Pathoma - Colon

Question 1

Hirschsprung’s disease

Answer 1

defective relaxation/peristalsis of rectum and distal colon

Question 2

Hirschsprung’s disease: cause

Answer 2

congenital failure of ganglion cells to descend

Question 3

Hirschsprung’s disease: association

Answer 3

Down’s syndrome

Question 4

Hirschsprung’s disease: clinical features

Answer 4

failure to pass meconium
massive dilation of bowel (megacolon)
lack of ganglion cells on rectal biopsy