Pathophysiology of Bacterial Infections: Pneumonia, UTI, and IE Flashcards
What are the most common infection sites?
Respiratory tract
Urinary tract
What is virulence?
The strength of a microorganism’s pathogenicity
Virulence factors: adhesins, protective capsules
What is inoculum?
The quantity of microorganisms
“How many microorganisms cause ___?”
ex. COVID, the inoculum is higher in an enclosed space rather than outside
The chain of transmission of an infection
Infectious agent
Reservoir
Portal of exit
Mode of transmission
Portal of entry
Susceptible victim
What is a nosocomial infection?
An infection acquired during the course of a stay in a hospital, nursing home, or other healthcare facilities
What are the stages of infection? Describe each one
Incubation: between exposure and symptoms
Prodrome: non-specific symptoms
Illness: overt s/sx of infection
Recovery: return toward homeostasis
Chronic Carrier State: is possible in some infections
What is community-acquired pneumonia (CAP)?
Acquired outside of hospitals or extended-care facilites
What is hospital-acquired pneumonia (HAP)?
Acquired in the hospital
> 48 hours after admission
Increased risk for MDR (multi-drug resistant) bacteria
What is ventilator-associated (VAP)?
Diagnosis made 48-72 hours after endotracheal intubation
What is healthcare-associated (HCAP)?
Diagnosis made while in the community or < 48 hours after hospital admission
Usually following ICU admission
What is the most common pathogen in all types of locations?
Streptococcus pneumonia
What are some risk factors for pneumonia?
Young and old people
Smoker
Lung disease
Dysphagia
Immobility and/or depressed cough reflex
IVDU
What is pneumonitis?
Pneumonia caused by a chemical source
Inhalation of liquid, gases, or small particles
What is atypical pneumonia? How is it presented?
Pneumonia with different symptoms than typical pneumonia
Appear different on x-ray
Respond to different antibiotics
Extrapulmonary s/sx: confusion/change in mental status, GI symptoms, ear pain, sore throat
DOES not mean it is uncommon
What is walking pneumonia?
Patient will look fine and healthy but have pneumonia
no s/sx
Name the normal respiratory tract defense mechanisms
Cilia
Mucus
Mucociliary Escalator
Cough Reflex/ Swallowing
Alveolar Macrophages
What virulence factors does S. pneumoniae have?
- Able to avoid phagocytosis
- Secretes a protein that permits it to adhere to the mucosa
- Secretes a protein that lyses and destroys ciliated cells
- Secretes a protease that inhibits the function of IgA
- Secretes hydrogen peroxide –> damage to host cells
- Activates inflammatory cascade
- Induces vascular permeability
- May become invasive –> move into blood or BBB
How does S. pneumoniae avoid phagocytosis?
Its external polysaccharide capsule prevents opsonization by complement
** Most important virulence factor
What does IgA do? How does S. pneumoniae affect it?
IgA normally binds bacteria to mucus to facilitate clearance from the respiratory tract
S. pneumoniae secretes a protease that inhibits function of secretory IgA
How does bacteria make its way to the lungs?
Inhalation (nose)
Aspiration (mouth)
Hematogenous (bloodstream)
Which patients are we going to be most concerned about, regarding their risk for aspiration?
Patients with dysphagia (ex stroke patients)
What are neutrophil extracellular traps (NETS? What do they do?
A meshwork containing antimicrobial proteins that trap and kill bacteria
Extruded by neutrophils
Can also cause damage
What happens when alveolar air spaces fill with exudative fluid and debris?
Decreased gas exchange
What causes the clinical manifestations of pneumonia?
The inflammatory response rather than the proliferation of the bacteria
S/Sx of Pneumonia
Fever
Chills
Dyspnea
Productive cough
Pleuritic chest pain
Tachycardia
Diminished breath sounds
Inspiratory crackles