Pathways Flashcards
RLE of Glycolysis
Phosphofructokinase (PFK)
RLE of Pentose Phosphate Pathway (PPP)
Glucose-6-phosphate Dehydrogenase (G6PD)
RLE of Pyruvate Oxidation
Pyruvate Dehydrogenase (PDH)
RLE of Kreb’s Cycle
Isocitrate Dehydrogenase (IDH)
RLE of Electron Transport Chain (Oxidative Phosphorylation)
Complex IV
RLE of Gluconeogenesis
All enzymes reversing glycolysis:
- Pyruvate Carboxylase
- PEP Carboxykinase
- Fructose-1,6-biphosphatase
- Glucose-6-phosphatase
RLE of Glycogenesis
Glycogen synthase
RLE of Glycogenolysis
Glycogen phosphorylase
RLE of Fatty Acid Synthesis
Acetyl-CoA Carboxylase (ACC)
RLE of Mevalonate Pathway
HMG-CoA Reductase
RLE of Methylerythritol Pathway (MEP)
DOXP Reductoisomerase
RLE of Beta Oxidation
Carnitine Palmitoyl Transferase (CPT1)
RLE of Ketogenesis
HMG-CoA Synthase
RLE of De Novo (nucleotide)
Purine: Amidophosphoribosyltransferase (ATase)
Pyrimidine: Aspartate Transcarbamoylase (ATCase)
RLE of Purine breakdown
Xanthine oxidase
RLE of Porphyrin synthesis
ALA synthase
RLE of Shikimate Pathway
No clear winner
Site of Glycolysis
Cytosol
Site of Pentose Phosphate Pathway
Cytosol
Site of Pyruvate Oxidation
Mitochondrial matrix
Site of Kreb’s Cycle
Mitochondrial matrix
Site of Electron Transport Chain (Oxidative Phosphorylation)
Inner mitochondrial membrane
Site of Gluconeogenesis
Cytosol
Site of Glycogenesis
Cytosol
Site of Glycogenolysis
Cytosol
Site of Fatty Acid synthesis
Cytosol
Site of Mevalonic Acid Pathway
Cytosol
Site of Methylerythritol Pathway
Plastid
Site of Beta Oxidation
Mitochondrial matrix
Site of Ketogenesis
Mitochondrial matrix
Site of De Novo (nucleotide)
Cytosol
Site of Purine breakdown
Cytosol
Site of Urea Cycle
Both matrix and cytosol
Site of Porphyrin synthesis
Both matrix and cytosol
Site of Shikimate Pathway
Cytosol
Major human organ of Glycolysis
Universal
Major human organ of Pentose Phosphate Pathway
Universal
Major human organ of Pyruvate oxidation
Universal
Major human organ of Kreb’s Cycle
Universal
Major human organ of Electron Transport Chain (Oxidative Phosphorylation)
Universal
Major human organ of Gluconeogenesis
Liver
Major human organ of Glycogenesis
Liver and Muscle
Major human organ of Glycogenolysis
Liver
Major human organ of Fatty Acid synthesis
Liver and Adipose
Major human organ of Mevalonic Acid Pathway
Liver
Major human organ of Methylerythritol Pathway
Other organisms
Major human organ of Beta oxidation
Primary: Heart
Fasted: Liver, Muscle, Kidney
Major human organ of Ketogenesis
Liver
Major human organ of De Novo (nucleotide)
Liver
Major human organ of Purine breakdown
Liver
Major human organ of Urea Cycle
Liver
Major human organ of Porphyrin synthesis
Bone marrow
Major human organ of Shikimate Pathway
Other organisms