Pathologies of the respiratory system Flashcards

1
Q

CATEGORIES of PATHOLOGY of respiration system

A

Pleural
Atelectasis
Obstructive Airways Disease
Consolidation
Lung Masses
Trauma

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2
Q

What does atelectasis mean?

A

Partial collapse or incomplete inflation of the lung.
Obstructive atelectasis due to tumour, FB or mucus plug
Can witness mediastinal shift
It occurs when the tiny air sacs (alveoli) within the lung become deflated or possibly filled with alveolar fluid.

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3
Q

What is the pleural?

A

Pleura is a thin layer of tissue that covers the lungs and also lines the interior wall of the chest cavity.
Between these two layers a serous fluid fills the space. About 10-20mls in the healthy person.

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4
Q

What is dyspnoea?

A

Shortness of breath — known medically as dyspnoea — is often described as an intense tightening in the chest, air hunger, difficulty breathing, breathlessness or a feeling of suffocation.

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5
Q

What is the parietal pleura?

A

Parietal pleura lines the inner aspect of the thoracic cavity and the mediastinum. It is thicker and more robust than the visceral pleura.
Its the pleura side that lines your chest.

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6
Q

What is Visceral Pleura?

A

Lines the surface of the lungs.

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7
Q

What is PNEUMOTHORAX?

A

We get a leak of air into the pleura cavity. So this causes the differences in pressure within your chest to be misaligned, leaving to air escaping your lung into that plural cavity, causing the lung to shrink and collapse.

Abnormal collection of air in the pleural space between the lung and the chest wall.

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8
Q

What are the symptoms of pneumothorax?

A

Symptoms = sudden onset of sharp, one-sided chest pain and SOB

If you were to listen to the chest with a stethoscope patient, you would hear decreased sounds of breath on the one side with a numerical set.

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9
Q

What is the difference between primary pneumothorax, secondary pneumothorax and haemothorax?
and Traumatic Pneumothorax

A

Primary pneumothorax = no lung disease

Secondary pneumothorax = lung disease

Haemothorax - collection of blood in the pleural space and may be caused by blunt or penetrating trauma.

Traumatic Pneumothorax- May be due to traumatic injury, e.g. Rib fracture
Could also be due to surgical intervention e.g.
Thoracotomy, Tracheostomy, Biopsy, NG Perforation

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10
Q

Pneumothorax is more common in who?

A

More typical men and more typical people who are ectomorphic. So people who are quite tall, slim.
Also quite more common people who have connected tissue disorders like Mart Max disease or Ella Danlos.

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11
Q

PNEUMOTHORAX CXR appearance

A

When viewing on a chest image, you will see a lack of lung markings to one side of the chest. This makes the lung look black

It can happen to both and this is known as a bilateral pneumothorax. This is rare and often happens during trauma.

They can also be very subtle.

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12
Q

PNEUMOTHORAX CXR appearance

A

When viewing on a chest image, you will see a lack of lung markings to one side of the chest. This makes the lung look black

It can happen to both and this is known as a bilateral pneumothorax. This is rare and often happens during trauma.

They can also be very subtle.

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13
Q

Pneumothorax on CT

A

You can see the Lung window to see all the markings clearly. In pneumothorax, there will be a lack of lung markings in an area and it will be black as there is air there.

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14
Q

Lateral Decubitus CXR technique

A

Patient Preparation
Remove all clothing waist up and put on a hospital gown
Remove any artefacts

Patient Positioning
Lie on the unaffected side for a pneumothorax x-ray (lie on affected side if looking for fluid, e.g. pleural effusion)
Extend arms above head to avoid any superimposition on lung fields
Same checks for rotation as with any chest x-ray

Can be achieved AP or PA
Position patient for 5 minutes prior to exposure to allow air to rise if present
Breathe in… Breathe out… Breathe in (Max Insp)
Place appropriate marker so we know which side is up!
Ensure you add Decubitus annotation when post-processing the image

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15
Q

What is TENSION PNEUMOTHORAX?

A

A complicated pneumothorax where air enters the pleural cavity but cannot escape due to the formation of a one-way valve at the rupture point. Pressure builds.

Pneumothorax is when air collects in between the parietal and viscera pleurae resulting in lung collapse. It can happen secondary to trauma (traumatic pneumothorax). When mediastinal shifts accompany it, it is called a tension pneumothorax

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16
Q

Tension pneumothorax CXR?

A

Mediastinal shift, diaphragm lowered. Its similar to normal pneumothorax but the heart shifts the opposite way due to the pressure. So rather the heart being in the middle like a normal chest x-ray its off to the side.

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17
Q

How to treat pneumothorax?

A

Treatment for a pneumothorax usually involves inserting a needle or chest tube between the ribs to remove the excess air. However, a small pneumothorax may heal on its own.
The drain can be seen on chest x-rays as radiopaque.

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18
Q

What is Pleural Effusion?

A

Excess fluid accumulation in the pleural cavity

Pressure of fluid can impair breathing

Can be due to a build up of different fluids

Exudate or Transudate

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19
Q

What are the common causes of Pleural effusion?

A

The most common causes of pleural effusion are congestive heart failure, cancer, pneumonia, and pulmonary embolism.

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20
Q

What does exudate mean?

A

Means to ooze

Increased permeability of the pleural capillaries or interference with drainage of the pleural space to the lymph nodes

Associated with pulmonary malignancy or lymphatic drainage interference

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21
Q

What does transudate mean?

A

Increased pressure within the pleural capillaries causing the pressure within the vessels to increase

Associated with heart failure, hypertension, ascites

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22
Q

Pleural effusion appearance on CXR?

A

small amount-Horizontal Fluid Level /
Blunted Costophrenic Angle, the fluid is white/radiopaque

Large amount- Meniscus Sign, large white lung

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23
Q

Pleural effusion appearance on ultrasound?

A

Liquid is black on ultrasound, so the area would be black

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24
Q

What is Haemothorax?

A

Haemothorax is a collection of blood in the space between the chest wall and the lung (pleural cavity) and can be life threatening if untreated.
On CXR it can look like pleural effusion so further imaging (CT) is needed for diagnosing.

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25
Q

Examples of OBSTRUCTIVE AIRWAYS DISEASE?

A

COPD
EMPHYSEMA
BRONCHIECTASIS

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26
Q

What is emphysema?

A

Mucus in bronchiole

Long term obstructive lung disease

Loss of airway support and inflammation

Gas exchange is either slowed or stopped due to very reduced movement of gases in the alveoli

Causes change to healthy lung anatomy
Destruction of lung tissue surrounding bronchioles
Capillary networks affected

Shortness of breath due to hyperinflation of the alveoli

Associated hypertension

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27
Q

What causes Emphysema?

A

Smoking
Risk increases with quantity and length of time
Scarring due to long term irritation and inflammation of the lungs

Rarely;
Fumes
Dust
Air pollution
Genetics

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28
Q

What does emphysema look like on CT?

A

It looks like almost large area/ or a large bubble called a bullae

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29
Q

EMPHYSEMA CXR appearance

A

Large overinflated lungs, heart appears long and thin, this happens because the alveoli dilate.

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30
Q

Surgical Emphysema (AKA Subcutaneous Emphysema or Tissue Emphysema), what does it look like on a CXR?

A

Lucent stripes across soft tissue (this is the air in the tissue)
Usually you can also see the cause e.g Chest drain

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31
Q

Subcutaneous Emphysema on CT appearance?

A

Black spots/strips/bubbles throughout the soft tissue, it can be on either side of the patient

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32
Q

What is Bronchiectasis? common symptoms?

A

Bronchiectasis is a long-term condition where the airways of the lungs become widened, leading to a build-up of excess mucus that can make the lungs more vulnerable to infection.
The most common symptoms of bronchiectasis include: a persistent cough that usually brings up phlegm (sputum) shortness of breath. Sometimes the cause is unknown.

Abnormal widening of the airways – up to 4 x size
Increased mucus production

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33
Q

Causes of Bronchiectasis?

A

A childhood lung infection that damages the bronchi

Underlying immune system disorders

Allergic Bronchopulmonary Aspergillosis

Cystic Fibrosis

Idiopathic

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34
Q

Idiopathic meaning?

A

relating to or denoting any disease or condition which arises spontaneously or for which the cause is unknown.

35
Q

Bronchiectasis CXR appearance?

A

Increased density within the airways, giving it this kind of morts spread out mosaic kind of patterns.
X rays are two dimensional image of a three dimensional object.
So lots of this will be superposed, and a lot of it will also be bronchial and bronchitis that are facing us head on which can account for some of the higher density, lower densities and, the lack of homogeneity

36
Q

CT Bronchiectasis appearance

A

On CT you can see cross sections through the bronchioles so you can see the thicken wall and see that its dilated.

37
Q

What is Bronchography?

A

Bronchography is a radiological technique, which involves x-raying the respiratory tree after coating the airways with contrast. Bronchography is rarely performed, as it has been made obsolete with improvements in computed tomography and bronchoscopy

38
Q

What is Consolidation?

A

Non-specific airspace opacification

Alveoli and terminal bronchioles filled with dense material
Pus (pneumonia)
Fluid (oedema)
Blood (haemorrhage)
Cells (cancer)

Dense and white appearance

Consolidation refers to an area of homogeneous increase in lung parenchymal attenuation that obscures the margins of vessels and airway walls. Pathologically, consolidation represents an exudate or other product of disease that replaces alveolar air, rendering the lung solid, hence, the dense white appearance.

39
Q

What is Pneumonia?

A

An infection of the lungs characterised by inflammation of the alveoli that become fluid and pus filled
Bacterial or viral
Symptoms
Productive cough with green/brown sputum
SOB or DIB
Chills/Fever
Rigors
Fatigue
Sweating
Chest pain

Lobar pneumonia affects one or more sections (lobes) of the lungs

40
Q

Pneumonia CXR appearance?

A

APPEARANCE
Non-uniform shadowing
Air bronchogram
Ill-defined border of area of whiteness/increased density
Shadowing likely to be more dense at the bases, or lower border of affected lobe

41
Q

HOW ELSE DO WE IMAGE PNEUMONIA?

A

Ultrasound- If pleural effusion is also suspected

MRI- Rule out other causes of pathology

Needle Biopsy of the Lung- To identify the cause of pneumonia

WHY CT?
Finer detail of the lungs
More sensitive than CXR
Demonstrates airways clearly
Can assess lymph nodes for enlargement

42
Q

What is Pulmonary Oedema?

A

Abnormal fluid accumulation in the lungs which collects in the alveoli

Affects ability for gas exchange to occur

Cardiogenic vs. Non-Cardiogenic

Low oxygen saturations

43
Q

What is Pulmonary Oedema?

A

Abnormal fluid accumulation in the lungs which collects in the alveoli

Affects ability for gas exchange to occur

Cardiogenic vs. Non-Cardiogenic

Low oxygen saturations

44
Q

Pulmonary oedema CXR appearance?

A

Patchy densities in lungs
Fluid in alveoli – white
Air still retained in bronchioles – black
Overall – a patchy/fluffy effect
Cardiogenic: originating in the heart or caused by a cardiac condition cardiogenic pulmonary oedema.

45
Q

What are nodules? information about them?

A

Found on 1 in 500 CXRs
Lesion 3cm or less in size

Benign
Slow growing, smooth and regular shape
Malignant
Fast growing, irregular shape, rough surface, heterogenous appearance

Monitoring – Fleischner Society Recommendations

small masses in the lungs

46
Q

Lung carcinoma stats

A

Lung carcinoma
Small Cell Lung Cancer (SCLC) – 10-15%
Non-Small Cell Lung Cancer (NSCLC) – 85-90%
Other – 5%

47
Q

Non-SMALL CELL LUNG CARCINOMA (NSCLC) types and info

A

Largest group of lung malignancies

Adenocarcinoma
40% of lung cancers
Start in cells which would normally secrete mucus
Commonly seen in current/former smokers however also the most common lung cancer in non-smokers
More likely to affect younger people and women
Slow-growing – likely to be found before it has spread

Squamous Cell Carcinoma
25-30% of all lung cancers
Develops from cells that line the airways
Linked to history of smoking
Tend to be found in central parts of the lungs, near the bronchi

Large Cell Carcinoma
10-15% of lung cancers
Appear in any part of the lung
Grows and spreads quickly

48
Q

Small Cell Lung Cancer (SCLC) info

A

About 10-15% of all lung cancers

Very small cancer cells seen under microscope

Starts in the bronchi (central chest)

Grows and spreads quickly

Difficult to differentiate on imaging – histology provides diagnosis of SCLC

49
Q

Other Types of Lung Tumour?

A

Carcinoid tumours of the lung
Less than 5% of all lung tumours
Slow growing

Lymphomas and Sarcomas

Metastatic Cancers (Metastatic cancer is a cancer that has spread from the part of the body where it started (the primary site) to other parts of the body. When cancer cells break away from a tumor, they can travel to other parts of the body through the bloodstream or the lymph system)

50
Q

Other imaging for lung tumours

A

MRI
Allows assessment of location and size of tumour- Difficult due to movement of lungs
Metastatic spread

Needle lung biopsy
Can be CT or Ultrasound guided
Sample of tissue is taken from lungs for analysis
CT scanner or U/S probe used to guide the needle to the area where the biopsy should be taken
Usually takes 30-45 minutes
Can demonstrate any complications

51
Q

Apical Projection technique and why do it?

A

Indications – suspect apical lesion on PA

Patient erect, AP
Stands forward, leans back
30 degrees
Horizontal beam
Centre at sternal angle in the midline

Allows you to see the Pancoast area of lung, as clavicles are not in the way

52
Q

What is Pulmonary Contusion?

A

Bruising of the lung due to chest trauma
Haemorrhages in the alveoli

Can be associated with rib fractures and flail chest injuries
Low sats, cyanosis, dyspnoea, tachypnoea, tachycardia, wheezing, haemoptysis, hypotension
May see a contre-coup injury

53
Q

Pulmonary contusion CXR appearance

A

Areas of consolidation appear more dense on the image (whiter)

Not sensitive immediately after injury unless very severe injury

6 hours post injury average time taken to show on CXR

54
Q

What are the benefits and limitations of CXR?

A

BENEFITS
Quick
Readily available
Cheap compared to other modalities
Low dose of ionising radiation

LIMITATIONS
Almost ½ of the lungs can be obscured
Variations in technique affect image quality and diagnosis

55
Q

What is HIGH RESOLUTION CT (HRCT)?

A

Used in the assessment of generalised lung disease
Scan does not image the entire chest – nearer 10%
Offers a selection of images that are representative of the lungs in general
Narrow Beam Collimation
2 stages
1.5mm thick images taken at 10mm spacings on inspiration
1.5 mm thick images at 30 mm spacing on expiration
Improves appearance of vessels and bronchi
High spatial reconstruction algorithm
Edge enhancing
Makes structures sharper but increases noise

Small field of view
Maximum diameter of reconstructed image by minimising the size of each pixel
Increases spatial resolution

56
Q

What is RESPIRATORY GATING MRI?

A

RESPIRATORY GATING MRI is a technique used to measure when there is no movement in the chest cavity. The way we do this is with a sensory placed on the chest that will begin scanning on expiration and stop scanning as soon as inspiration occurs.

57
Q

What is RNI – VQ SCANNING used for?

A

Ventilation – Perfusion
Uses radioactive material to examine airflow (ventilation) and blood flow (perfusion) in the lungs

Used to identify blood clots in the lungs – diagnosis of Pulmonary Embolism

Perfusion scan alone can be used to rule out PE

58
Q

Information about Positron Emission Tomography (PET)?

A

Shows how the lungs and surrounding tissues are working in the presence of pathology

Used for;
Thoracic malignancy prior to surgery

Can also identify;
Infection
Inflammation

Low spatial resolution so best interpreted alongside either CT or MRI

High specificity and sensitivity for detecting size, shape and location of tumour

59
Q

Information about ARTERIOGRAPHY?

A

High sensitivity and specificity for detecting PE

Invasive and high risk procedure

Often undertaken in CT or MRI now as an alternative

Conventional Arteriography still undertaken for pulmonary arteriovenous malformations

60
Q

What is DIFFUSE INTERSTITIAL LUNG DISEASE?

A

A large number of disorders that are characterised by cellular infiltrates in a periacinar (around the alveoli) location.

Affects interstitium of the lung

On x-ray interstitial pattern – linear/reticular/nodular/reticulo-nodular

Number of causes – can be due to genes, inhaled irritants, idiopathic, radiation, infection, drugs

Most common is idiopathic pulmonary fibrosis
Lower zone, bilateral, peripheral predominance

61
Q

What is the interstitium (in reference to the lungs)?

A

The interstitium refers to the tissue area in and around the wall of the airsacs (alveoli) of the lung area where oxygen moves from the alveoli into the capillary network (small blood vessels) that covers the lung like a thin sheet of blood.

62
Q

Pulmonary oedema information?

A

Broad descriptive term and is usually defined as an abnormal accumulation of fluid in the extravascular compartments of the lung.
Cardiogenic cause = heart failure (congestive)
Non cardiogenic = smoke inhalation, ARDS, near drowning/aspiration, post operative, fluid overload
Chest x-ray = fluffy, homogenous, bilateral

63
Q

What does ARDS mean?

A

adult respiratory distress syndrome.

64
Q

What is Respiratory failure?

A

Respiratory failure = inadequate gas exchange
Can be acute or chronic
ARDS – acute respiratory distress syndrome

Appearances on chest x-ray – usually bilateral – homogenous opacification – widespread

Acute = high mortality – 50% those that survive have chronic lung disease

Treatment = depends on chronic/acute + underlying cause.
Oxygen therapy, ventilation (invasive/non-invasive), fluids (beware too much) lung transplant

65
Q

Cardiogenic Pulmonary Oedema CXR appearance

A

“Batwing” – peri hilar opacification
Pleural effusion
Kerley B/septal lines

Its dense around the heart

66
Q

Non-Cardiogenic Pulmonary Oedema CXR appearance

A

Diffuse
Bilateral
Widespread
Homogenous

Its dense all over the lungs, common cause could be drowning.

67
Q

What does CAP mean?

A

Community-acquired pneumonia

68
Q

What does HAP mean?

A

Hospital-acquired pneumonia

69
Q

Differences between HAP and CAP

A

Homogenous opacification, can be sharply defined at the fissures, air bronchograms Diffuse alveolar pattern (more homogenous opacification) widespread/bilateral)

70
Q

What is chronic lung disease?

A

Long term condition – irreversible
Many causes – strongly linked to COPD
Abnormal widening of the airways – up to 4 x size
Increased mucus production
Symptoms include a persistent productive cough and SOB
Can be exacerbated by chest infections
Abx and physiotherapy to treat – lung transplant
Difficult to appreciate on chest x-ray – CT is more sensitive
However “tramlines” or “donut sign” indicate bronchial wall thickening

CXR-lungs appear to be really long

71
Q

Lobar collapse + atelectasis of RUL

A

RUL
Increased density in the upper medial aspect of the right hemithorax
Elevation and/or superior bowing of the horizontal fissure loss of the normal right medial cardio-mediastinal contour
Elevation of the right hilum

72
Q

Lobar collapse + atelectasis of RML

A

RML
Right mid to lower zone air space opacification (which can be subtle)
The normal horizontal fissure is no longer visible (as it rotates inferiorly)
Obscuration of the right heart border
Increased opacity adjacent to the right heart border requires a degree of consolidation as well as atelectasis

73
Q

Lobar collapse + atelectasis of RLL

A

RLL
Triangular opacity at the right lower zone (usually medially) with the apex pointing towards the right hilum
Obscuration of the medial aspect of the dome of right hemi-diaphragm
Inferior displacement of the right hilum
preservation of a clear right heart border, which is contacted by the right middle lobe
inferior displacement of the horizontal fissure

74
Q

Lobar collapse + atelectasis of LUL

A

LUL
Hazy, vailing opacity (collapses anteriorly)
Fades out inferiorly, originates at left hilum
Parts of the aortic arch may be obscured
Left hilum displaced superiorly – horizontal left main bronchus, vertical left lower lobe bronchus

75
Q

Lobar collapse + atelectasis of LLL

A

LLL
triangular opacity in the posteromedial aspect of the left lung (retrocardiac sail sign)
left lower zone opacification (usually medially) with the apex pointing towards the left hilum
edge of the collapsed lung may create a ‘double cardiac contour’
inferior displacement of the left hilum
obscuration of the left hemidiaphragm
obscuration of the descending aorta
preservation of a clear left heart border, which is contacted by the lingular segments of the left upper lobe

76
Q

Benign calcifications- diffuse meaning

A

Widespread density over a larger area.

77
Q

Benign calcifications- central meaning

A

A central tight lesion will have a higher and more densely packed middle, and then a less dense outer rim.

78
Q

Benign calcifications- Laminated meaning

A

A laminated lesions will have layers to it. So some areas of high density in layered areas and some dont.

79
Q

Benign calcifications- popcorn meaning

A

Looks like a popcorn, it is bumpy almost

80
Q

What is mesothelioma?

A

Mesothelioma – tumour of the mesothelium (the tissue that surrounds the organs of the chest, pleura and pericardium)
Strong association with asbestos exposure (40-80% of patients have a history of exposure). More commonly affects men (traditional worked in roles where asbestos exposure was greater).
On x-ray pleural opacity that covers lung, reduced volume of the affected hemithorax, possible pleural effusions.
CT – pleural mass, inward infilltartion, chest wall/diaphragm involvement

81
Q

What is flail chest?

A

Three or more ribs are each broken in more than one place, causing a segment of bone to detach from the chest wall.
Paradoxical breathing – moves in when inspiration occurs and out on expiration
Requires urgent treatment
Usually accompanied by pulmonary contusion

82
Q

What is Bronchogenic cyst?

A

Congenital malformation of the bronchial tree
Usually present as a mediastinal mass
Can enlarge and cause compression
Usually asymptomatic
Do not communicate with bronchial tree – therefore can be…
Pulmonary
Mediastinal (most common)

Fluid filled, not air, which explains their appearance on x-ray (appear similar to a mass)

83
Q

What is Pulmonary sequestration?

A

Also called accessory lung
No communication with bronchial tree or pulmonary arteries
V rare – incidence 0.1%
Prone to infection
Usually surgically removed

Extralobar sequestration (ELS) more commonly presents in newborns as respiratory distress, cyanosis, or infection, whereas intralobar sequestration (ILS) presents in late childhood or adolescence with recurrent pulmonary infections.