Pathology of The Symptoms Of BpAD Flashcards
What is bipolar?
Mood disorder
Mania
Presents with Impaired judgement
Hypomania…Mania but functional
What contributes to bipolar?
Genetics
Changes to the ion channels in the presynaptic zones of neurons causing them to fire more easily
Effects to calcium channel levels inside the neurons which increases excitability
Environment
Sleep disturbance ews of Mania
Major illness with use of corticosteroids
Childhood trauma and lacknof social support
Chemical
Glial cells have receptors for corticoteopin releasing factor
When glial cells are activated by CRF they produce inflammation around these neurons in the brain
This increases atrocities
Thisbincreases glutamate which causes increased firing of neurons
Cortisol decreases seratonin
Patho of BPAD
Changes in thr balance of neurotransmitters
Manic
Increased elevation
Racing thoughts
Rapid HR and BP
Flight of thoughts
Rapid pressured speech with tangential thoughts
Risk taking behaviour increases
Grandiosity
Highly distractable
Impulsive
Depression
Anhedonia
Low mood or sadness
Guilt worthlessness
Slow movement and behaviour
Fatigue
Increase of Dopamine evident in some cases of psychotic Mania
Dexrease of noradrenaline in depressive phases
