Pathology of Obstructive Diseases Flashcards
What is atelectasis?
Incomplete expansion of the lung of collapse of previously inflated lung
What is the major issue with atelectasis?
Predisposes to infx
What is the resorptive type of atelectasis? What happens to the mediastinum with this?
Atelectasis that follows complete airway obstruction
Mediastinum will shift toward the affected side
What is compressive atelectasis? What happens to the mediastinum with this?
Excessive air, fluid, blood etc in pleural space causing compression
Mediastinum will shift away from the affected lung
What is patchy atelectasis? What usually causes this?
Loss of surfactant, usually post surgical complication
What is contraction atelectasis?
FIbrosis around the lung causing collapse
Which way does the trachea/mediastinum shift with a tension pneumothorax?
Away from the affected lung
What are the two primary causes of pulmonary congestion and edema?
- Hemodynamic disturbances
- Microvascular injury
What happens in ARDS?
Breakdown of capillary cell walls and lung interstitium usually due to sepsis
What are the hemodynamic disturbances that can cause pulmonary edema?
Increased hydrostatic pressure from heart failure
What are the gross characteristics of pulmonary edema?
Heavy, wet lungs
What are the histological characteristics of hemodynamic pulmonary edema? (3)
- Engorgement of alveolar capillaries
- Intraalveolar HF cells
- Fibrosis
What is transudate?
extravascular fluid with low protein content and a low specific gravity (
What is exudate?
any fluid that filters from the circulatory system into lesions or areas of inflammation.
What is the microvascular injury type of pulmonary edema?
Capillaries of alveolar septa. Either the endothelial cells, or the alveolar epithelial cells
What are the localized forms of microvascular injury type forms of pulmonary edema?
Pneumonia and ALI
What is the systemic form of microvascular injury type forms of pulmonary edema?
ARDS
What are the four major obstructive diseases?
- Emphysema
- chronic bronchitis
- asthma
- bronchiectasis
What is COPD?
Emphysema + chronic bronchitis
What is the main feature of obstructive pulmonary disease?
Air cannot get out of the lung efficiently
What is the main feature of restrictive pulmonary disease?
Air cannot get in the lung efficiently
Which of the obstructive diseases is/are reversible?
Asthma
What is the pathophysiology behind emphysema?
Breakdown of the elastin in alveoli, causing overexpansion
Which airways are primarily affected with emphysema?
Small airways–acinus and respiratory bronchioles