down to the inferior aspect of the knees bili is appx?

Answer 9

10-15 mg/dL (171-257 μmol/L)

Question 10

Baby of Mediterraean descent think?

Answer 10

G6PD deficiency

Question 11

Breastfeeding jaundice vs. breastmilk jaundice?

Answer 11

breastfeeding jaundice presents 1st WoL in NN w/ poor PO intake -> incr enterohepatic circ -> jaundice; breast-milk jaundice occurs in infants feeding well and starts on days 4-7 may not peak ‘til 10-14, cause??, maybe inhib subs in milk -> incr enterhep circ

Question 12

Physiologic jaundice appears on which days?

Answer 12

3 or 4

Question 13

Direct bilirubin measures?

Answer 13

unconjugated bilirubin

Question 14

Indirect bilirubin measures?

Answer 14

conjugated