PE 3 Flashcards

1
Q

What is the first step in research projects involving humans?

A

Composing a clear and detailed definition of the study population.

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2
Q

What is the ‘population of interest’ in a study?

A

The group of people or entities that the study is focusing on.

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3
Q

What are some limits for individuals in the population of interest?

A
  • Where they live
  • Their race/ethnicity
  • How old they are
  • Their gender
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4
Q

What is the ‘target population’?

A

A specific group of people or entities that can take part in a study.

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5
Q

What is a ‘sampling frame’?

A

The set of units from which the sample is drawn, operationalized representation of the target population.

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6
Q

Why is it important for the sampling frame to contain an adequate number of units?

A

To enable the collection of an entire information set, which is vital for study accuracy.

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7
Q

What is the purpose of probability sampling methods?

A

To ensure equal chances of selection through random selection.

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8
Q

What is simple random sampling?

A

A method where every member of a group has the same chance of being chosen.

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9
Q

What does stratified random sampling involve?

A

Dividing the population into subgroups based on characteristics and selecting samples from each stratum proportionally.

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10
Q

What is cluster sampling?

A

A sampling method where the population is split into smaller groups, and a sample is taken from these clusters.

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11
Q

What is single-stage cluster sampling?

A

Each unit of selected clusters is picked as a sample.

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12
Q

What distinguishes double-stage cluster sampling?

A

Data is collected from a random subsample of individual units within selected clusters.

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13
Q

What is multi-stage cluster sampling?

A

Sampling method that involves multiple sampling steps to gather enough samples.

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14
Q

What is two-phase sampling?

A

A method where a sample is first selected for auxiliary information and then a second sample is selected for the variable of interest.

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15
Q

What is convenience sampling?

A

A method where the researcher selects individuals who are most convenient to contact.

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16
Q

What is purposive sampling?

A

Choosing individuals purposefully based on specific traits or qualities.

17
Q

What is quota sampling?

A

Dividing individuals according to criteria and setting goals for how many from each group to include.

18
Q

What is snowball sampling?

A

Participants are asked to refer others they know to participate in the study.

19
Q

What is volunteer sampling?

A

Individuals who willingly participate in a study are selected.

20
Q

What five variables should be considered when calculating sample size for cohort studies?

A
  • Alpha (type I error)
  • Beta (type II error)
  • The minimum effect size
  • The expected incidence of the outcome in the unexposed group
  • The number of unexposed control subjects per exposed subject
21
Q

What is alpha (α) in the context of sample size calculations?

A

The probability of concluding there is a difference between groups when no difference exists (type I error).

22
Q

What does beta (β) represent in sample size calculations?

A

The probability of concluding there is no difference between groups when a difference does exist (type II error).

23
Q

What is the minimum effect size in cohort studies expressed as?

A

Relative risk.

24
Q

What is the expected incidence of the outcome of interest in the unexposed control group?

A

The occurrence rate of the outcome in the control group that is not exposed.

25
Q

What is the significance of having equal numbers of exposed and unexposed subjects?

A

It provides the most statistical power for the study.

26
Q

What is a key distinction between case-control and cohort studies?

A

Case-control studies select subjects based on the presence or absence of the disease, while cohort studies select based on exposure.

27
Q

What is the expected prevalence of exposure control in a case-control study?

A

It refers to the prevalence of exposure in the un-diseased control group.

28
Q

What is an example of a study that utilized a case series?

A

The Phase IV post-marketing study for prazosin involving 10,000 newly exposed subjects.