Pathophysiology lecture 4

Question 1

What are key components of innate immune system

Answer 1

-Physical barriers
-Sentinal cells
-circulating phagocytes and granules
-Blood proteins like complement
-cytokines

Question 2

What are physical barriers component composed of

Answer 2

-skin
-Gi tract
-respiroty tract
-genitourinary tract

Question 3

What are the epithelial barriers of composed of

Answer 3

physical and anti microbial
-physcial composed of tight junctions, keratin layers (physcial barriers),and mucose

Question 4

What are antimicrobial components composed of and are aprt of what?

Answer 4

Apart of epithelial barriers composed of Defensin: peptides work by inserting themselve in pathogen creating pores
and
Cathelicidins: same as defensins but also play role in modulaitng the immune repsonse.

Question 5

When are defensin and cathelcidins made?

Answer 5

either constitutive:baisclly these are made all the time OR
Enhanced production: Toll like receptors recognize germs and TRIGGER production.