PBL, TBL, HS, LM, MDM, and HQPS Flashcards

1
Q

five stages of readiness to change

A

pre-contemplation, contemplation, preparation, action, and maintenance

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2
Q

four of the most useful processves of change

A

consciousness raising, environmental reevaluation, helping relationships, self-reevaluation

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3
Q

Health Belief Model

A

the principle that health behavior change is a function of the individual’s perceptions regarding his or her vulnerability to illness and perceived effectiveness of treatment

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4
Q

Self-Determination and Motivational INterviewing

A

people are motivated to act by very different types of factors, either because thye value a particular activity (internal motivation) or because there is strong external coercion (external motivation)

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5
Q

sequence that all behaviors pass through

A

control by others, control by self, and automatization

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6
Q

four general principles of MI to explore resolve ambivalence

A

express empathy, develop discrepancy, support self-efficacy, and roll with resistance

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7
Q

behavioral gap

A

the importance of change and the distance a patient’s behavior would need to travel in order to reach the desired level

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8
Q

social cognitive theory/ecological models

A

emphasizes the interactions between the person and his or her environment

behavior is a function of aspects of both the environment and the person, all of which is in constant reciprocal interaction

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9
Q

two central concepts of social learning theory

A

self-efficacy - patient’s belief to in his or her ability to change or maintain a specific behavior under a variety of circumstances

outcome expectations - the degree to which a patient believes that a given course of action will lead to a particular outcome

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10
Q

theory of planned behavior

A

the intention to act is guided by three belief considerations - behavioral beliefs, normative beliefs, and control beliefs

behavioral chagne is always immediately preceded by intetnion as well as perceived and actual control

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11
Q

behavioral belief

A

the patient’s perceived outcomes and attitudes toward engaging in the behavior

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12
Q

normative beliefs

A

the subjective norms or pressure of others in the family or community regarding the behavioral change

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13
Q

control beliefs

A

the presence of factors that may facilitate or iumpede performance of the behavior and the perceived power of these factors

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14
Q

cognitive behavioral therapy

A

focuses on short-term, problem-oriented tratements that address the present and future

primary goal is cognitive change, paying attention to inner thoughts, attitudes, and emotions as well as the events that both trigger and result from our actions

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15
Q

three key traditional cognitive behavior therapy techniques for treating patients with obesity

A

self-monitoring - recording behavior

stimulus control - avoiding behavior or thoughts that incite a behavior

cognitive restructuring - change internal dialogue and be more aware of distructive or distorted thoughts and beliefs

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16
Q

three content areas of HS

A

personal health, population health, and global health

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17
Q

five determinants of health

A

socail environment, individual behavior, biology and genetics, health services, physical environment

HS covers everything except biology and genetics

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18
Q

barriers to accessing health services

A

lack of availability

high cost

lack of insurance coverage

limited language access

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19
Q

non-communicable diseases

A

cardiovascular diseases

chronic respiratory disease

diabetes

boesity

cancer

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20
Q

calculation of LDL cholesterol

A

LDL = Total cholesterol - (HDL + triglycerides/5)

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21
Q

HbA1C

A

correlates with blood glucose levels, monitors long-term blood glucose levels

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22
Q

blood cholesterol measurements

A

less than 200 - desirable

200-239 - borderline high

>= 240 - high

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23
Q

LDL choleserol level

A

less than 100 - optimal

100-129 - near optimal

130-159 - borderline high

160-189 - high

>=190 - very high

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24
Q

triglyceride level

A

less than 150 - normal

150 - 199 - borderline-high

200-499 - high

>= 500 - very high

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25
Q

glucose levels

A

51-99 - normal

100-125 - pre-diabetes

>= 126 - diabetes

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26
Q

HbA1c levels

A
  1. 0-5.6 - normal
  2. 7-6.4 - pre-diabetes

>=6.5 - diabetes

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27
Q

What is social medicine?

A

seeks to understand individual clinical problems in a social context and to improve health at multiple levels:

clinical care

community outreach

research and advocacy

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28
Q

social determinants of health

A

The social determinants of health are the conditions in which people are born, grow, live, work and age, including the health system. These circumstances are shaped by the distribution of money, power and resources at global, national and local levels, which are themselves influenced by policy choices.

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29
Q

public health

A

Health-activities that society undertakes to ensure the conditions in which people can be healthy. These include organized community efforts to prevent, identify and counter threats to the health of the public.

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30
Q

population health

A

the physical, mental, and social well-being of defined groups of individuals and the differences or disparities in health between and among population groups

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31
Q

global health

A

the area of study, research and practice that places a priority on improving health and achieving equity in health for all people worldwide

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32
Q

epidemiology

A

study of risk factors and causes of health problems

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33
Q

upstream determinants

A

those that occur at the macro level and include global forces and government policies

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34
Q

midstream determinants

A

intermediate factors such as health behaviors

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35
Q

downstream determinants

A

occur at micro level and include one’s genetics

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36
Q

prevalence

A

proportion of a given disease or condition in a population at a snap shot in time (cross-section)

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37
Q

incidence

A

number of new diagnoses of a disease or condition that develop over time in a population (rate)

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38
Q

cumulative incidence

A

accumulated number of events in a population in a fixed time: good for short and consistent follow-up time

25 events out of 108 students with normal baseline BP: 25/108 = 23% phase I CUMULATIVE incidence

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39
Q

incidence rate

A

number of events per person-years of follow-up time: good for long and variable follow-up time

25 events per (108 students x 20 months of phase I = 2,160 person-months or 180 person-years), which is 14 per 100 person-years incidence RATE

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40
Q

PDSA cycle

A

PLAN - the change to be tested or implemented

DO - carry out the test or change

STUDY - data before and after the change and relfect on what was learned

ACT - plan the next change cycle or full implementation

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41
Q

Heisenberg Principle

A

The very act of observing a phenomenon alters that phenomenon in some way

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42
Q

Hawthorne Effect

A

The tendency of some people to work harder and perform better when they are observed

Individuals may change their behavior due to the attention they are receiving

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43
Q

Developing Goals - SMART

A
  • S Specific: choose one specific behavior modifier per goal to work on
  • M Measurable: Can you measure this against a baseline?
  • A Attainable or Action Based behavior: Is the goal attainable? Use action words when writing goals such as “I will” or “I do”, rather than “try, should, would, could.”
  • R Realistic: Do you have honest and realistic expectations of yourself with your time, body, likes/dislikes?
  • T Timely: is the time allotted reasonable and manageable for you right now?
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44
Q

Health Equity

A

depends vitally on the empowerment of individuals to challenge and change unfair and steeply graded distribution of social resources to which everyone has equal claims and rights

inequity in power interacts across four main dimensions - political, eocnomic, social, and cultural - atogether constituting a continuum along which groups are to a varying degree excluded or included

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45
Q

cultural competence

A

implies having the capacity to function effectively as an individual and an organization within the context of the cultural beliefs, behaviors, and needs presented by consumers and their communities

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46
Q

cultural knowledge

A

familiarization with selected cultural characteristics, history, values, belief systems and behaviors of the members of another ethnic group

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47
Q

cultural awareness

A

developing sensitivity and understanding of another ethnic group. This usually involves internal changes in terms of attitudes and values. Awareness and sensitivity also refer to the qualities of openness and flexibility that people develop in relation to others

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48
Q

cultural sensitivity

A

knowing that cultural differences as well as similarities exist, without assigning values, i.e better or worse, right or wrong, to those cultural differences

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49
Q

reccommended daily nutrition intake

A

less than 2,300mg of salt

10% of calories from saturated fatty acids

less than 300mg of dietary cholesterol

reduce sugar and fat intake

limit refined grains

no more than two drinks per day

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50
Q

food desert

A

areas that lack access to affordable fruits, vegetables, whole grains, lowfat milk, and other foods that make up the full range of a healthy diet

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51
Q

food security

A

high food security - no reported indications of food-access problems or limitations

marginal food security - anxiety over food sufficiency or shortage of food in teh house, little or not indication of changes in diets or food intake

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52
Q

food insecurity

A

low food security - reports of reduced quality, variety, or desirability of diet, little or no indication of reduced food intake

very low food security - reports of multiple indications of disrupted eating patterns and reduced food intake

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53
Q

WIC

A

women, infants, and children - a federally funded health an dnutrition program for women, infants, and children

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54
Q

SNAP

A

the Supplemental Nutrition Assistance program - helps low-income people and families buy the food they need for good health

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55
Q

Link

A

the Illinois Link card is a plastic card that looks and works like a debit card

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56
Q

NSLP

A

National School Lunch Program - available nationwide for low income children to provide free or reduced cost for lunches depending upon the family income

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57
Q

DRIs

A

Dietary Reference Intakes - reference values used to plan and evaluate diets for healthy populations with an emphasis on prevention of chronic diseases and promotion of optimal health

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58
Q

social-ecological model of influences on health behavior

A
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59
Q

SEGUE

A

Set the stage

Elicit informatin

Give information

Understand patient’s perspective

End the encounter

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60
Q

blood pressure ranges

A

120-139/80-89 prehypertension

140-159/90-99 Stage I Hypertension

>160/>100 Stage II Hypertension

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61
Q

BMI ranges

A

18.5-24.9 healthy weight

25-29.9 overweight

30-34.9 class I obesity

35-39.9 class II obesity

>= 40 class III obesity

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62
Q

normal waist circumference

A

men

women >35 in

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63
Q

OLDCARTS

A

Onset, Location, Duration, Characteristics/quality, Aggravatin/alleviating factors, Radiation, Treatment, Significance

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64
Q

health literacy

A

the degree to which people have the capacity to obtain, process, and understand basic health information and services needed to make appropriate health decisions

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65
Q

past medical history

A

general state of health

childhood diseases

mediucal illnesses

surgeries

gynecological history

psychiatric

hospitalizations

exposes to contageons

immunizations

screetning tests

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66
Q

medications

A

name, strength, dose, frequency

inhalers, birth control, over-th-counter, home remedies, supplements, herbal medications

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67
Q

allergies

A

to medications, foods, inhalants, or skin exposures

record the reaction

68
Q

family history

A

first-degree and second-degree relatives

relationship, age, illness, death

focus on cancer, anemia, peptic ulcer, tb, diabetes, heart attack, hypertension, thyroid disease, kidney disease, osteoporosis, mental illness, allergies, other

69
Q

social history

A

home situation

daily life and activities

support systems

stresses

educational and occupational history

travel history

tobacco

alcohol

drugs

nutrition

physical activity

sexual history

trauma risks

intimate partner violence

70
Q

review of systems

A

general, skin, head, ears, nose, mouth and throat, neck, polmonary, CV, gastro, genitourinary, gynecologic, musculoskeletal, neurologic, psychologic

71
Q

enzymatic defect in Gaucher Disease

A

aced beta-glucosidase (glucocerebrosidase)

acts to cleave glucosyl group, separating it from a ceramide

72
Q

symptoms of Gaucher

A

hepatomegaly and splenomegaly

thrombocytopenia, anemia, leukopenia

bone disease, bone pain (erlenmeyer flask deformity)

73
Q

treatment of Gaucher Disease

A

enzyme replacement therapy

74
Q

Type I Gaucher Disease

A

autosomal recessive, one of the most common

1 in 40,000-60,000 in general population

1/500 in Ashkenazi Jews

75
Q

Orphan Drug Act

A

law passed to promote development of drugs for rare diseases

76
Q

Fabry Disease

A

1 in 40,000 to 1 in 60,000 males

X-linked inheritance

defect in gene that encodes for lysosomal enzyme alpha-galactosidase A

unable to break down lipids, especially bglobotraosyl-ceramide (GL-3)

77
Q

symptoms/pathophysiology of Fabry Disease

A

end-organ damage from GL-3 accumulation

narrowing of blood vessels

accumulation in nerve cells and other tissues

severe episodes of pain

decreased or absent sweating

corneal opacities (verticillata)

angiokeratomas

kidney failure, heart failure, stroke in adults

78
Q

sarcoidosis

A

autoimmunde disease affecting lungs, lymph nodes, joints, kidneys, liver, and heart

prevalence of abou 10-20 per 100,000

difficult to diagnose

79
Q

six aims for improvement in medicine

A

safe, timely, effective, efficient, equitable, patient-centered

80
Q

Levels of System in quality

A
81
Q

implicit and explicit measuring

A

implicit - another professional reviews and makes judgments about the quality of care

explicit - measurement using defined criteria

82
Q

kapp statistic for binary outcome

A

0 = amount of agreement expected by chance

1 = perfect agreement

83
Q

topology of quality measures

A

structures - measure of a static characteristic such as policy or procedure

processes - measurements of what takes place during the delivery of care such as the tratments prescribed or the procedures done

outcomes - measurements of health status or clinical condition, can include costs or reported outcomes of the consumer

84
Q

types of outcomes

A

intermediate, end point, or expenditure

85
Q

barriers to outcome measures

A

remotemenss, relative rarity of end points, confounders

86
Q

adverse event

A

an injury caused by medical management not the disease process that led to a prolonged hospital stay or disability at discharge

87
Q

swiss cheese model

A
88
Q

A complex system exhibits complex interactions when it has:

A

Unfamiliar, unplanned, or unexpected sequences which are not visible or not immediately comprehensible

Design features such as branching, feedback loops

Opportunities for failures to jump across subsystem boundaries.

89
Q

A complex system is tightly coupled when it has:

A

Time-dependent processes which cannot wait

Rigidly ordered processes

Only one path to a successful outcome

Very little slack (requiring precise quantities of specific resources for successful operation)

90
Q

human factors and ergonomics paradigm

A

physical ergonomics - environment, tools, and artifacts

cognitive ergonomics - tasks, people

macro ergonomics - interrelations and organization

91
Q

affordances

A

perceived and actual properties that give an idea how the device might be used

92
Q

mappings

A

connection between what is intended and the means to accomplish it

93
Q

conceptual model

A

mental picture of “how things work”

94
Q

constraints

A

physical/cultural limits to “what can be done”

95
Q

design principles for physical ergonomics

A

importance - more important items should be more accessible

ferquency - more frequently used items should be mroe accessible

function - group components together according to function

sequence of use - group components in “natural” sequence of use

96
Q

design constraints for physical ergonomics

A

clearance - space in and around equipment

reach - frequently used objects should be closer

adjustability - make customization to human variation easy

97
Q

taxonomy of error

A

automatic mode - effortless and rapid, attention only when change, parallel processing

problem solving mode - conscious and slow, intense mental activity, requires utilization of stored knowledge

98
Q

cognitive biases

A

anchoring, attentional bias, availability heuristic, confirmation bias, frequency illusion, hindsight bias, information bias, irrational escalation

99
Q

anchoring

A

the tendency to rely too heavily, or “anchor,” on a past reference or on one trait or piece of information when making decisions

100
Q

attentional bias

A

the tendency of emotionally dominant stimuli in one’s environment to preferentially draw and hold attention and to neglect relevant data when making judgments of a correlation or association

101
Q

availability heuristic

A

the tendency to overestimate the likelihood of events with greater “availability” in memory, which can be influenced by how recent the memories are, or how unusual or emotionally charged they may be.

102
Q

confirmation bias

A

the tendency to search for or interpret information in a way that confirms one’s preconceptions

103
Q

frequenct illusion

A
104
Q

hindsight bias

A

sometimes called the “I-knew-it-all-along” effect, the tendency to see past events as being predictable[29] at the time those events happened. Colloquially referred to as “Hindsight is 20/20“

105
Q

information bias

A

the tendency to seek information even when it cannot affect action

106
Q

irrational escalation

A

the phenomenon where people justify increased investment in a decision, based on the cumulative prior investment, despite new evidence suggesting that the decision was probably wrong.

107
Q

processing of a clinical lab speciman

A

collect, receive and process, analysis, storage, discard

108
Q

lab test results are used to aid…

A

diagnosis of a disease

prognosis or outcome predictions

patient management

109
Q

brain-to-brain loop

A
110
Q

turnaround time (TAT)

A

the time between the lab receiving a specimen and the time that the result is produced

111
Q

priority of lab tests

A

routine - collected whenever convenient and analyzed as a batch or as received

timed - collected at a specific time and analyzed in batch or as recieved, prioritized with/after stat

stat - collected immediately and analyzed/reported without delay

112
Q

possibilities for error in specimen collection

A

patient variables

proper technique

tube color

collection volume

temperature/time

113
Q

possibilities for error in specimen receiving

A

unlabeled/mislabeled specimen

specimen rejection

delays in receiving

wrong orders received

errors in storage

114
Q

mint green, dark green, lavender, blue top tubes

A

contains blood plasma

liquid fraction of whole blood (uncoagulated)

contains clotting factors and fibrinogen

115
Q

red and gold top tubes

A

contains blood serum

liquid fraction of coagulated blood

116
Q

possibilities for error in specimen processing

A

unlabeled/mislabeled specimen

specimen rejection

delays in processing

errors in processing

errors in storage

117
Q

possibility for error in specimen analysis

A

equipment malfunction

poor assay calibration or precision

technologist error

test interferences or other effects on measurement

118
Q

causes of optical interference

A

hemolysis, lipemia, and icterus

119
Q

critical values

A

those that represent a life-threatening situation and require immediate communication to a medical provider that can provide necessary intervention

120
Q

possible errors in the post-analytical phase

A

delayed results

technologist error (manual entry error, verification error, failure to notify clinician of critical value)

121
Q

red cap

A

serum, no additives or clot activator

122
Q

gold cap

A

serum, additive of clot activator and serum-separator gel

123
Q

light blue cap

A

plasma, addition of citrate

124
Q

purple cap

A

whole blood or plasma

addition of ETDA

125
Q

mint green cap

A

plasma

additive of lithium heparin

126
Q

dark green cap

A

whole blood or plasma

additive of sodium heparin

127
Q

gray cap

A

plasma

additive of fluoride and/or oxalate

128
Q

yellow cape

A

plasma or whole blood

additive of acid/citrate/dextrose

129
Q

methods of PCR fluorescent detection

A

SYBR Green, Taqman, Molecular Beacons, Light Cycler

130
Q

qPCR (target region, resolution, comments)

A

quantitative PCR, uses fluorsecence to measure the initial concentraiton of the DNA of interest

single targeted region

resolution of a few bases

need prior knowledge of sequence

131
Q

NASBA

A

DNA amplification method that does not require heat cycles

132
Q

signal amplifcation methods

A

branched DNA

hybrid capture

invader technology

133
Q

target vs. signal amplification

A

target amplification methods have the advantage of greater analytical sensitivity (lower limit of detection)

however, target amplification carries a risk of contamination of negative samples with amplified product leading to false positive results

134
Q

advantages and disadvantages of Array CGH (target region, resolution, comments)

A

advantage: allows detection of much smaller deletions or duplications
disadvantage: unable to detect translocations and conditions where there are no copy number variants

whole genome, single exon resolution

135
Q

Multiplex ligation-dependent probe amplification (target region, resolution, comments)

A

widely used to support sequencing

two probes for every target - contains specific sequence

can do up to 50 probes at a time

few base resolution

need prior knowledge of sequence

136
Q

FISH (target region, resolution, comments)

A

few loci targeted

about 200kb resolution

advantage of seeing mechanism

137
Q

chromosome analysis (target region, resolution, comments)

A

whole genome targeted, 3-10 Mb resolution, advantage of seeing mechanism

138
Q

Sanger Sequencing

A

limitations - cis vs. trans ambiguity, only see what is sequenced, cannot detect low-level mosaicism or allele burden, cannot detect whole exon deletions or duplications, not quantitative

139
Q

advantages and disadvantages of next gen sequencing

A

advantages - massive amount of sequence data, quantitative, can detect rare events, no cis v. trans ambiguity

disadvantages - complex, still requires target enrichment, requires software and bioinformativs to analyze

140
Q

explain the advantages and disadvantages of Sanger sequencing v. gene panel sequencing v. whole exome/ whole genome sequencing

A
141
Q

types of probability

A

objective probability - based on experiments or a theoretical model

subjective probability - a person’s opinion, hunch or best guess about whether an outcome will occur

142
Q

conditional probability

A

the probability of an event occurring given that another event has already occurred

p(A|B)

143
Q

unconditional probability

A

assumes no prior knowledge about event B

144
Q

joint probability

A

the probability that two simultaneous events occur

145
Q

p(A or B) when not mutually exclusive events

A

p(A) + p(B) - p(A and B)

146
Q

complementary events

A

if event A and event B are mutually exclusive, and together account for all possible events, then they are complementary

p(A) + p (B) = 1

p(A) = 1 - p(B)

147
Q

probability of A and B for non-independent events

A

p(A and B) = p(A|B)p(B)

p(A|B) = p(A and B)/p(B)

148
Q

internal validity

A

A study is internally valid if the results are not biased with respect to the study sample

149
Q

external validity

A

A study is externally valid if the results are generalizable to the population for which the study question is relevant

150
Q

spectrum bias (sampling bias)

A

systematic differences between target population and subjects chosen for study

151
Q

cumulative incidence

A

number who developed outcome/total number followed

**for studies of a fixed population and equal follow-up times

152
Q

incidence density

A

the number of people who developed the outcome/number of person years of follow-up

153
Q

2x2 table

A
154
Q

sensitivity

A

given the presence of disease, the probability that a test will be positive

Sensitivity = TP/(TP + FN)

155
Q

specificity

A

given the absence of disease, the probability that a test will be negative

specificity = TN/(FP + TN)

156
Q

ROC curve

A
157
Q

posttest probability positive

A

if your patient has a positive test result, the probability that disease is present

predictive value (+) = posttest prob (+)

158
Q

posttestprobability negative

A

if your patient has a negative test result, the probability that disease is still present but your test missed it

159
Q

predictive value negative

A

the probability of not having the disease, given a negative result

psttest prob (-) = 1 - predictive value (-)

160
Q

uses of genetic testing

A

diagnosis, prognosis, risk, pharmacogenomics, obstetrical

161
Q

analytic validity

A

the ability to accurately and reliably measure the genotype of interest

includes analytic sensitivity, specificity, reliability, and assay robustness

162
Q

clinical validity

A

the ability to accurately and reliably predict the disorder of interest, encompasses clinical sensitivity and clinical specificity

may be affected by variability in allele/genotype frequencies in racial/ethnic subpopulations

163
Q

clinical utility

A

the evidene of improved measureable clinical outcome, and its usefulness and added value to decision-making compared with current strategies without genetic testing

if a test has clinical utility, the results provide information of value to the person, or to the family, in making decisions about effective treatment or preventive measures

164
Q

biopsychosocial model

A

psychosocial factors play into the biology of disease and must be addressed alongside

165
Q

biochemical model of PKU

A

defect in phenylalanine hydroxylase, prevents conversion of phenylalanine to tyrosine

leads to a buildup of phenylalanine and byproducts in the blood, which causes intellectual disability

can be treated with dietary means

autosomal recessive