Pediatric PK/PD- Elimination Flashcards by Kim Nguyen

Q

Major organ of elimination for drugs and metabolites

A

Kidneys

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Q

Renal blood flow in infants vs. adults

A

5% of cardiac output at birth vs. 15% in adults

(Decreased in the beginning)

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Q

GFR in kids

A

Doubles during the first 2 weeks of life, then reaches adult capacity by 1-2 years

(Decreased GFR in the beginning)

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Q

Tubular secretion in kids

A

20% of adult capacity at birth, reaches adult values at 12 months

(Decreased in the beginning)

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Q

Effects of elimination in kids on drug dosing: CL

A

Slower CL

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Q

Effects of elimination in kids on drug dosing: half-life

A

Longer 1/2 life

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Q

Effects of elimination in kids on drug dosing: in general

A

Less frequent dosing is required

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