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Cardio 2 > Cardiomyopathy and Myocarditis > Flashcards

Cardiomyopathy and Myocarditis Flashcards

1
Q

Dilated sx, ECG, other

A

CHF (left)
DOE/PND
PE risk
Dedema

SInus tachy, AV arrhythmias
Conduction defects
ST changes

Impaired systolic fxn

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2
Q

Restirctive sx, ECG, other

A

Right sided
Peripheral edema

Low voltage
Cnduction defects

Impaired diastolic

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3
Q

Hypertrophic sx, ECG, other

A

Faituge etc

Systolic murmur

LVH, A/V arrhythmias, ST changes, Q waves

Vigorous systolic pump activity

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4
Q

EF in each type

A

Dliated - dec
Hypertrophic - inc
Restrictive - same

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5
Q

DCM

A

1/3 inherited (present 20-50)

Other 2/3 - HTN, alcohol, postpartum, coxsackie, chagas, adriamycin, herceptin

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6
Q

DCM prgoression

A

Large heart with 4 chamber dilation
Thrombi often present
Comps of pulm and systemic emboli
Eval for HT

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7
Q

Idiopathic DC M

A

Suspect gene defect

Sarcolemmal protein (like dystrophin)
Cytoskeletal protein
Nuclear envelope protein

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8
Q

COR pulmonale

A

Must be excluded

Right heart hypertrophy and failure secondary to chonric lung or vascular dz leading to pulm HTNT

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9
Q

Chem oinduced CM

A

Dilated

Breast cancer pts

Anthracyclinees - check for low LVEF (doxorubicin and daunorubicin)

Herceptin - Her 2 receptor block….also on breast cancer cells

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10
Q

Mech of trastuzamab

A

Herceptin

Reversible

Her2 antagonist…worse if cotx with adriamycin

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11
Q

Restrictive major causes

A

Sarcodiosis
Amyloidosis
Post radiation fibrosis

Familial/genetic

Could also be hemochromatosis

Diastolic ONLY and can low voltage ECG

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12
Q

Endomyocardial biopsy

A

Used to eval in CM and study of HT

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13
Q

Amyloidosis

A

Restrive CM

Insoluble extracellular fibrillar deposits of protein fragments secreted by B cells

Congo red stain

Deposit around cardiomyocytes, vessel walls, or endocardium

Contrast cardiac MRI is sensitive

Transthyetin gene mutation in AAs

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14
Q

Sarcoidosis

A

Noncaseating granulomatous myocarditis

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15
Q

Acute HS myocarditis

A

Antibiotics, diuretics, anti-HTN meds

Elderly taking multiple meds with allergies

Eosinophilia

Rarely - Virmani

Heart biospy shows eosinophils

If necrosis present - necortizing eosinophilic myocarditis

Recover normal fn…remove offneeing agent

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16
Q

IHSS

A

Idiopathic hypertrophic cardiomyopathy

Young men

Contractile protein defect in beta myosin heavy chain gene

Cardiomegaly

Dynamic LV outflow obstruction…muscle push against ant mitral leaflet

Disarray of cardiomycotes

DOE - arrhytnmia and sudden death

17
Q

Txs of IHSS

A

DOE and progressive MI

Palliative resection of muscle

Cardiac pacing may be required

ASH may be detected by echo of 1st deg relatives

18
Q

Stillborn hypertrophic cardiomyopathy

A

Fetus exposed to elevated glucose…islet beta cell hyperplasia…hyperinsulinism

Reversible if survives

19
Q

ARVC

A

Cardiomyopathy of RV
RV develops small bulges
AICD placement due to electricla instability

10-20% of SCD under 65…20% in athletes

Genetic - cell jxn proteins of cardiomyocuytes

Desmosomopathy

May be with cardiocutaenous syndrome

20
Q

LVNCC

A

Left ventricular non-compaction CM

Trabeculations in LV lead to thrombi formaiton

Recent cong CM with spongy myocardium

LV apex

Arrest of normal embryonic development

LV systolic fxn and CHF with mural thrombi

Long term aspirin

Isolated genetics

21
Q

Rasopathies

A

At risk for hypertrophic

Noonan, CFC syndrome, costello syndrome

Due to intracellular Ras MapKinase singlaing defects…same path as herceptin

22
Q

Chronic severe CHF
Exclusions
Rare causes
Viral

A

May need transplant

Systemic HTN, valve dz, CAD< cor pulmonale, constrictive pericarditis

Sarcoid, amyloid, iron prob

Acute HF recovery…chornic - —-DCM

23
Q

Alcohol and drugs
Isolated HCM
Syndromes with HCM

A

Reveresible

Genetic and some others genetic

Noonan, costello, CFC

Cardio 2 (23 decks)

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