Pathology4 Flashcards
Which of the following make up the triad of Stevens-Johnson syndrome (SJS)? • stomatitis • lesions of the eye • genital lesions • maculopapular rash
• stomatitis
• lesions of the eye
• genital lesions
an immune-complex—mediated hypersensitivity complex that is a severe expression of erythema multiforme. It is now known also as erythema multiforme major
pathognomonic of Stevens-Johnson syndrome?
bull’s-eye-shaped” target lesions (Blindness can occur due to secondary infection)
The lesion is a small (2 mm-5 mm in diameter), whitish sore with a red border.The patient states that it usually begins as a reddish area with a burning or tingling sensation. The most likely diagnosis is:
recurrent aphthous minor
Erythema multiforme (EM) is an acute self-limited eruption characterized by a distinctive clinical eruption, the hallmark of which is the: • chronic desquamative gingivitis • petechial hemorrhage • iris or target lesion • mucocutaneous rash
iris or target lesion — appears as a central lesion surrounded by concentric rings of pallor and redness over the dorsal aspect of the hands and forearms
The diagnosis of Erythema multiforme is primarily based on ?
the classic skin lesion appearance
Behcet syndrome is a rare disorder that causes chronic inflammation in ?. Manifestations include ?. Treatment with ? and other immunosuppressive drugs prevents serious complications, such as blindness.
- blood vessels throughout the body
- oral and genital aphthous-type ulcers, conjunctivitis, uveitis, arthritis, headache, and other CNS symptoms
- corticosteroids
A 43-year-old man presents to the ER with a purple lump of the jaw that is painful. He has an extraoral sinus tract presenting with yellowish crust. The ER places the individual on a long-term penicillin regimen. What was the most likely diagnosis? • coccidioidomycosis • histoplasmosis • tuberculosis • actinomycosis • scarlet fever
actinomycosis (lumpy jaw is used)
Histoplasmosis is a chronic lung infection caused by inhalation of spores of Histoplasma capsulatum. It is endemic to the American Midwest. The classic oral manifestation of histoplasmosis infection is ?
a chronic nonhealing ulcer
Scarlet fever is a systemic infection caused by Streptococcus pyogenes. It is characterized by pharyngitis, fever, malaise, and its oral manifestation is ?
strawberry tongue (has a white coating with red, inflamed fungiform papillae)
Treportema pallidum is the infectious organism of which disease? • syphilis • gonorrhea • chlamydia • tuberculosis
syphilis
An oral manifestation of gonorrhea is ?
oral pharyngitis
name dental defects seen in congenital syphilis are caused by direct invasion of tooth germs by Treponema organisms?
“Screwdriver” incisors (hutchinson incisors) and “Mulberry molars”
Which of the following fungal infections is most commonly associated with diabeites mellitus? • coccidioiodomycosis • mucormycosis • aspirgillosis • zygornycosis
mucormycosis
A 4-year-old patient comes with her mother for a routine appointment. The mother states that her daughter just started not feeling well and had a mild fever earlier in the day. The daughter has been having trouble swallowing. An intraoral exam reveals multiple 1-mm to 2- mm vesiculopapular lesions of the nasopharynx and soft palate. Your working diagnosis is: • herpangina • hand-foot-and-mouth disease • herpes simplex infection • pemphigus vulgaris
herpangina
- herpangina
* Type 1 Herpes
- the ulcerations of herpangina are localized to the posterior soft palate and nasopharynx
- lesions are found typically more forward in the mouth on the tongue, gingiva, and buccal mucosa and appear as vesicles (small, clear blisters that ulcerate and crust) around the mouth and on the lips.
Hand-foot-and-mouth disease is a highly contagious systemic infection of limited duration in which vesicular eruptions occur on the palms of hands, soles of feet, and mucosa of the anterior part of the mouth. It is ? in the oropharyngeal area (unlike herpangina).
uncommon
Which type of herpes virus is associated with the lesion on the lower lip? • HSV-1 • HSV-2 • HSV-3 • HSV-4
HSV-1 (The majority of oral herpes cases are caused by HSV-1 and the majority of genital herpes cases are caused by HSV-2.)
Herpetic lesion on the finger is called ?
herpetic whitlow
The dormancy state with latency in trigeminal ganglion is associated with which form of herpes? • cytomegalovirus • epstein-barr virus • herpes simplex virus type 1 • herpes simplex virus type 2
herpes simplex virus type 1
? are a manifestation of recurrent HSV infection around the mouth. The most common site is on ?
- Cold sores
* the lips
The characteristic cells of the herpetic lesion are known as: • lipschutz bodies • civatte bodies • lisch nodules • reed-sternberg cells
lipschutz bodies
A 65-year-old man presents to your clinic in regards to upper dentures. When getting his health history, you ask about history of infectious diseases. He mentions that a year ago, his eldest son died and later he broke out in blisters on only half of his back. He says he doesn't remember what the doctor called it, but he remembers the physician saying it "stopped at the midline." What is the most likely diagnosis? • herpes zoster • herpangina • recurrent herpes • chickenpox
herpes zoster (the virus causes the disease chickenpox (varicella) and shingles (herpes zoster))
The histology for both chickenpox and shingles shows ? as seen in herpes simplex
the same cytopathic effect
Over 90% of primary herpes simplex viral infections are:
• manifested as ANUG
• associated with HIV
• subclinical
• characterized by severe lymphadenopathy and acute dermatitis
subclinical (flu-like symptoms)
