Pathophysiology of Thrombosis and Embolism

Question 1

What is virchow’s triad?

Answer 1

Changes in the blood vessel wall
Changes in the blood constituents
Changes in the pattern or force of blood flow

Question 2

What is thrombosis?

Answer 2

Formation of a solid mass from the constituents of blood within the vascular system during life

Question 3

What are the pathogenesis of thrombosis?

Answer 3

Endothelial injury
Stasis or turbulent blood flow
Hypercoagubility 
Atheromatous coronary artery 
Hypercholesterolaemia

Question 4

What is an embolus?

Answer 4

Detached intravascular solid, liquid or gaseous mass

Question 5

Risk factors for DVT and pulmonary thromboembolism?

Answer 5

Cardiac failure
Severe trauma/burns
Post-op/ postpartum 
Nephrotic syndrome
Disseminated malignancy
Oral contraceptive
Increased age
Bed rest or immobilisation 
Obesity 
PMH of DVT