PATHOLOGY - Overview Flashcards

1
Q

What is pathology?

A

The study of disease in the whole body

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2
Q

What is the importance of pathology?

A
  • Understand how a disease works
  • Disease diagnosis
  • Disease treatment
  • Disease prevention
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3
Q

What is disease?

A

Any alteration from the normal, healthy state - whether or not this is clinically apparent

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4
Q

What are the roles of clinical pathologists?

A

To examine haematology, clinical biochemistry, cytology and fluid cytology

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5
Q

What are the roles of anatomic pathologists?

A

To examine biopsies, necropsies/post-mortems

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6
Q

What are the roles of skin pathologists?

A

To examine samples of the skin to identify any underlying causes of disease
- Includes punch biopsies, incision biopsies and excision biopsies

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7
Q

Define aetiology

A

Aetiology is the underlying cause of disease

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8
Q

Define pathogenesis

A

Pathogenesis is the development of disease

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9
Q

Define aetiopathogenesis

A

Aetiopathogenesis is the combination of the aetiology and pathogenesis of a disease

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10
Q

What are the two main disease classifications?

A
  • Simple disease (only one aetiological factor)
  • Multifactorial disease (more than one aetiological factor)
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11
Q

List and define the four different types of multifactorial disease

A
  • Congenital: disease present at birth
  • Acquired: disease acquired throughout life
  • Idiopathic: disease with no known cause
  • Iatrogenic: disease that develops directly after medical/surgical intervention
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12
Q

What is diagnosis?

A

A concise statement or conclusion concerning the nature, cause or name of disease

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13
Q

What is gross diagnosis?

A

Diagnosis made on the basis of post-mortem examination

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14
Q

What is histological diagnosis?

A

Diagnosis made on the basis of the microscopical examination of tissue sections

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15
Q

What is morphological diagnosis?

A

Diagnosis which summarises predominant lesions/structural changes

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16
Q

What is aetiological diagnosis?

A

Diagnosis of the underlying cause of disease

17
Q

List the normal post-mortem changes

A
  • Algor mortis
  • Rigor mortis
  • Livor mortis
  • Autolysis
  • Putrefaction
18
Q

What is algor mortis?

A

The cooling of the body after death

19
Q

What is rigor mortis?

A

The rigidity of the body after death

20
Q

What is autolysis?

A
  • The cell and tissue breakdown after death causes by a lack of oxygen

there would be no inflammatory response

20
Q

What is livor mortis?

A
  • Hypostatic congestion (the pooling of blood in the veins and capillaries) after death
  • Blood clotting
21
Q

What is putrefaction?

A

Death tissue is invaded by anaerobic saprophytic bacteria which leads to rotting/decay

22
Q

Describe the two different types of clots that can be seen in post-mortem examinations

A
  • Current jelly clots: erythrocyte clots
  • Chicken fat clots: serum clots
23
Q

If an organism has been dead for less than three hours, how would the body appear?

A

Warm and flaccid

24
Q

If an organism has been dead for between 3-8 hours, how would the body appear?

A

Warm and rigid

25
Q

If an organism has been dead for between 8-36 hours, how would the body appear?

A

Cold and rigid

26
Q

If an organism has been dead for over 36 hours, how would the body appear?

A

Cold and flaccid

27
Q

Define artefacts

A

A structure or appearance that is not natural due to man-made manipulation