Pathophysiology of Heart Disease

Question 1

Frank starling relationship with HF

Answer 1

Plot SV (or CO) against LVEDP

Will inc CO for a given EDP

If inc contractility, then higher CO for a given EDP

If dec contractility (HF), then lower CO for a given EDP and leads to hypotension and pulmonary congestions

Question 2

Important corners of P-V curve

Answer 2

Bottom right - filling pressure and EDV intersect

Top left - where afterload and and systolic P/V intersect

Question 3

Vasodilator effect on P-V curve

Answer 3

Dec afterload and dec preload as well

Question 4

Sarcomeric sturcture

Answer 4

Mutations to most sarcomeric proteins cause cardiomyopathies

Myosin and myosin binding protein-C are most common in hypertrophic cardiomyopathy

Question 5

Dilated
Hypertrophic
Restrictive

Answer 5

Dilated LV with minimal hypertrophy

Marked LV hypertrophy

Infiltrated or fibrotic LV