Pathology 3 Flashcards
Causes of carpal tunnel syndrome
Signs of carpal tunnel syndrome
numbness in first 3 digits
wasting of thenar eminence
tinels +ve
phalens +ve
Type of vasculitis that is
-common F>M
-upper limb claudication
-diminished pulses
-raised ESR
Takayasu’s arteritis
Type of vasculitis
-common M>F
-young smokers
-affects large and medium vessels
-on angio shows tortuous corkscrew vessels
Buerger’s vasculitis
Type of vasculitis
-is systemic necrotising granulomatous vasculitis
-cutaneous lesions (ulcers/nodules)
-affects small/ medium sized vessels
-sinus imaging shows a thickened mucosa and air fluid levels
Granulomatous polyangitis
Type of vasculitis
-is systemic necrotising vasculitis
-angio shows saccular/ fusiform aneurysms + aterial stenosis
-prevalent in populations with Hep B
Polyarteritis nodosa
Causes of a psoas abscess
Infection:
-haem spread from other source
-endocarditis
-diverticulitis
-UTI
INflammation:
-Crohn’s
Clinical features of a psoas abscess
-back/flank pain
-fever
-limp
What cells do GIST originate from?
interstitial cells of Cajal
Pacemaker cells of the GUT
What are the common sites for GIST (most-least common)
-Stomach
-small bowel
-colon
-rectum
T/F: GIST are the least common mesenchymal tumours/ sarcoma
False-are the most common mesenchymal tumour but are rare
What is the mutation seen in most GIST
mutation of the c-KIT tyrosine kinase receptors
Where are the interstitial cells of cajal found
Pacemaker cells found between the circular and longitudenal layers of the gut wall that regulate peristalsis
Name 4 thrombophilic conditions
-antithrombin deficiency
-protein S/C deficiency
-Factor V leiden
-antiphospholipid syndrome
pathophysiology of antithrombin deficiency
Reduced anti-thrombin= not enough AT to break down thrombin= hence fibrin clots keep being formed
causes of antithrombin deficiency
acquired:
-liver disease
-DIC
-nephrotic syndrome
-pregnancy