Pathoma - IBD

Question 1

IBD

Answer 1

chronic, relapsing inflammation of bowel

Question 2

IBD - presentation

Answer 2

females, teens-30’s

bloody diarrhea + abdominal pain

Question 3

Wall involvement

Answer 3

UC: mucosa and submucosa ulcerations

Crohn’s: full-thickness

Question 4

Location

Answer 4

UC: Continuous-starts at rectum, can extend as far as cecum

Crohn’s: mouth to anus w/ skip lesions

Question 5

Inflammation

Answer 5

UC: crypt abscesses w/ neutrophils

Crohn’s: lymphoid aggregates w/ granulomas

Question 6

Gross appearance

Answer 6

UC: “Lead pipe colon” (loss of haustra) and pseudopolyps

Crohn’s: “Cobblestone” appearance and strictures (“String sign”)

Question 7

Complications

Answer 7

UC: Toxic megacolon and carcinoma

Crohn’s: malabsorption + nutritional issues, fistulas, carcinoma

Question 8

Associations

Answer 8

UC: p-ANCA (+), primary sclerosing cholangitis

Crohn’s: ankylosing spondylitis, polyarthritis, erythema nodosum, uveitis

Question 9

Smoking

Answer 9

UC: protects against

Crohn’s: increases risk