Pathology of Rashes

Question 1

Which types of collagen are present in the dermis?

Answer 1

Type 1 and 3

Question 2

Hyperkeratosis means what?

Answer 2

Increased keratin thickness

Question 3

Parakeratosis is defined as what?

Answer 3

Persistence of nuclei in keratin layer

Question 4

Acanthosis is defined as what?

Answer 4

Increased epithelial thickness (dermis + epidermis)

Question 5

Papillomatosis is defined as what?

Answer 5

Irregular thickening of epithelia (irregular c.f. acanthosis)

Question 6

Spongiosis is defined as what?

Answer 6

Oedema between squamous cells

Question 7

Tumours which are above the basement membrane always metastasise. True/false?

Answer 7

False - they never do.

Question 8

What are the 4 main types of inflammatory skin disease?

Answer 8

1) Spongiotic-intraepidermal oedema (e.g. eczema)
2) Psoriasiform-elongation of the rete ridges (e.g. psoriasis)
3) Lichenoid-basal layer damage (e.g. lichen planus)
4) Vesiculobullous blistering (e.g. pemphioid, dermatitis herpetiformis)

Question 9

Spongiotic intraepidermal oedema is buzzword for which condition?

Answer 9

Eczema

Question 10

Lichenoid basal layer damage may be buzzword for which condition?

Answer 10

SLE

Question 11

Complement mediated attack on keratin layer causing “munro micro abscesses” is buzzword for what?

Answer 11

Psoriasis

Question 12

Lichenoid disorders are caused by damage to which skin layer?

Answer 12

Basal epidermis

Question 13

Irregular, sawtooth acanthosis with cytoid bodies is a buzzword for

Answer 13

Lichen planus

Question 14

Wickham Striae is buzzword for

Answer 14

Lichen planus

Question 15

Pemphigus vulagris is caused by what?

Answer 15

IgG autoantibodies against Desmoglein 3

Question 16

What’s common to all variants of pemphigus (histology)?

Answer 16

Acantholysis (loss of intracellular adhesion sites)

Question 17

In pemphigus vulgaris the basement membrane is lost. True/false?

Answer 17

False (BM disrupted only in pemphiGOID)

Question 18

Bullous pemphigoid has evidence of acantholysis. True/false?

Answer 18

False - only pemphiGUS has acantholysis

Question 19

Dermatitis herpetiformis is strongly associated with which haplotype & condition?

Answer 19

HLA-DQ2 and Coeliac disease

Question 20

What’s the pathological hallmark of dermatitis herpetiformis?

Answer 20

Dermal microabscesses.

Question 21

What’s the pathophysiology of dermatitis herpetiformis?

Answer 21

IgA autoantibodies against gliadin component of gluten

Question 22

Thickening of the nose in rosacea is termed what?

Answer 22

Rhinophyma