Pathophysiology of Lung Cancer Flashcards
1
Q
What is small cell lung carcinoma?
A
- 15% of lung cancers
- Due to smoking
- Grows rapidly
- Spreads easily
- Responsive to Chemotherapy
2
Q
What are the stages of small cell lung carcinoma?
A
- Limited stage (one side of the chest and one part of the lung)
- Extensive stage (Spreads to other parts of the chest or. body)
3
Q
How do you treat small cell lung carcinoma?
A
- Chemotherapy
- Radiotherapy
- Surgery for non-metastatic cancer
4
Q
What is non-small cell lung carcinoma?
A
- 85% of lung cancers
- included adenocarcinoma (most common)
- Squamous cell carcinoma
5
Q
How is non-small cell carcinoma treated?
A
- Chemotherapy
- Radiotherapy
- Surgery
- EGFR
- VEGF
6
Q
What is epidermal growth factor receptor in NSCLC?
A
- NSCLC = non-small cell lung carcinoma
- EGFR is a Target in NSCLC as it is expressed in high levels
7
Q
What are two EGFR tyrosine kinase inhibitors?
A
EGFR = Epidermal Growth Factor Receptor
- Erlotinib and Gefitinib
- prevent cancer proliferation
- prevent cancer invasion
- prevent cancer angiogenesis
8
Q
What is angiogenesis?
A
-Formation of new blood vessels from pre-existing vessels
9
Q
What is the name of the drug which is anti-angiogenesis?
A
-Avastin for metastatic adenocarcinoma
